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Single-use instrumentation in posterior lumbar fusion could decrease incidence of surgical site infection: a prospective bi-centric study.

PURPOSE: Single-use surgical instruments were recently introduced to improve OR efficiency and reduce infection risks. This study aimed to investigate clinical results 1 year after instrumented lumbar fusion, with the aid of single-use surgical instruments, with particular attention to surgical site infection and Oswestry Disability Index (ODI). METHOD: This prospective bi-centric study included 21 men and 28 women, aged 61.6 ± 12.8 years, that underwent short instrumented lumbar fusion for degenerative disc disease, canal stenosis, or degenerative spondylolisthesis. All patients underwent po

[Prostatic secretion microbiota: a comparative analysis of the hronical prostatitis II and IIIA category].

BACKGROUND: Chronic bacterial prostatitis (CBP) and chronic prostatitis/chronic pelvic pain syndrome IIIa (CP/CPPS IIIa) are separate nosolo … (CBP) discovered some representatives of the non-clostridial anaerobic flora (NAB: Peptococcus sp., Propionibacterium spp. and others), coagulase-negative staphylococci (CNS: S.haemolyticus, S.warneri) and certain taxa of gram-positive microorganisms (Corynebacterium spp. and Str. agalacticae). In turn, when analyzing the PS contamination, it was found that integra …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… Propionibacterium spp. Acinetobacter spp. A. baumanii Yeasts Pityrosporum spp. Candida spp. … Propionibacterium spp. P. acne Gram-positive facultatively Enterococcus spp. E. faecalis , E. faecium Anaerobic cocci Staphylococcus spp. S . epidermidis Streptococcus spp. S. milleri , S. mitis , S. oralis , S. bovis Gram-positive anaerobic cocci Peptococcus s pp. Peptostreptococcus spp. …

Purulent pericarditis: report of 2 cases and review of the literature.

Purulent pericarditis, a localized infection within the pericardial space, has become a rare entity in the modern antibiotic era. Although historically a disease of children and young adults, this is no longer the case: the median age at the time of diagnosis has increased by nearly 30 years over the past 6 decades. Despite advances in diagnostic and treatment modalities, purulent pericarditis remains a life-threatening illness. Unfortunately, the diagnosis is made postmortem in more than half the cases. Thus, a high index of clinical suspicion is crucial. We present 2 cases of purulent perica

Shotgun metagenome sequencing identification of a set of genes encoded by Actinomyces associated with medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is intractable and severely affects a patient's quality of life. Although many cases of MRONJ have been reported in the past decade, the disease pathophysiology is unclear and there are no evidence-based therapeutic strategies. MRONJ usually features bone inflammation and infection. Prior studies that explored the association between MRONJ and microbial infection used the culture-based approach, which is not applicable to hundreds of unculturable taxa in the human oral microbiome, or 16S ribosomal RNA gene sequencing, which does not provide q

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… E-values of the BLASTn searches as well as abundance of each genus in oral microbiota of each sample calculated from the taxonomic profiling are shown in S3 Table . gcpE was detected only in Actinomyces and Schaalia , and dps only in Actinomyces and Propionibacterium . … Compared to Actinomyces with on average 5.3% abundance across the 5 healthy control samples, Schaalia and Propionibacterium were not usual members of human oral microbiome because their abundances were always zero or < 0.5% ( S3 Table ). …

Pathogenetic Mechanisms Linking Sarcoidosis to Lymphoma.

Sarcoidosis and lymphoma share immunopathological characteristics that suggest a complex, interconnected relationship. This article examines the multi-faceted mechanisms linking sarcoidosis to lymphoma, a phenomenon called sarcoidosis-lymphoma syndrome (SLS). SLS is hard to diagnose, requiring distinct criteria and imaging to differentiate overlapping features and histological differences. The co-occurrence of these diseases may be explained by genetic predispositions, immune dysregulation, and environmental factors that enhance malignancy risk. In active sarcoidosis, chronic inflammation and

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… Bacteria (e.g., Borrelia [ 69 ], Propionibacterium acnes [ 69 , 75 , 76 ]) and fungi [ 69 , 75 ] are the other organisms that have been associated with sarcoidosis. Propionibacterium acnes, a skin commensal bacterium, is the only documented micro-organism cultured from sarcoid tissues. … Propionibacterium acnes antibodies have been rarely reported in patients with sarcoidosis and lymphoma, specifically MALT lymphoma [ 78 ], while sporadic reports have correlated tuberculosis infection to lymphoma [ 79 , 80 ]. …

Bacterial Involvement in Progression and Metastasis of Adenocarcinoma of the Stomach.

Gastric cancer metastasis is a process in which the tumor microenvironment may carry significant influence. Helicobacter pylori (H. pylori) infection is well-established as a contributor to gastric carcinoma. However, the role that these bacteria and others may play in gastric carcinoma metastasis is a current focus of study. A review of the literature was conducted to elucidate the process by which gastric adenocarcinoma metastasizes, including its ability to utilize both the lymphatic system and the venous system to disseminate. Studies that investigate the tumor microenvironment at both the

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… Bik et al. showed an overabundance of Propionibacterium acnes , Streptococcus anginosus , and Prevotella melaninogenica in the gastric tumoral microenvironment, which are associated with gastric cancer tumorigenesis through their specific mechanisms that increase local inflammation [ 118 ]. … Propionibacterium Acnes Overabundance and Natural Killer Group 2 Member D System Activation in Corpus-dominant Lymphocytic Gastritis. J. Pathol. 2016;240:425–436. doi: 10.1002/path.4782. 120. Coker O.O., Dai Z., Nie Y., Zhao G., Cao L., Nakatsu G., Wu W.K., Wong S.H., Chen Z., Sung J.J.Y., et al. …

Informed appropriate imaging for low back pain management: A narrative review.

Most patients with acute low back pain (LBP), with or without radiculopathy, have substantial improvements in pain and function in the first 4 weeks, and they do not require routine imaging. Imaging is considered in those patients who have had up to 6 weeks of medical management and physical therapy that resulted in little or no improvement in their LBP. It is also considered for those patients presenting with suspicion for serious underlying conditions, such as cauda equina syndrome, malignancy, fracture and infection. In western country primary care settings, the prevalence has been suggeste

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… Dudli et al reported that a low-grade infection by Propionibacterium acnes might promote the development of Modic changes [83] . … Propionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with Modic changes. J Orthop Res. 2016;34:1427–1455. doi: 10.1002/jor.23265. 84. Albert H.B., Sorensen J.S., Christensen B.S., Manniche C. …

Antifibrotic therapy for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia.

BACKGROUND: Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) are a ubiquitous condition estimated to affect over 50% of men over the age of 50 years. Various treatment options exist for men presenting with LUTS/BPH, including lifestyle and behavioral modification and medical or surgical treatment. Although multiple medical treatments exist, innovation for the medical treatment of BPH has not significantly progressed. METHODS: A comprehensive narrative review was performed to evaluate prostate fibrosis as a contributor to LUTS/BPH and to identify potential anti

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… Infiltrating Treg and Th17 cells of the prostate hypertrophy gland associated with Propionibacterium Acnes Infection . Res Rep Urol . 2020 ; 12 : 593 – 7 . 33299822 10.2147/RRU.S284066 PMC7721300 75. Radej S , Szewc M , Maciejewski R . … Prostate infiltration by Treg and Th17 cells as an immune response to propionibacterium acnes infection in the course of benign prostatic hyperplasia and prostate cancer . Int J Mol Sci . 2022 ; 23 . 10.3390/ijms23168849 PMC9408129 36012113 76. …

Derivation and validation of a scoring system to identify patients with bacteremia and hematological malignancies at higher risk for mortality.

BackgroundThe aim of this study was to develop and validate a reliable clinical prediction rule that could be employed to identify patients at higher likelihood of mortality among those with hematological malignancies (HMs) and bacterial bloodstream infections (BBSIs).Methods and findingsWe conducted a retrospective cohort study in nine Italian hematological units. The derivation cohort consisted of adult patients with BBSI and HMs admitted to the Catholic University Hospital (Rome) between January 2002 and December 2008. Survivors and nonsurvivors were compared to identify predictors of 30-da

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… A BBSI was defined as an infection manifested by (I) the presence in at least 1 blood culture of bacteria other than skin contaminants (i.e., diphtheroids, Bacillus spp., Propionibacterium spp., CoNS, micrococci) or (II) the presence of any bacterial species in at least 2 consecutive blood cultures in …

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects.

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest develo

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… Moreover, curcumin-mediated aPDT has shown efficacy against various pathogens, including Escherichia coli ( E. coli , inactivated up to 3 log CFU/mL), Listeria innocua ( L. innocua , inactivated more than 5 log CFU/mL) in food systems ( 38 ), Propionibacterium acnes ( P. acnes , inhibition ratio was … Low-dose blue light irradiation enhances the antimicrobial activities of curcumin against Propionibacterium acnes. J Photochem Photobiology. B Biol (2018) 189:21–8. doi: 10.1016/j.jphotobiol.2018.09.021 40. Lee H-J, Kang S-M, Jeong S-H, Chung K-H, Kim B-I. …

The Link Between the Gut Microbiome and Bone Metastasis.

The gut microbiome is essential for regulating host metabolism, defending against pathogens, and shaping the host's immune system. Mounting evidence highlights that disruption in gut microbial communities significantly impacts cancer development and treatment. Moreover, tumor-associated microbiota, along with its metabolites and toxins, may contribute to cancer progression by promoting epithelial-to-mesenchymal transition, angiogenesis, and metastatic spread to distant organs. Bones, in particular, are common sites for metastasis due to a rich supply of growth and neovascularization factors an

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… Propionibacterium -related production of propionate and acetate had a protective effect via suppressed colon cancer cell proliferation and induced cancer cell death [ 66 ]. … Colorectal Cancer Cells Increase the Production of Short Chain Fatty Acids by Propionibacterium freudenreichii Impacting on Cancer Cells Survival. Front. Nutr. 2018;5:44. doi: 10.3389/fnut.2018.00044. 67. …

Целые пищевые рационы на основе растений являются практически осуществимыми при автоматическом воздействии на организм человека и связаны с модификацией микробиома в зависимости от дозы.

Целые пищевые рационы, основанные на кратком планете, могут представлять собой целенаправленный подход к смягчению последствий нарушения микробиома и улучшению последствий для пациентов, проходящих аутологическую трансплантацию гематопоиетических клеток (auto-HCT) в случае множественной миеломы, в которой кишечный дисбиоз связан с более низким уровнем выживаемости. Мы провели одностороннее клиническое испытание в нашем центре, в ходе которого участники прошли автоHCT (n = 22) получили свежее, заранее подготовленное, растительное питание 5 Недели, охватывающие кондиционирование, нейтрализацию и

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… ICM47 (GCF_000278725) Other anaerobe 22+ +6.3 .035 Increased Lachnospiraceae sp900757145 SCFA producer 7-21 +5.6 .037 Increased Nanosynbacter (genus) Other 22+ +3.5 .030 Increased C andidatus Paralachnospira caecorum SCFA producer 7-21 +3.3 .036 Decreased Propionibacterium acidifaciens Other anaerobe … ICM47 (GCF_000278725) | Other anaerobe | 22+ | +6.3 | .035 | Increased Lachnospiraceae sp900757145 | SCFA producer | 7-21 | +5.6 | .037 | Increased Nanosynbacter (genus) | Other | 22+ | +3.5 | .030 | Increased C andidatus Paralachnospira caecorum | SCFA producer | 7-21 | +3.3 | .036 | Decreased Propionibacterium …

Кишечная флора связана с риском возникновения хронических неинфекционных заболеваний.

КИСЛОТА: Кишечная флора (IF) связана с риском неинфекционных заболеваний, особенно различных видов рака, инсульта и болезни Альцгеймера. Однако на различных этапах роста, развития и старения все еще существует много неопределенностей в отношении этих ассоциаций. Поэтому необходимы дальнейшие углубленные исследования. AIM: Изучение связей человека с риском заболевания на различных этапах роста, развития и старения в целях получения более точных и убедительных выводов.МЕТОДЫ: Коорт, кросс-секции, контроль за конкретными случаями и исследования по случайной менделии, опубликованные в базах данных

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… In addition, lymphocytic gastritis caused by Propionibacterium acnes may enhance the development of gastric cancer by increased production of pro-inflammatory cytokines, such as interleukin (IL)-15[ 24 ]. …

Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study.

BackgroundWe aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk of central line associated bloodstream infections (CLABSI) in haematology patients.MethodsMulticentre retrospective cohort study among haematology patients receiving PICCs between 2013 and 2015. Occurrence of CLABSI based on CDC definitions was assessed. We calculated incidence rates, determined risk factors for CLABSI and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time. We compared diagnoses and treatment character

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… Table 2 Cultured pathogens in CLABSI *In 14 episodes, blood cultures showed 2 different pathogens ** Chrysobacterium indologenes, Citrobacter freundii, Enterococcus casselflavius, Fusarium dimerum, Gemella haemolysans, Micrococcus spp., Mycobacterium chelonae, Neisseria subflava, Ochrobactrum anthropi, Propionibacterium …

Combination strategies of gut microbiota in cancer therapy through metabolic reprogramming and immune remodeling.

Over the past decade, there has been a qualitative improvement in the understanding of gut microbiota in cancer development and treatment. Gut microbiota regulates metabolic reprogramming that occurs in the competition between tumor cells and immune cells for essential nutrients in the tumor microenvironment (TME). Besides, gut microbiota dysbiosis is one of the key factors leading to the formation of aging environment, which has many similarities with the TME. Accumulating research findings have demonstrated that gut microbiota enhances the efficacy of cancer therapies by activating the immun

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… Accumulation of lactate stimulates Propionibacterium freudenreichii to produce acetic acid which could further modulate the metabolic reprogramming of cancer cells [ 24 ]. Bacteria with the ldh, mgsA, and lldD genes have been correlated with the facilitation of lactate production[ 25 ]. …

Feline infectious peritonitis.

The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this disease in the last years, there are still many unanswered questions. The objective of this article is to review recent knowledge and to increase understanding of the complex pathogenesis of FIP.

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… Some veterinarians prescribe immune modulators (eg, Propionibacterium acnes , acemannan) to treat cats with FIP, with no documented controlled evidence of efficacy. Immune modulators and IFN inducers are widely used and induce synthesis of IFNs and other cytokines. …

Evaluation of bloodstream infections in febrile neutropenic patients with hematological malignancy: a retrospective cohort study.

BACKGROUND: Patients with hematological malignancies (HMs) are at high risk of bloodstream infections (BSIs) during episodes of febrile neutropenia (FN). However, empirical treatment initiated before isolation of the causative agent from blood cultures is crucial. The aim of this study was to determine the distribution and antimicrobial resistance profile of microorganisms isolated from BSIs in patients with HMs, and to evaluate the association with the need for intensive care unit (ICU) and mortality at 30 days. METHODS: Single-centre data from patients with HMs who were admitted to the hema

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… Second, isolation of skin flora (e.g., diphtheroids, Bacillus spp., Propionibacterium spp., coagulase-negative staphylococci (CoNS), and micrococci) from two or more consecutive blood cultures with clinical evidence of infection. …

Ferret coronavirus-associated diseases.

A novel coronavirus of ferrets was first described in 1993. This coronavirus caused an enteric disease called epizootic catarrhal enteritis (ECE). Recently, a ferret systemic coronavirus (FRSCV)-associated disease was discovered. This new systemic disease resembles the dry form of feline infectious peritonitis (FIP) and has been reported in the United States and Europe. This article addresses the clinical signs, pathology, pathogenesis, diagnosis, treatment, and prevention of this ferret FIP-like disease.

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… Effect of interferon or Propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random-source cats Am J Vet Res 51 5 1990 726 733 2159739 30 Ishida T. Shibanai A. Tanaka S. …

Sarcoidosis and autoimmunity: In the depth of a complex relationship.

Sarcoidosis is a chronic granulomatous disease that can virtually affect any organ. Its etiology is unknown, although it has been proposed that environmental or biological agents can act as triggers, ultimately leading to chronic inflammation in genetically predisposed individuals. The main component of sarcoid inflammation is represented by an exaggerated T- lymphocytic cellular response to a putative antigen that could not be efficiently cleared in the patient. However, several clinical and immunological observations, such as the association of sarcoidosis to autoimmune diseases or the prese

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… disease of unclear etiology: it has been postulated that an exaggerated immunological response in the disease is triggered in genetically predisposed individuals by the exposure to hypothesized antigens: infectious agents such as Mycobacterium tuberculosis , atypical mycobacteria, mycoplasma species and Propionibacterium …