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Меняющиеся модели новых зоонотических заболеваний в дикой природе, домашних животных и людей связаны с утратой биоразнообразия и глобализацией.

Основные угрозы для биоразнообразия человека, включая разрушение местообитаний, глобализацию и утрату видов, привели к сбоям в экосистемах, изменяющим модели передачи инфекционных заболеваний, накоплению токсичных загрязнителей и вторжению чужеродных видов и патогенов. Кроме того, глубокая роль изменения климата во многих экологических процессах сказывается на неспособности многих видов адаптироваться к этим относительно быстрым изменениям. В этом специальном выпуске, озаглавленном "Экологическая среда Зупотических заболеваний: воздействие на людей, домашних животных и живую природу", рассматр

Совпадение в аннотации оригинала
The fundamental human threats to biodiversity including habitat destruction, globalization, and species loss have led to ecosystem disruptio … of these anthropogenic and environmental drivers. Selected emerging zoonoses including RNA viruses, Rift Valley fever, trypanosomiasis, Hanta virus infection, and other vector-borne diseases are discussed in detail. Also, coprophagous beetles are proposed as important vectors in the transmission and maintenance of infectious pathogens. An overview of the impacts of …

Simultaneous detection of five notifiable viral diseases of cattle by single-tube multiplex real-time RT-PCR.

Multiplexed real-time PCR (qPCR) assays enable the detection of several target genes in a single reaction, which is applicable for simultane … n for Animal Health, namely foot-and-mouth disease virus, epizootic haemorrhagic disease virus, and Rift Valley fever virus, was integrated using the identical fluorophore for the respective RT-qPCR assays. Every pathogen-specific assay had an analytical sensitivity of at least 100 genome copies per reaction within the multiplex approach, and a series of reference …

β-Catenin Upregulates the Constitutive and Virus-Induced Transcriptional Capacity of the Interferon Beta Promoter through T-Cell Factor Binding Sites.

Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral resp … asizing the role of β-catenin in the innate antiviral response, we show here that highly pathogenic Rift Valley fever virus (RVFV) targets the Wnt/β-catenin pathway and the formation of active TCF/β-catenin complexes at the transcriptional and protein level in RVFV-infected cells and mice.

Использование данных о характеристиках животных для подтверждения того, что в ходе эпизоотики не были представлены данные о стадах скота: применение к вспышке блютонги в скоте.

После появления серотипа 8 Bluetongue (BTV-8) во Франции в 2006 году была внедрена система наблюдения (как пассивная, так и активная) для обнаружения и предварительного наблюдения за развитием эпизоотической волны. Эта система не позволяла точно оценить масштабы эпизоотии. Инфекция BTV-8 связана с снижением рождаемости. Цель этого исследования состояла в том, чтобы оценить, можно ли использовать снижение рождаемости для подтверждения занижения данных о случаях в период эпизоотии, и дать количественную оценку того, в какой степени несообщенные случаи способствуют общему бремени эпизоотики. Рожд

Совпадение в аннотации оригинала
Following the emergence of the Bluetongue virus serotype 8 (BTV-8) in France in 2006, a surveillance system (both passive and active) was im … pathogens that affect cattle's performance, including zoonotic agents such as Coxiella burnetii or Rift Valley fever virus.

Spatial and temporal distribution of West Nile virus in horses in Israel (1997-2013)--from endemic to epidemics.

With the rapid global spread of West Nile virus (WNV) and the endemic state it has acquired in new geographical areas, we hereby bring a thorough serological investigation of WNV in horses in a longstanding endemic region, such as Israel. This study evaluates the environmental and demographic risk factors for WNV infection in horses and suggests possible factors associated with the transition from endemic to epidemic state. West Nile virus seroprevalence in horses in Israel was determined throughout a period of more than a decade, before (1997) and after (2002 and 2013) the massive West Nile f

Arbovirus vaccines; opportunities for the baculovirus-insect cell expression system.

The baculovirus-insect cell expression system is a well-established technology for the production of heterologous viral (glyco)proteins in c … fective vaccines against some highly pathogenic arboviruses such as Chikungunya, dengue, West Nile, Rift Valley fever and Bluetongue viruses. This comprehensive review discusses the biology and current state of the art in vaccine development for arboviruses belonging to the families Togaviridae, Flaviviridae, Bunyaviridae and Reoviridae and the potential of the bac …

Verification of poultry carcass composting research through application during actual avian influenza outbreaks.

An avian influenza outbreak in 2002 affected 197 poultry farms in Virginia and cost an estimated $130 million in losses and cleanup. In 2004 … adicate the avian influenza virus can also be used to control other EIDs such as H1N1, Nipah virus, Rift Valley Fever, and plague.

The foot-and-mouth disease epidemic of 2001 in the UK: implications for the USA and the ""war on terror".

While there is no evidence to suggest that the recent epidemic of foot-and-mouth disease (Fmd) in the Uk and its subsequent spread to contin … ificant role in protecting the public's health, since several epidemic diseases of animals, such as rift valley fever, are zoonotic. However, improved financial support at the federal and state levels is urgently needed to support epidemic-diseases research and teaching in colleges of veterinary medicine.

The RNA helicase eIF4A as a novel target in insect cells to combat arboviral infections.

Arthropod-borne viruses cause major global health burdens, yet few vaccines or antivirals exist. Targeting host factors required for viral replication offers a promising approach. The DEAD-box RNA helicase eIF4A, a core component of the translation initiation complex eIF4F, unwinds structured 5' UTRs and is therefore critical also for the translation of many viral RNAs. The compound classes rocaglates and pateamines are potent eIF4A inhibitors in mammalian cells. Here we show that the natural rocaglate silvestrol strongly inhibits Rift Valley fever virus replication (RVFV) in human cells witho…

Oropouche virus NSs protein suppresses host transcription by targeting the RNA polymerase II RPB1 protein.

UNLABELLED: Oropouche fever is a debilitating disease caused by Oropouche virus (OROV), an arthropod-borne member of the Peribunyaviridae fa … of its C-terminal domain (CTD) at serine 2 and serine 5 residues. When expressed from a recombinant Rift Valley fever virus MP-12 strain, OROV NSs colocalized with NPM1 and contributed to its nucleolar redistribution. Furthermore, expression of OROV NSs induced a marked reduction in the hyperphosphorylated RNAP IIo form, which was largely restored upon treatment wi …

Viral haemorrhagic fevers and malaria co-infections among febrile patients seeking health care in Tanzania.

BACKGROUND: In recent years there have been reports of viral haemorrhagic fever (VHF) epidemics in sub-Saharan Africa where malaria is endem … a, Crimean-Congo haemorrhagic fever (CCHF), Ebola virus disease (EVD), Marburg virus disease (MVD), Rift Valley fever (RVF) and yellow fever (YF). Malaria infections were tested using rapid diagnostics tests while exposure to VHFs was determined by screening for immunoglobulin M antibodies using commercial enzyme-linked immunosorbent assays. The Chi-square test was …

RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis.

Infection of Rift Valley fever virus (RVFV), a highly pathogenic mosquito-borne zoonotic virus, triggers severe inflammatory pathogenesis but the underlying mechanism of inflammation activation is currently unclear. Here, we report that the non-structural protein NSs of RVFV triggers mitochondrial damage to activate the NLRP3 inflammasome leading to viral pathogenesis in vivo. It is found that the host transcription inhibition effect of NSs causes rapid down-regulation of myeloid cell leukemia-1(MCL-1), a pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) protein family. MCL-1 down-r…

Extended protection against phlebovirus infection conferred by recombinant adenovirus expressing consensus interferon (DEF201).

Punta Toro virus (PTV; Bunyaviridae, Phlebovirus) is related to Rift Valley fever virus (RVFV), a pathogenic agent which causes severe disease in humans and livestock primarily in the sub-Saharan region of Africa. The recent range expansion of RVFV and the potential for its intentional release into naïve populations pose a significant threat to public health and agriculture. Studies modeling disease in rodents and nonhuman primates have shown that PTV and RVFV are highly sensitive to the antiviral effects of alpha interferon (IFN-α), an important component of the innate antiviral host response…

Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases.

The World Health Organization (WHO) monitors the spread of diseases globally and maintains a list of diseases with epidemic or pandemic potential. Currently listed diseases include Chikungunya, cholera, Crimean-Congo hemorrhagic fever, Ebola virus disease, Hendra virus infection, influenza, Lassa fever, Marburg virus disease, Neisseria meningitis, MERS-CoV, monkeypox, Nipah virus infection, novel coronavirus (COVID-19), plague, Rift Valley fever, SARS, smallpox, tularemia, yellow fever, and Zika virus disease. The associated pathogens are increasingly important on the global stage. The majorit…

Companion Animals as a Source of Viruses for Human Beings and Food Production Animals.

Companion animals comprise a wide variety of species, including dogs, cats, horses, ferrets, guinea pigs, reptiles, birds and ornamental fis … luetongue virus, African swine fever virus, foot-and-mouth disease virus, lumpy skin disease virus, Rift Valley fever virus, porcine circovirus, classical swine fever virus, equine herpesvirus 9, peste des petits ruminants virus and equine infectious anaemia virus. Viruses of highest concern for food production fishes included cyprinid herpesvirus 3 (koi herpesviru …

Disease Risks for Restoring Endangered Sahelo-Saharan Antelope: A Literature Review.

In 1994, the Convention on the Conservation of Migratory Species of Wild Animals identified six species of Sahelo-Saharan antelope in immedi … 9 distinct infectious agents or parasites. Frequently identified viruses included bluetongue virus, Rift Valley fever virus, and small ruminant morbillivirus. Commonly reported bacterial and protozoal agents included Anaplasma spp., Theileria spp., and Toxoplasma spp., while common ectoparasites included Hyalomma and Rhipicephalus ticks. Sixty-nine (43%) of the inf …

Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales.

Transgenic human monoclonal antibodies derived from humanized mice against different epitopes of the Middle East respiratory syndrome coronavirus (MERS-CoV), and chimeric llama-human bispecific heavy chain-only antibodies targeting the Rift Valley fever virus (RVFV), were produced using a CHO-based transient expression system. Two lead candidates were assessed for each model virus before selecting and progressing one lead molecule. MERS-7.7G6 was used as the model antibody to demonstrate batch-to-batch process consistency and, together with RVFV-107-104, were scaled up to 200 L. Consistent exp…

Identification of host blood from engorged mosquitoes collected in western Uganda using cytochrome oxidase I gene sequences.

Emerging infectious disease events are frequently caused by arthropod-borne viruses (arboviruses) that are maintained in a zoonotic cycle be … ata, our results suggest possible vector-reservoir relationships for several arboviruses, including Rift Valley fever virus and West Nile virus.

Host genetic variation in susceptibility to Punta Toro virus.

Infection of small laboratory animals by Punta Toro virus (PTV), family Bunyaviridae, genus Phlebovirus, is a model for the study of the human pathogen Rift Valley fever virus (RVFV). We have identified inbred mouse strains with significant differences in host response to the Adames strain of PTV. Nine inbred strains of mice representing major branches in the Mus musculus phylogeny were inoculated subcutaneously with a high dose of PTV in survival experiments. Two inbred strains of mice, NZW/LacJ and 129S1/SvImJ, died ~4 days after PTV infection, whereas 7 other strains survived the challenge …

Characterization of the non-specific humoral and cellular antiviral immunity stimulated by the chloroform-methanol residue (CMR) fraction of Coxiella burnetii.

Modulation of the immune response by the chloroform-methanol residue (CMR) of phase I Coxiella burnetii whole cell was studied in Rift Valley fever virus-infected, or in naive endotoxin-non-responder C3H/HeJ mice. A single dose of CMR completely protected the mice from viral infection. Treating virus-infected mice with antibodies directed against interferons alpha/beta (IFN-alpha beta) and gamma (IFN-gamma) eliminated the CMR-induced protection. CMR stimulated the production of high levels of IFN-alpha/beta and 2'-5'-oligoadenylate synthetase activities in sera of the CMR-treated mice. IFN-gam…