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Декодирование связи между микроорганизмами и автоиммунизацией: многоаспектный обзор данных по конкретным патогенам, которые вызывают аутоиммунные заболевания.

Происхождение и прогрессирование аутоиммунных заболеваний (АИД) являются результатом совокупного воздействия генетической восприимчивости, дефектов иммунной реакции и экологических факторов. Среди них микроорганизмы, являющиеся ключевыми экологическими факторами, широко гипотезуют для того, чтобы сыграть свою роль в инициировании АИД, однако точная причинно-следственная связь еще не доказана. Цель этого обзора заключается в глубоком изучении ключевой роли конкретных микробных инфекций в инициировании АИД путем интеграции данных, полученных с помощью three - измерения: эпидемиологические исслед

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… Clinical and experimental studies have highlighted the role of microorganisms in RA development, with the most important including EBV, Porphyromonas gingivalis ( P.gingivalis ), Proteus mirabilis ( P. mirabilis ) and Escherichia coli ( E. coli ) [ 29 ]. … Mirabilis , E. coli , PV、HIV、HBV、HCV 10-fold higher EBV DNA load in RA patients; 2-fold increased RA risk in periodontitis patients Anti-CCP/ACPA (cross-reactive with EBV citrullinated peptides); elevated anti-EBNA-2 antibodies Humanized NOG mice (human HSC) inoculated with EBV → 65% develop erosive …

Malnutrition-related hyperammonemic encephalopathy presenting with burst suppression: a case report.

BACKGROUND: Hyperammonemia is a common cause of metabolic encephalopathy, mainly related to hepatic cirrhosis. Numerous nonhepatic etiologies exist but they are infrequent and not well known, thus, leading to misdiagnosis and inadequate care. Electroencephalography has a proven diagnostic and prognostic role in comatose patients. Burst suppression is a preterminal pattern found in deep coma states and is rarely associated with metabolic causes. CASE PRESENTATION: We report the case of an 81-year-old Caucasian man presenting with rapidly progressive somnolence and mutism. Soon after his arriva

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… Undermetabolism Excessive protein supply (enteral or parenteral) Portosystemic shunting Muscles catabolism: cachexia, starvation, seizure Medications interfering with urea cycle: valproic acid, carbamazepine, salicylate, glycine, ribavirin Urease producing bacteria urinary tract infections: Proteus mirabilis … Undermetabolism Excessive protein supply (enteral or parenteral) | Portosystemic shunting Muscles catabolism: cachexia, starvation, seizure | Medications interfering with urea cycle: valproic acid, carbamazepine, salicylate, glycine, ribavirin Urease producing bacteria urinary tract infections: Proteus mirabilis …

[Surveillance of resistance in the intensive care units using a cumulative antibiogram].

Empiric treatment with broad-spectrum antibiotics exerts condensed pressure in intensive care units (ICUs) for the selection of multidrug-re … coli was the most commonly isolated species among urinary enteric bacilli, K.pneumoniae and Proteus mirabilis were the most resistant isolates. A statistically significant decrease in susceptibility rates against all antibiotics was observed in P.mirabilis isolates between the years 2015-2016. Carbapenem susceptibility rates decreased below 70%. E.coli, Ser …

Characteristics of infections after BCMA-directed CAR T-cell therapy for multiple myeloma: a real-world analysis.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… (63.2%) Fungal 2 (7.1%) 1 (3.4%) 3 (5.3%) Pathogens: bacterial Escherichia coli 1 (3.6%) 4 (13.8%) 5 (8.8%) Enterobacter cloacae 0 (0%) 1 (3.4%) 1 (1.8%) Enterococcus spp. 1 (3.6%) 0 (0%) 1 (1.8%) Haemophilus influenzae 0 (0%) 1 (3.4%) 1 (1.8%) Klebsiella pneumoniae 2 (7.1%) 0 (0%) 2 (3.5%) Proteus mirabilis … 5.3%) Pathogens: bacterial | | | Escherichia coli | 1 (3.6%) | 4 (13.8%) | 5 (8.8%) Enterobacter cloacae | 0 (0%) | 1 (3.4%) | 1 (1.8%) Enterococcus spp. | 1 (3.6%) | 0 (0%) | 1 (1.8%) Haemophilus influenzae | 0 (0%) | 1 (3.4%) | 1 (1.8%) Klebsiella pneumoniae | 2 (7.1%) | 0 (0%) | 2 (3.5%) Proteus mirabilis …

Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic.

Cardamom (cardamum) is a spice produced from the seeds of several Elettaria and Amomum plants of the Zingiberaceae family. Cardamom has been demonstrated to offer numerous benefits, including its antioxidant, antimicrobial, anti-inflammatory, and other metabolic (anti-diabetic) properties, and its potential to reduce cancer risk. Recently, researchers have extracted and tested multiple phytochemicals from cardamom to assess their potential effectiveness against various types of human malignancy. These studies have indicated that cardamom can help overcome drug resistance to standard chemothera

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… typhi , Shigella dysenteriae , Shigella sonnei , Staphylococcus aureus , Streptococcus-β-haemolytica , Bacillus subtilis , B. megaterium , and Sarcina lutea | [ 136 ] Staphylococcus aureus , Streptococcus pneumonia , S.epidermidis , P. aeroginosa , K. pneumonia , Proteus mirabilis , Enterobacter spp … Antibacterial Effect of Seed Extracts of Cardamom (Elettaria cardamomum) against Staphylococcus aureus and Proteus mirabilis. Tikrit J. Pure Sci. 2012;17:14–18. 136. Islam M., Rahman M., Sheikh M.M.I., Rahman, Jamal M.A., Firoz A. …

Sepsis in patients with haematological versus solid cancer: a retrospective cohort study.

ObjectivesThis study aims to examine the outcome of haematological and patients with solid cancer presenting with sepsis to the emergency department (ED).DesignSingle-centred, retrospective cohort study. Setting conducted at an academic emergency department of a tertiary hospital.ParticipantsAll patients >18 years of age admitted with sepsis were included.InterventionsPatients were stratified into two groups: haematological and solid malignancy.Primary and secondary outcomeThe primary outcome of the study was in-hospital mortality. Secondary outcomes included intensive care unit (ICU) mortalit

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… Streptococcus species, n (%) | 12 (3.9) | 3 (2.2) | 0.41 Enterococcus species, n (%) | 7 (2.3) | 2 (1.5) | 0.73 Pseudomonas aeruginosa , n (%) | 9 (3.0) | 8 (5.8) | 0.14 Staphylococcus coagulase negative, n (%) | 27 (8.9) | 12 (8.8) | 0.97 Staphylococcus aureus , n (%) | 5 (1.6) | 3 (2.2) | 0.71 Proteus mirabilis … (0.7) | 0 (0.0) | 1 Bacteria urine, n (%) | Klebsiella pneumonia , n (%) | 13 (4.3) | 1 (0.7) | 0.07 E. coli , n (%) | 43 (14.1) | 16 (11.7) | 0.49 Enterococcus species, n (%) | 7 (2.3) | 1 (0.7) | 0.44 P. aeruginosa , n (%) | 4 (1.3) | 3 (2.2) | 0.68 S. aureus , n (%) | 1 (0.3) | 1 (0.7) | 0.52 P. mirabilis …

Infections and Their Outcomes in Cancer Patients With and Without Neutropenia: A Single-Center Experience.

Background Patients with cancer are at a high risk of developing infections due to immunosuppression resulting from cancer treatment. Infections may occur both during neutropenic and non-neutropenic episodes and negatively impact outcomes both in terms of hospital stay and mortality. In this study, we aimed to determine the infection types, microbiological picture of infections, their outcomes, and associated factors in cancer patients during neutropenic and non-neutropenic episodes. Methods This is a retrospective cross-sectional study conducted at the Department of Medical Oncology, Geetanja

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… pneumoniae | 0 | 7 | 7 Pseudomonas aeruginosa | 0 | 2 | 2 Bronchial aspirate | Candida albicans | 0 | 1 | 1 Escherichia coli | 0 | 1 | 1 Pus | Staphylococcus aureus | 0 | 1 | 1 Citrobacter freundii | 0 | 1 | 1 Escherichia coli | 0 | 4 | 4 Enterobacter cloacae | 0 | 1 | 1 K.pneumoniae | 0 | 1 | 1 Proteus mirabilis … | 0 | 1 | 1 Pseudomonas aeruginosa | 0 | 1 | 1 Urine | Candida albicans | 0 | 2 | 2 Candida tropicalis | 0 | 1 | 1 Citrobacter koseri | 0 | 1 | 1 Escherichia coli | 5 | 14 | 19 Enterococcus spp . | 3 | 0 | 3 Klebsiella pneumoniae | 1 | 5 | 6 Proteus mirabilis | 0 | 1 | 1 Pseudomonas aeruginosa | 1 | …

Fungal Planet description sheets: 1478-1549.

Novel species of fungi described in this study include those from various countries as follows: Australia, Aschersonia mackerrasiae on white … iae on dead leaf of Faidherbia albida, and Aureobasidium welwitschiae on dead leaves of Welwitschia mirabilis. Netherlands, Gaeumannomycella caricigena on dead culms of Carex elongata, Houtenomyces caricicola (incl. Houtenomyces gen. nov.) on culms of Carex disticha, Neodacampia ulmea (incl. Neodacampia gen. nov.) on branch of Ulmus laevis, Niesslia phragmi …

Hyperammonemic Encephalopathy in Multiple Myeloma: A Case Report.

Multiple myeloma (MM) typically presents as lytic bony lesions, hypercalcemia, anemia, and renal failure. Only a few cases of hyperammonemic encephalopathy (HE) attributed to multiple myeloma have been reported. We report a case of a 68-year-old Hispanic female diagnosed with multiple myeloma and presented with altered mental status and elevated ammonia levels found to have HE. The pathology behind HE is associated with higher ammonia levels produced by myeloma cell lines in the absence of liver disease. Due to the wide range of differentials for altered mental status (AMS), HE often gets miss

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… Certain urase-producing organisms, such as proteus mirabilis, Escherichia (E.) coli, Klebsiella pneumonia, Pseudomonas, and Helicobacter (H.) pylori were also known to cause elevated ammonia levels and HE, which had not been seen in our patient [ 10 ]. …

Представление результатов анализа диабетических осложнений с головы до ног: всеобъемлющий радиологический обзор.

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… The most commonly identified organisms are Proteus mirabilis and Escherichia coli [ 46 ]. It is frequently associated with long-standing urinary tract obstruction, nephrolithiasis (often staghorn calculus), and DM, which predispose patients to persistent infection and impaired host defense. … The most commonly identified organisms are Proteus mirabilis , Escherichia coli , and Klebsiella pneumonia [ 46 ]. The symptoms may be nonspecific; however, fever, flank pain, dysuria, and nausea are common [ 12 ]. …

Multidrug-Resistant Bacteria in Immunocompromised Patients.

The increasing incidence of antibiotic resistance in bacteria is a major problem in terms of therapeutic options, especially in immunocompromised patients, such as patients from intensive care units (ICUs), HIV-positive patients, patients with malignancies or transplant patients. Commensal bacteria, especially anaerobes, serve to maintain microbial stability by preventing overpopulation with pathogenic bacteria. In immunocompromised patients, microbiota imbalance caused by antibiotic therapy and decreased host immunity favors intestinal overpopulation with pathogenic species, leading to increa

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… Among the frequently isolated GNB, P. aeruginosa (95.2%), Proteus mirabilis (86.4%), K. pneumoniae (83.3%) and E. coli (79.4%) were MDR. All isolates of A. baumannii were MDR and all isolates of Burkholderia cepacia were PDR [ 29 ]. … The most common species isolated were E. coli (58.5%), K. pneumoniae (15.7%) and P. mirabilis (7.5%). An increased rate of resistance to penicillins and combinations of penicillins with beta-lactamase inhibitors was observed in HIV-positive patients. …

Risk factors and characteristics of blood stream infections in patients with newly diagnosed multiple myeloma.

BackgroundPatients with multiple myeloma are generally immune-compromised either due to pronounced depression in primary antibody responses or because of anti-myeloma therapy. Infection is a major risk factor for early deaths among these patients. The impact of blood stream infections (BSI) on newly diagnosed myeloma patients has been less studied. We aimed to study the incidence and risk factors of BSI within 3 months after diagnosis of multiple myeloma in a tertiary referral center.MethodsBetween November 2002 and December 2008, consecutive patients with multiple myeloma in Taipei Veterans G

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… Imipenem/vancomycin/amikin Y 9 (175) Y VAD - - Escherichia coli Cefuroxime/metronidazole - 10 (150) Y VAD - - Enterobacter gergoviae Oxacillin - 11 (14) Y VAD Implanted port - Enterobacter cloacae - 12 (94) - VAD Non-tunneled CVC - Pseudomonas Aeruginosa Cefepime Y 13 (115) Y VAD Implanted port - Proteus mirabilis … | Cefuroxime/metronidazole | - 10 (150) | Y | VAD | - | - | Enterobacter gergoviae | Oxacillin | - 11 (14) | Y | VAD | Implanted port | - | Enterobacter cloacae | | - 12 (94) | - | VAD | Non-tunneled CVC | - | Pseudomonas Aeruginosa | Cefepime | Y 13 (115) | Y | VAD | Implanted port | - | Proteus mirabilis …

Множественный склероз, инфекция мочевого тракта и бесплодие: всеобъемлющий обзор аналитического исследования.

Множественный склероз (MS) — аутоиммунное заболевание, связанное с центральной нервной системой. ПМС широко распространены среди взрослых молодых людей и постепенно уничтожают аксоны и миелин. Лица, страдающие НР, часто сталкиваются с такими осложнениями, как дефункция мочевого тракта, инфекция мочевого тракта и сексуальная дисфункция. У молодых людей РС может вызывать сексуальную дисфункцию и бесплодие, которое ухудшается по мере развития болезни. Были рассмотрены имеющиеся данные из различных исследований (микробиологические и клинические исследования, полученные из баз данных PubMed и Scopu

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… In the MS population specifically, bacteria responsible for UTI were: Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Escherichia coli , beta-hemolytic Streptococcus B, and Coagulase-negative Staphylococcus ( 35 , 45 , 46 ). …

Evaluation of bloodstream infections in febrile neutropenic patients with hematological malignancy: a retrospective cohort study.

BACKGROUND: Patients with hematological malignancies (HMs) are at high risk of bloodstream infections (BSIs) during episodes of febrile neutropenia (FN). However, empirical treatment initiated before isolation of the causative agent from blood cultures is crucial. The aim of this study was to determine the distribution and antimicrobial resistance profile of microorganisms isolated from BSIs in patients with HMs, and to evaluate the association with the need for intensive care unit (ICU) and mortality at 30 days. METHODS: Single-centre data from patients with HMs who were admitted to the hema

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… Other Gram-negative bacteria include Stenotrophomonas maltophilia , Enterobacter spp., Serratia spp., Proteus mirabilis , Morganella morganii , Salmonella spp., and Sphingomonas paucimobilis . Other Gram-positive bacteria include Streptococcus pneumoniae and alpha-hemolytic streptococci. … Other Gram-negative bacteria include Stenotrophomonas maltophilia , Enterobacter spp., Serratia spp., Proteus mirabilis , Morganella morganii , Salmonella spp., and Sphingomonas paucimobilis . Other Gram-positive bacteria include Streptococcus pneumoniae and alpha-hemolytic streptococci. …

C-Reactive Protein Monitoring and Clinical Presentation of Fever as Predictive Factors of Prolonged Febrile Neutropenia and Blood Culture Positivity after Autologous Hematopoietic Stem Cell Transplantation-Single-Center Real-Life Experience.

BackgroundFebrile neutropenia (FN) is a medical emergency that requires urgent evaluation, timely administration of empiric broad-spectrum antibiotics and careful monitoring in order to optimize the patient's outcome, especially in the setting of both allogeneic and autologous hematopoietic stem cell transplant (ASCT).MethodsIn this real-life retrospective study, a total of 49 consecutive episodes of FN were evaluated in 40 adult patients affected by either multiple myeloma (thirty-eight) or lymphoma (eleven), following ASCT, with nine patients having fever in both of the tandem transplantatio

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… The most frequently isolated Gram-negative non-multidrug-resistant bacteria in the study population was Escherichia coli in 15 patients, with extended-spectrum β-lactamase in most cases, while Stenotrophomonas maltophilia , proteus mirabilis and enterobacter cloacae were isolated in one patient each. …

Response to pneumococcal vaccination in multiple myeloma.

BackgroundStreptococcus pneumoniae infection causes morbidity and mortality in multiple myeloma patients. Pneumococcal vaccination is commonly given to immunocompromised myeloma patients; however response data are sparse. Here, we present longitudinal response data to pneumococcal vaccination in multiple myeloma patients.MethodTwenty-eight multiple myeloma patients were included, 25 of whom were newly diagnosed. All the patients received two vaccines Prevnar13® and Pneumo23®. Serotype-specific IgG was measured by ELISA for all 23 vaccine serotypes at baseline, and then sequentially at differen

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… Indeed, one patient presented with Staphylococcus haemolyticus and Enterococcus faecalis , another with Streptococcus oralis , Bacteroides fragilis , and Proteus mirabilis , and two other with Klebsiella pneumoniae and Streptococcus salivarius . …

Регенеративная терапия на основе коллагена в критическом ишемическом диабиотическом ульце: доклад по делу о лимб-алкоголе.

58-летний мужчина с диабетом, конечной стадией почечных заболеваний и тяжелой периферической артерией страдал от хронической ишемической язвы ступни до одного года традиционной терапии. Инъекционная регенеративная терапия на основе коллагена привела к полной эпителиализации в течение трех месяцев и к долговременному спасению конечностей даже после техногенного рецидива, требующего реваскуляции.

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… later isolation of an extended‐spectrum β‐lactamase [ESBL]–producing strain), Pseudomonas aeruginosa , Acinetobacter species, Enterococcus species, coagulase‐negative Staphylococcus , methicillin‐resistant Staphylococcus epidermidis (MRSE), Enterobacter cloacae , and Proteus mirabilis …

Adult-Onset Hyperammonemia: Case Report and Review of Literature.

INTRODUCTION: Hyperammonemia is a life-threatening condition most associated with liver disease, though non-cirrhotic causes are increasingly recognized. CASE PRESENTATION: We report an 18-year-old female presenting with 1 week of progressive confusion, abdominal pain, and nausea. Initial evaluation showed normal routine laboratories but markedly elevated ammonia and respiratory alkalosis. She rapidly deteriorated, requiring intubation and intensive care. Ammonia peaked at 795 µg/dL and improved rapidly after urgent venous hemofiltration and medical therapy, with full neurological recovery by

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… Multiple myeloma − Leukemia − Fibrolamellar hepatocellular carcinoma − Bone marrow transplant − Organ transplantation (lung, liver) | Chemotherapeutic agents − Vincristine − Cytarabine − Etoposide − L-Asparaginase − Cyclophosphamide − 5-Fluorouracil | Infections with urea-producing bacteria − P. mirabilis …

Idiopathic Multicentric Castleman Disease with Cutaneous Manifestation: Case Report.

Castleman disease constitutes a rare class of lymphoproliferative disorders, with an estimated incidence of 21 to 25 per million patient years. The idiopathic subtype exhibits a significantly diverse clinical presentation, which can imitate many autoimmune, malignant, and infectious diseases. Cutaneous manifestations are uncommon and require in-depth investigation, especially when concurrent lymphadenopathy is present. A 79-year-old female, with a chronic, complicated erysipelas-like lesion, presented with bilaterally enlarged inguinal lymph nodes; after surgical excision, their histopathologi

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… The patient had been hospitalized numerous times in the past for local, recurrent bacterial and fungal infections, often with resistant strains of Pseudomonas aeruginosa , Proteus mirabilis, and Klebsiella pneumoniae , and in need of surgical debridement. …

Bloodstream Infections in Patients with Hematologic Diseases: Causative Organisms and Factors Associated with Resistance.

BackgroundPatients with hematologic diseases are at high risk of bloodstream infections (BSIs). This study aimed to analyze clinical features and distributions of microorganisms in patients with hematologic diseases presenting at a tertiary care university-affiliated hospital in Korea.Materials and methodsWe retrospectively reviewed all BSI episodes recorded in patient medical records at two hematologic wards of the Catholic Hematology Hospital from January to December 2020. Our aim was to analyze demographic and clinical characteristics relevant to BSIs. We also described the antimicrobial re

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… Table 2 Microorganisms isolated from bloodstream infections a Capnocytophaga sputigena (n = 2), Serratia marcescens (n = 2), Proteus mirabilis (n = 1), Haemophilus parainfluenza (n = 2), Campylobacter jejuni (n = 2), Raoultella planticola (n = 1), Pantoea spp. …