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Risk of developing multiple sclerosis after uncomplicated optic neuritis: a long-term prospective study.

We prospectively studied 60 white patients living in New England who presented with uncomplicated optic neuritis (ON) to determine the risk of developing multiple sclerosis (MS). The diagnoses of ON and MS were made solely on the basis of clinical criteria. Patients were followed for a mean of 14.9 years. Life table analysis indicated that 74% of the women and 34% of the men will have developed MS 15 years after their attack of ON. The risk of developing MS was 3.4 times greater for women than for men. Onset of ON between the ages of 21 and 40 years may have had a modest effect in increasing t…

Evaluation of central nervous system involvement in uncomplicated optic neuritis after prolonged follow-up.

Magnetic resonance imaging (MRI), multimodal evoked responses (ER) and HLA antigens were examined in 10 patients with idiopathic acute optic neuritis (ON) without any clinical symptoms or signs of multiple sclerosis (MS) during 9-14 years. In MRI, abnormalities compatible with MS were seen in 4 patients. In spite of clinically unilateral ON, a bilateral abnormality in visual evoked responses (VER) was seen in 3 of 9 cases. Brain stem auditory evoked responses (BAER) were normal in all cases, short latency somatosensory evoked response (SER) in all but one. The cerebrospinal fluid at time of ON…

Cytomegalovirus retinitis and optic neuritis in acquired immune deficiency syndrome. Report of a case.

A 33-year-old man with acquired immune deficiency syndrome (AIDS) was found to have bilateral cytomegalovirus (CMV) retinitis with concomitant unilateral optic neuritis. The patient died and postmortem examination of both eyes disclosed CMV inclusions in all layers of the involved retinas including the retinal pigment epithelium (RPE). Also found were CMV inclusions in the optic nerve of his left eye. Immunohistochemical stains for glial fibrillary acid protein demonstrated that glial cells were infected in the optic nerve.

Color vision and visually evoked response (VECP) in the recovery period of optic neuritis.

Color vision and visually evoked cortical potentials (VECPs) are compared in a group of patients with optic neuritis. In the early recovery period, both were disturbed in a similar degree, whereas in the late recovery period, the VECPs remained more affected than color vision.

Structural-visual functional relationships detected by optical coherence tomography in varying age-cohorts' patients with optic neuritis.

AIM: To assess the relationships of final best-corrected visual acuity (BCVA) and the optic nerve structural loss in varying age-cohorts of optic neuritis (ON) patients. METHODS: This is a retrospective, cross-sectional study. Totally 130 ON subjects (200 eyes) without ON onset within 6mo were included, who underwent BCVA assessment, peripapillary retinal nerve fibre layer (pRNFL) and macular segmented layers evaluation by optical coherence tomography (OCT). RESULTS: For the 0-18y cohort, the final BCVA (logMAR) was significantly better and less frequent recurrences than adult cohorts (P=0.0…

MOG35 - 55 модель зрительного нерва EAE по сравнению с MS, MOGAD и NMOSD подтипов человеческого оптического неврата.

Оптический неврит (ON) или воспаление зрительного нерва является распространенным симптомом демиелинации нервно-воспалительных заболеваний, которые приводят к значительной потере негативного зрения. С учетом его связи с нарушениями зрения и различными масштабами визуального восстановления " ОН " была признана серьезным бременем для здоровья и потребность в новых терапевтических стратегиях для улучшения долгосрочных визуальных результатов. Среди ресурсов, используемых для проведения исследований, в качестве мощного инструмента изучения основ патофизиологии и эффективности предлагаемых

Совпадение в аннотации оригинала
Optic neuritis (ON), or inflammation of the optic nerve, is a common presenting symptom of demyelinating neuroinflammatory conditions that result in significant, subacute vision loss. Given its association with visual impairment and varying extent of visual recovery, ON has been recognized as a significant health burden with a need for new therapeutic strate…

Deep learning system for distinguishing optic neuritis from non-arteritic anterior ischemic optic neuropathy at acute phase based on fundus photographs.

PURPOSE: To develop a deep learning system to differentiate demyelinating optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (NAION) with overlapping clinical profiles at the acute phase. METHODS: We developed a deep learning system (ONION) to distinguish ON from NAION at the acute phase. Color fundus photographs (CFPs) from 871 eyes of 547 patients were included, including 396 ON from 232 patients and 475 NAION from 315 patients. Efficientnet-B0 was used to train the model, and the performance was measured by calculating the sensitivity, specificity, and area under the …

Erdheim-Chester Disease Presenting as Optic Neuritis: A Case Report and Review of the Literature.

We report a case of Erdheim-Chester disease in a patient who presented to the ophthalmology clinic with unilateral vision loss, optic disc swelling, and cluster-type headaches. Erdheim-Chester disease is a rare form of non-Langerhans cell histiocytosis characterized by a xanthogranulomatous process with multisystem organ involvement. The condition can be fatal due to renal or cardiovascular complications. Diagnosis is challenging due to the highly variable presentations and rarity of the disease, as demonstrated in this case. Our patient did not have systemic involvement and tested negative fo

Isolated Optic Neuritis as the Presenting Feature of Neurosarcoidosis: A Case Report and Diagnostic Approach.

We report a rare case of neurosarcoidosis presenting as isolated optic neuritis in a 43-year-old man with a history of obstructive sleep apnea and daily marijuana use. The patient experienced progressive, painless unilateral vision loss over six weeks, highlighting an atypical initial manifestation of this condition. Ophthalmologic examination revealed left optic disc swelling, afferent pupillary defect, and impaired color vision. MRI demonstrated left optic nerve enhancement, while chest imaging identified bilateral hilar lymphadenopathy with noncalcified nodules. Mediastinoscopic biopsy conf…

Prevalence of pediatric and adult optic neuritis in the United States from 2016 to 2023.

BACKGROUND/OBJECTIVES: Data on the prevalence of optic neuritis (ON) is limited with reported rates between 5.5 and 115.3 per 100,000. The US data is even more limited with the largest study performed in a single county, finding a prevalence of 115.3. This study aims to fill the gap in US data on ON. METHODS: This (2016-2023) cross-sectional study included patients with ICD-10 codes of retrobulbar neuritis, other ON, unspecified ON, and excluded those with optic papillitis, nutritional optic neuropathy, toxic optic neuropathy. Data was collected through a series of queries in a large platform…

Присутствие реакций MRZ улучшает прогнозирование множественного склероза у детей с оптическим невритом.

Фон/Цель: Оптический неурит (ON) является редким заболеванием, которое может оставаться одним эпизодом или преобразовываться в MS. ОХБ и повреждения позвоночника МРТ уже были определены в качестве прогнозируемых факторов. Цель: Наша цель заключалась в оценке того, является ли наличие более чем одного повышенного индекса антител кори, краснухи и/или варицелла-зостера (MRZ) показателем риска конверсии. Методы: В общей сложности в это ретроспективное исследование было включено 228 пациентов с диагнозом НО в период 1990−2013 годов. Все дети имели набор данных, включающий данные о возрасте, поле, т

Совпадение в аннотации оригинала
Background/Purpose: Optic neuritis (ON) is a rare disease that may remain a single episode or transform into MS. OCBs and spinal MRI lesions have already been identified as prognostic factors. Aim: Our aim was to evaluate if the presence of more than one elevated antibody index of measles, rubella, and/or varicella-zoster (MRZ) is an indicator of risk of con…

A Comparative Review of Typical and Atypical Optic Neuritis: Advancements in Treatments, Diagnostics, and Prognosis.

Optic neuritis (ON) is a debilitating condition that through various mechanisms, including inflammation or demyelination of the optic nerve, can result in partial or total permanent vision loss if left untreated. Accurate diagnosis and promptly initiated treatment are imperative related to the potential of permanent loss of vision if left untreated, which can lead to a significant reduction in the quality of life in affected patients. ON is subtyped as "typical" or "atypical" based on underlying causative etiology. The etiology of ON can be differentiated when appropriate diagnostic testing is…

Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis.

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) featuring numerous neuropathologies, including optic neuritis (ON) in some patients. However, the molecular mechanisms of ON remain unknown. Galectins, β-galactoside-binding lectins, are involved in various pathophysiological processes. We previously showed that galectin-3 (gal-3) is associated with the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of MS. In the current study, we investigated the expression of gal-3 in the visual pathway in EAE mice to clarify…

Hyperacute optic neuritis in a patient with COVID-19 infection and vaccination: a case report.

BACKGROUND: As scientific knowledge continues to grow regarding coronavirus disease 2019 (COVID-19) infection, several neuro-ophthalmological manifestations have emerged, including rare reports of optic neuritis. Optic neuritis is an inflammatory demyelinating condition of the optic nerve that typically presents as subacute, unilateral vision loss and pain on eye movement. Several cases of COVID-19 infection and COVID-19 vaccination related cases of optic neuritis have been reported. We present a case of hyperacute, unilateral optic neuritis after both recent COVID-19 infection and subsequent …

Retinal Oxygen Metabolism and Haemodynamics in Patients With Multiple Sclerosis and History of Optic Neuritis.

Vascular changes and alterations of oxygen metabolism are suggested to be implicated in multiple sclerosis (MS) pathogenesis and progression … ss (GCIPLT) in patients with diagnosed relapsing multiple sclerosis (RMS) and history of unilateral optic neuritis (ON). 16 RMS patients and 18 healthy controls (HC) were included in this study. Retinal oxygen extraction was modeled using O2 saturations and Doppler optical coherence tomography (DOCT) derived retinal blood flow (RBF) data. CD and LVD were assesse …

A Case of Acute Pancreatitis in a Patient Receiving High-Dose Steroids for Optic Neuritis.

Although rare, drug-induced pancreatitis is an important cause of acute pancreatitis. The diagnosis of drug-induced pancreatitis remains a challenge for clinicians. Steroids are one of the frequently used drugs in hospitals for many acute illnesses. Patients presenting with signs and symptoms of acute pancreatitis, with a recent history of steroid use, in the absence of other potential causes, should be approached with a high suspicion for steroid-induced pancreatitis to ensure a timely diagnosis. We describe a case of a 57-year-old female treated for optic neuritis of the left eye with high d…