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The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke.

Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality … bolic processes. Although numerous studies have explored the relationship between IS and intestinal microbiota, comprehensive analyses of specific microbiota is relatively scarce. Therefore, this paper provides an overview of the typical changes in gut microbiota following IS and investigates the role of specific microorganisms in this context. Additionally, …

Characterization of intestinal microbiota in patients with psoriasis combined with metabolic syndrome.

The co-morbidity of psoriasis (PsO) and metabolic syndrome (MetS) is prevalent. While the mechanisms causing PsO in MetS remain unknown, it is understood that gut microbiota plays a critical role in maintaining immune and metabolic balance. However, the specific mechanisms and whether biomarkers are involved in the pathophysiological process of PSO in MetS patients have yet to be elucidated. This study involved 29 patients with PSO and MetS (PM) and 29 with MetS (M). It analyzed their clinical parameters, microbial composition, function, diagnostic, and predictive performance. The results unve…

Paeoniflorin improves atherosclerosis by regulating the gut microbiota and fecal metabolites.

Atherosclerosis (AS) is a chronic inflammatory disease and a key factor in cardiovascular disease. Paeoniflorin (PF), a monomer component ex … ic effect may be related to improvements in intestinal metabolic disorders and altered abundance of microbiota.IMPORTANCEAtherosclerosis (AS) is a chronic progressive disease mainly characterized by vascular endothelial cell damage, inflammation, and lipid deposition. Inflammatory and immune-related mechanisms play a key role in the occurrence and developmen …

Vertical transmission of mosquito microbiota and its effects on offspring development.

BACKGROUND: The mosquito's gut microbiota plays a crucial role in determining its capacity to transmit harmful viruses and parasites. Accordingly, manipulating mosquito gut microbiota is a promising avenue towards reducing mosquito-borne human pathogen transmission. A successful microbial control campaign will require a thorough understanding of how bacteria are transmitted through mosquito populations. Through two parallel but complementary studies using the yellow fever mosquito Aedes aegypti as a focal host species, we surveyed vertical transmission of bacteria from individual mothers to co…

The gut microbiota during tamoxifen therapy in patients with breast cancer.

Tamoxifen is essential in treating estrogen receptor-positive (ER+) breast cancer, primarily through its active metabolite, endoxifen. Emerging research suggests potential interactions between tamoxifen and gut microbiota. This study investigates the effects of tamoxifen on gut microbiota composition in postmenopausal ER+ and human epidermal growth factor receptor 2 negative (HER2-) breast cancer patients and explores correlations between gut microbiota and endoxifen plasma levels. This prospective observational study included postmenopausal ER+/HER2- breast cancer patients. Fecal and blood sa…

Awareness of the Vaginal Microbiome and Willingness to Undergo Vaginal Microbiota Transplant.

OBJECTIVE: To examine awareness of the vaginal microbiome and vaginal microbiota transplant, willingness to undergo vaginal microbiota transplant, and factors that influence the decision to undergo the procedure. DESIGN: Cross-sectional descriptive survey study. SETTING: Online distribution from October 2024 to January 2025. PARTICIPANTS: Respondents (N = 210) who self-identified as women (n = 198), men (n = 2), gender nonconforming (n = 14), transgender (n = 3), other (n = 2), and not specified (n = 2) and had vaginas. METHODS: The survey included questions about patient demographics, gyn…

Antibacterial Siderophores of Pandoraea Pathogens and Their Impact on the Diseased Lung Microbiota.

Antibiotic-resistant bacteria of the genus Pandoraea, frequently acquired from the environment, are an emerging cause of opportunistic respi … st insight into niche factors of Pandoraea and indicate that pandorabactins shape the diseased lung microbiota through the competition for iron.

Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review.

Cryptosporidiosis is a zoonotic protozoan parasite-born disease, equally significant in both animals and humans, especially affecting immuno … g bacteria, e.g., Firmicutes. Recent investigations have highlighted the interrelations between gut microbiota and epithelial barrier integrity, especially during cryptosporidiosis, demonstrating the modulations regarding tight junctions (TJs), immune reactions, and SCFA production, all of which are main players in alleviating this protozoal parasitic infect …

Обнаружить важную роль гута микробиота и диета в многоразовом склерозе.

Множественный склероз (MS) — хроническое воспалительное заболевание центральной нервной системы (CNS), характеризующееся нейродегенерацией, повреждением аксона, обезвоживанием и воспалением. В последнее время кишечный дисбиоз связан с MS и другими аутоиммунными условиями. А именно, кишечная микробиота играет жизненно важную роль в регулировании иммунной функции, оказывая влияние на развитие иммунных клеток, производство цитокина и целостность кишечника. В то время как сбалансированная микробиота способствует иммунной терпимости, дисбиоз нарушает иммунное регулирование, наносит ущерб проницаемо

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), characterized by neurodegeneration, axonal damage, demyelination, and inflammation. Recently, gut dysbiosis has been linked to MS and other autoimmune conditions. Namely, gut microbiota has a vital role in regulating immune function by influencing immune cell devel…

Микробиота гута и метаболиты связаны с развитием болезней в множестве склерозов.

Прогрессивный множественный склероз (MS) — неврологическое заболевание с ограниченным пониманием биологии, связанной с переходом от повторного заболевания к прогрессивному. Кишечные микробы и метаболиты изменяются в MS, но отношение к прогрессии заболеваний в значительной степени неизвестно. Мы исследуем микробиоту и метаболиты в субъектах с стабильными MS, у тех, кто ухудшился, и у тех, у кого вновь появились MS, которые стали прогрессивными. 2 Годы. Мы считаем, что эубактериум-халлий, бутириккацеа, блаутия и другие короткоцепные микробы, производящие жирные кислоты, имеют благоприятные связи

Совпадение в аннотации оригинала
Progressive multiple sclerosis (MS) is a neurological disease with limited understanding of the biology associated with transition from relapsing to progressive disease. Intestinal microbes and metabolites are altered in MS, but relation to disease progression is largely unknown. We investigate microbiota and metabolites in subjects with stable MS, those who…

Comparison of Intestinal Microbiota of Blue Fox before and after Weaning.

Intestinal flora plays an important role in maintaining the internal stability and health of the intestine. Currently, intestinal microbes are considered an important "organ" but are mostly ignored by people. This study evaluated the flora structure of each intestinal segment of blue foxes pre-weaning and explored the differences between the fecal flora and intestinal flora structure of each segment after weaning. Samples of intestinal contents from three blue foxes at 45 days of age (before weaning) and intestinal contents and feces samples from at 80 days (after weaning) were collected for 1

Hypoglycemic and intestinal microbiota-regulating effects of melanoidins in diabetic mice.

BACKGROUND: The aqueous extraction of sesame oil is a traditional process that generates a large amount of melanoidins. However, little is k … can regulate T2DM by activating the IRS-1/PI3K/Akt and AMPK-signaling pathways and ameliorating gut microbiota imbalances in T2DM mice. © 2024 Society of Chemical Industry.

The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut.

Chronic stress disrupts microbiota-gut-brain axis function and is associated with altered tryptophan metabolism, impaired gut barrier function, and disrupted diurnal rhythms. However, little is known about the effects of acute stress on the gut and how it is influenced by diurnal physiology. Here, we used germ-free and antibiotic-depleted mice to understand how microbiota-dependent oscillations in tryptophan metabolism would alter gut barrier function at baseline and in response to an acute stressor. Cecal metabolomics identified tryptophan metabolism as most responsive to a 15-min acute stres…

Diet and Microbiota Modulation for Chronic Pouchitis: Evidence, Challenges, and Opportunities.

Chronic pouchitis occurs in about 50% of patients undergoing a restorative proctocolectomy for ulcerative colitis. This affection represents a significant therapeutic challenge, particularly for symptomatic patients who do not respond to antibiotic treatments and biologic therapies. Several dietary approaches, including low FODMAP diets and the Mediterranean diet, have shown promising results in improving symptoms and disease burden. The rationale for dietary intervention lies in the reduction in inflammation and modulation of gut microbiota. However, conflicting results and methodological het…

Flavonoids and Their Role in Preventing the Development and Progression of MAFLD by Modifying the Microbiota.

With the increasing prevalence and serious health consequences of metabolic-associated fatty liver disease (MAFLD), early diagnosis and intervention are key to effective treatment. Recent studies highlight the important role of dietary factors, including the use of flavonoids, in improving liver health. These compounds possess anti-inflammatory, antioxidant, and liver-protective properties. Flavonoids have been shown to affect the gut microbiota, which plays a key role in liver function and disease progression. Therefore, their role in preventing the development and progression of MAFLD throug…

Convergence of Neuroinflammation, Microbiota, and Parkinson's Disease: Therapeutic Insights and Prospects.

Parkinson's disease (PD) is a complex neurodegenerative disorder. Recent evidence reveals connections between neuroinflammatory processes and intestinal microbiota alterations in the progression of this pathology. This comprehensive review explores the intricate relationships between them, highlighting their combined impact on PD. Neuroinflammation, characterized by immune activation in the central nervous system, is increasingly acknowledged as a critical factor in the development of PD. Concurrently, alterations in the gut microbiota composition have been linked to PD, suggesting a potential…

A review on gut microbiota and miRNA crosstalk: implications for Alzheimer's disease.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and progressive neuronal damage. Recent research has highlighted the significant roles of the gut microbiota and microRNAs (miRNAs) in the pathogenesis of AD. This review explores the intricate interaction between gut microbiota and miRNAs, emphasizing their combined impact on Alzheimer's progression. First, we discuss the bidirectional communication within the gut-brain axis and how gut dysbiosis contributes to neuroinflammation and neurodegeneration in AD. Changes in gut microbiota composition in Alzh…

Potential role of gut microbiota in major depressive disorder: A review.

Interactions between the gut microbiota and host immunity are sophisticated, dynamic, and host-dependent. Scientists have recently conducted research showing that disturbances in the gut bacterial community can lead to a decrease in some metabolites and, consequently, to behaviors such as depression. Exposure to stressors dropped the relative abundance of bacteria in the genus Bacteroides while soaring the relative abundance of bacteria in the genus Clostridium, Coprococcus, Dialister, and Oscillibacter, which were also reduced in people with depression. Microbiota and innate immunity are in a…

Mechanistic Review on the Role of Gut Microbiota in the Pathology of Cardiovascular Diseases.

Cardiovascular diseases (CVDs), which stand as the primary contributors to illness and death on a global scale, include vital risk factors like hyperlipidemia, hypertension, diabetes, and smoking, to name a few. However, conventional cardiovascular risk factors offer only partial insight into the complexity of CVDs. Lately, a growing body of research has illuminated that the gut microbiome and its by-products are also of paramount importance in the initiation and progression of CVDs. The gastrointestinal tract houses trillions of microorganisms, commonly known as gut microbiota, that metaboliz…

Gut microbiota profile and atopic dermatitis in the first year of life.

The connection between the immune response and the composition of gut microbiota has been associated with an increased prevalence of atopic dermatitis in the first year of life. The study aimed to investigate gut microbiota characteristics in infants with atopic dermatitis compared to healthy infants to better understand the link between early-life microbiota composition and the development of atopic dermatitis. The study analyzed the intestinal microbiota of 121 infants with clinical signs of atopic dermatitis, divided into Group I (infants with atopic dermatitis) and Group II (healthy contro…