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Molluscum contagiosum of the eyelid: case report in a man receiving methotrexate and literature review of molluscum contagiosum in patients who are immunosuppressed secondary to methotrexate or HIV infection.

BACKGROUND: Molluscum contagiosum is a benign viral infection of the skin. Lesions typically present as dome-shaped, flesh-colored, umbilica … osum is generally self-limiting and often resolves spontaneously within18 months. However, topical (cantharidin) or locally destructive (curettage, cryotherapy, and/or laser) therapy may be indic tedfor patients who are concerned about persistent lesions and for children who are particularly susceptible to autoinoculation.

[Transcapillary filtration of plasma proteins in patients with diabetes type II microangiopathy complications].

UNLABELLED: This study presents the results of the research on transcapillary filtration of plasma proteins in patients with non-insulin dep … diabetic volunteers aged 31-76 years. The mean age in both groups did not differ significantly. The cantharidin blister method was used to study the permeability of capillary vessels. The following laboratory tests were done: concentrations of serum urea, creatinine, glucose, fructosamine, glycated hemoglobin, cholesterol, and triglycerides. Electrophoretic s …

EXPERIMENTAL ACUTE NEPHRITIS: THE VASCULAR REACTIONS AND THE ELIMINATION OF NITROGEN.

By combining physiological and anatomical methods in the study of experimental nephritis it is possible to distinguish types of nephritis in … atation of the vessels and increased diuresis. On the other hand, the vascular poisons, arsenic and cantharidin, which produce but little injury to the tubules, tend to cause anuria and are characterized by minimal contraction and dilatation of the vessels and little or no flow of urine. From the physiological point of view these two types may be, for practic …

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.

The tumour microenvironment contributes to cancer metastasis and drug resistance. However, most high throughput screening (HTS) assays for drug discovery use cancer cells grown in monolayers. Here we show that a multilayered culture containing primary human fibroblasts, mesothelial cells and extracellular matrix can be adapted into a reliable 384- and 1,536-multi-well HTS assay that reproduces the human ovarian cancer (OvCa) metastatic microenvironment. We validate the identified inhibitors in secondary in vitro and in vivo biological assays using three OvCa cell lines: HeyA8, SKOV3ip1 and Tyk

Topical Imiquimod is an Effective and Safe Drug for Molluscum Contagiosum in Children.

Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usuall … rodessication, cryotherapy, laser therapy) and topical or systemic pharmacologic agents (tretinoin, cantharidin, trichloroacetic and salicylic acid, potassium hydroxide, interferon-alfa, and cimetidine). Imiquimod is a topically applicable Toll-like receptor (TLR)-7/8 agonist, which is capable of stimulating the innate cutaneous immunity and the cellular arm …

Topical treatments for cutaneous warts.

BACKGROUND: Viral warts are a common skin condition, which can range in severity from a minor nuisance that resolve spontaneously to a troub … not identify any RCTs that evaluated surgery (curettage, excision), formaldehyde, podophyllotoxin, cantharidin, diphencyprone, or squaric acid dibutylester. AUTHORS' CONCLUSIONS: Data from two new trials comparing SA and cryotherapy have allowed a better appraisal of their effectiveness. The evidence remains more consistent for SA, but only shows a modest t …

Disorders of the Gastrointestinal System

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2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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Изучение связи между ядерными рецепторами в гематологических галереях.

Гематологические магнации (ГМ) представляют собой подмножество новообразований, затрагивающих кровь, костный мозг и лимфатические системы, которые в основном подразделяются на лейкемию, лимфому и множественную миелому. Их прогнозы значительно отличаются друг от друга, причем, несмотря на текущее лечение, часто возникает опасность рецидива. Несмотря на то, что современные терапевтические стратегии расширили общее выживание пациентов, они не предлагают лечения на продвинутых этапах и часто приводят к таким проблемам, как приобретение лекарственной устойчивости, рецидивы и серьезные побочные эффе

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… | ↑ Apoptosis, cleaved Caspase-3, -8, PARP, Cell cycle arrest at G2/M phase, Differentiation, Nur77 ↓ Cell viability, Colony formation, Proliferation | [ 78 ] | In vivo | NOD/SCID mice (HL-60) xenograft | Cantharidin | ↑ Survival, RBC count ↓ Liver weight, Spleen weight, WBC count | [ 78 ] | In vitro … Yu et al. (2020) reported that cantharidin, a main medicinal component of Mylabris (blister beetle) treatment caused a reduction in cell viability, colony formation ability, proliferation, induced apoptosis, cell cycle arrest at the G2/M phase and increased Nur77 expression in AML cells (HL-60). …

Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers.

Alternative splicing of mRNA leads to an increase in proteome biodiversity by allowing the generation of multiple mRNAs, coding for multiple protein isoforms of various structural and functional properties from a single primary pre-mRNA transcript. The protein isoforms produced are tightly regulated in normal development but are mostly deregulated in various cancers. In HIV-infected individuals with AIDS, there is an increase in aberrant alternative splicing, resulting in an increase in HIV/AIDS-related cancers, such as Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer. This aberra

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… kinases 110 Mitomycin C | Increase in the levels of VEGF 111b 120 Kinase inhibitor Camptothecin | Topoisomerase 1 inhibitor 110 Doxrubicin | Topoisomerase 2 inhibitor 110 TG003 | CLK inhibitor 114 AR-A014418 | Glycogen synthase kinase 3 inhibitor 114 Protein phosphatase-1 inhibitor Tautomycin | 114 Cantharidin … Tautomycin and cantharidin inhibit PP1 and PP2A, leading to changes in alternative splicing patterns. 114 Epigallocatechin-3-gallate (EGCG) and ibuprofen synergistically act to suppress proliferation and enhance apoptosis of prostate cancer cell lines by increasing the level of pro-apoptotic variants …

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review.

Cancer is the second biggest cause of death worldwide. Despite a number of studies being conducted, the effective mechanism for treating cancer has not yet been fully understood. The tumor-microenvironment such as hypoxia, low nutrients could disturb function of endoplasmic reticulum (ER) to maintain cellular homeostasis, ultimately leading to the accumulation of unfolded proteins in ER, so-called ER stress. The ER stress has a close relation with cancer. ER stress initiates unfolded protein response (UPR) to re-establish ER homeostasis as an adaptive pathway in cancer. However, persistent ER

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… Cantharidin (CTD; a natural terpenoid extracted from Mylabris phalerata Pallas) induced cytotoxic effects on NCI-H460 cells through ER stress along with the release of intracellular Ca 2+ , leading to mitochondrial dysfunction. … Cantharidin induces apoptosis of h460 human lung cancer cells through mitochondria-dependent pathways Int. J. Oncol. 2014 45 245 254 10.3892/ijo.2014.2428 24818581 111. Xu W.S. Dang Y.Y. Guo J.J. Wu G.S. Lu J.J. Chen X.P. Wang Y.T. …

CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer.

BACKGROUND: Gamabufotalin (CS-6), a bufadienolide derived from Chansu, has been reported to exhibit anti-tumor effects in various cancers, including glioblastoma, nonsmall cell lung cancer, and breast cancer. However,its role in colorectal cancer (CRC) remains unexplored. OBJECTIVE: Our study aimed to evaluate the inhibition of CS-6 to CRC cells by cell viability assay, colony formation assay, comet assay, and cell cycle analysis firstly. And its molecular mechanism was studied by immunofluorescence (IF) assay, western blot (WB) assay, siRNA transfection, protein-protein interaction (PPI) net

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… Molecular biology of cantharidin in cancer cells . Chin. Med. 2 ( 8 ), 8 . 10.1186/1749-8546-2-8 17610718 PMC1934358 Roos W. P. Thomas A. D. Kaina B. ( 2016 ). DNA damage and the balance between survival and death in cancer biology . Nat. Rev. …

Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.

Most breast cancers at an advanced stage exhibit an aggressive nature, and there is a lack of effective anticancer options. Herein, the development of patient-derived organoids (PDOs) is described as a real-time platform to explore the feasibility of tailored treatment for refractory breast cancers. PDOs are successfully generated from breast cancer tissues, including heavily treated specimens. The microtubule-targeting drug-sensitive response signatures of PDOs predict improved distant relapse-free survival for invasive breast cancers treated with adjuvant chemotherapy. It is further demonstr

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… Our results showed that most PDOs lines were sensitive to bortezomib (a proteasome inhibitor) and cantharidin (a protein/DNA/RNA synthesis inhibitor). …

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines.

Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional

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… The combination of TP and sodium cantharidinate exhibited a synergistically cytotoxic effect against human hepatoma 7721 cells via increasing capase-3 activity and suppressing NF-κB ( Zhou et al., 2016 ). …

Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was condu

Emerging and underexplored ginsenosides in cancer therapy (2020-2025): Beyond cytotoxic mechanisms.

Ginsenosides from Panax plants have long been studied as potential anticancer agents. In earlier years, most research focused on a few well-known ginsenosides that showed strong direct cytotoxicity, such as Rg3 and Rh2. As a result, many other ginsenosides were considered less active and received limited attention. However, studies published between 2020 and 2025 indicate that several previously underexplored ginsenosides also exhibit meaningful anticancer activity. These compounds often do not function as strongly cytotoxic agents. Instead, they act through broader and more indirect mechanism

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… In combination with cantharidin, Rc enhances mitochondrial apoptosis by modulating the ubiquitin–proteasome system and activating PP2A [ 147 ]. These findings suggest that Rc mainly affects the tumor vasculature and supports other anticancer agents rather than directly killing tumor cells. …

Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges.

Uncontrolled inflammation is a salient factor in multiple chronic inflammatory diseases and cancers. In this review, we provided an in-depth analysis of the relationships and distinctions between uncontrolled inflammation, fibrosis and cancers, while emphasizing the challenges and opportunities of developing novel therapies for the treatment and/or management of these diseases. We described how drug delivery systems, combination therapy and the integration of tissue-targeted and/or pathways selective strategies could overcome the challenges of current agents for managing and/or treating chroni

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… 345541 [ 135 ] and IMD 0354 [ 136 ]; IκB degradation inhibitors such as BAY 11-7082 [ 137 ], parthenolide [ 138 ], lactacystin [ 139 ], MG-132 [ 140 ] and MG-115 [ 139 , 141 ]; NF-κB DNA binding inhibitors such as GYY 4137 [ 142 ] and p-XSC [ 143 ]; proteasome inhibitor bortezomib and natural product cantharidin …

Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.

Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porok

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… Topical 0.7% cantharidin in the form of a thin film was applied in two PM patients (8 h exposure time), leading to blister formation and complete clearance within 1 week. …

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… cantharides, cantharidin [ kan-thar′ľ-dēz ] toxic substance obtained from dried blister beetles ( Cantharis vesicatoria ). The toxin can cause severe irritation of the digestive tract and even death when consumed by livestock. … cantharidin [ kan-thar′ľ-din ] see cantharides . Cantharis vesicatoria [ kan′th -ris ] the source of commercial cantharides. Called also Spanish fly, Lytta vesicatoria , blister fly. …

Current advance of nanotechnology in diagnosis and treatment for malignant tumors.

Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engineered nanoparticles can be employed as contrast agents in cancer diagnostics to enable high sensitivity and high-resolution tumor detection by imaging examinations. Novel approaches for tumor labeling and detection are also made possible by the use of nanoprobes and nanobiosensors. The achievement of targeted medication delivery in cancer therapy can be acc