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Сопоставительное исследование полисомнографии и расстройства сна у людей, живущих с множественным склерозом, по сравнению с совпадающим контролем от населения в целом.

Структура сна и нарушения сна сравнивались между людьми с множественным склерозом (MS; n = 39) и возрастом, полом и БМИ-сопоставимыми представителями населения в целом (n = 39), использующими полисомнографию в ночное время (PSG). По сравнению с мерами регулирования численности населения люди, имеющие MS, имели более высокую частотность периодических нарушений движения конечностей (PLMD; 59% против 18%, p < 0,001) и связанных с PLM возбуждения (PLMI: 21,1 против 0,8, p < 0,001); а также более продолжительную продолжительность сна (402,9 [59,8] против 370,4 [54,0] мин., p = 0,014), более продолж

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… Restless legs syndrome was established with the 2003 International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria for both MS and matched controls (Allen et al.  2014 ). Statistical Analysis Data were analysed using R (R Core Team, 2021, Vienna, Austria). … It is possible that such lesions may not be mirrored in corresponding sensory pathways, which aligns with our observation of increased limb movements despite the typical discomfort characteristic of restless leg syndrome (RLS). …

Subject index

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A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview.

BackgroundComorbidity is an area of increasing interest in multiple sclerosis (MS).ObjectiveThe objective of this review is to estimate the incidence and prevalence of comorbidity in people with MS and assess the quality of included studies.MethodsWe searched the PubMed, SCOPUS, EMBASE and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles. Two reviewers independently screened abstracts. One reviewer abstracted data using a standardized form and the abstraction was verified by a second reviewer. We assessed study quality using a standardized approach.

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… Deriu M Cossu G Molari A Restless legs syndrome in multiple sclerosis: A case-control study . Mov Disord 2009 ; 24 : 697 – 701 . 19117365 10.1002/mds.22431 67. … Manconi M Fabbrini M Bonanni E High prevalence of restless legs syndrome in multiple sclerosis . Eur J Neurol 2007 ; 14 : 534 – 539 . 17437613 10.1111/j.1468-1331.2007.01740.x 162. …

Utilization of medications for neuropathic pain in patients with and without knee and hip osteoarthritis in Sweden: A population-based cohort study.

ObjectiveUse of neuropathic pain medications is increasing in OA patients, but it is unclear if this is driven by OA-specific use or presence of comorbidities. We aimed to investigate the use of neuropathic pain medications attributable to knee and hip OA pain.DesignWe included all residents aged ≥35 years of the Skåne region, Sweden, in 2018. After exclusions, 645,991 individuals remained, where 81,606 had diagnosed knee and/or hip OA. We compared prevalence of dispensed neuropathic pain medications between those with and without OA using logistic regression (odds ratios approximated risk rat

Complementary and alternative therapies in the palliative setting.

Complementary and alternative medicine (CAM) encompasses a wide range of medication, herbal, dietary and physical therapies that are not usually considered within the realm of conventional therapeutics. Approximately two thirds of the Australian population use CAMs and only around half of this number will discuss their use of these products with their doctor. Clinical use is commonly seen in patients with life-limiting illness, often because they experience a high burden of symptoms. However, it is also the case that many of these therapies do not have demonstrated efficacy, particularly for t

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… No significant difference in QoL or symptom improvement has been demonstrated in hypnotherapy trials. 2 Restless legs syndrome is commonly experienced by patients with end‐stage kidney disease on dialysis. … Sleep disorders, restless legs syndrome, and uremic pruritus: diagnosis and treatment of common symptoms in dialysis patients. J Kidney Dis 2017; 69: 117–28. 17. Therapeutic Guidelines Psychotropic. Insomnia in Adults. Available from URL: https://tgldcdp.tg.org.au.acs.hcn.com.au/viewTopic? …

Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.

Fibromyalgia (FM) is a chronic non-inflammatory disorder mainly characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and a constellation of other symptoms. For this reason, delineating a clear distinction between pure FM and FM-like picture attributable to other common diseases can be extremely challenging. Physicians must identify the most significant confounders in individual patients and implement an appropriate diagnostic workflow, carefully choosing a minimal (but sufficient) set of tests to be used for identifying the most plausible diseases in the specific case

Identifying core symptom clusters based on symptom distress levels in patients with maintenance hemodialysis: a cross-sectional network analysis.

BACKGROUND: To explore the symptom clusters of patients undergoing maintenance hemodialysis and construct a symptom network to identify the core symptoms and core symptom clusters, to provide reference for precise symptom management. METHODS: Conveniently selected 354 patients with maintenance hemodialysis were surveyed cross-sectionally using the general information questionnaire, the Dialysis Symptom Index and the Kidney Disease Questionnaire. Symptom clusters were extracted using exploratory factor analysis, and core symptom clusters were identified using hierarchical regression and networ

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… Prevalence of restless legs syndrome in maintenance hemodialysis patients: a systematic review and meta-analysis . Sleep Med . 2024 ; 114 : 15 – 23 . doi: 10.1016/j.sleep.2023.11.1138 . 38147712 2 Yu H , Huang M , Tao Y , et al. …

Pruritus in hemodialysis patients.

BackgroundPruritus is one of the most bothersome symptoms in patients on maintenance hemodialysis (HD), however little progress is seen in our understanding of its pathogenesis. The aim of this study was to evaluate the frequency of pruritus in HD patients in Tehran, Iran, and to correlate its presence and intensity with relevant clinical and laboratory parameters.MethodsOne hundred sixty-seven patients on maintenance HD at three out-patient HD units were enrolled in the study. Itch intensity was scored as mild, moderate and severe. Some relevant clinical and laboratory parameters (age, sex, x

Нарушения сна у пациентов с множественным склерозом.

Множественный склероз (МС), от которого в 2020 году во всем мире пострадало около 2,8 миллиона человек, часто связан с расстройствами сна. Эти нарушения могут быть вызваны самим заболеванием, таким, как боль или побочные эффекты симптоматического и иммунологического лечения. МЕТОДЫ: Настоящее исследование представляет собой межсекторальное аналитическое исследование. Обследованное население состоит из пациентов с НР, проживающих в городе Кашан. Расследуемый размер выборки состоит из 174 пациентов с диагнозом MS. Эта информация была собрана с помощью демографических информационных вопросников,

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… The most common sleep problems among MS patients include insomnia, sleep apnea, restless legs syndrome, narcolepsy, and Rapid Eye Movement )REM( sleep behavior disorder [ 12 ]. … One of the primary contributors to insomnia and resultant sleepiness in MS patients is pain, which may stem from muscle spasms, periodic limb movements, restless legs syndrome, urinary incontinence, and depression related to the disease [ 29 ]. …

Targeting large middle molecules: Clinical implications of expanded hemodialysis in hemodialysis care.

End-stage kidney disease (ESKD) presents a major clinical burden, with maintenance hemodialysis (HD) patients facing high cardiovascular mortality and impaired quality of life (QoL). Despite advances from low-flux to high-flux HD and the introduction of hemodiafiltration (HDF), clearance of large middle molecules (LMMs >25 kDa) remains inadequate. These molecules contribute to inflammation, oxidative stress, atherogenesis, and mineral-bone disorders, all of which worsen patient outcomes. Expanded hemodialysis (HDx), utilizing medium cutoff membranes, represents a novel approach that combines d

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… Theranova) to HF-HD across 22 studies (1811 patients) showed improved quality of life, reduced symptoms (e.g., pruritus, restless legs syndrome), faster recovery time after dialysis, lower erythropoiesis resistance index and iron use, and fewer hospitalizations, with no increase in mortality or adverse … Sleep disorders, restless legs syndrome, and uremic pruritus: Diagnosis and treatment of common symptoms in dialysis patients. Am J Kidney Dis. 2017;69:117–28. doi: 10.1053/j.ajkd.2016.07.031. 12. Kalantar-Zadeh K, Lockwood MB, Rhee CM, Tantisattamo E, Andreoli S, Balducci A, et al. …

Распространение и риск анемии у людей с множественным склерозом (MS): систематический обзор и мета-анализ.

ВВЕДЕНИЕ: Анемия проявляется как общая коморбида в другом времени и лежащем в основе патофизиологии у людей с MS (PwMS) и предлагается в качестве продрома в MS. Этот систематический обзор и метаанализ направлены на удовлетворение потребности в уточнении некоторых характеристик анемии в PwMS. МЕТОДЫ: Систематический поиск литературы проводился с использованием баз данных MedLINE PubMed, Scopus и Google Scientific. Соответствующие исследования прошли оценку качества с использованием &quot; Робинз-Е &quot; , и был проведен метаанализ пропорциональности. Риск анемии в PwMS в сравнении со здоровыми

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… A. et al., Restless Legs Syndrome in Iranian Patients With Multiple Sclerosis, Neurological Sciences. (July 2013) 34, no. 7, 1105–1108, 10.1007/s10072-012-1186-7. 27. Shaygannejad V., Ardestani P. … E., Ghasemi M., and Meamar R., Restless Legs Syndrome in Iranian Multiple Sclerosis Patients: A Case-Control Study, International Journal of Preventive Medicine. (May 2013) 4, no. Suppl 2, S189–S193. 28. Koudriavtseva T., Renna R., Plantone D., Mandoj C., Piattella M. …

The prevalence of obstructive sleep apnea-hypopnea syndrome in patients with multiple sclerosis: a systematic review and meta-analysis.

OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome is the most common respiratory disorder in patients with multiple sclerosis. The purpose of this meta-analysis was to evaluate the prevalence of OSAHS in MS patients and to analyze their sleep monitoring indicators of patients. METHODS: Online databases such as PubMed, EMBASE, Web of Science, CNKI, and WanFang were used to review the Chinese and English literature about OSAHS in MS patients in detail. Two researchers analyzed the Quality of included studies based on the Quality Assessment of Diagnostic Accuracy Studies. The prevalence and s

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… Ma et al. ( 31 ) conducted a cross-sectional self-report survey of 231 MS patients and 265 sex—and age-matched controls, which also indicated a higher incidence of restless leg syndrome in MS patients (21.6% vs. 5.3%). … Comparison of prevalence rates of restless legs syndrome, self-assessed risks of obstructive sleep apnea, and daytime sleepiness among patients with multiple sclerosis (MS), clinically isolated syndrome (CIS) and Neuromyelitis Optica Spectrum disorder (NMOSD). …

KDIGO 2026 Clinical Practice Guideline for Anemia in Chronic Kidney Disease (CKD): a commentary from the European Renal Best Practice (ERBP).

The 2026 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Anemia in Chronic Kidney Disease represents a substantial update, coming more than a decade since the previous KDIGO guideline on the topic. This time lapse was necessary in order to accumulate new scientific evidence that was meaningful for an updated guideline. The new guideline now includes updated recommendations and practice points for anaemia management, incorporating recent evidence on intravenous iron therapies and hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs). This European R

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… Restless legs syndrome (RLS) is more common in CKD, and especially in dialysis patients, than in the general population. ID has been suggested to play a role in this complication [ 48 ]. … Restless legs syndrome in chronic kidney disease- a systematic review . Tremor Other Hyperkinet Mov (N Y) 2023 ; 13 : 10 . 10.5334/tohm.752 PMC10064886 37008995 49. Bernstein P , Monk RD. …

Карта знаний транскраниальной магнитной стимуляции бессонницы: библиометрический и визуальный анализ.

Бессонница - это one :: наиболее распространенные нарушения сна, серьезно сказывающиеся на физическом и психическом здоровье человека, снижающие эффективность и бдительность работы и потенциально даже приводящие к несчастным случаям, усугубляющие тем самым экономическое бремя как отдельных лиц, так и общества. Первичное лечение бессонницы включает фармакологическую и нефармакологическую терапию. С учетом потенциальных побочных эффектов, связанных с фармакологической терапией, существует настоятельная необходимость в применении безопасных и эффективных нефармакологических мер. Такие технологии,

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… Distinctive patterns of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome, restless legs syndrome, insomnia, and sleep deprivation . … Clinical and electrophysiological impact of repetitive low-frequency transcranial magnetic stimulation on the sensory-motor network in patients with restless legs syndrome . …

Атлас о факторах риска для множественного склероза: Менделианское исследование случайности.

ЦЕЛИ: Мы провели систематический обзор и широкомасштабное исследование на предмет случайной менделизации (MR) для изучения связи между возможными факторами риска и множественным склерозом (MS). Мы использовали анализ MR для оценки связей между 65 возможные факторы риска и НР с использованием данных, полученных в результате исследования, проведенного в масштабах всего генома, включая 14 498 случаи и случаи 24 091 контроль за европейским происхождением. Для 18 Мы провели систематический обзор воздействия, не подходящего для анализа МР, с целью получения последних данных метаанализа их связей с Н

Drug Repurposing for the Management of Depression: Where Do We Stand Currently?

A slow rate of new drug discovery and higher costs of new drug development attracted the attention of scientists and physicians for the repurposing and repositioning of old medications. Experimental studies and off-label use of drugs have helped drive data for further studies of approving these medications. A deeper understanding of the pathogenesis of depression encourages novel discoveries through drug repurposing and drug repositioning to treat depression. In addition to reducing neurotransmitters like epinephrine and serotonin, other mechanisms such as inflammation, insufficient blood supp

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… legs syndrome | Nonergot dopamine agonist with specificity for the D 2 subfamily dopamine receptor. … injury | Parkinson disease, restless legs syndrome Pregabalin Lyrica ® , Lyrica CR ® [ 86 ] | Fibromyalgia, neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, partial-onset seizures, postherpetic neuralgia | modulates calcium influx at the nerve terminals, thereby …

Spectrum of Movement Disorders in Hematological Malignancies: A Comprehensive Systematic Review of Clinical Phenotypes, Mechanisms, and Outcomes.

BACKGROUND: Movement disorders associated with hematologic malignancies remain incompletely defined. This review synthesized published articles to clarify clinical patterns, mechanisms, and outcomes across hematologic malignancies. METHODS: A PRISMA-compliant systematic search of PubMed, Embase, Scopus, and Google Scholar was conducted to identify reports describing movement disorders associated with hematologic malignancies. Eligible reports were screened according to predefined criteria, and data were extracted on demographics, hematologic diagnosis, central nervous system (CNS) involvement

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… A further 6 cases, also 27.3 percent, showed other movement-disorder presentations including tardive-dyskinesia–like syndromes, multifocal myoclonus, dystonia, restless legs syndrome, stiff-person syndrome, and non-specific involuntary movements. … Legs Syndrome; SPS: Stiff-Person Syndrome; TMP-SMX: Trimethoprim-Sulfamethoxazole; WHO: World Health Organization. …

Topiramate as a rare cause of reversible Fanconi syndrome and acute kidney injury: a case report and literature review.

Cervical spine is affected in more than a half of patients with rheumatoid arthritis (RA). Depending on the degree of damage to the individual joints and ligaments RA-related cervical spine instability takes the form of atlanto-axial subluxation, subaxial subluxation or cranial settling. In the advanced cases spinal stenosis can occur as well as spinal cord injuries with typical neurological symptoms. The identification of patients with cervical spine instability before the occurrence of neurological complications still constitutes a diagnostic challenge. The article presents the methods of ce

Iron Sucrose: A Wealth of Experience in Treating Iron Deficiency.

Iron deficiency and iron-deficiency anemia are associated with increased morbidity and mortality in a wide range of conditions. In many patient populations, this can be treated effectively with oral iron supplementation; but in patients who are unable to take or who do not respond to oral iron therapy, intravenous iron administration is recommended. Furthermore, in certain conditions, such as end-stage kidney disease, chronic heart failure, and inflammatory bowel disease, intravenous iron administration has become first-line treatment. One of the first available intravenous iron preparations i

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… Legs Syndrome Study Group rating scale, IS iron sucrose, IV intravenously administered, MI myocardial infarction, q.2.w. every 2 weeks, q.w. weekly, RLS restless legs syndrome, SAE serious adverse event, SF serum ferritin, t.i.d. three times daily, t.i.w. three times weekly, TSAT transferrin saturation … Iron sucrose was found to substitute iron loss in blood donors more efficiently compared with oral iron sulfate treatment, especially in women, and also reduced the severity of restless leg syndrome, which can occur as a complication of iron deficiency. …

An approach to treating older adults with chronic kidney disease.

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