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Treatment of Psoriasis with Secukinumab in Challenging Patient Scenarios: A Review of the Available Evidence.

Psoriasis (PsO) is a common, systemic, chronic, inflammatory disease characterized by key clinical symptoms, including itching, pain, and scaling. PsO is associated with a high prevalence of comorbidities, including other autoimmune diseases and malignancies. Furthermore, special populations, such as pregnant, pediatric, and elderly patients, and those with erythrodermic PsO, are challenging to treat and require tightly monitored disease and treatment management. Because certain populations have demographic or clinical characteristics that can affect the presentation of PsO and complicate trea

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… Strober BE, Clay Cather J, Cohen D, et al. A Delphi consensus approach to challenging case scenarios in moderate-to-severe psoriasis: part 2. Dermatol Ther (Heidelb) 2012;2(1):2-012-0002-x. doi: 10.1007/s13555-012-0001-y. 10. Amin M, No DJ, Egeberg A, Wu JJ. …

Current Landscape of Genome-Wide Association Studies in Acute Myeloid Leukemia: A Review.

Acute myeloid leukemia (AML) is a clonal hematopoietic disease that arises from chromosomal and genetic aberrations in myeloid precursor cells. AML is one of the most common types of acute leukemia in adults; however, it is relatively rare overall, comprising about 1% of all cancers. In the last decade or so, numerous genome-wide association studies (GWAS) have been conducted to screen between hundreds of thousands and millions of variants across many human genomes to discover genetic polymorphisms associated with a particular disease or phenotype. In oncology, GWAS has been performed in almos

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… Clay-Gilmour A.I. Karaesmen E. Rizvi A. Zhu Q. Yan L. Preus L. Liu S. Wang Y. Griffiths E. Genome-Wide Association Analyses Identify Variants in Front. Genet. 2021 12 554948 10.3389/fgene.2021.554948 34220922 PMC8248805 28. Ramazzotti G. Billi A.M. Manzoli L. Mazzetti C. Ruggeri A. Erneux C. …

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulate the expression of both normal and mutant HTT is a promising therapeutic approach. We previously developed a small hairpin RNA (shRNA), vectorized in an HIV-1-derived lentiviral vector (LV), that reduced pathology in an HD rodent model. Here, we modified this vector for preclinical development by using a tat-independent third-generation LV (pCCL) ba

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… Finally, pCCL-H1-shHTT6 and pCCL-H1-shLUC were generated from pENTR/D-TOPO-H1-shHTT6 and pENTR/D-TOPO-H1-shLUC by digesting them with NotI blunt and PvuII and cloning the H1-shHTT6 and H1-shLUC fragments into ClaI-EcoRI blunt digested pCCL-mPGK-nls-LacZ-WPRE-SINΔXbaI. … Genet. 81 2012 117 122 22151007 10.1111/j.1399-0004.2011.01823.x PMC3320660 11 Clay E. De Nicola A. Dorey J. Squitieri F. Aballéa S. Martino T. Tedroff J. Zielonka D. Auquier P. Verny C. Toumi M. …

Telerehabilitation's Safety, Feasibility, and Exercise Uptake in Cancer Survivors: Process Evaluation.

BackgroundAccess to exercise for cancer survivors is poor despite global recognition of its benefits. Telerehabilitation may overcome barriers to exercise for cancer survivors but is not routinely offered.ObjectiveFollowing the rapid implementation of an exercise-based telerehabilitation program in response to COVID-19, a process evaluation was conducted to understand the impact on patients, staff, and the health service with the aim of informing future program development.MethodsA mixed methods evaluation was completed for a telerehabilitation program for cancer survivors admitted between Mar

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… Newton RU, Hart NH, Clay T. Keeping patients with cancer exercising in the age of COVID-19. JCO Oncol Pract. 2020 Oct;16(10):656–664. doi: 10.1200/OP.20.00210. http://europepmc.org/abstract/MED/32603253 . 11. Cox A, Lucas G, Marcu A, Piano M, Grosvenor W, Mold F, Maguire R, Ream E. …

SCS 6th Annual Meeting-EEVFA-11th International Congress of Biochemistry and Physiology of Exercise, Athens, Greece, 2023.

On behalf of the Strength and Conditioning Society (SCS) and the Hellenic Society of Biochemistry and Exercise Physiology (EEVFA), we are pleased to present the abstracts of the SCS 6th Annual Meeting and EEVFA-11th International Congress of Biochemistry and Physiology of Exercise. The event was held at the Hellenic Olympic Committee headquarters in Athens, Greece, on 19-22 October 2023, and comprised several invited sessions from international and national speakers on a variety of topics related to biochemistry and exercise physiology, strength and conditioning practices and their application

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… According to the results, the performance of Group A was higher during all field tests on the respective training court surface (hard court) ( p ≤ 0.01; 0.05), while Group B showed higher performance in the clay court only during the Hit and Turn test ( p ≤ 0.05). … In addition, both groups showed enhanced performance in all tests when evaluated on hard court ( p ≤ 0.05), compared to clay court, with the exception of Hit and Run test where no differences were observed. …

Digital Life Coaching During Stem Cell Transplantation: Development and Usability Study.

BACKGROUND: For patients with multiple myeloma receiving high-dose chemotherapy followed by autologous stem cell transplantation (SCT), acute life disruptions and symptom burden may lead to worsened quality of life (QOL) and increased emotional distress. Digital life coaching (DLC), whereby trained coaches deliver personalized well-being-related support via phone calls and SMS text messaging, has been shown to improve QOL among SCT survivors. However, DLC has not been investigated during the acute peri-SCT period, which is generally characterized by symptomatic exacerbations and 2-week hospita

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… Johnson PC, Bhatt S, Reynolds MJ, Dhawale TM, Ufere N, Jagielo AD, Lavoie MW, Topping CE, Clay MA, Rice J, Yi A, DeFilipp Z, Chen Y, El-Jawahri A. Association between baseline patient-reported outcomes and complications of hematopoietic stem cell transplantation. …

Циркуляция уровней инсулиновоподобных факторов роста I (IGF-I) и риска множественной миэломы: исследование наблюдений и менделии случайности.

Доказательства взаимосвязи между инсулиновыми факторами роста (ИПФ) и множеством миэломы (ММ) являются непоследовательными. Мы изучили общие концентрации ФУИ-I и риск ММ путем объединения исходных серологических данных среди участников Биобанка Соединенного Королевства (n = 444 187; 732 ДТП MM) с two- выборка менделианского анализа случайности (MR) с использованием выявленных генетических вариантов, связанных с циркуляцией общего ФУИ-I и связывающего белка ФУИ; 3 (В тыс.IGFBP-3) в консорциуме " ИнтерЛимф " ( " Интерлимф " )2434 ММ и их 2567 - контроль). Наконец, для сравнен

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… Nat Genet . 2014 ; 46 ( 11 ): 1233 – 1238 . 10.1038/NG.3105 25261932 PMC4213349 32 Clay‐Gilmour AI , Hildebrandt MAT , Brown EE , Hofmann JN , Spinelli JJ , Giles GG , et al. Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance . …

Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions.

Chemotherapy induced peripheral neuropathy (CIPN) is an often severe and debilitating complication of multiple chemotherapeutic agents that can affect patients of all ages, across cancer diagnoses. CIPN can persist post-therapy, and significantly impact the health and quality of life of cancer survivors. Identifying patients at risk for CIPN is challenging due to the lack of standardized objective measures to assess for CIPN. Furthermore, there are no approved preventative treatments for CIPN, and therapeutic options for CIPN remain limited once it develops. Biomarkers of CIPN have been studie

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… Sucheston-Campbell LE Clay-Gilmour AI Barlow WE Budd GT Stram DO Haiman CA . Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci . Pharmacogenet Genomics. ( 2018 ) 28 : 49 – 55 . 10.1097/FPC.0000000000000318 29278617 PMC5824720 69. …

The Impact and Molecular Mechanisms of Exercise in Cancer Therapy.

Cancer is a major global health issue, and exercise has become a key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, and aiding recovery, especially for survivors. However, the exact mechanisms, such as how exercise reduces cancer risk or enhances treatment, are still unclear. Current research often focuses on specific cancer types, ignoring the diverse needs of patients. This limits the development of personalized exercise plans. Additionally, there is insufficient comparison of exercise types-like aerobic, resistance, and high-intensity interval training-re

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… Clay T. Keeping patients with cancer exercising in the age of COVID-19 JCO Oncol. Pract. 2020 16 656 664 10.1200/OP.20.00210 32603253 PMC7564134 27. Rao R.M. Amritanshu R. Vinutha H. Vaishnaruby S. Deepashree S. Megha M. Geetha R. Ajaikumar B. …

Interleukin-1 Beta-A Friend or Foe in Malignancies?

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and its multi-facetted role in pathophysiological conditions. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4+ T cells towards T helper type (Th) 1 and Th17 cells. Therefore, IL-1β has been attributed a largely beneficial

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… Clay W.C. Leesnitzer L.M. Ways J.P. Gray J.G. NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site J. Immunol. 1994 153 712 723 8021507 23. Roshan M.H. Tambo A. Pace N.P. … Clay W.C. Stinnett S.W. Haneline S.A. Lorenz J.J. Patel I.R. Wisely G.B. Furdon P.J. Taylor J.D. A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines Mol. Cell. …

Genetic architecture of multiple myeloma: From somatic alterations to germline susceptibility and clinical implications.

Multiple myeloma (MM) is best understood as a dynamically evolving genomic ecosystem shaped by inherited susceptibility, early oncogenic events, and continuous selective pressures. We propose an evolutionary genomics framework integrating germline risk, disease initiation, clonal diversification, and therapeutic adaptation into a unified model of MM biology. Polygenic risk burden, rare predisposing variants, and alterations in DNA repair and telomere pathways create a permissive background that influences precursor states and immune interactions. Primary cytogenetic events, particularly immuno

Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization.

Multiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promoting resistance to treatments. To date no studies have determined the impact of genetic variation in autophagy-related genes on MM risk. We performed meta-analysis of germline genetic dat

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… Clay-Gilmour A.I. Hildebrandt M.A.T. Brown E.E. Hofmann J.N. Spinelli J.J. Giles G.G. Cozen W. Bhatti P. Wu X. Waller R.G. …

Treating Lows: Management of Orthostatic Hypotension.

AbstractOrthostatic hypotension is a prevalent clinical condition, caused by heterogenous etiologies and associated with significant morbidity and mortality. Management is particularly challenging in patients with uncontrolled hypertension. A thorough assessment is needed to draw an appropriate management plan. The treatment aims to improve postural symptoms while minimizing side effects and reducing iatrogenic exacerbation of supine hypertension. A personalized management plan including rationalizing medications, patient education, identification, and avoidance of triggers, as well as nonphar

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… Lanier JB Mote MB Clay EC . Evaluation and management of orthostatic hypotension . Am Fam Physician . 2011 ; 84 : 527 – 536 . 21888303 21. Proudman RGW Pupo AS Baker JG . …

Multisystemic sarcoidosis-important lessons learnt from one of the great imitators.

We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigat

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… She also denied any tea coloured urine and clay coloured stools. The rest of her review of systems was unremarkable. Physical examination The patient was afebrile and normotensive. She appeared comfortable. …

Survival protection of patients undergoing hematopoietic stem cell transplantation: grounded theory.

PurposeFor patients with blood malignancies, hematopoietic stem cell transplantation (HSCT) is a significant challenge. These patients have hope to be completely cured after the transplantation, but deal with the dread of dying at the same time. This study presents a deep understanding of the psychological process of the treatment including perception, emotion, interactions, and its consequences in patients undergoing HSCT.MethodsThis study utilized a qualitative method based on the Strauss and Corbin Approach toward the grounded theory. The research population comprised all patients undergoin

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… Amonoo HL Topping CEW Clay MA Reynolds MJ Rice J Harnedy LE Longley RM LeBlanc TW Greer JA Chen Y-B DeFilipp Z Lee SJ Temel JS El-Jawahri A Distress in a pandemic: association of the coronavirus disease-2019 pandemic with distress and quality of life in hematopoietic stem cell transplantation Transplant …

MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance.

MicroRNAs (miRNAs, or miRs) are single-strand short non-coding RNAs with a pivotal role in the regulation of physiological- or disease-associated cellular processes. They bind to target miRs modulating gene expression at post-transcriptional levels. Here, we present an overview of miRs deregulation in the pathogenesis of multiple myeloma (MM), and discuss the potential use of miRs/nanocarriers association in clinic. Since miRs can act as oncogenes or tumor suppressors, strategies based on their inhibition and/or replacement represent the new opportunities in cancer therapy. The miRs delivery s

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… Clay T.M. Valente N. Shreeniwas R. Sutton M.A. Delcayre A. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer J. Transl. Med. 2005 3 9 10.1186/1479-5876-3-9 15723705 PMC551593 107. Hanna J. Hossain G.S. Kocerha J. …

Client preferences in noncommunicable diseases management in Australia: A scoping review.

Noncommunicable diseases (NCD) are the leading causes of mortality in Australia. Understanding clients' preferences is essential to implement effective care models that revitalize utilization of services. This study aims to review existing evidence on client preferences of service delivery among people with NCD in Australia. We followed PRISMA extension for scoping review. Articles conducted with discrete choice experiment were included. Clients with NCD in general or one of the five major diseases: cardiac diseases, diabetes, cancer, chronic respiratory diseases, and mental health disorders.

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… Clay-Williams R, Hibbert P, Loy G, Braithwaite J. Innovative Models of Care for Hospitals of the Future. Int J Health Policy Manag. 2024;13:7861. doi: 10.34172/ijhpm.2024.7861 13. Endalamaw A, Zewdie A, Wolka E, Assefa Y. …

Double Repositioning: Veterinary Antiparasitic to Human Anticancer.

Drug repositioning, the approach of discovering different uses for existing drugs, has gained enormous popularity in recent years in the anticancer drug discovery field due to the increasing demand for anticancer drugs. Additionally, the repurposing of veterinary antiparasitic drugs for the treatment of cancer is gaining traction, as supported by existing literature. A prominent example is the proposal to implement the use of veterinary antiparasitics such as benzimidazole carbamates and halogenated salicylanilides as novel anticancer drugs. These agents have revealed pronounced anti-tumor act

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… Clay T.M. Chen W. Morse M.A. Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations Cancer Res. 2011 71 4172 4182 10.1158/0008-5472.CAN-10-3978 21531761 PMC3117125 70. Wang J. Ren X.-R. Piao H. Zhao S. Osada T. …

Safety, Precautions, and Modalities in Cancer Rehabilitation: an Updated Review.

Purpose of reviewProviding rehabilitation to patients with cancer can be challenging due to the medical complexity associated with the illness and its treatments. This article provides the reader with a summary of frequently encountered medical conditions in the cancer population and associated safety considerations and precautions. An update on treatment modalities commonly used for symptom management is also presented.Recent findingsCancer and cancer treatments can cause changes in multiple organ systems. Special considerations and precautions are necessary to provide safe and effective reha

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… Hart NH, Galvão DA, Saunders C, Taaffe DR, Feeney KT, Spry NA, Tsoi D, Martin H, Chee R, Clay T. …

Recent Progress of Exosomes in Multiple Myeloma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Strategies.

Multiple myeloma (MM) is a hematological malignancy that is still incurable. The bone marrow microenvironment (BMM), with cellular and non-cellular components, can create a favorable environment for the survival, proliferation and migration of MM cells, which is the main reason for the failure of MM therapies. Many studies have demonstrated that exosomes play an important role in the tumor-supportive BMM. Exosomes are nanoscale vesicles that can be released by various cells. Some exosomes contribute to the pathogenesis and progression of MM. MM-derived exosomes act on different cells in the BM

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… Morse M.A., Garst J., Osada T., Khan S., Hobeika A., Clay T.M., Valente N., Shreeniwas R., Sutton M.A., Delcayre A., et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med. 2005;3:9. doi: 10.1186/1479-5876-3-9. 90. …