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Gamma Knife radiosurgery for multiple sclerosis-associated trigeminal neuralgia.

BACKGROUND: Gamma Knife radiosurgery (GKRS) has well-known efficacy in the treatment of idiopathic trigeminal neuralgia (TN). However, few studies have evaluated the effects of GKRS in the treatment of multiple sclerosis (MS)-related TN. This study analyzed the efficacy and complications of GKRS for MS-related TN. METHODS: This retrospective study included 28 MS-related TN patients who underwent GKRS with a median follow-up of 27 (range, 12-181) months. The cisternal segment of the trigeminal nerve was targeted with a median radiation dose of 80 (80-90) Gy. Pain intensity was assessed using B…

Ocular Manifestations of Multiple Sclerosis: A Population-Based Study.

BACKGROUND: To evaluate the population-based frequency and severity of multiple sclerosis (MS)-related ocular diseases. METHODS: Retrospective, population-based study examining patients with MS between January 1, 1998 and December 31, 2011. Patients were identified using the Rochester Epidemiology Project, which is a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota residents. Diagnosis of MS was confirmed based on neuroimaging, cerebrospinal fluid studies, and serum studies for each patient according to the 2017 McDonald criteria. P…

Гематологические маркеры как прогнозные индикаторы в множестве склерозов.

AIMS: Оценка стандартных параметров подсчета крови в качестве диагностических и прогнозных маркеров в прогрессии множественных склерозов (MS). ПАТИЕНТЫ/МЕТХОДЫ: 182 пациента с релапсирующими-излучающими MS (RRMS) и 60 пациентов с вторичными прогрессивными MS (SPMS) были проанализированы на параметры крови. Результаты: В RRMS оценка Расширенной шкалы статуса инвалидов (EDSS) положительно соотносится с оценкой распределения красных клеток (RDW). В SPMS оценка EDS положительно соотносится с количеством белых кровяных клеток (WBC) и средним объемом талонов (MPV). RDW предсказывал более высокие оце

Совпадение в аннотации оригинала
AIMS: To evaluate routine blood count parameters as diagnostic and prognostic markers in Multiple Sclerosis (MS) progression. PATIENTS/METHODS: 182 patients with Relapsing-Remitting MS (RRMS) and 60 with Secondary Progressive MS (SPMS) were analyzed for blood parameters. RESULTS: In RRMS, the Expanded Disability Status Scale (EDSS) score correlated positiv…

Микробиота грибкового кишечника в педиатрии с множественным склерозом.

По имеющимся данным, кишечный микробиом может играть определенную роль в множестве склероза (MS). Однако в большинстве исследований основное внимание уделяется кишечным бактериальным сообществам; ни одно из них не изучало грибковую микробиоту (mycobiota) у лиц с педиатрическим множественным склерозом (POMS). Мы изучили кишечник микобиота у людей с ПОМС и без нее посредством перекрестного обследования кишечника микобиота из 46 Образцы стульев участниковthree группы: 18 ПОМЫ, 13 приобретенные монофазные демиелинизирующие синдромы [моноАДС], и 15 Не связанные с этим меры контроля). Использование

Совпадение в аннотации оригинала
Evidence suggests that the gut microbiome may play a role in multiple sclerosis (MS). However, the majority of the studies have focused on gut bacterial communities; none have examined the fungal microbiota (mycobiota) in persons with pediatric-onset multiple sclerosis (POMS). We examined the gut mycobiota in persons with and without POMS through a cross-sec…

Диагностический потенциал биомаркеров на основе крови в множестве склерозов.

Множественный склероз (MS) — хроническое воспалительное заболевание, затрагивающее центральную нервную систему (CNS). Существует значительная задержка с диагностированием MS, поскольку симптомы и тесты пересекаются с другими заболеваниями. Биомаркеры на основе крови, которые дают количественную оценку фрагментам белков, участвующих в патофизиологии MS, обладают потенциалом в качестве диагностических биомаркеров. В этом исследовании мы провели оценку биомаркеров иммуномассами, разрушения тканей, что нашло отражение в крупнокананской деградации матричных металлических протеинов (ММП) (МГМ), кате

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). There is a significant delay in diagnosing MS as the symptoms and tests overlap with other diseases. Blood-based biomarkers, which quantify fragments of proteins involved in MS pathophysiology, have the potential as diagnostic biomarkers. In this study, we e…

Границы микроРНК: Просветление путей раннего обнаружения в множестве склерозов.

Множественный склероз (MS) проявляется как постепенная инвалидность, обусловленная демиэлизацией аксонов в центральной нервной системе, что приводит к нейрональной потере и атрофии в мозге и спинном мозге. Диагноз, как правило, предполагает тщательную оценку медицинской истории, симптомов, физических осмотров и различных диагностических процедур, включая магнитную резонансную съемку, анализ цереброспинной жидкости, анализ крови и электрофизиологию. Однако существующие биомаркеры часто не могут надежно соотноситься с развитием заболеваний. Понимание молекулярных механизмов, определяющих прогрес

Совпадение в аннотации оригинала
Multiple sclerosis (MS) manifests as progressive disability stemming from the demyelination of axons within the central nervous system, resulting in neuronal loss and atrophy in the brain and spinal cord. Diagnosis typically entails a thorough assessment of medical history, symptoms, physical examination, and various diagnostic procedures, including magnetic…

[Gut microbiota in patients with relapsing-remitting multiple sclerosis].

Microorganisms in human life play a huge role: in particular, those that coexist with the host organism, inhabiting the skin, upper respirat … t data on the composition of bacteriome, mycobiome, and virome in patients with relapsing-remitting multiple sclerosis.

Multiple sclerosis and autoimmune diseases - a case control study.

INTRODUCTION: Multiple sclerosis (MS) is one of the most common autoimmune diseases worldwide, and various autoimmune comorbidities have been reported with MS. The aim of this study was to estimate the prevalence of autoimmune disease comorbidity in patients with MS and their relatives in a Polish population. MATERIAL AND METHODS: In this retrospective multicentre study, we investigated a group of patients with MS, and their relatives, in terms of age, gender, and the presence of simultaneous autoimmune diseases such as Graves's Disease, Hashimoto's thyroiditis, type 1 diabetes mellitus, myas…

Unilateral Pendular Nystagmus in Multiple Sclerosis: A Case Series.

BACKGROUND: Acquired pendular nystagmus is most often seen in patients with demyelinating disease. Although it is often bilateral, rare case … describe 5 patients (3 women) aged 31-49 with monocular pendular nystagmus. All had a diagnosis of multiple sclerosis. Three patients had horizontal and 2 had vertical pendular nystagmus. The Snellen visual acuity in the eye with pendular nystagmus varied from 20/20 to 20/200. Two patients were asymptomatic and 3 suffered visually debilitating oscillopsia. Treatmen …

Pregnancy-related healthcare utilization among women with multiple sclerosis.

IntroductionMany studies have investigated pregnancy in women with multiple sclerosis (MS). However, no study has measured prenatal healthcare utilization in women with MS or adherence to follow-up recommendations to improve antenatal care quality. A better knowledge of the quality of antenatal care in women with MS would help identify and better support women with insufficient follow-up. Our objective was to measure the level of compliance to prenatal care recommendations in women with MS using data from the French National Health Insurance Database.MethodsThis retrospective cohort study incl…

Alopecia associated with dimethyl fumarate treatment for multiple sclerosis.

After 2 weeks of treatment, a woman with multiple sclerosis treated with dimethyl fumarate developed alopecia. Considering the adverse events, the therapy was discontinued, leading to alopecia regression during the next 3 months. Although the precise mechanism has not been completely elucidated, glutathione depletion or downregulation of aerobic glycolysis are considered to be potential reasons for hair loss induction. The incidence and mechanism of this uncommon adverse reaction to dimethyl fumarate should be further investigated.

Moving toward personalized B cell depletion in multiple sclerosis?

B cell depletion is becoming a preferred long-term treatment even in early multiple sclerosis, but concerns about the risks of impaired immune competence persist. In their observational study Schuckmann et al. thoroughly assessed the impact of B cell-adapted extended interval dosing on immunoglobulin levels as a surrogate of adverse immunosuppressive effects.

Dissecting shared genetic architecture between obesity and multiple sclerosis.

BACKGROUND: Observational studies have associated obesity with an increased risk of multiple sclerosis (MS). However, the role of genetic factors in their comorbidity remains largely unknown. Our study aimed to investigate the shared genetic architecture underlying obesity and MS. METHODS: By leveraging data from genome-wide association studies, we investigated the genetic correlation of body mass index (BMI) and MS by linkage disequilibrium score regression and genetic covariance analyser. The casualty was identified by bidirectional Mendelian randomisation. Linkage disequilibrium score regr…

Primary Hyperparathyroidism overlapping with Multiple Sclerosis: a catastrophic marriage.

Primary hyperparathyroidism (PHPT) often leads to neurological or psychiatric disorders, thus mimicking different diseases. Here we present a 77-years old man visited in the Emergency Department complaining for fatigue, multiple falls, nausea, anorexia, and constipation. Symptoms were rapidly worsening, and on admission he appeared sleepy, responsive to verbal stimulus, disoriented, dehydrated, unable to maintain upright position. He suffered from mild, relapsing and remitting Multiple Sclerosis (MS) since the age of 45, at that moment not requiring treatment. The laboratory tests displayed se…

Neuroimaging Correlates of Patient-Reported Outcomes in Multiple Sclerosis.

BACKGROUND: Patient-reported outcomes (PROs) are increasingly associated with concurrent and future impairments in persons with multiple sclerosis (pwMS). The structural and pathological relationships with PROs in pwMS have not been elucidated. METHODS: One hundred and forty-two pwMS and 47 healthy controls (HCs) were scanned using 3T MRI and completed a PRO questionnaire named Lifeware® that outlines the physical and psychosocial abilities. Beck's Depression Inventory (BDI) assessed levels of depression. T1- and T2-lesion volume, volumes of the whole brain (WBV), gray matter (GMV), white mat…

Vaccination frequency in people newly diagnosed with multiple sclerosis.

BACKGROUND: Infections are discussed as risk factor for multiple sclerosis (MS) development and relapses. This may lead to decreased vaccination frequency in newly diagnosed patients. OBJECTIVE: The aim of this study was to evaluate the relation of MS diagnosis to subsequent vaccination frequency. METHODS: Based on German ambulatory claims data from 2005 to 2019, regression models were used to assess the relation of MS diagnosis (n = 12,270) to vaccination. A cohort of patients with MS was compared to control cohorts with Crohn's disease, psoriasis, and without these autoimmune diseases (tot…

Coexistence of multiple sclerosis and spinocerebellar ataxia type-8.

Cerebellar dysfunction is likely to cause severe and treatment-resistant disability in multiple sclerosis (MS). Certain spinocerebellar ataxia (SCA)-related alleles can increase MS susceptibility, and channel polymorphisms can impact disability measures. Following an index patient with the coexistence of MS and SCA Type-8 (SCA8) in the MS clinic, an institutional engine search for MS and hereditary ataxia coexistence was conducted but did not reveal any other cases. This extremely rare coexistence of MS and SCA8 in our index patient may be incidental; however, a yet-to-be-identified contributi…