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Interventions for preventing the progression of autosomal dominant polycystic kidney disease.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the leading inherited cause of kidney disease. Clinical management has h … death. There may be no difference in serious adverse events; however, treatment probably increases nocturia, fatigue and liver enzymes, may increase dry mouth and thirst, and may decrease hypertension and urinary and upper respiratory tract infections. Data on the impact of other therapeutic interventions were largely inconclusive. Compared to placebo, so …

[Electrolyte and acid-base balance disorders in advanced chronic kidney disease].

1. The kidneys are the key organs to maintain the balance of the different electrolytes in the body and the acid-base balance. Progressive l … vely approaches plasma osmolality and becomes isostenuric. This manifests clinically as symptoms of nocturia and polyuria, especially in tubulointerstitial kidney diseases. Water overload will result in hyponatremia and a decrease in water intake will lead to hypernatremia. Routine analyses of serum Na levels should be performed in all patients with advanc …

Palliative radiotherapy.

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… In patients experiencing these symptoms initially; haematuria improved in 88%; urinary frequency in 82%; nocturia in 64%, and dysuria in 72% of assessable patients at 3 months after treatment. … If diarrhoea severe (>6 bowel movements daily) or fails to improve within 12 hours, discuss with the treating oncology team | Recommendation based on regional guidelines and palliative prescribing as no randomised evidence identified 83 84 Bladder | Dysuria, frequency, and nocturia. …

Fanconi syndrome developing and worsening during anti-myeloma therapy in multiple myeloma: a case report and literature review.

BACKGROUND: Fanconi syndrome (FS) is a rare renal complication of monoclonal gammopathies including multiple myeloma (MM), typically diagnosed before or at the time of MM presentation. Onset and progression of FS during anti-myeloma treatment are extremely rare and easily misdiagnosed, resulting in delayed electrolyte correction and clinical deterioration. CASE PRESENTATION: We report a 55-year-old woman with κ light chain MM who developed FS during induction therapy and experienced recurrence after autologous stem cell transplantation (ASCT). Initial workup showed subclinical tubular dysfunc

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… Reference | Age (years) | Sex | Underlying disease | Type of monoclonal gammopathy | Time to presentation | Typical symptoms | Sequence of FS and MG onset | Treatments | Hematological response | Renal response | Follow-up ( 5 ) | 38 | Male | MM | NA | 3 years | Fatigue, nocturia | Simultaneous | Supplement … 14 | IgA-κ 3 IgG-κ 9 IgM-κ 2 K 15 IgG-λ 3 | Bone pain 15/32(47%) Fatigue 7/32(22%) Renal Insufficiency, Proteinuria, or Glycosuria 10/32(31%) | NA | NA | Chemotherapy 22/32 | NA | ESRD 5 ( 23 ) | 8 (complete FS 7/8) | 45.5 (23-68) | Male 3 Female 5 | MM 2 MCUS 6 | IgG-κ 2 K 5 IgA-λ 1 | Bone pain6/8 Nocturia …

Воздействие транскутановой стимуляции голени на мозговую функцию у пациентов с избыточным мочевым пузырем: перспективное продольное самоконтрольное исследование.

ЦЕЛЬ: Данное исследование было направлено на изучение деятельности мозга и функциональных изменений в связи с транскутановой стимуляцией берцового нерва (TTNS) у пациентов с нейрогеническим сверхактивным мочевым пузырем (OAB) наряду с изменениями клинических симптомов. МЕТОДЫ: Это перспективное продольное самоконтрольное испытание, проведенное в Китайском научно-исследовательском центре реабилитации с 2024 по 2025 год, охватывало 15 взрослых с определённым симптомами нейрогенного OAB, связанного с повреждением спинного мозга или множественным склерозом. Функциональная магнитно-резонансная съем

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… OAB was defined clinically by urinary urgency, usually accompanied by frequency and/or nocturia, with or without urgency urinary incontinence, after exclusion of urinary tract infection, urinary obstruction, and other relevant pathology. … A 3 day voiding diary indicated frequent daytime voids (15.53 ± 2.97 episodes/24 h), urgency incontinence (1.53 ± 1.51 episodes/24 h) and nocturia (4.87 ± 1.46 episodes/24 h). …

Grading Central Diabetes Insipidus Induced by Immune Checkpoint Inhibitors: A Challenging Task.

Central diabetes insipidus (CDI) is a rare endocrine disease deriving from an insufficient production or secretion of anti-diuretic hormone. Recently, CDI has been reported as a rare side effect triggered by immune checkpoint inhibitors (ICI) in cancer patients. Despite its current rarity, CDI triggered by ICI is expected to affect an increasing number of patients because of the expanding use of these effective drugs in a growing number of solid and hematologic malignancies. An appropriate assessment of the severity of adverse events induced by anticancer agents is crucial in their management,

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… Nocturia may be the main symptom in mild DI and the first clue to its diagnosis ( 2 , 44 ). … Moreover, other symptoms are reported among those that may worsen the “day and night” quality of life of patients affected by DI (e.g., thirst and the compelling need for quick water drinking, urinary frequency, nocturia, and the quality of sleeping, etc.). …

ДиметилФумарат Аттенуаты циклофосфамидозные повреждения мочевого пузыря и усиление цитотоксичной активности против клеток SH-SY5Y.

Острый кистит, вызванный циститом цилофосфамида (КХ), является изнурительной дисфункцией мочевого пузыря, которая, как правило, наблюдается у больных раком, главным образом в результате окислительных повреждений и воспаления тканей мочевого пузыря. Диметилфумарат (DMF) — эстер фумарной кислоты, утвержденный для лечения множественных склерозов в силу его антиоксидантов и противовоспалительных свойств. Таким образом, мы намеревались изучить многообразное воздействие ДМФ, включая как его потенциальное синергетическое воздействие с ХП на клетки SH-SY5Y, так и его незащищенное воздействие на острый

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… In general, patients experience suprapubic pain, increased urinary frequency, urinary retention, nocturia and hematuria. Due to the lack of effective treatment options, CP‐induced cystitis remains a significant clinical problem that negatively impacts the compliance of cancer patients [ 1 , 6 ]. …

Множественный склероз, инфекция мочевого тракта и бесплодие: всеобъемлющий обзор аналитического исследования.

Множественный склероз (MS) — аутоиммунное заболевание, связанное с центральной нервной системой. ПМС широко распространены среди взрослых молодых людей и постепенно уничтожают аксоны и миелин. Лица, страдающие НР, часто сталкиваются с такими осложнениями, как дефункция мочевого тракта, инфекция мочевого тракта и сексуальная дисфункция. У молодых людей РС может вызывать сексуальную дисфункцию и бесплодие, которое ухудшается по мере развития болезни. Были рассмотрены имеющиеся данные из различных исследований (микробиологические и клинические исследования, полученные из баз данных PubMed и Scopu

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… The most frequent symptoms indicative of lower urinary tract dysfunction in MS are polyuria, urinary retention, urinary urgency, nocturia, and incontinence ( 34 , 35 ). … The most common symptoms of UTI in MS patients are urine retention, nocturia, urinary urgency, polyuria, and incontinence. Moreover, UTI in these patients can complicate the disease, cause additional damage, and even lead to severe neurological deterioration. …

Laparoscopic pelvic autonomic nerve-preserving surgery for patients with lower rectal cancer after chemoradiation therapy.

OBJECTIVE: This is a phase II study, the aim of which is to determine if a laparoscopic approach can be used in pelvic autonomic nerve-prese … core were used: incomplete emptying, frequency, intermittency, urgency, week stream, straining, and nocturia. Any voiding problems recovered within 3 months after the operation were considered to be transient bladder voiding dysfunction; all other voiding problems were deemed persistent. The interview and scoring of the questionnaire were done by the resea …

Women suffering from overactive bladder syndrome exhibit a higher urethral viral abundance compared to healthy controls: a pilot study.

The interactions between the human bacterial microbiome and essential bodily functions are well established for organ systems such as the oral cavity, gut, and female reproductive tract. However, the urinary microbiome, particularly its viral component, remains largely unexplored. Emerging evidence suggests that the urinary microbiome may play a significant role in the development of overactive bladder syndrome (OAB). This study aims to fill this knowledge gap by investigating the potential link between the urethral virome and female overactive bladder syndrome, and by aligning these findings

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… Overactive bladder syndrome (OAB) is characterized by urinary urgency, frequent toileting, nocturia and with or without urinary incontinence 3 . … Controls ( n = 5) Median (IQR) | | | Age (years) | 61 (56–70) | 63 (56–72) | 60 (56–61) BMI (kg/m 2 ) | 27.49 (25–29) | 28.28 (26–30) | 21.36 (21–27) Vaginal deliveries (n) | 1 (0–2) | 1 (0–2) | 0 (0–0) POP-Q stage (1–3) | 2 (2–2) | 2 (2–2) | NA Diuria (n) | 7.75 (4–10) | 9.5 (4–11) | 3.5 (4–8) Nocturia …

Spinal cord infarction attributed to SARS-CoV-2, with post-acute sequelae of COVID-19: A case report.

BACKGROUND: While stroke and lower extremity venous thromboemboli have been commonly reported following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spinal cord infarction or ischemia has been extremely rare. Findings of long coronavirus disease (COVID) in this select population have not been studied. CASE SUMMARY: We present the case of a 70-year-old female with sudden onset of trunk and lower extremity sensorimotor loss due to spinal cord infarction, attributed to acute infection with SARS-CoV-2. Diagnostic work up confirmed a T3 complete (ASIA impairme

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… Their group has also linked COVID-19 inflammation to an increase in urine cytokines and to bladder hyperreflexia, nocturia, and urge incontinence[ 27 ]. In a person with SCI, such factors could certainly contribute to frequent urinary tract infections. …

Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.

Fibromyalgia (FM) is a chronic non-inflammatory disorder mainly characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and a constellation of other symptoms. For this reason, delineating a clear distinction between pure FM and FM-like picture attributable to other common diseases can be extremely challenging. Physicians must identify the most significant confounders in individual patients and implement an appropriate diagnostic workflow, carefully choosing a minimal (but sufficient) set of tests to be used for identifying the most plausible diseases in the specific case

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… conduction studies; skin biopsy (small fiber neuropathy) Obstructive sleep apnea | Obesity, heart failure, acromegaly, hypothyroidism, smoking, craniofacial abnormalities | Daytime sleepiness, fatigue, non-refreshing sleep, snoring, paroxysmal nocturnal dyspnea, decreased concentration and memory, headache, nocturia … Typical symptoms of OSA are sleep problems, such as restless and non-refreshing sleep, snoring, awakening with paroxysmal nocturnal dyspnea, and sleep fragmentation; moreover, patients refer excessive daytime sleepiness with decreased concentration and memory, morning headaches, and sometimes nocturia …

Dynamics of Patient-Based Benefit-Risk Assessment of Medicines in Chronic Diseases: A Systematic Review.

BackgroundA critical gap exits in understanding the dynamics of patient-based benefit-risk assessment (BRA) of medicines in chronic diseases during the disease journey.PurposeTo systematically review and synthesize current evidence on the changes of patients' preferences about the benefits and risks of medicines during their disease journey including the influence of disease duration and severity, and previous treatment experience.MethodsA systematic review of studies identified in PubMed and Embase, from inception to November 2020, was conducted in accordance with the PRISMA (Preferred Report

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… Athavale et al 2018 43 The United States Discrete choice experiment Recruitment from an independent respondent panel 514 Treatment-naïve overactive bladder Respondents with nocturia put higher relative importance for treatments that reduced nocturia Brooks et al 2019 44 Japan Discrete choice experiment … Athavale et al 2018 43 | The United States | Discrete choice experiment Recruitment from an independent respondent panel | 514 | Treatment-naïve overactive bladder | Respondents with nocturia put higher relative importance for treatments that reduced nocturia Brooks et al 2019 44 | Japan | Discrete choice …

Проблемы с диагностикой и оказанием неотложной медицинской помощи в случае быстро прогрессирующего заболевания лёгких, вторичного и многократного заболевания миеломой.

Одновременное представление множественной миеломы (ММ) и межститиальной болезни легких (МЛ) остается исключительно редким, при этом ограниченная литература описывает оптимальные стратегии управления для этой двойной патологии. Мы сообщаем о сложном случае 62-year-old Мужчина с недавно поставленным диагнозом MM с цитогенетикой промежуточного риска (del13q, набирающий 1q), который одновременно представил быстро прогрессирующий ILD, демонстрирующий обычную интерститальную пневмонию (МСАГВ). Пациентка 6-month Клинический курс был отмечен участием многих организаций, периодическими инфекциями, тром

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… Case presentation A 62-year-old male, controlled hypertensive, presented to the medicine outpatient with lower urinary tract symptoms (dysuria, increased urinary frequency, nocturia) and nocturnal cough. He had a long-standing history of bilateral ankle pain (8 years’ duration). …

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.

Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research

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… Productivity, vitality and utility in a group of healthy professionally active individuals with nocturia. BJU Int. 2003;91:190–195. doi: 10.1046/j.1464-410X.2003.04062.x. 9. Cakir O.O., McVary K.T. LUTS and sleep disorders: Emerging risk factor. Curr. Urol. … The effect of nocturia on sleep. Sleep Med. Rev. 2011;15:91–97. doi: 10.1016/j.smrv.2010.03.002. 11. Johnson T.V., Abbasi A., Ehrlich S.S., Kleris R.S., Owen-Smith A., Raison C.L., Master V.A. …

Анализ начала симптомов более низкого мочевого тракта у нескольких больных склерозом.

ЦЕЛЬ: Оценка временны́х интервалов начала симптомов нижних мочевых путей (LUTS) в ходе множественного склероза (MS), определение того, какие из этих симптомов обычно появляются первыми, и определение факторов риска для раннего развития LUTS у пациентов с MS (PwMS). МЕТОДЫ: Это исследование, проведенное в порядке наблюдения, включало 1167 Фумс. Среди участников были преимущественно женщины (см.72%), средний возраст 45 (КВП) 36;53) лет и средняя продолжительность болезни 11 (КВП) 6;16) годы. Критерием включения является возраст старше 18 Годы, подтвержденный диагноз MS в соответствии с критериям

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… developed LUTS prior to the time of data collection ( n  = 709) Absolute frequency Relative frequency %(95%CI) Storage symptoms 549 77 (74; 80)  Urgency 360 51 (47; 55)  Frequency 76 11 (8.5; 13)  Urgency urinary incontinence 67 9.4 (7.4; 12)  Stress urinary incontinence 26 3.7 (2.4; 5.3)  Nocturia …

Symptomatic Hypoalbuminemia as an Indication for Treatment of Waldenström Macroglobulinemia: A Case Report and Review of the Literature.

Hypoalbuminemia has been reported as common in patients with symptomatic Waldenström macroglobulinemia (WM), but it is not typically mentioned as a manifestation of the disease in review articles or articles discussing indications for treatment. We present the case of a patient with WM for whom symptomatic hypoalbuminemia was the primary reason for initiating treatment. Except in rare cases of WM with renal or gastrointestinal involvement, hypoalbuminemia is thought to be due to the effects of elevated levels of inflammation-associated cytokines, and it has been associated with greater likelih

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… However, over the next six months despite stabilization of his anemia, he began to develop increasing lower extremity edema, nocturia, and more frequent and severe myalgias. All these symptoms significantly worsened in the month prior to initiating chemotherapy. …

Частота и факторы риска возникновения проблем со сном у египетских пациентов с множественным склерозом.

КОЛИЧЕСТВО: Проблемы со сном затрагивают более 65% пациентов с множественным склерозом (МС), что значительно выше, чем в целом по населению. Цель этого исследования заключалась в оценке частотности и связанных с риском факторов проблем со сном в большой группе MS и в оценке их воздействия на качество жизни (QoL). В исследовании приняли участие 103 участника, в том числе MS на различных этапах заболевания и 62 специалиста по контролю за состоянием здоровья. Инструменты оценки включали в себя Расширенную шкалу взносов для инвалидов (EDSS), Индекс качества сна Питтсбурга (PSQI), шкалу показателей

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… Furthermore, various MS-associated symptoms, including muscular spasms, nocturia, and fatigue, were identified as primary contributors to sleep disturbance in MS ( 6 ). …

'Unpacking' pathways to lymphoma and myeloma diagnosis: Do experiences align with the Model of Pathways to Treatment? Findings from a UK qualitative study with patients and relatives.

ObjectivesTo explore alignment of experiences before lymphoma and myeloma diagnosis with the appraisal, help seeking and diagnostic intervals in the Model of Pathways to Treatment (MPT).DesignA qualitative study using in-depth semistructured interviews with patients and relatives. Interviews were transcribed verbatim, anonymised and analysed using qualitative description.SettingA UK population-based haematological malignancy patient cohort.ParticipantsFifty-five patients (35 lymphoma, 20 myeloma: diagnosed 2014-2016) and 28 relatives participated, within around a year of the patient's diagnosi

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… Interestingly, some patients reported symptoms that were present before and after diagnosis (eg, nocturia: L24). …

Treating Lows: Management of Orthostatic Hypotension.

AbstractOrthostatic hypotension is a prevalent clinical condition, caused by heterogenous etiologies and associated with significant morbidity and mortality. Management is particularly challenging in patients with uncontrolled hypertension. A thorough assessment is needed to draw an appropriate management plan. The treatment aims to improve postural symptoms while minimizing side effects and reducing iatrogenic exacerbation of supine hypertension. A personalized management plan including rationalizing medications, patient education, identification, and avoidance of triggers, as well as nonphar

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… This diurnal variation is because of a reversed pattern of natriuresis, usually associated with a reversed BP diurnal variation, resulting in significant nocturia, and reduced intravascular volume at night, the effects of which are seen when the patient wakes up in the morning. 27 In patients with non-nOH … Likewise, a bedtime snack may be preferable in patients with co-existent SH because BP could lower as a response to eating, unless the patient has significant symptomatic nocturia and tends to stand up frequently at night in which case, it is imaginably detrimental. …