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Functional Foods as Vehicles for Bioactive Compounds: Chemical and Nutritional Perspectives on Health and Disease Prevention.

Functional foods are a central paradigm in modern nutrition science, acting as effective vehicles for the delivery of bioactive compounds th … and water-soluble vitamins, and the complex interactions between functional foods, gut microbiota, prebiotics, probiotics, and dietary fibers. Overall, this review aims to provide a comprehensive scientific framework for understanding how functional foods can be strategically engineered and utilized as bioactive compound vehicles in health promotion and dis …

Implication of probiotics with berry phenolic extracts against Avibacterium paragallinarum.

Avibacterium paragallinarum (AP), the causative agent of infectious coryza, induces severe upper respiratory disease and major production losses in chickens of all ages. With increasing restrictions on antibiotic use and limited vaccine efficacy, alternative emerging strategies such as probiotics, prebiotics, and synbiotics are urgently needed to control this pathogen. This study evaluated the antagonistic activity of Lacticaseibacillus casei (LC) and a metabolically engineered LC strain overproducing conjugated linoleic acid (LC + CLA), alone or combined with berry pomace polyphenol extract (…

The interplay between gut microbiota and gestational diabetes mellitus: mechanisms, characteristics, and intervention strategies.

Gestational diabetes mellitus (GDM) is a common metabolic complication during pregnancy that poses significant risks to maternal and infant … ediction. Interventions targeting the gut microbiota, including lifestyle modifications, probiotics/prebiotics supplementation, and fecal microbiota transplantation, have demonstrated potential in improving glucose metabolism by modulating microbial composition. However, current research faces challenges such as high heterogeneity, unclear causal mechanisms, …

The oral microbiome as a regulatory hub for systemic health: a systematic review of mechanistic links and clinical implications.

BACKGROUND: The human oral microbiome is a highly diverse ecosystem with important roles in oral and systemic health. Beyond dental caries a … tection and disease monitoring. Emerging microbiome-modulating interventions, including probiotics, prebiotics, and bacteriophage therapy, show potential for restoring oral eubiosis and improving systemic outcomes. CONCLUSIONS: Oral dysbiosis is an important regulator of systemic disease processes and a promising target for diagnosis, prevention, and therap …

The potential role of the gut microbiota in the development of autoantibodies associated with Spondyloarthritis: a narrative review.

Spondyloarthritis (SpA) is a set of immune-inflammatory conditions characterized by musculoskeletal and extra-articular manifestations. Incr … itive parallels.We further review microbiome-targeted therapeutic strategies, including probiotics, prebiotics, and bacterially based therapies, and highlight differences between preclinical findings and available clinical data. Although biologically plausible mechanisms, direct causal evidence linking gut dysbiosis to autoantibody production in SpA remains …

The Gut-Brain Axis: Exploring the Role of Gut Microbiota in Alzheimer's Disease Pathogenesis and Therapeutics.

INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau hyperph … and altered microbial metabolite production. Microbiota-targeted interventions, such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation, have the potential to modulate these pathways and improve cognitive outcomes, although results vary across studies. CONCLUSIONS: The gut microbiota acts as an upstream regulator of AD pathology thr …

Current Innovations in Meat Fermentation with a View to Producing More Sustainable, Healthier and Safer Products.

Fermentation is a longstanding preservation process used in meat manufacture to improve product stability, safety and sensory quality. Renew … al preservatives, smoking alternatives, fat reformulation, functional starter cultures, probiotics, prebiotics and bacteriocins. Developments in non-thermal and accelerated processing, edible and active packaging, intelligent monitoring systems and emerging culture-development technologies are also considered. Evidence indicates that selected functional cult …

Фармакомикробиомика: От взаимодействия хост-микробиома-наркотики к клиническому переводу в докторскую медицину.

Заметная межиндивидуальная изменчивость реакции на наркотики по-прежнему является серьезной проблемой в области клинической фармакологии и не может быть в полной мере объяснена только генетикой принимающей страны. Растущие данные свидетельствуют о том, что кишечная микробиота является дополнительным фактором, определяющим эффективность и токсичность наркотиков посредством двустороннего взаимодействия с фармакологической терапией. Это признание привело к появлению фармакомикробиомики - области, которая изучает, как микробные сообщества влияют на утилизацию наркотиков и реагирование на них, и ка

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Marked interindividual variability in drug response remains a major challenge in clinical pharmacology and cannot be fully explained by host … ited validation in controlled clinical trials. Strategies to modulate the gut microbiota, including prebiotics, probiotics, and faecal microbiota transplantation, have shown preliminary promise in optimising drug efficacy and reducing adverse effects, although methodological heterogeneity and incomplete mechanistic understanding limit their current clinical …

Unraveling the gut microbiota's role in PCOS: a new frontier in metabolic health.

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting reproductive-age women, characterized primarily by h … ammation. Addressing gut dysbiosis through the modulation of patients' microbiomes-such the use of, prebiotics, fecal microbiota transplantation, and optimizing diet lifestyle-may offer strategies for improving metabolic abnormalities and alleviating clinical symptoms in PCOS. Additionally, the gut microbiome promises as a potential marker, aiding in the pre …

Heat-killed Lacticaseibacillus paracasei 6235 is more effective than live on DSS-induced colitis via modulation of intestinal microbiota and MAPK/NF-κB signaling pathways.

This study compared the protective effects of both live Lacticaseibacillus paracasei 6235 (LLP 6235) and heat-killed Lacticaseibacillus para … athways, resulting in a greater improvement. Moreover, considering the high stability and safety of prebiotics and their wide applicability, HK-LP 6235 is recommended for use as a modulator of intestinal inflammatory diseases.

The metabolites of gut microbiota: their role in ferroptosis in inflammatory bowel disease.

Inflammatory bowel disease (IBD) includes chronic inflammatory conditions, such as Crohn's disease and ulcerative colitis, characterized by … lly, we discuss the potential of current therapeutic approaches, including antibiotics, probiotics, prebiotics, and fecal microbiota transplantation, in modulating the gut microbiota, affecting ferroptosis, and improving IBD symptoms. With a deeper understanding of the interaction mechanisms between the gut microbiota and ferroptosis, it is expected that mor …

Common mechanisms of Gut microbe-based strategies for the treatment of intestine-related diseases: based on multi-target interactions with the intestinal barrier.

The concurrent occurrence and exacerbation of multiple diseases, including geriatric diseases and chronic diseases, impose a heavy burden on … ctal cancer, and type 2 diabetes. We identified gut microbe-based strategies, including probiotics, prebiotics, synbiotics, postbiotics, as well as potential targets in faecal microbiota transplant and berberine. The common mechanisms and key targets in the treatment of these diseases mainly include increasing the abundance of beneficial genera Bifidobacteri …

Comparative analysis of barley dietary fiber fermented with and without Lactiplantibacillus plantarum dy-1 in promoting gut health and regulating hepatic energy metabolism in high-fat diet-induced obese mice.

A previous study has revealed that Lactiplantibacillus plantarum (Lp. plantarum) dy-1 fermentation changed the structural properties and in … his study indicated the potential of using FBDFs as healthy food resources to prevent obesity or as prebiotics to improve gut microbiota.

Progress and Perspectives on the Estrogen-Microbiota-Brain Axis in Alzheimer's Disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder shaped by genetic, metabolic, environmental, and sex-specific factors. … tegration of hormone replacement therapy with microbiota-targeted interventions such as probiotics, prebiotics, and fecal microbiota transplantation. Such combined strategies may synergistically enhance neuroprotection, though their efficacy depends on timing, dosage, and individual variability. Future precision approaches integrating multi-omics profiling a …

Influence of the Gut Microbiota, Metabolism and Environment on Neuropsychiatric Disorders.

The two-way communication between intestinal microbiota and the central nervous system (the microbiota-gut-brain axis) is involved in the re … tic strategies that target gut microbiota in the treatment of neuropsychiatric disorders, including prebiotics, probiotics, Fecal microbiota transplant (FMT), and antibiotics. Based on these data, possible strategies for microbiota-targeted intervention could improve people's lives and prevent neuropsychiatric disorders in the future.

Decoding TMAO in the Gut-Organ Axis: From Biomarkers and Cell Death Mechanisms to Therapeutic Horizons.

The gut microbiota and its metabolites are bi-directionally associated with various human illnesses, which has received extensive attention. … zyme activity to influence TMAO metabolism and reduce TMAO levels, including the use of probiotics, prebiotics, antibiotics, anti-inflammatory drugs, antiplatelet drugs, hypoglycemic drugs, lipid-lowering drugs, and natural products.

Gut Microbiota-Based Interventions for Parkinson's Disease: Neuroprotective Mechanisms and Current Perspective.

Recent evidence links gut microbiota alterations to neurodegenerative disorders, including Parkinson's disease (PD). Replenishing the abnormal composition of gut microbiota through gut microbiota-based interventions "prebiotics, probiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT)" has shown beneficial effects in PD. These interventions increase gut metabolites like short-chain fatty acids (SCFAs) and glucagon-like peptide-1 (GLP-1), which may protect dopaminergic neurons via the gut-brain axis. Neuroprotective effects of these interventions are mediated by several m…

Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential.

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by chronic inflammation and multi-organ damage, influenced … he therapeutic implications of modulating gut microbiota through dietary interventions, probiotics, prebiotics, and other microbiota-targeted therapies are discussed as promising strategies for managing SLE. The findings suggest that a deeper understanding of the gut microbiota's role in SLE could lead to more personalized and effective treatments, potential …

New Insights into Synergistic Boosts in SCFA Production Across Health Conditions Induced by a Fiber Mixture.

Background/Objectives: Short-chain fatty acids (SCFAs) produced by gut microbiota from dietary fiber fermentation play crucial roles in heal … hance SCFA production regardless of health status, offering potential for developing more effective prebiotics for superior therapeutic outcomes.

Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments.

The intestine is an important segment of the gastrointestinal tract, which is involved in complex processes that maintain the body's normal … dies show that the use of drugs that stimulate and restore the gut microbiota (e.g., probiotics and prebiotics) have the potential to alleviate some of the symptoms associated with conditions such as Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Tic Disorder, Tourette Syndrome, epilepsy, and Down Syndrome. In addition, due to the challe …