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[First experience with the cobalt binding capacity (ACB) test in the diagnosis of acute coronary syndrome (a pilot study)].

INTRODUCTION: Commonly used laboratory markers of coronary damage in individuals with acute coronary syndrome (ACS) are not specific for myo … ts with ACS diagnosis were examined via coronarography. All the respondents were examined for cTnI, myoglobin, and ACB immediately at the admission (0) and 2, 6, and 12 hours after admission. Cobalt binding capacity of albumin has been given in absorbance units. The group of respondents was subsequently divided into subgroups according to presence of ACS an …

Intravenous lidocaine reduces systemic inflammation but not myocardial injury following thoracic surgery for lung cancer: a randomized controlled trial.

BACKGROUND: Elevated high-sensitivity troponin T levels shortly after noncardiac surgery are closely linked to myocardial injury, a key fact … roponin T levels of 14 ng l− 1 or higher within 48 h after surgery; (3) levels of NT-proBNP, CK-MB, myoglobin, hs-CRP, and inflammatory markers on the first and second postoperative days; (4) overall opioid use during surgery; and (5) hemodynamic parameters during the operation. RESULTS: Between June 12, 2021, and June 12, 2022, we enrolled 119 patients who …

[CT radiomics-driven lung cancer subtyping based on pretreatment imaging: A single-center retrospective cohort study].

OBJECTIVES: Platinum-based chemotherapy for advanced lung cancer is frequently challenged by platinum resistance, and effective early identi … istance status, selected biochemical indicators (carbon dioxide, serum creatinine, creatine kinase, myoglobin), and tumor markers (carcinoembryonic antigen) (all P<0.05). Within specific threshold probability ranges, all 4 clinical laboratory models based on baseline characteristics and laboratory data demonstrated clinical benefit and outperformed the trad …

[Prognostic evaluation and risk factors analysis of septic right ventricular dysfunction based on bedside ultrasound].

OBJECTIVE: To evaluate the prognosis of septic right ventricular dysfunction (SRVD) based on bedside ultrasound and explore its risk factors … ansfer and infection site ≥ 2 ratio, APACHE II score, SOFA score, higher cardiac troponin I (cTnI), myoglobin (Mb), MB isoenzyme of creatine kinase (CK-MB), N-terminal pro-brain natriuretic peptide (NT-proBNP), serum creatinine (SCr), arterial blood lactic acid (Lac) and lower left ventricular ejection fraction (LVEF), platelet count (PLT) within 24 hours a …

IMRC-exo alleviates limb injury by inhibiting ferroptosis in a rabbit model of deinagkistrodon acutus snakebite envenomation.

Deinagkistrodon acutus is one of the unique venomous snakes native to Southeast Asia. Limb injury caused by this species is the main cause o … s measured regularly and the serum levels of muscle injury markers such as Creatine Kinase (CK) and Myoglobin (Mb) were detected. At the end of the experiment, muscle tissue samples of the injured limb were obtained to detect gross pathological damage and cell apoptosis. Ferroptosis-related products including iron deposition, reactive oxygen species(ROS), m …

Clinico-haematobiochemical and cardiac alterations in Trypanosoma evansi infected buffaloes of Andhra Pradesh, India.

The present research aimed to document the incidence, clinical signs, haematological, and serum biochemical alterations, as well as electroc … 046), lactate dehydrogenase (p = 0.009), gamma-glutamyl transferase (p = 0.004) and creatine kinase-myoglobin binding levels (p = 0.005). Electrocardiography explorations in buffaloes with trypanosomosis revealed sinus tachycardia, low voltage QRS complex, ST segment elevation, wide QRS complex, sinus arrhythmia, sinus bradycardia, wandering pace maker, fir …

The Paradoxical Effect of Creatine Monohydrate on Muscle Damage Markers: A Systematic Review and Meta-Analysis.

BACKGROUND: Several studies have examined the effect of creatine monohydrate (CrM) on indirect muscle damage markers and muscle performance, … ficantly lower indirect muscle damage markers (i.e., creatine kinase, lactate dehydrogenase, and/or myoglobin) at 48-90 h post-exercise for the acute training response (SMD - 1.09; p = 0.03). However, indirect muscle damage markers were significantly greater in the CrM group at 24 h post-exercise (SMD 0.95; p = 0.04) for the chronic training response. Altho …

Rhabdomyolysis secondary to COVID-19 infection and vaccination: a review of literature.

Rhabdomyolysis (RML), characterized by the breakdown of skeletal muscle fibers and the release of muscle contents into the bloodstream, has emerged as a notable complication associated with Coronavirus disease 2019 (COVID-19) infection and vaccination. Studies have reported an increased incidence of RML in individuals with severe COVID-19 infection. However, the exact mechanisms remain unclear and are believed to involve the host's immune response to the virus. Furthermore, RML has been documented as a rare adverse event following COVID-19 vaccination, particularly with mRNA vaccines. Proposed

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… by toxic compounds formed by myoglobin release. … However, using myoglobin as a conventional diagnostic test is limited by its short half-life. However, an elevated concentration of myoglobin in individuals suspected of having RML may indicate the first stage of the condition ( 24 , 26 ). …

Minimally invasive port access versus conventional mitral valve surgery: prospective randomized study.

BACKGROUND: We compared the port access mitral valve surgery with the conventional procedure through median sternotomy in a prospective randomized study. METHODS: Forty elective patients with mitral valve disease were prospectively randomized to undergo minimally invasive (group I) or conventional (group II) mitral valve operation. The patients of group I had limited access through right small anterior thoracotomy and a femorofemoral cardiopulmonary bypass system using the endoclamp technique. To assess the efficiency and safety of the procedure, intraoperative and postoperative clinical data

[Effects of Hydrogen Sulfide on Inflammatory Factors and Mitochondrial Energy Metabolic Disorders After Reperfusion Injury in Rats].

Objective To explore the effect of hydrogen sulfide on inflammatory factors and energy metabolism of mitochondria after limbs reperfusion injury in rats. Methods Sixty rats were divided into three groups:sham operation group,control group(ischemia-reperfusion injury + saline group),and experimental group(ischemia-reperfusion injury + H2S group).Wistar rat models of limb ischemia-reperfusion injury were established.Skeletal muscle samples were collected to determine the levels of necrosis decomposition products [including myoglobin(MB),lipoprotein complex(LPC)and lipid peroxide(LPO)];blood samp…

[A report of first fatal case of H10N8 avian influenza virus pneumonia in the world].

OBJECTIVE: To report the treatment process of the first case of human pneumonia resulted from H10N8 avian influenza virus infection in the w … mg/L), but the platelet count, creatine kinase, lactate dehydrogenase, alanine aminotransferase and myoglobin were not increased, while leucocyte count was increased slightly (10.34×10(9)/L). The changes in above indexes did not match the characteristics of H7N9 avian influenza. However, the aggravated consolidation of the lung conformed to that of H7N9 avi …

Expanded haemodialysis: news from the field.

Expanded haemodialysis (HDx) has emerged as a promising solution to improve haemodialysis effectiveness. A medium cut-off membrane allows the removal of a wider range of uraemic toxins. However, little is known about the potential interesting applications of HDx therapy. Feedback from the first routine use of HDx therapy under real-life conditions in European facilities was excellent for priming and rinse back. There was no adverse event after 5191 HDx treatments. Patients suffering from itching, restless legs syndrome, persistent asthenia or malnourishment could benefit from HDx therapy. More

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… HDx therapy could be an interesting option to improve myoglobin clearance in rhabdomyolysis-related AKI, and further studies need to be conducted to shed light on its potential benefits ( Figure 1 ). FIGURE 1 Potential development paths and clinical applications of HDx therapy. … High cut-off renal replacement therapy for removal of myoglobin in severe rhabdomyolysis and acute kidney injury: a case series. Nephron Clin Pract 2013; 121: c159–c164 17. Massy ZA, Liabeuf S.. Middle-molecule uremic toxins and outcomes in chronic kidney disease. …

Postmortem biochemical investigations in hypothermia fatalities.

Despite the progress made during the past several decades in forensic pathology, the possibilities for the postmortem diagnosis of hypothermia remains relatively limited. Aside from histology and immunohistochemistry, numerous authors have investigated the postmortem biochemistry of hypothermia fatalities. Several biochemical markers (e.g., glucose, electrolytes, hormones, ketone bodies, and neurotransmitters) and various biological samples (e.g., blood, urine, heart, liver, skeletal muscle as well as pericardial and cerebrospinal fluids) have been proposed as potentially useful markers to imp

Lenalidomide-Associated Rhabdomyolysis Progressing to Bilateral Compartment Syndrome and Permanent Foot Drop.

Lenalidomide is widely used for the treatment and maintenance of multiple myeloma and is generally considered to have a favorable safety profile. However, severe skeletal muscle toxicity associated with lenalidomide has been rarely reported. We describe a 52-year-old man with multiple myeloma who developed acute bilateral lower-extremity pain, cramping, weakness, and paresthesia while receiving lenalidomide therapy. Laboratory evaluation revealed marked rhabdomyolysis, and imaging and clinical findings were consistent with bilateral lower-leg compartment syndrome. Despite emergent bilateral fa

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… Rhabdomyolysis is a potentially life‐threatening syndrome characterized by skeletal muscle breakdown with release of intracellular contents, including creatine kinase (CK) and myoglobin, into the circulation. … Urine myoglobin was 75 mg/L. Figure 2 Serial changes in serum creatine kinase, creatinine, AST, and ALT levels since admission. (A) Creatine kinase (CK) reached a peak of 46,256 U/L on Day 3, consistent with severe rhabdomyolysis secondary to lenalidomide treatment. …

Coronary health index based on immunoglobulin light chains to assess coronary heart disease risk with machine learning: a diagnostic trial.

BackgroundRecent studies suggest a connection between immunoglobulin light chains (IgLCs) and coronary heart disease (CHD). However, current diagnostic methods using peripheral blood IgLCs levels or subtype ratios show limited accuracy for CHD, lacking comprehensive assessment and posing challenges in early detection and precise disease severity evaluation. We aim to develop and validate a Coronary Health Index (CHI) incorporating total IgLCs levels and their distribution. Additionally, we aim to evaluate its effectiveness by integrating patient data and using machine learning models through d

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… Myo: Myoglobin. CK-MB: Creatine kinase-MB isoenzyme. … Myo: Myoglobin. CK-MB: Creatine kinase-MB isoenzyme. …

Serum biomarkers for detecting ectopic pregnancy.

Unless an ectopic pregnancy is visible by ultrasound, diagnosis can be a challenge. Differentiating ectopic pregnancies from intrauterine pregnancies can be impossible without intervention or follow-up. This poses a clinical dilemma to the practitioner given the inherent danger to the mother of tubal rupture of an ectopic pregnancy versus the fear of intervening in the case of a desired pregnancy without certainty of diagnosis. Early diagnostic modalities are clearly lacking, and serum biomarkers are currently being investigated as a solution to need for a rapid and accurate test for ectopic p

[Observation on the efficacy of continuous veno-venous hemodia-filtration combined with hemoperfusion HA380 in the treatment of 15 cases of heat stroke with multiple organ dysfunction syndrome].

OBJECTIVE: To investigate the clinical efficacy of continuous veno-venous hemodia-filtration (CVVHDF) combined with hemoperfusion (HP) HA380 … ST), creatine kinase (CK), lactate dehydrogenase (LDH), creatinine (Cr), cardiac troponin T (cTnT), myoglobin (Myo), MB isoenzyme of creatine kinase (CK-MB), sequential organ failure assessment (SOFA)] and inflammatory indicators [including white blood cell count (WBC), neutrophil count (NEU), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 …

Safety and pharmacokinetics of NXN-188 after single and multiple doses in five phase I, randomized, double-blind, parallel studies in healthy adult volunteers.

BACKGROUND: NXN-188 is a dual-action oral therapeutic being developed for the treatment of acute migraine. The mechanism of action of NXN-18 … tory analyses (chemistry, hematology, and urinalysis) and measurements of serum creatine kinase and myoglobin levels were conducted at screening, admission, discharge, and follow-up. Baseline and postexposure values were compared to assess tolerability. Electrocardiography and physical examination were conducted at screening and at discharge and follow-up i …

Membrane-to-Patient Optimization: Individualized Dialyzer Selection for Extracorporeal Dialysis.

Extracorporeal dialysis for uremic toxin removal and fluid regulation relies on specialized dialyzers whose membranes differ markedly in polymer chemistry, pore architecture, adsorption capacity, surface bioactivity, and convective performance. These structural and material distinctions result in wide variation in the clearance of chemically diverse uremic solutes. Despite the expanding range of dialyzer options, membrane selection in clinical practice remains largely non-individualized. In this review, we propose a phenotype-based model for dialyzer membrane selection. We outline how distinct

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… Finally, large–middle molecules, including free light chains, myoglobin, and certain pro-inflammatory mediators, require higher permeability or internal convection to be removed effectively. 3. … In rhabdomyolysis, pilot studies confirm myoglobin removal without clear clinical benefit [ 60 ]. Overall, HCO dialyzers are investigational, and larger studies are needed to define their role and safety. 6. …

Targeting B Cells for the Treatment of Idiopathic Inflammatory Myopathy.

Idiopathic inflammatory myopathy (IIM) is a group of heterogeneous diseases that can affect multiple systems. Currently, it is classified into different subtypes based on myositis-specific antibodies and muscle tissue pathology. These subtypes vary in treatment response and clinical prognosis, with poor treatment outcomes observed in cases of rapidly progressive interstitial lung disease and severe muscle involvement. Despite conventional treatments, there remains a high rate of mortality and disability. The production of B cells and autoantibodies plays a crucial role in the pathogenesis of I

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… : 2945 µg/L → 53 µg/L Chuan Qin [ 20 ] BCMA CAR-T Case report SRP + IMNM 1 Refractory case / Improve / Upper limb strength: Regained ability to lift arms; Lower limb strength: Regained ability to walk;MMT-8 score: 96 → 137;CK: 4,778 IU/L → 260 IU/L; Myoglobin: 837 ng/mL → 66.2 ng/mL. … : 2945 µg/L → 53 µg/L Chuan Qin [ 20 ] | BCMA | CAR-T | Case report | SRP + IMNM | 1 | Refractory case | / | Improve | / | Upper limb strength: Regained ability to lift arms; Lower limb strength: Regained ability to walk;MMT-8 score: 96 → 137;CK: 4,778 IU/L → 260 IU/L; Myoglobin: 837 ng/mL → 66.2 ng/ …