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Difficult Airway Management in a Conscious Patient With Ankylosing Spondylitis: A Case Report.

Ankylosing spondylitis (AS) is a chronic inflammatory disease that may cause cervical deformity and ankylosis, complicating airway management. The success rate of direct laryngoscopy in this population is low, and awake endotracheal intubation with minimal cervical manipulation is recommended. We report the case of a 65-year-old man with AS and complete loss of cervical mobility scheduled for laparoscopic cholecystectomy. Airway evaluation revealed Mallampati III, mouth opening >3 cm, sternomental distance of 10 cm, and severe restriction of cervical extension. Due to the unavailability of equ…

Volumetric Examination of Cerebellum by Automatic Segmentation Method in Individuals with Ankylosing Spondylitis.

Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease primarily affecting the axial skeleton and is frequently associated with postural instability, impaired balance, and altered motor control. The cerebellum plays a central role in sensorimotor integration; however, cerebellar volumetric alterations in AS remain insufficiently elucidated. This study aimed to investigate cerebellar and cerebellar lobular volumetric changes in individuals with AS using a fully automated magnetic resonance imaging (MRI) segmentation method. This retrospective study included 15 patients wi…

[A CASE OF PYOGENIC SPONDYLITIS CAUSED BY MESH INFECTION AFTER LAPAROSCOPIC SACROCOLPOPEXY].

We report a case involving an 81-year-old woman who developed pyogenic spondylitis following laparoscopic sacrocolpopexy (LSC) for a cystocele in November year X. During concomitant uterine resection, purulent discharge was observed, and oral levofloxacin was administered for 5 days postoperatively. Pathological examination revealed xanthogranulomatous endometritis, which was considered the source of the mesh infection. The patient was discharged on postoperative day 7 without complications. In early January year X＋1, she developed buttock pain that persisted for approximately 2 weeks without …

Anterior and Posterior Ocular Changes in Patients with Active and Inactive Ankylosing Spondylitis.

BACKGROUND The 6-item Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is a method for evaluating disease activity in ankylosing spondylitis (AS). This study included 78 patients with active and inactive AS and aimed to evaluate anterior and posterior segment ocular changes. MATERIAL AND METHODS Seventy-eight patients and 70 control subjects were enrolled in this study. All participants underwent a complete ophthalmic evaluation. The patients were subdivided into 2 groups according to their BASDAI scores: the active group (BASDAI³4) (n: 38) and the inactive group (BASDAI<4) (n: 40).…

Evaluation of Vertebrae in Patients With Ankylosing Spondylitis Using Hounsfield Unit Values.

OBJECTIVE: To evaluate vertebral Hounsfield Unit (HU) values on computed tomography (CT) in patients with ankylosing spondylitis (AS) compared to patients without AS and to examine differences in HU values between ankylosed and nonankylosed vertebrae in patients with AS. METHODS: This cross-sectional study included 34 patients with AS and 73 patients without AS who underwent spinal CT between 2004 and 2022. HU values were measured from C3 to L5 in patients with AS and from L1 to L5 in patients without AS. Propensity score (PS) matching based on age and sex was performed to compare HU values b…

Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis.

BACKGROUND: Interleukin (IL)-41 is a novel cytokine, also known as Metrnl, and its role in ankylosing spondylitis (AS) remains unknown. The aim of this study is to measure the serum IL-41 levels in AS patients and their correlation with other clinical indicators. METHODS: This study recruited 106 participants, including 32 active AS patients, 32 inactive AS patients, and 42 healthy controls (HC). Basic information and clinical indicators of participants were obtained through physical examination and blood sample testing. Enzyme-linked immunosorbent assay was used to detect IL-41 levels. RESU…

Identification of plasma protein biomarkers for ankylosing spondylitis by integrating proteome with genome.

OBJECTIVES: The relationship between circulating proteome and the risk of ankylosing spondylitis (AS) remains unclear, which presents significant potential for therapeutic interventions. Therefore, we performed a proteome-wide Mendelian randomization (MR) study, followed by colocalization analysis, to identify potential biomarkers and therapeutic targets for AS. METHODS: Genetic association data for 4907 plasma proteins were obtained from a large-scale protein quantitative trait locus (pQTL) study involving 35,559 individuals. Summary-level data for AS were derived from the FinnGen study, whi…

The association between ankylosing spondylitis and the risk of venous thromboembolism: a meta-analysis.

BACKGROUND: Autoimmune diseases are frequently associated with an increased risk of venous thromboembolism (VTE). However, the relationship between ankylosing spondylitis (AS) and VTE remains unclear. This meta-analysis was conducted to evaluate the association between AS and VTE risk, with the aim of providing evidence-based insights to guide clinical practice. METHOD: We searched PubMed, Embase, the Cochrane Library, and Web of Science for studies published from database inception until June 2025 that compared VTE risk in patients with AS. Two researchers independently screened the literatu…

[Frequency and clinical and laboratory features of ankylosing spondylitis with secondary AA-amyloidosis].

BACKGROUND: Pathogenesis of ankylosing spondylitis (AS) is based on long-term chronic inflammation, which can lead to the development of secondary amyloidosis. AIM: To analyze the frequency of secondary amyloidosis in a hospital cohort of patients with AS and describe their clinical and laboratory features. MATERIALS AND METHODS: Four hundred and fifty eight patients with AS were examined. Patients' disease activity and functional status were assessed according to the Russian expert recommendations. Additionally, in all patients, SAA in blood serum was determined using nephelometric method. …

Efficacy and Safety of Tofacitinib in the Management of Ankylosing Spondylitis: A Comprehensive Systematic Review.

Ankylosing spondylitis (AS) is a chronic, immune-mediated inflammatory arthritis that can severely impair the quality of life. Although biologic therapies have significantly advanced disease management, a substantial number of patients continue to experience suboptimal treatment outcomes. This systematic review evaluated the efficacy and safety of tofacitinib, an oral Janus kinase (JAK) inhibitor, in the management of AS. We conducted a comprehensive search across multiple databases for studies published between 2015 and 2025, ultimately including 11 relevant studies (two randomized controlled…

Терапевтические проблемы у пациентов с множественным склерозом и анкилосирующим спондилитом: серия случаев.

Множественный склероз (MS) — хроническая иммунная болезнь, затрагивающая более 2 миллионов человек во всем мире. Сообщалось о сосуществовании с другими аутоиммунными расстройствами, такими, как системная волчанка (SLE). Однако сообщения о том, что пациенты, страдающие склерозом, одновременно диагностировали анкилозирующий спондилит (АС), редки, вероятно, из-за различий в иммуногенных путях. Регулирование пациентов, имеющих как MS, так и AS, сопряжено с клинической проблемой, особенно из-за кондиционирования ингибиторов TNF-α (TNFi) в MS. Мы представляем трёх пациентов с соотечественниками MS и

Совпадение в аннотации оригинала
BACKGROUND: Multiple Sclerosis (MS) is a chronic immune-mediated disease affecting >2 million people worldwide. Coexistence with other autoimmune disorders, such as systemic lupus erythematosus (SLE), has been reported. However, reports of MS patients concurrently diagnosed with ankylosing spondylitis (AS) are rare, likely due to their differing immunogenic …

Total Hip Arthroplasty in Ankylosing Spondylitis: A Case Report of Ankylosed Hip.

Ankylosing spondylitis (AS) is a chronic inflammatory arthritic disease that primarily affects the axial skeleton, and its association with the secondary development of osteoarthritis (OA) in peripheral joints, particularly the hips, is increasingly recognized. This case report elucidates the diagnostic and therapeutic challenges encountered in a patient with bilateral hip osteoarthritis secondary to AS. The patient's medical history included AS and a failed attempt at core decompression of the left hip joint. The patient was managed with total hip arthroplasty (THA) on the left side due to pe…

Progression of subclinical atherosclerosis in ankylosing spondylitis: a 10-year prospective study.

Chronic systemic inflammation contributes to increased CVD burden in Ankylosing Spondylitis (AS). Since long-term follow-up data on subclinical atherosclerosis acceleration are lacking, we examined its progression in contemporary AS patients during 10 years. Fifty-three (89% male, aged 50.4 (36.3-55.9) years,) non-diabetic, CVD-free AS patients and 53 age-sex-matched non-diabetic, control individuals were re-evaluated after 9.2-10.2 years by ultrasonography for carotid/femoral atheromatosis, pulse wave velocity (PWV) and intima-media thickness (IMT), performed by the same operator/protocol. Ne…

Gut microbiome and metabolome to discover pathogenic bacteria and probiotics in ankylosing spondylitis.

OBJECTIVE: Previous research has partially revealed distinct gut microbiota in ankylosing spondylitis (AS). In this study, we performed non-targeted fecal metabolomics in AS in order to discover the microbiome-metabolome interface in AS. Based on prospective cohort studies, we further explored the impact of the tumor necrosis factor inhibitor (TNFi) on the gut microbiota and metabolites in AS. METHODS: To further understand the gut microbiota and metabolites in AS, along with the influence of TNFi, we initiated a prospective cohort study. Fecal samples were collected from 29 patients with AS …

Course of Uveitis in Patients with Ankylosing Spondylitis during the Interleukin17 Inhibitors Therapy.

Biological disease-modifying antirheumatic drugs (bDMARDs) can have different effects on various clinical manifestations of ankylosing spondylitis (AS). Data on the effects of interleukin 17 inhibitors (IL17-i) on uveitis in AS continue to accumulate. Objective: to evaluate the effect of IL17-i therapy on the course of uveitis in AS. The study involved 73 patients with AS (New York criteria, 1984), who received IL17-i (57-secukinumab (SEC), 22-netakimab (NTK)) for at least 1 year. The average age of patients at the time of inclusion in the study was 41.93 ± 8.95 years, the average duration of …

Opioid Use and Healthcare Utilization in Adults With Psoriatic Arthritis and Ankylosing Spondylitis.

OBJECTIVE: Opioid use among individuals with spondyloarthritis is common; however, data on whether these individuals have higher utilization of the healthcare system are lacking. We examined the association between opioid use and healthcare utilization and costs among patients with psoriatic arthritis (PsA) and ankylosing spondylitis (AS). METHODS: We included adults with PsA or AS enrolled in the FORWARD registry, with ≥ 1 completed disease activity or disability questionnaire between 2010 and 2019. The exposure was patient-reported opioid use, and the outcomes were annualized healthcare uti…