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Hemoadsorption and plasma adsorption: two current options for the 3rd dimension of dialysis purification.

The adsorption technique has opened a new frontier in the field of purification through hemodialysis. This technique has proved to be effective in removing uremic toxins previously deemed inaccessible due to their size or charge, as well as to their molecular interactions with blood proteins. In this context, this review provides a detailed explanation of the role of Polyester-polymer alloy (PEPA®) membranes and hemodiafiltration with endogenous reinfusion. The polyester-polymer alloy membrane is a three-layered dialysis membrane with adsorbent properties, representing an innovative approach t

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… Similarly, polyester-polymer alloy filters, particularly the FDY dialyzer, have been shown to achieve higher reduction ratios for light chains and myoglobin compared to conventional filters, making them valuable tools in managing acute conditions associated with multiple myeloma [ 14 ]. … In addition, while hemodiafiltration with endogenous reinfusion has been effective in removing myoglobin during rhabdomyolysis AKI only in pilot studies [ 50 , 51 ], there are still no studies that have demonstrated filter efficacy in polyester-polymer alloy membranes in this type of AKI. …

Epidemiological and clinical characteristics of COVID-19 patients in Hengyang, Hunan Province, China.

BACKGROUND: In December 2019, an ongoing outbreak of coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China. The character … lanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (γ-GT), myoglobin (MB), and creatine kinase (CK) were increased in 64.6%, 44.7%, 43.2%, 37.0%, 29.5%, 22.9%,20.8%, 21.6%, 13.6%, and 12.8% of patients, respectively. The incidence of ALT elevation in male patients was remarkably higher than that in females (P < 0.01) …

Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study.

BackgroundCOVID-19 has spread globally. Epidemiological susceptibility to COVID-19 has been reported in patients with cancer. We aimed to systematically characterise clinical features and determine risk factors of COVID-19 disease severity for patients with cancer and COVID-19.MethodsIn this multicentre, retrospective, cohort study, we included all adult patients (aged ≥18 years) with any type of malignant solid tumours and haematological malignancy who were admitted to nine hospitals in Wuhan, China, with laboratory-confirmed COVID-19 between Jan 13 and March 18, 2020. Enrolled patients were

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… n=181 <0·0001 Globulin, g/L (n=372) 31·8 (28·9–35·3) 32·1 (29·5–35·9); n=279 30·7 (26·8–33·4); n=93 0·00061 Albumin–globulin ratio (n=372) 1·2 (1·0–1·4) 1·1 (1·0–1·3); n=279 1·2 (1·0–1·5); n=93 0·40 NT-proBNP, pg/mL (n=331) 171·0 (59·0–558·0) 171·5 (56·0–519·0); n=214 158·0 (68·0–678·0); n=117 0·28 Myoglobin … 38·0); n=111 0·00021 Globulin, g/L (n=93) 30·7 (26·8–33·4) 30·2 (25·2–33·3); n=32 30·7 (27·0–34·4); n=61 0·21 Albumin–globulin ratio (n=93) 1·2 (1·0–1·5) 1·3 (1·0–1·6); n=32 1·1 (0·9–1·3); n=61 0·024 NT-proBNP, pg/mL (n=117) 158·0 (68·0–678·0) 134·3 (68·0–247·0); n=46 321·0 (73·0–501·0); n=71 0·013 Myoglobin …

Exploring the health benefits of outdoor exercise for cancer survivors: a systematic review of more than 700 individuals.

BackgroundCancer's rising incidence and growing survivor population underscore the need for strategies to enhance health and quality of life. Outdoor physical activity (PA) settings may provide unique benefits, yet evidence in this context is scarce. This systematic review aims to evaluate the impact of outdoor PA and exercise interventions on the health and well-being of cancer survivors.MethodsA systematic search was conducted in PubMed, Web of Science, and PsycINFO databases from their inception until April 23, 2024. Studies included randomized controlled trials (RCTs) and non-RCTs involvin

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… , and lactate dehydrogenase | • ↓ Serum myoglobin concentration and ↑ in 25(OH)D3 and total calcium concentrations Fields et al., 2016 [ 26 ] | RCT | • EG : n = 20 women,60 ± 8 ys • CG : n = 20 women, 66 ± 7 ys • 100% breast cancer • 100% cancer undertreatment | EG • Type : Nordic walking • Intensity … Blood parameters were also evaluated in another study with an intervention based on Nordic walking [ 24 ], in which serum concentrations of vitamin 25(OH)D3, myoglobin, and calcium showed better values. …

Rhabdomyolysis and pandemic (H1N1) 2009 pneumonia in adult.

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… Urine myoglobin peaked at 286,000 μg/L (reference range 0–28 μg/L). Renal function remained at baseline until the patient was discharged 2 weeks later; measured glomerular filtration rates were >120 mL/min. …

SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway.

PurposeTo evaluate the expression of sry-box transcription factor 9 (SOX9) in orbital fibroblasts (OFs) of thyroid eye disease (TED) and to find its potential role and underlying mechanism in orbital fibrosis.MethodsOFs were cultured from orbital connective tissues obtained from patients with TED (n = 10) and healthy controls (n = 6). SOX9 was depleted by small interfering RNA or overexpressed through lentivirus transduction in OFs. Fibroblast contractile activity was measured by collagen gel contraction assay and proliferation was examined by EdU assay. Transcriptomic changes were assessed by

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… Therefore, these primary cells were identified as fibroblasts as they were positively marked with VIM and negatively marked with DES, KRT17, myoglobin, and S100B. Figure 1. … Immunofluorescence staining showed that primary cells were stained positive for VIM, whereas negative for DES, keratin 17 (KRT17), myoglobin (MB), and S100B. Scale bar, 50 µm. …

A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial.

OBJECTIVES: The pathophysiology of SARS-Cov-2 is characterized by inflammation, immune dysregulation, coagulopathy, and endothelial dysfunct … he upper limit of normal [ULN]) and with creatinine elevation (usually with brown urine and urinary myoglobin) observed during the hospital stay. RANDOMIZATION: Computer-generated block randomization will be used to randomize the participants in a 1:1 ratio to the active intervention group A (Aspirin, Atorvastatin, Nicorandil) plus conventional therapy and …

Сепсис, вызванный Clostridium Perfringens у женщины пожилого возраста, больной раком груди: доклад по делу.

ЦЕЛЬ: Сообщить о редком случае заболевания раком груди, у которого септический шок и множественные повреждения органов. В нем анализируются клинические характеристики, патогенные факторы и прогноз, связанные с смешанной инфекцией, вызванной Clostridium perfringens и Escherichia coli, в целях обеспечения основы для раннего выявления и вмешательства аналогичных клинических случаев. МЕТОДЫ: Был проведен ретроспективный анализ клинических данных 75-year-old Женщина, больная раком груди, которая также страдала гипертонией и диабетом. Были резюмированы клинические проявления, результаты этиологическ

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… 5.77 7.84 D-dimer (DD) mg/L 0-1 21.32 28.4 / Fibrinogen degradation products (FDP) mg/L 0-5 47.5 65.32 / Lactate dehydrogenase (LDH) U/L 120-250 438.3 417 / Creatine kinase (CK) U/L 40-200 1133 442 / Creatine kinase isoenzyme MB (CK-MB) U/L 0-25 52.2 35.4 / Troponin I (TnI) ng/mL 0.01–0.023 0.10 1.4 / Myoglobin … Fibrinogen degradation products (FDP) | mg/L | 0-5 | 47.5 | 65.32 | / Lactate dehydrogenase (LDH) | U/L | 120-250 | 438.3 | 417 | / Creatine kinase (CK) | U/L | 40-200 | 1133 | 442 | / Creatine kinase isoenzyme MB (CK-MB) | U/L | 0-25 | 52.2 | 35.4 | / Troponin I (TnI) | ng/mL | 0.01–0.023 | 0.10 | 1.4 | / Myoglobin …

The Use of Extracorporeal Organ Support Therapies for Acute Kidney Injury in Cancer Patients.

Acute kidney injury (AKI) is a frequent and serious complication in patients with cancer, associated not only with increased morbidity and mortality, but also with the interruption or modification of anticancer therapy. In critically ill patients with cancer, AKI arises from a complex interplay of cancer-related, treatment-related, and patient-related factors, with many patients requiring renal replacement therapy (RRT) and admission to the intensive care unit (ICU). This narrative review summarizes the etiology of AKI in patients with cancer and discusses the role of extracorporeal organ supp

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… Hemadsorption refers to the passage of blood, or of an ultrafiltrate, through a cartridge containing a porous sorbent that binds target solutes—such as cytokines, bilirubin, myoglobin or certain drugs—by hydrophobic and size-selective interactions, whereas extracorporeal blood purification (EBP) is a … Blood purification with a cytokine adsorber for the elimination of myoglobin in critically ill patients with severe rhabdomyolysis Crit. Care 2021 25 41 10.1186/s13054-021-03468-x 33509234 PMC7844984 46. Haselwanter P. Scheiner B. Balcar L. Semmler G. Riedl-Wewalka M. Schmid M. Reiberger T. …

Advanced Diagnostic Techniques

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… G, Myoglobin is only detected in striated muscle (asterisk) of esophagus when no antigen retrieval is used. H, Nonspecific staining due to antigen retrieval with proteinase K in blood vessels (v), smooth muscle (s), and mucosal epithelium (e). … G, Myoglobin is only detected in striated muscle (asterisk) of esophagus when no antigen retrieval is used. H, Nonspecific staining due to antigen retrieval with proteinase K in blood vessels (v), smooth muscle (s), and mucosal epithelium (e). …

I

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… . ► Clinical symptoms and signs Idiopathic inflammatory myopathies are characterised by the presence of symmetrical, predominantly proximal muscle weakness, biopsy evidence of muscle fibre impairment, elevated serum levels of muscle enzymes or myoglobin and the presence of multifocal myopathic signs … weakness, progressive over weeks or months, with or without myalgias Biopsy evidence of muscle fibre necrosis and regeneration with a mononuclear inflammatory infiltrate (perivascular or intravascular) with or without perifascicular atrophy Elevated serum creatine kinase (MM-isoenzyme), aldolase and myoglobin …

Одинокая плазмоцитома ребер: доклад о рейдовом деле.

Одинарная плазмоцитома кости (СБ) — редко злокачественная плазма, состоящая из неоплазмы. 6% из всех опухолей плазменных клеток. Для него характерно одиночное остеолитическое повреждение. В настоящем докладе содержится описание асимптомного СПБ в ребре 66-year-old Чувак. Рентгеновское излучение и вычисленная томография (CT) первоначально показали локализованную ресорбцию костей и разрушение правого пятого заднего ребра с помощью а 4.0×2.4×2.8 масса мягких тканей. Одинокие фотовыбросы, рассчитанные на томографию (SPECT), подтвердили наличие изолированных ребер без множественных повреждений скел

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… Immunohistochemical staining results were as follows: CD3 (−), CD20 (−), CD79a (+), Pax-5 (−), Ki-67 (approximately 50%), CD10 (+), Bcl-6 (−), Bcl-2 (weak +), SOX11 (−), Kappa (+), lambda (−), CD99 (−), CK (−), p53 (1+, wild-type), CD138 (+), CD38 (+), MUM-1 (+), myoglobin (−), SOX-10 (−), CD56 (+). …

Targeting large middle molecules: Clinical implications of expanded hemodialysis in hemodialysis care.

End-stage kidney disease (ESKD) presents a major clinical burden, with maintenance hemodialysis (HD) patients facing high cardiovascular mortality and impaired quality of life (QoL). Despite advances from low-flux to high-flux HD and the introduction of hemodiafiltration (HDF), clearance of large middle molecules (LMMs >25 kDa) remains inadequate. These molecules contribute to inflammation, oxidative stress, atherogenesis, and mineral-bone disorders, all of which worsen patient outcomes. Expanded hemodialysis (HDx), utilizing medium cutoff membranes, represents a novel approach that combines d

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… Hemodiafiltration (HDF) efficiently clears medium-middle molecules (15–25 kDa), including leptin, myoglobin, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-10, retinol-binding protein 4, prolactin, κ-free light chains (κ-FLC), complement factor D, IL-18, and IL-6. … Homocysteine | 0.135 | Urea | 0.06 | IGF-1 | 7.6 | Leptin | 16.0 | β-Trace protein | 26.0 | Modified albumin | 58.0 Phenylacetic acid | 0.150 | TMAO | 0.075 | IL-8 | 8.0 | TNF-α | 17.0 | Adiponectin | 30.0 | Albumin | 68.0 Indole acetic acid | 0.175 | Creatinine | 0.113 | Parathyroid hormone | 9.5 | Myoglobin …

Sarcoidosis With Muscular and Peripheral Nervous System Involvement: An Atypical Presentation of a Rare Disease.

Neuromuscular sarcoidosis is uncommon and may represent a diagnostic challenge, particularly in the absence of more typical sarcoidosis manifestations such as pulmonary involvement. We report a case of a 71-year-old male presenting with constitutional symptoms, weight loss, progressive gait impairment, hypercalcemia, and acute kidney injury. Initial evaluation excluded malignancy, active infection, and monoclonal gammopathy. Advanced imaging showed diffuse muscular involvement, and muscle biopsy confirmed non-caseating granulomatous myositis, establishing the diagnosis of muscular sarcoidosis.

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… C-reactive protein (CRP) | 39.9 mg/L | <5.0 Total protein | 5.4 g/dL | 6.4–8.3 Albumin | 2.6 g/dL | 3.4–4.8 Thyroid-stimulating hormone (TSH) | 2.27 µIU/mL | 0.35–4.94 Free thyroxine (Free T4) | 13.3 pmol/L | 9.0–19.0 Parathyroid hormone (PTH) | 1.5 pmol/L | 1.6–7.2 Creatine kinase (CK) | 54 U/L | 30–200 Myoglobin …

Advanced Diagnostic Techniques

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… G, Myoglobin is only detected in striated muscle ( asterisk ) of esophagus when no antigen retrieval is used. H, Nonspecific staining due to antigen retrieval with proteinase K in blood vessels ( v ), smooth muscle ( s ), and mucosal epithelium ( e ). … G, Myoglobin is only detected in striated muscle ( asterisk ) of esophagus when no antigen retrieval is used. H, Nonspecific staining due to antigen retrieval with proteinase K in blood vessels ( v ), smooth muscle ( s ), and mucosal epithelium ( e ). …

ER-mitochondria tethering and its signaling: A novel therapeutic target in breast cancer.

Communication between the endoplasmic reticulum (ER) and mitochondria through mitochondria-associated ER membranes (MAMs) is assisted by tethering proteins and signaling pathways, manifesting the dynamic exchange of lipids, calcium, and signaling molecules. However, dysregulation of tethering and signaling proteins contributes to the progression of breast cancer (BC). Abnormal MAM structures and altered ER-mitochondrial tethering impair mitochondrial functions and thereby drive BC progression. Altered mitochondrial dynamics, often characterized by dysregulated dynamin-related protein 1 (Drp1)

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… Braganza et al. demonstrated that myoglobin, an oxygen storage protein, positively regulates mitochondrial fusion and inhibits BC growth under hypoxic stress by modulating PARKN. 128 This study, using cell lines and xenograft murine models, observed that myoglobin protects against BC by attenuating growth … Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation. J. Biol. Chem. 2019;294:7269–7282. doi: 10.1074/jbc.RA118.006673. 129. Si L., Fu J., Liu W., Hayashi T., Nie Y., Mizuno K., Hattori S., Fujisaki H., Onodera S., Ikejima T. …

Secondary Hyperparathyroidism Presenting as a Brown Tumor: A Case Report and Review of the Literature.

Severe secondary hyperparathyroidism in advanced stages of chronic kidney disease (CKD) is associated with CKD-related mineral and bone disease (CKD-MBD). A 70-year-old woman was admitted at the Hospital for generalized bone pain and peripheral edema. Initial laboratory tests revealed normocytic anemia and severe renal dysfunction, and further tests evidenced severe secondary hyperparathyroidism. Full-body computerized tomography showed an osteolytic lesion in the right iliac wing. The iliac bone lesion was biopsied and histological examination was consistent with the diagnosis of a brown tumo

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… WBC) count 16.100/µL (NR 4.000 - 11.000/µL) with 93% neutrophils, blood urea nitrogen 189 mg/dL (NR 7 - 22 mg/dL), creatinine 4.3 mg/dL (NR 0.7 - 1.2 mg/dL), glomerular filtration rate 10 mL/min/1.73 m 2 [NR 90 mL/min/1.73 m 2 according to CKD EPI 2021), alkaline phosphatase 248 U/L (NR 45-117 U/L), myoglobin …

Myocardial amyloidosis following multiple myeloma in a 38-year-old female patient: A case report.

Multiple myeloma (MM) is an immunoglobulin-producing tumor of plasma cells, which occurs commonly in the elderly. The incidence of myocardial amyloidosis with MM is extremely low and early clinical manifestations are nonspecific. The diversity of clinical manifestations and first episode symptoms often cause misdiagnosis in young patients with myocardial amyloidosis following MM. In this study, we analyzed the clinical data of a young woman with MM and impaired cardiac function combined with echocardiography, electrocardiography (ECG), laboratory data, cell Congo Red staining, and other manife

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… Laboratory results revealed the following: N-terminal pro-B-type natriuretic peptide (NT-proBNP), 12,800 pg/mL; cardiac troponin T, 63.67 pg/mL; creatine kinase-MB, 9.02 ng/mL; and myoglobin, 97.68 ng/mL ( Table 1 ). …

Effects of Expanded Hemodialysis with Medium Cut-Off Membranes on Maintenance Hemodialysis Patients: A Review.

Kidney failure is associated with high morbidity and mortality. Hemodialysis, the most prevalent modality of renal replacement therapy, uses the principle of semipermeable membranes to remove solutes and water in the plasma of patients with kidney failure. With the evolution of hemodialysis technology over the last half century, the clearance of small water-soluble molecules in such patients is adequate. However, middle molecules uremic toxins are still retained in the plasma and cause cardiovascular events, anemia, and malnutrition, which significantly contribute to poor quality of life and h

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… Uremic Toxin Class | Molecular Weight (kDa) | Representative Biomarkers Small water-soluble molecules | <0.5 | Urea (60 Da), creatinine (113 Da), uric acid (168 Da) Small-middle molecules | 0.5–15 | PTH (9.5 kDa), β2-MG (11.8 kDa), cystatin C(13.3 kDa) Medium-middle molecules | 15–25 | Myoglobin (17 … It is noteworthy that expanded hemodialysis with MCO membranes is also significantly associated with a higher myoglobin (17 kDa) reduction ratio than hemodialysis with high-flux membranes [ 53 , 54 ]. …

AL type renal amyloidosis with cardiac involvement: A case report and literature review.

RATIONALE: Systemic amyloidosis refers to a spectrum of diseases characterized by extracellular deposition of amyloids, with commonrenal involvement; however, simultaneous involvement of cardiac amyloidosis remains rare. The purpose of this report was to enhance the understanding of the diagnosis and treatment of light chain (AL)-type renal amyloidosis with cardiovascular involvement, reduce misdiagnosis and missed diagnosis, and enable timely and effective treatment for such patients. PATIENT CONCERNS: A 74-year-old male patient was admitted to our hospital because of recurrent edema for ove

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… Cardiac biomarkerscreatine kinase 52 U/L, creatine kinase-MB 1.57 µg/L, α hydroxybutyrate dehydrogenase 133 U/L, high-sensitivity cardiac troponin T (hs-TnT)0.029 µg/L↑, myoglobin 63 µg/L, NT-proBNP 568.6 pg/mL↑. …