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Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations.

INTRODUCTION: While genome-wide association studies (GWAS) have identified numerous susceptibility loci in Colorectal cancer (CRC), most fin … tified 25 genome-wide significant loci for CRC and colon polyps, including three novel loci in East Asian populations: BET1L (rs12226698, 11p15.5), OAS1 (rs2525858, 12q24.13), and BMP2 (rs4813802, 20p12.3). While BMP2 had been previously reported in European CRC studies, BET1L and OAS1 represent novel associations in East Asians. Colocalization analysis …

Oral health disorders among visually impaired children in South Asian countries: a systematic review.

BACKGROUND AND AIM: Despite the convergence of visual impairment and poor oral health among children, there is a scarcity of data on the com … (aged <18 years); assessment using dental examination; children with no other impairment from South Asian regions. Due to the high variability across age groups within the target population, we have synthesized and presented the data in a narrative format. RESULTS: The search across databases yielded a total of 1,681 studies, out of which 9 studies wer …

Dermatofibrosarcoma protuberans: A clinical and pathological observational report of Asian samples from one center.

BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade fibrohistiocytic tumor with malignant potential. It is considered to … venteen patients provided informed consent for detailed pathological examinations. RESULTS: Twenty Asian patients with a mean age of 42.55 years were included in this study. The location of the DFSP varied among the individuals; seven were closed by sutures, four were full-thickness skin grafts, and nine were closed using a pedicled flap. The average f …

Азиатские культурные ценности и поиск помощи: перекрестное исследование на тему навязчивого сексуального поведения.

Сексуальность является сложной конструкцией, на которую влияют различные социальные и культурные факторы, и хотя сексуальное поведение, как правило, считается адаптивным к физическому и психическому благополучию, оно может стать неконтролируемым и вредным, что ведет к навязчивому сексуальному поведению (CSB). Ограниченные исследования были посвящены изучению вопроса о том, как азиатские культурные ценности могут способствовать психологическим последствиям деятельности ЦСБ и влиять на отношение к поиску профессиональной психологической помощи. В этом исследовании рассматриваются взаимосвязи меж

Совпадение в аннотации оригинала
BackgroundSexuality is a complex construct influenced by various social and cultural factors, and while sexual behavior is generally considered adaptive for physical and mental well-being, it can become uncontrollable and harmful, leading to Compulsive Sexual Behavior (CSB). Limited research has explored how Asian cultural values may mediate the psychologica…

Disease outbreaks substantially enhance greenhouse gas emissions from Asian seabass (Lates calcarifer) aquaculture pond.

Asian seabass (Lates calcarifer) is a globally important aquaculture species. Rising demand for food has driven the development of high-density and intensive farming systems. However, these practices have also heightened the risk of disease outbreaks, which now represent a major challenge for the aquaculture industry. Notably, little is known about greenhouse gas (GHG) flux dynamics during seabass culture, particularly under disease outbreak conditions. In this study, we monitored a traditional earthen pond, measuring CO2, CH4, and N2O fluxes with environmental parameters. A giant seaperch iri…

Disparities in Cancer and Cardiovascular Disease Mortality Among Asian Americans Diagnosed with Urologic Cancer.

BACKGROUND: Asian Americans (AA) in the United States represent a heterogenous population from various ethnic backgrounds. We compared cancer and cardiovascular disease (CVD) mortality between various AA groups and Non-Hispanic White (NHW) patients diagnosed with urologic cancer. METHODS: We assembled a population-based cohort that included 389,114 prostate cancer, 98,721 renal cell cancer, and 126,485 bladder cancer patients. Cumulative cancer and CVD mortality were compared between AA and NHW groups, accounting for competing risk of death. Multivariable Cox models were used to quantify the …

One-year outcome of retrograde vascular access in peripheral arterial disease of Asian origin.

BACKGROUND: Retrograde puncture is a safe alternative after the antegrade approach has failed, and complications at the puncture site are rare. However, the differences in the retrograde puncture side, outcomes, and complications between intermittent claudication (IC) and chronic limb ischaemia (CLI) remain unclear, particularly for Asian populations, and studies on this population are scarce. MATERIAL AND METHODS: A retrospective analysis was conducted on 255 consecutive patients with symptomatic peripheral arterial disease undergoing tibio-pedal or distal femoral artery retrograde puncture …

Machine Learning-Based Prediction of First Trimester Down Syndrome Risk in East Asian Populations.

PURPOSE: Down syndrome is the most common chromosomal abnormality in newborns, often leading to developmental delays and congenital structural anomalies. This study employed multiple machine learning models to perform risk prediction and result exploration for first-trimester Down syndrome in East Asian populations, aiming to identify an optimal risk prediction model that will enhance future predictions of Down syndrome risk and improve the efficiency of the screening process. PATIENTS AND METHODS: This study collected data from the Down syndrome screening database at Taipei Chang Gung Memori…

Genetic analysis of two bladder exstrophy populations of South Asian and North American origin.

INTRODUCTION: Bladder exstrophy-epispadias complex (BEEC) is a devastating congenital anomaly of the urinary tract and is associated with an increased risk of bladder cancer. The etiology of the BEEC is unknown, but a clear genetic component has been highlighted. Currently, all genetic studies suffer from small populations, limited to a European background. OBJECTIVES: To identify copy number variations (CNVs) in a South Asian and North American bladder exstrophy cohorts. To identify novel non-European CNVs to expand the literature beyond its European ethnic background. STUDY DESIGN: Patient…

Does Low-Value Care Explain Health Care Utilization Inequities Among Asian and Latino Populations?

OBJECTIVES: To examine differences in the utilization of low-value care among Asian and Latino subpopulations compared to the White population. STUDY SETTING AND DESIGN: We analyzed data from a repeated cross-sectional national survey. DATA SOURCES AND ANALYTICAL SAMPLE: Our sample included a non-Latino White population and Asian and Latino subpopulation groups using data from the 2013-2021 Medical Expenditure Panel Survey. PRINCIPAL FINDINGS: Asian and Latino subpopulations used health care services less frequently than the White population, with adjusted differences ranging from -3.2% poi…

Spectrum of cancer risk in Asian American and Pacific Islander solid organ transplant recipients.

BACKGROUND: Solid organ transplant recipients (SOTRs) have increased cancer risk, which may differ across racial groups. Cancer risk among Asian American and Pacific Islander SOTRs is ill-defined. METHODS: We evaluated Asian, Pacific Islander, and White SOTRs from a linkage of the United States SOTR registry with 34 cancer registries (1990-2019). We calculated age- and sex-adjusted incidence rate ratios (aIRRs) to compare cancer risk between races and standardized incidence ratios (SIRs) to measure risk relative to race-matched general populations. RESULTS: Compared with Asian SOTRs, Pacific…

Vitiligo and Depression in Western versus South Asian Countries: Cultural Background Should Be Considered.

Reported psychosocial outcomes in vitiligo vary considerably across geographic and cultural contexts, yet no comprehensive review has compared these differences. In this study, we aimed to review the psychological and social impact of vitiligo, with a comparative focus on South Asia and Western countries. In this review, Western countries were defined as Europe, the United States, Canada, and Australia, whereas South Asian countries included India, Pakistan, Bangladesh, Sri Lanka, and Nepal. This narrative review was conducted using PubMed, Scopus, Web of Science, and PsycINFO, including Engli…

Genetic Insights Into Skin Diseases and Depression: Evidence From East Asian Mendelian Randomization Analysis.

BACKGROUND: This Mendelian randomization (MR) study systematically examines the causal links between skin disorders and depression in individuals of East Asian descent. METHODS: MR analysis employed summary-level genome-wide association study (GWAS) data from East Asian populations. Exposures included six skin diseases: atopic dermatitis (AD) (n = 168,103), urticaria (n = 172,083), vitiligo (n = 13,327), systemic lupus erythematosus (SLE) (n = 51,009), psoriasis (n = 69,688) and acne (n = 2062). Depression was assessed using major depressive disorder (MDD) data from the Psychiatric Genomics C…

Incidence of Heart Failure in Asian American, Native Hawaiian, and Other Pacific Islander Populations.

BACKGROUND: Asian American, Native Hawaiian, and Other Pacific Islander (AANHPI) persons comprise ∼10% of the U.S. population-24 million people-yet a significant gap exists in contemporary data on incident heart failure (HF). OBJECTIVES: The purpose of this study was to investigate the incidence of HF across disaggregated AANHPI individual groups. METHODS: We identified adults aged ≥30 years without cardiovascular disease (CVD) within Kaiser Permanente Northern California and Kaiser Permanente Hawaii from 2012 to 2022. Incident HF through 2023 was defined as a hospitalization, ≥3 clinic visi…

Pathogenic piscine intestinal coccidia infection alters gut microbiome in juvenile Asian seabass (Lates calcarifer).

BACKGROUND: Piscine intestinal coccidiosis has been associated with increased susceptibility to secondary bacterial infections, potentially … ut microbiota composition and the relative abundance of potentially pathogenic bacteria in juvenile Asian seabass (Lates calcarifer). Intestinal samples from seven coccidia-infected and five uninfected fish were analyzed using 16S rRNA gene sequencing. Infected fish demonstrated greater microbial diversity and marked compositional shifts across multiple …

Association Between HLA-DRB1 Alleles and Graves' Disease in Asian Populations: A Meta-Analysis.

Graves' disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is the most common cause of hyperthyroidism. Gene … <0.0001) and DRB1*0701 (OR=0.44, 95% CI=0.35-0.55, pc<0.0001). The meta-analysis indicated that, in Asian populations, DRB1*1403 is a risk allele for GD, and DRB1*0101 and DRB1*0701 are protective against the occurrence of GD. We surprisingly discovered that the susceptibility alleles for GD in Asian populations are completely different from Caucasians …

Metabolic Comorbidities in Pediatric Psoriasis-A Comparative Cross-Sectional Study in South-Asian Children.

BACKGROUND: There is only limited data on the association between psoriasis and metabolic comorbidities in South-Asian children. OBJECTIVE: To examine metabolic comorbidities among South-Asian children with and without psoriasis. MATERIALS AND METHODS: A hospital-based, comparative, cross-sectional study was conducted in children with and without psoriasis over 19 months. Anthropometric, clinical, and metabolic comorbidity details (including disease extent and severity scores, obesity, systemic hypertension, diabetes mellitus, lipid abnormalities, and metabolic syndrome) were obtained in bot…

Brachiocephalic Artery Access Without Sternotomy in Older Asian Patients Undergoing Transcatheter Aortic Valve Replacement.

There are numerous approaches for transcatheter aortic valve replacement (TAVR); however, access-related complications remain a point of concern. We analyzed consecutive patients who underwent TAVR for severe aortic stenosis via the brachiocephalic artery (BCA) without sternotomy (TBc group, n = 10) and via the trans-ascending aortic (TAo group, n = 8). The median BCA diameter and distance between the access point and suprasternal notch or superior margin of the clavicle were 11.3 mm and 8.3 mm, respectively. No patients in the TBc group underwent a partial sternotomy. Compared with the TAo gr

Prevalence of low vitamin D levels among older US Asian and Pacific Islander adults.

UNLABELLED: While US Asian and Pacific Islander adults have lower 25-hydroxyvitamin D (25(OH)D) levels than White adults, ethnic subgroup data remain limited. In a large California population, the adjusted prevalence of 25(OH)D < 20 ng/mL (50 nmol/L) was 1.5- to 2.7-fold higher for Asian/Pacific Islander compared to White adults, with substantial variation by ethnicity. PURPOSE: US Asian and Pacific Islander (PI) adults generally have lower 25-hydroxyvitamin D [25(OH)D] levels than non-Hispanic White (NHW) adults, but subgroup data remain limited. We compared sex- and ethnicity-specific preva…

Does the palpebral morphology influence the tear meniscus height between Caucasian and Asian eyes?

PURPOSE: The central lower TMH is used as a clinical measure of tear volume in the assessment of contact lens candidates and patients with dry eyes. Ethnic differences in eyelid morphology may influence the measurement of the TMH. Furthermore, with the advent of larger contact lenses, such as scleral lenses, it would be of clinical value to assess the TMH centrally and peripherally. The purpose of this study was to evaluate and compare the TMH at different positions along the palpebral margin between Caucasian and Asian eyes. METHODS: This prospective study evaluated the lower TMH in five pos…