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Preclinical evaluation of the antibody fragment targeting fibronectin EDB in the theranostics of radioactive iodine-resistant thyroid cancer.

OBJECTIVE: Radioactive iodine-resistant thyroid cancer (RAIR-TC) poses diagnostic and therapeutic challenges due to the absence of sodium/iodide symporter (NIS) expression. This study aims to evaluate the preclinical value of 89Zr-DFO-EDB and 177Lu-DTPA-EDB, an antibody fragment targeting fibronectin EDB (FN-EDB), in the theranostics of RAIR-TC. METHODS: A CAL-62 human iodine-resistant thyroid cancer xenograft mouse model was established. The EDB antibody fragment (approximately 100 kD), selected through phage display technology, was labeled with 89Zr and 177Lu, respectively. The targeting ch

Retrospective preliminary clinical study on mandibular full-arch segmented implant-borne fixed dental prostheses developed via digital workflow: A 3-year follow-up of 14 patients.

OBJECTIVES: Multiple implants for facilitating the fabrication of shorter-span prostheses can reduce the complications associated with implant-borne fixed dental prostheses. This retrospective clinical study aimed to assess the short-term clinical and radiological outcomes of two- and three-piece mandibular full-arch implant-borne fixed dental prostheses. METHODS: Immediate implant placement was performed in the lower jaw, and patients received an immediate temporary acrylic prosthesis on multiunit abutments. At least six implants supported the segmented full-arch prostheses. Final prostheses

PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.

UNLABELLED: Hypoxic tumor cells are resistant to radiotherapy and various chemotherapeutic agents. The pretherapeutic assessment of intratumoral hypoxia may allow selection of patients for intensified treatment regimens. Carbonic anhydrase IX (CAIX) is an endogenous hypoxia-related protein involved in pH regulation and is upregulated in many tumor types. Radionuclide imaging using a monoclonal antibody against CAIX, such as cG250, may allow noninvasive PET of hypoxia in these tumor types. The aims of this study were to investigate whether (89)Zr-labeled cG250-F(ab')(2) allowed visualization of

Preserving pulpal health of a geminated maxillary lateral incisor through multidisciplinary care.

AIM: To report the multidisciplinary care of an unaesthetic geminated maxillary lateral incisor tooth, which allowed its preservation in the mouth. SUMMARY: Preoperative examination of an unsightly geminated maxillary lateral incisor (tooth 22) demonstrated two pulp chambers and open apices, with normal pulp sensitivity responses. At surgery, a periodontal mucoperiosteal flap was reflected and the distal part of the geminated tooth was removed. The exposed root canal of the preserved tooth was sealed with mineral trioxide aggregate (MTA). The extraction socket and osseous defect was grafted w

Response of human pulps capped with a self-etching adhesive system.

OBJECTIVE: The aim of this study was to evaluate the human pulp response following direct pulp capping with a current self-etching bonding agent and calcium hydroxide (CH). METHODS: Thirty-three sound human premolars had their pulp tissue mechanically exposed. Sterile distilled water was used to control the hemorrhage and exudation from the pulp exposure site. The pulps were capped with Clearfil Liner Bond 2 (CLB-2) or CH and the cavities were filled with a resin composite (Z-100) according to the manufacturer's instructions. After 5, 30 and 120-300 days, the teeth were extracted and processe

The influence of customized abutments and custom metal abutments on the presence of the interproximal papilla at implants inserted in single-unit gaps: a 1-year prospective clinical study.

OBJECTIVES: To assess and compare the papilla presence mesially and distally to dental implants restored with customized abutments and custom metal abutments in the anterior maxilla. MATERIAL AND METHODS: Thirty-eight patients receiving 38 single-tooth implants, restored with 26 customized abutments and 12 custom metal abutments in the anterior maxillary region were enrolled in this study. The cases where did not existed contact point were excluded. Presence/absence of the interproximal papilla, inter-tooth-implant distance (ITD) and distance from the base of the contact point to dental crest

Early bacterial colonization and soft tissue health around zirconia and titanium abutments: an in vivo study in man.

AIM: To compare the early bacterial colonization and soft tissue health of mucosa adjacent to zirconia (ZrO(2)) and titanium (Ti) abutment surfaces in vivo. MATERIALS AND METHODS: Twenty edentulous subjects received two endosseous mandibular implants. The implants were fitted with either a ZrO(2) or a Ti abutment (non-submerged implant placement, within-subject comparison, left-right randomization). Sulcular bacterial sampling and the assessment of probing pocket depth, recession and bleeding on probing were performed at 2 weeks and 3 months post-surgery. Wilcoxon matched-pairs, sign-rank tes

A prospective study of implant-supported full-arch yttria-stabilized tetragonal zirconia polycrystal mandibular fixed dental prostheses: three-year results.

PURPOSE: The development of high-strength oxide ceramic materials has led to increased interest in all-ceramic fixed dental prostheses (FDPs). Success rates reported in clinical studies for all-ceramic FDPs based on high-strength oxide ceramic materials reportedly approach those of porcelain-fused-to-metal FDPs. These reconstructions, however, are still of limited size and have mainly concerned FDPs supported by natural teeth. The purpose of this study was to evaluate the clinical performance of multiunit all-ceramic FDPs supported by dental implants. MATERIALS AND METHODS: Ten patients recei

Radiometals in Imaging and Therapy: Highlighting Two Decades of Research.

The present article highlights the important progress made in the last two decades in the fields of molecular imaging and radionuclide therapy. Advancements in radiometal-based positron emission tomography, single photon emission computerized tomography, and radionuclide therapy are illustrated in terms of their production routes and ease of radiolabeling. Applications in clinical diagnostic and radionuclide therapy are considered, including human studies under clinical trials; their current stages of clinical translations and findings are summarized. Because the metalloid astatine is used for

Совпадение в полном тексте источника
… Radioisotopes of Zirconium 4.3.1. … Table 5 Decay characteristics of Zirconium-89 # . # Data on 89 Zr are from [ 105 ]. Please refer to decay Scheme 1 A. …

Squeaking Is Common and Increases Over Time Among Patients With Long-term Follow-up After Ceramic-on-ceramic THA.

BACKGROUND: Ceramic-on-ceramic (CoC) is a durable bearing with excellent wear characteristics, but squeaking remains a concern. The proporti … patients in this group. Squeaking was more common in patients who received the titanium-molybdenum-zirconium-iron stem than in patients with the titanium-aluminum-vanadium stem (63% [29 of 46] versus 31% [4 of 13]; odds ratio 3.8 [95% CI 1.02 to 14.4]; p = 0.046). We found no differences in the likelihood a patient would report squeaking based on component …

Prosthodontic maintenance of overdentures on zirconia implants: 1-year results of a randomized controlled trial.

PURPOSE: The purpose of this study was to determine the prosthodontic outcomes of one-piece zirconia implants and their attachment systems in edentulous participants with maxillary and mandibular overdentures after 1 year of a randomized controlled trial. MATERIALS AND METHODS: Random allocation of 24 edentulous participants (age range: 45 to 86 years) into titanium (control) or zirconia (test) groups using onepiece implants and a planned unsplinted prosthodontic design was performed. Four maxillary implants (one midpalatal; three anterior crestal) and three mandibular implants (one midsymphy

Cytotoxicity and alkaline phosphatase activity evaluation of endosequence root repair material.

INTRODUCTION: The purpose of this in vitro study was to evaluate the cytotoxicity and alkaline phosphatase (ALP) activity of a new bioceramic root repair material, EndoSequence Root Repair Material (ESRRM; Brasseler USA, Savannah, GA), and to compare these characteristics with those of ProRoot MTA (Dentsply Tulsa Dental, Tulsa, OK) and Geristore (GR; Den-Mat LLC, Santa Maria, CA). METHODS: Human Saos-2 osteoblast-like cells were exposed to 1-, 3-, and 7-day elutes of the materials (100% and 50% strength) for 24 hours after which the bioactivity and ALP activity of the cells were evaluated usi

Influence of veneer thickness on residual stress profile in veneering ceramic: measurement by hole-drilling.

OBJECTIVES: The veneering process of frameworks induces residual stresses and can initiate cracks when combined with functional stresses. The stress distribution within the veneering ceramic as a function of depth is a key factor influencing failure by chipping. This is a well-known problem with Yttria-tetragonal-zirconia-polycrystal based fixed partial dentures. The objective of this study is to investigate the influence of veneer thickness on the stress profile in zirconia- and metal-based structures. METHODS: The hole-drilling method, often used for engineering measurements, was adapted fo

Zirconia-based crowns up to 5 years in function: a retrospective clinical study and evaluation of prosthetic restorations and failures.

PURPOSE: The purpose of this retrospective study was to evaluate the 5-year clinical performance and failure rate of single- or multiple-unit zirconia-based crowns. MATERIALS AND METHODS: A total of 148 patients (39 men and 109 women, mean age: 46.9 ± 10.6 years) treated in university and private practices with 618 single- or multiple-unit zirconia-based (Lava) crowns made on natural teeth from January 2007 to December 2008 were included. Two hundred fifty-nine anterior and 359 posterior crowns were examined. A core and/or veneer fracture that required replacement of the restoration was consi

Early complications and short-term failures of zirconia single crowns and partial fixed dental prostheses.

STATEMENT OF PROBLEM: Ceramic single crowns fabricated from newer materials, especially zirconia, have shown relatively high survival rates. However, early reversible complications may increase the risk of an irreversible failure later. PURPOSE: The purpose of the study was to evaluate the early complications and short-term failures of zirconia single crowns and partial fixed dental prostheses (FDPs) made by predoctoral dental students. MATERIAL AND METHODS: Data were collected from the patient records. Altogether, 264 zirconia single crowns and 120 FDPs (342 abutments and 190 pontics) were

Zirconia ceramic inlay-retained fixed dental prostheses - first clinical results with a new design.

OBJECTIVES: The purpose of this prospective study was to evaluate the clinical outcome of inlay-retained fixed dental prostheses (IRFDPs) with a new design made from a zirconia ceramic. METHODS: Twenty-three 3-unit IRFDPs were placed in 23 patients, restoring five second premolars and 18 first molars. Preparations were performed in accordance with general principles for ceramic inlay restorations and modified with a retainer-wing bevel preparation in the enamel at the buccal and oral sides. The frameworks were scanned and milled out of zirconia ceramic, using the InLab CAD/CAM-system and the

Preliminary results of fixed, fiber-reinforced resin bridges on four 4- × 5-mm ultrashort implants in compromised bony sites: a pilot study.

PURPOSE: To determine the effectiveness of fixed, fiber-reinforced resin bridges on 4 ultrashort implants with a sufficient implant survival success rate of at least 90% in highly atrophic jaws. MATERIALS AND METHODS: A prospective temporal cohort study was designed, with the inclusion of 10 patients. Of the 10 patients, 8 had atrophic jaws (7 women, 1 man; mean age at implant placement 58.5 years, range 40.7 to 73.9) and 2 had fibula-mandibular transplants (1 woman, aged 76.5 years; and 1 man, aged 69.3 years). All 10 patients had their dentition restored with 4 ultrashort implants. The impl

Three-year randomized clinical trial to evaluate the clinical performance and wear of a nanocomposite versus a hybrid composite.

OBJECTIVES: Compare the 3-year clinical performance (wear as an additional parameter) of a nanocomposite and a microhybrid composite, versus ADA guidelines (2001) using direct (clinical/USPHS) and indirect (quantitative/3D laser scan and qualitative/SEM) methods, in parallel. MATERIALS AND METHODS: 18 Filtek Supreme and 17 Z100 restorations were placed in molars (split mouth model) and bonded with Single bond Adhesive. Restorations were evaluated at baseline and 6-, 12-, 24-, 36-months of clinical service according to modified USPHS criteria. The gypsum replicas at each recall were used for 3

Dentin bonding and sealing ability of a new root canal resin sealer.

The aims of this study were to find a dentin bonding system suitable for root canal treatment using a newly developed root canal resin sealer, and to examine its sealing ability. The sealer was composed of vinylidene fluoride/hexafluoropropylene copolymer, methyl methacrylate, zirconia, and tributylborane catalyst. The effects of dentin conditioners and primers on dentin bonding were studied by tensile bond strength testing and scanning electron microscopy. Apical and coronal leakage were evaluated at 1-, 4-, and 12-wk intervals by a dye penetration test using a methylene blue solution. Pulp C