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Gut microbiota modulates nonalcoholic fatty liver disease (NAFLD) progression via regulation of gluconeogenesis: mechanisms and translational research.

The terminology of fatty liver disease has evolved from non-alcoholic fatty liver disease (NAFLD) to alternative metabolically oriented fram … s precision intervention strategies aimed at enhancing IGN and restoring glucose homeostasis (e.g., prebiotics, traditional Chinese medicine polysaccharides, FMT), which are of considerable translational and scientific importance.

The gut microbiota in Graves' disease: mechanistic insights and clinical implications.

Graves' disease (GD) is an autoimmune form of hyperthyroidism characterized by loss of immune tolerance to the thyrotropin receptor and sust … of disease-associated dysbiosis. In parallel, microbiota-directed approaches, including probiotics, prebiotics, synbiotics, dietary modulation, and fecal microbiota transplantation, are being explored as possible adjuncts in GD management. Overall, gut microbial disturbance offers a biologically plausible link between environmental exposure, immune disequili …

Gut microbiota and uveitis: exploring novel mechanisms of inflammatory ocular diseases via the gut-eye axis.

Uveitis is an inflammatory ocular condition that primarily affects young adults and is often associated with systemic and autoimmune disorde … explored innovative therapeutic strategies targeting GM and its metabolites, including probiotics, prebiotics, antibiotics, immunomodulators, phage therapy, fecal microbiota transplantation, and dietary interventions. This review systematically examined the association between GM dysbiosis and uveitis pathogenesis, offering new insights and directions for f …

Biomaterial-based microbiota strategies for targeting the intestinal immune microenvironment in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with an unclear etiology. Its onset and pr … ew systematically summarizes various biomaterial-based microbiota strategies, including probiotics, prebiotics, synbiotics, postbiotics, fecal microbiota transplantation, and bacteriophage therapy. Particular emphasis is placed on the critical role of biomaterials in enhancing the stability of microbiota-modulating agents, achieving colon-targeted release, a …

Gut modulation to regulate NF-κB in colorectal and gastric cancer therapy and inflammation.

The nuclear factor-kappa B (NF-κB) pathway plays a pivotal role in cancer progression, immune regulation, and inflammation. Aberrant activat … his review evaluates the therapeutic potential of gut-targeted interventions, including probiotics, prebiotics, faecal microbiota transplantation (FMT), and dietary modifications, in restoring microbial homeostasis and modulating NF-κB signalling. Despite promising findings, challenges remain regarding the clinical translation of microbiota-based therapies, …

Microbiome influence in gastric cancer progression and therapeutic strategies.

Gastric cancer (GC) remains a major global health burden, ranking as the fifth most commonly diagnosed malignancy and the fourth leading cau … rmed precision oncology. Furthermore, we examine how microbiota-targeted interventions, probiotics, prebiotics, dietary modulation, and fecal microbiota transplantation, can enhance chemotherapy and immunotherapy efficacy while mitigating treatment-related toxicity. Lastly, we discuss the implications of early H. pylori eradication, the impact of antibiotic …

The interplay between gut microbiome, epigenetics, and substance use disorders: from molecular to clinical perspectives.

Substance use disorders (SUDs) involve a complex series of central and peripheral pathologies, leading to impairments in cognitive, behavior … ults have been observed with gut microbiome-directed interventions in patients with SUDs, including prebiotics, probiotics, antibiotics, and fecal microbiota transplantation. Nonetheless, the long-term epigenetic effects of these interventions remain unexplored. Moreover, various confounding factors and study limitations have hindered the identification of m …

Microbial Metabolomes in Alzheimer's Disease: From Pathogenesis to Therapeutic Potential.

BACKGROUND: Accumulating evidence underscores the potential role of the gut microbiome in the pathogenesis of Alzheimer's disease, but much … ing Alzheimer's disease pathology. Therapeutics targeting the gut microbiome, including probiotics, prebiotics, and fecal microbiota transplantation, show promise in modulating neuroinflammation, reducing amyloid and tau pathology, and improving cognitive function in Alzheimer's disease. CONCLUSIONS: The gut microbiome significantly influences Alzheimer's d …

Microbiota-gut-brain axis pathogenesis and targeted therapeutics in sleep disorders.

Sleep constitutes an essential physiological process that is vital for maintaining physical and mental wellbeing. However, the science of sl … recent studies about MGBA-targeted therapeutic strategies for sleep disorders, such as probiotics, prebiotics, and fecal microbiota transplantation, which aim to restore microbial homeostasis and improve sleep quality. Furthermore, we discuss emerging interventions that modulate microbial metabolites and neuroimmune-endocrine signaling, as well as innovativ …

Targeting gut health: Probiotics as promising therapeutics in alcohol-related liver disease management.

Alcohol consumption represents a major global health issue, accounting for approximately 4.7% of annual deaths and 5.1% of the disease burde … ough the translocation of endotoxins. Recent research into the therapeutic potential of probiotics, prebiotics, and synbiotics highlights their ability to restore microbial balance and enhance intestinal barrier function. Studies demonstrate that these interventions can significantly improve liver enzymes and reduce inflammation, suggesting their complementa …

The role of the gut microbiota and metabolites in heart failure and possible implications for treatment.

The prevalence of heart failure has increased significantly in recent years, prompting investigations into novel contributory factors. Among … ailure can be managed by modulating the gut microbiota. Clinical interventions include antibiotics, prebiotics, and dietary changes. However, other approaches including fecal microbial transplantation, probiotics, and natural phytochemicals are still under study in animal models. This review highlights the significant yet underexplored link between gut micro …

Gut microbiota in hypothyroidism: pathogenic mechanisms and opportunities for precision microbiome interventions.

Hypothyroidism is a common endocrine disorder characterized by insufficient thyroid hormone synthesis or secretion, most frequently caused b … l framework for understanding the disease. Microbiota-targeted interventions, including probiotics, prebiotics, synbiotics, and dietary modulation, have demonstrated potential to improve microbial composition, alleviate systemic inflammation, enhance thyroid hormone utilization, and reduce autoantibody levels. This review systematically explores the mechanis …

Гут Микробиота как ключевой модулятор хронических заболеваний: последствия для диабета, автономного иммунитета и рака.

Кишечная микробиота (ГМ) представляет собой сложную, динамичную и сложную экосистему. Она играет ключевую роль в области здравоохранения и болезней. ГМ взаимодействует с принимающей стороной и модифицирует различные физиологические функции, включая метаболизм, иммунное регулирование и неврологическую функцию. В настоящем описательном обзоре всесторонне анализируется роль ГМ в развитии и развитии three Основные хронические заболевания, а именно диабет, аутоиммунные расстройства и рак. Используя структурированную стратегию поиска литературы в таких базах данных, как Google Scientist, PubMed, Sco

Совпадение в аннотации оригинала
The gut microbiota (GM) represents an intricate, dynamic, and complex ecosystem. It plays a key role in health and disease. The GM interacts … and the production of carcinogenic metabolites. Fecal microbiota transplantation (FMT), probiotics, prebiotics, and dietary modifications are being explored for their potential to restore microbial balance and improve clinical outcomes. In conclusion, this review highlights the GM's pivotal role in the pathogenesis of chronic diseases and its potential as a …

Ось кишечника: роль кишечника микробиота в патогенезе неврологических заболеваний и фармакотерапии.

Ось кишечника - это очень сложная, двунаправленная связь между кишечником и центральной нервной системой (ЦНС), главным образом через нейронные, эндокринные, иммунологические и метаболические пути. В настоящем обзоре описывается растущий вклад кишечного микробиота в восстановление неврологического здоровья, а также подчеркивается контрольная роль кишечного микробиота в синтезе нейротрансмиттеров. Появляющиеся данные показывают, что дисбиоз кишечника связан с различными нейродегенеративными и нейропсихиатрическими заболеваниями, такими как болезнь Паркинсона (PD), болезнь Альцгеймера (AD), множ

Совпадение в аннотации оригинала
The gut-brain axis is a highly complex, bidirectional communication link between the gut and the central nervous system (CNS), mainly throug … hways highlights their role in CNS inflammation. Microbiota-targeted interventions with probiotics, prebiotics, synbiotics, antibiotics, dietary modifications, and fecal microbiota transplantation are examined for their therapeutic potential. These strategies appear to be promising to reinstate microbial balance, enhance neuroplastic responses, and ameliorat …

Supplementation with a Symbiotic Induced Neuroprotection and Improved Memory in Rats with Ischemic Stroke.

After an ischemic stroke, various harmful mechanisms contribute to tissue damage, including the inflammatory response. The increase in pro-inflammatory cytokines has been related to greater damage to the neural tissue and the promotion of neurological alterations, including cognitive impairment. Recent research has shown that the use of prebiotics and/or probiotics counteracts inflammation and improves cognitive function through the production of growth factors, such as brain-derived neurotrophic factor (BDNF), by reducing inflammatory molecules. Therefore, in this study, the effect of the sym…

Microbial-Based Bioactive Compounds to Alleviate Inflammation in Obesity.

The increased prevalence of obesity with several other metabolic disorders, including diabetes and non-alcoholic fatty liver disease, has re … nks nutrition, metabolism, and the innate immune response. Here, we present the functional roles of prebiotics, probiotics, synbiotics, and postbiotics as bioactive compounds by underscoring their putative contributions to (1) the reduction in gut hyperpermeability due to lipopolysaccharide (LPS) inactivation, (2) increased intestinal barrier function as a c …

Potential role of gut microbiota in major depressive disorder: A review.

Interactions between the gut microbiota and host immunity are sophisticated, dynamic, and host-dependent. Scientists have recently conducted … l approaches to improving depressive symptoms via gut microbiota alterations, including probiotics, prebiotics, and fecal microbiota transplantation.

Effects of Reactive Oxygen and Nitrogen Species on Male Fertility.

Significance: In recent decades, male fertility has been severely reduced worldwide. The causes underlying this decline are multifactorial, … gut microbiota, thus leading to new strategies to solve male fertility problems, such as consuming prebiotics to regulate gut flora or treating psychological conditions. Critical Issues: The pathways where ROS or RNS may be involved as modulators are still under investigation. Moreover, the extent to which treatments can rescue male infertility as well as w …

The pathogenesis of gut microbiota in hepatic encephalopathy by the gut-liver-brain axis.

Hepatic encephalopathy (HE) is a neurological disease occurring in patients with hepatic insufficiency and/or portal-systemic blood shunting … atment aim of HE is to decrease intestinal ammonia production and intestinal absorption of ammonia. Prebiotics, probiotics, antibiotics, and fecal microbiota transplantation (FMT) can be used to manipulate the gut microbiome to improve hyperammonemia and endotoxemia. Especially the application of FMT, it has become a new treated approach to target microbial …

Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients.

Bariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a … ute to resolving NAFLD in BS patients. The knowledge acquired can help to design interventions with prebiotics and/or probiotics to promote a gut microbiome that favors NAFLD resolution.