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The capnography head-up tilt test for evaluation of chronic fatigue syndrome.

OBJECTIVES: To compare the hemodynamic and ventilatory responses to autonomic challenge evoked by upright tilt table testing in patients with chronic fatigue syndrome (CFS) to healthy individuals. METHODS: Thirty-two consecutive patients with CFS and 32 healthy volunteers were evaluated with the aid of the recently introduced capnography head-up tilt test (CHUTT). The main outcome measures were values of blood pressure (BP), heart rate (HR), respiratory rate (RR), and end-tidal pressure of co2 (ETPco2) recorded during recumbence and tilt. In addition, the end points of vasodepressor and cardi…

A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome.

OBJECTIVE: To provide a preliminary assessment of the efficacy and safety of fludrocortisone acetate treatment of chronic fatigue syndrome. DESIGN: A placebo-controlled, double-blind, random-allocation crossover trial of 6 weeks of fludrocortisone. SETTING: An outpatient clinical trials unit. PATIENTS: Twenty-five participants with chronic fatigue syndrome (mean age, 40 years; 19 [76%] women; mean duration of illness, 7.0 years) were recruited from a research and clinic registry. Five patients withdrew from the trial. INTERVENTIONS: All participants were scheduled to receive fludrocortison…

Chronic fatigue syndrome/myalgic encephalomyelitis as a twentieth-century disease: analytic challenges.

The challenges of chronic fatigue syndrome (often called myalgic encephalomyelitis, especially in the UK) (CFS/ME) to analytical and medical approaches are connected with our inability to understand its distressing somatic symptoms in terms of a single identifiable and understandable disease entity. The evidence for the roles of viral aetiologies remains inconclusive, as does our understanding of the involvement of the immune system. The history and social context of CFS/ME, and its relation to neurasthenia and psychasthenia are sketched. A symbolic attitude to the condition may need to be roo…

Metabolic heat production during fatigue from voluntary repetitive isometric contractions in humans.

The effect of repetitive isometric knee extensions on the energy cost of contraction was examined. The rate of temperature rise (dT/dt) was determined in test contractions at 30 and 50% of maximal voluntary contraction (MVC) force before and during 30% MVC repetitive isometric exercise (RIE) to exhaustion and regularly in a 30-min postexercise recovery period (n = 9). Pulmonary O2 uptake and muscle temperature (Tmus) were determined at regular intervals. During the 30% MVC test contractions, dT/dt was 5.6 +/- 0.6 mK/s in unfatigued muscle, increasing linearly by 68% during exercise. In the 50%…

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

This study used phylogenetic analysis based on a region of the 5' non-translated region (5'NTR) of a variety of enteroviral sequences to compare sequences associated with chronic fatigue syndrome (CFS) and those from enteroviruses causing acute infections. Direct sequencing of PCR products was used to obtain the nucleic acid sequences from CFS patients. The inferred phylogenetic tree identified three groupings, one correlating with the diagnosis of CFS. The analysis identified a close relationship between the chronic fatigue enteroviral sequences, and showed that 19/20 were distinct from previ…

Japanese patients with chronic fatigue syndrome are negative for known retrovirus infections.

Although chronic fatigue syndrome (CFS) is known to be the syndrome that begins with an acute flu-like illness that may be due to the exposure to an infectious agent, there has been no convincing evidence on the causative agents. Recently, human T-lymphotropic virus type II (HTLV-II)-like virus has been reported to be associated with the CFS by using HTLV Western blot analysis and polymerase chain reaction. However, some investigators could not detect HTLV-II by indirect immunofluorescence analysis. Lately, CFS patients have been reported in Japan. We detected all 30 tested patients with CFS w…

Changes of myoplasmic calcium concentration during fatigue in single mouse muscle fibers.

Measurements of the intracellular free concentration of Ca2+ ([Ca2+]i) were performed during fatiguing stimulation of intact, single muscle fibers, which were dissected from a mouse foot muscle and loaded with fura-2. Fatigue, which was produced by repeated 100-Hz tetani, generally occurred in three phases. Initially, tension declined rapidly to approximately 90% of the original tension (0.9 Po) and during this period the tetanic [Ca2+]i increased significantly (phase 1). Then followed a lengthy period of almost stable tension production and tetanic [Ca2+]i (phase 2). Finally, both the tetanic…

Spin-trappers and vitamin E prolong endurance to muscle fatigue in mice.

The involvement of free radicals in endurance to muscle effort is suggested by experimental and clinical data. Therefore, experiments have been performed to observe the effect of trapping free radicals on endurance to swimming in mice. Animals were injected intraperitoneally with each of three spin-trappers [N-tert-Butyl-alpha-Phenyl-Nitrone (PBN),alpha-4-Pyridyil-1-Oxide-N-tert-Butyl-Nitrone (POBN) and 5,5-Dimethyl-1-Pirrolyn-N-Oxide (DMPO): 0.2 ml of 10(-1) molar solution]. Each mouse was submitted to a swimming test to control resistance to exhaustion a) without any treatment, b) after admi

Preferential fatigue of the rib cage muscles during inspiratory resistive loaded ventilation.

Because the inspiratory rib cage muscles are recruited during inspiratory resistive loaded breathing, we hypothesized that such loading would preferentially fatigue the rib cage muscles. We measured the pressure developed by the inspiratory rib cage muscles during maximal static inspiratory maneuvers (Pinsp) and the pressure developed by the diaphragm during maximal static open-glottis expulsive maneuvers (Pdimax) in four human subjects, both before and after fatigue induced by an inspiratory resistive loaded breathing task. Tasks consisted of maintaining a target esophageal pressure, breathin…

Effects of undernutrition on diaphragm fiber size, SDH activity, and fatigue resistance.

The influence of prolonged nutritional deprivation on the succinate dehydrogenase (SDH) activity and cross-sectional areas of individual fibers in the rat diaphragm and deep portion of the medial gastrocnemius (MGr) muscles was determined. Fatigue resistance of the diaphragm was measured by means of an in vitro nerve-muscle strip preparation. Fiber SDH activity and cross-sectional area were quantified by means of an image processing system. Diaphragm fatigue resistance was significantly improved in the nutritionally deprived (ND) group. In both muscles, nutritional deprivation resulted in a si…

The chronic fatigue syndrome: definition, current studies and lessons for fibromyalgia research.

Chronic fatigue syndrome (CFS) is characterized by chronic, debilitating fatigue lasting greater than 6 months. Frequent chronic and recurrent findings include fever, pharyngitis, myalgias, adenopathy, arthralgias, difficulties in cognition and disorders of mood. In the majority of patients, the illness starts suddenly with an acute, "flu-like" illness. The following laboratory abnormalities are seen with some frequency, although none are seen in all patients: lymphocytosis, atypical lymphocytosis, monocytosis, elevation of hepatocellular enzymes, low levels of antinuclear antibodies, varying …

Fatigue and contractile responses of rat hindlimb muscles following excessive dexamethasone administration.

Muscle weight, protein content and contractile performance (tetanic tension, fatigue and recovery) of extensor digitorum longus and soleus were investigated in rat following systemic administration of Dexamethasone (DX), 5 mg/kg/day for ten days. These animals showed marked reduction in food intake during the course of DX treatment. As a control, a group of food restricted (FR) rats receiving equal amount of food consumed by the DX treated rats was also studied along with the saline control group, to differentiate the effect of DX on muscle from that of dietary deficiency. There was a greater …

Vocal fatigue and dysphonia in the professional voice user: Bogart-Bacall syndrome.

Over the past 5 years, the authors have treated 67 adult professional voice users with a musculoskeletal tension disorder involving the larynx and supporting structures and leading to vocal dysfunction. Common clinical features in both sexes were muscle tension in the neck, poor control of the breath stream, and an abnormally low-pitched speaking voice. Most of the men sounded like Humphrey Bogart and the women like Lauren Bacall. These cases represent a discrete clinical vocal fatigue syndrome, the treatment of which is patient education and voice therapy.

Visual fatigue phenomenon and prescribing tinted lenses in patients with optic neuritis.

The fatigue phenomenon of grating visual acuity was examined in 36 patients with optic nerve disorders by means of a laser interferometric acuity device. The phenomenon was found in 6 of 36 cases even under a luminance corresponding to the Japanese standards of office illumination. This fact indicated that the patients suffered visual fatigue in their everyday vision. After they were prescribed tinted lenses to eliminate the fatigue, the patients had comfortable sustained vision in their daily work.

The relationship between sleep quality and pain, fatigue, and mood in individuals with lipedema.

ObjectiveThis study aimed to comparatively evaluate sleep quality in individuals with lipedema and healthy controls. In addition, the relationships between sleep quality and depression, anxiety, fatigue, and clinical parameters were investigated.MethodsThis cross-sectional study included 30 women with lipedema and 30 healthy female controls aged 18-75 years. Pain severity in individuals with lipedema was assessed using the Visual Analog Scale (VAS). Lipedema stage, comorbidities, and symptom duration were also recorded. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI…

Specific Depressive Symptoms are Associated with Subtypes of Fatigue in Inflammatory Bowel Disease.

Fatigue is common in inflammatory bowel disease (IBD) yet firm understanding of its management remains unclear. While psychosocial factors influence fatigue, less is known about how these factors differ among fatigue subtypes. This study examined the contributions of self-reported disease activity and psychosocial factors to five fatigue subtypes. Patients with Crohn's disease or ulcerative colitis were recruited from an academic medical center. Participants completed online surveys including the Multidimensional Fatigue Inventory (MFI-20) and measures of depression, anxiety, pain interference…

Prevalence and biopsychosocial predictors of post-stroke fatigue in patients with minor strokes.

BACKGROUND: The majority of stroke patients suffer minor stroke. Little is known about the prevalence of post-stroke fatigue (PSF) and which factors are associated with fatigue in minor stroke patients. OBJECTIVE: To investigate the prevalence of PSF in a sample of minor stroke patients and to explore associations between biopsychosocial factors and fatigue 12 months post stroke. METHODS: In this observational study of 72 minor stroke patients fatigue symptoms were measured in the acute phase and 12 months post stroke using the Fatigue Severity Scale (FSS). At 12 months, data on psychologica…

Диссоциация утомляемости и утомимости при многоразовом склерозе: роль когнитивной скорости обработки.

Усталость у людей с множественным склерозом (PwMS) является распространенной и невыносимой, но плохо понимаемой. Цель этого исследования заключалась в том, чтобы уточнить различие между долгосрочной усталостью и жироспособностью, обусловленной выполнением задач, и их соответствующими патофизиологическими процессами, а также изучить вклад снижения скорости когнитивной обработки (КПС) в взаимосвязь между структурным повреждением мозга, усталостью и жироспособностью. МЕТОДЫ: Усталость была вызвана 34 PwMS (PwMS)18-49 годы) и 32 контроля за здоровым состоянием здоровья (НС, 24-44 ) с использование

Совпадение в аннотации оригинала
BACKGROUND: Fatigue in people with multiple sclerosis (PwMS) is common and disabling, yet poorly understood. This study aimed to clarify the distinction between long-term fatigue and task-induced fatigability and their respective pathophysiological processes, and to examine the contribution of decreased cognitive processing speed (CPS) to the relationship be…

Association Between Postdialysis Fatigue and Number of Comorbidities and Number and Prevalence of Symptoms.

PURPOSE: To investigate the association between postdialysis fatigue (PDF) and physical and emotional symptoms in patients receiving maintenance hemodialysis. METHODS: All prevalent patients undergoing maintenance hemodialysis at our Hemodialysis Service between June 2022 and September 2024 were considered eligible. The Dialysis Symptom Index questionnaire was administered during dialysis sessions. PDF was assessed using the approach recommended by Sklar et al. Patients were classified as having PDF if they spontaneously reported feeling fatigued after dialysis in response to the question: "D…