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A Rare and Severe Presentation of Henoch-Schönlein Purpura in an Adolescent With Crescentic Glomerulonephritis, Arrhythmia, Acute Gastrointestinal Bleed, and Neurological Complications.

Henoch-Schönlein purpura (HSP) is a childhood vasculitis disorder that involves the skin, joints, gastrointestinal (GI) tract, and kidneys. … sophagogastroduodenoscopy (EGD) was not suggestive of gastritis, duodenitis, or ulcer. The pill-cam capsule endoscopy revealed GI bleeding from the terminal ileum near Meckel's diverticulum. He subsequently required blood transfusions, and the bleeding eventually improved with symptomatic management. Six weeks after treatment initiation, he presented with dizziness …

Risk factors of symptomatic NSAID-induced small intestinal injury and diaphragm disease.

BACKGROUND: The aetiology for nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injuries has not been well characterised. AIM: To determine the risk factors of symptomatic NSAID-induced small intestinal injuries, including diaphragm disease. METHODS: Of the 1262 symptomatic patients who underwent videocapsule endoscopy and/or double-balloon enteroscopy, 156 consecutive patients were verified as having taken NSAIDs. Their CYP2C9*2, *3 and *13 single nucleotide polymorphisms (SNPs) were determined by allelic discrimination with Taqman 5'-nuclease assays. RESULTS: Of the 156…

A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis.

BACKGROUND: Patients with ankylosing spondylitis (AS) are at increased risk of developing inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin in AS over 5 years in relation to disease activity and medication and also to study the incidence of and predictors for development of IBD. METHODS: Fecal calprotectin was assessed at baseline (n = 204) and at 5-year follow-up (n = 164). The patients answered questionnaires and underwent clinical evaluations. At baseline and at 5-year follow-up, ileocolonoscopy was performed in patients with fecal calprotectin ≥50

Clinical Features and Management of Small Bowel Masses Detected During Device-Assisted Enteroscopy: A Multi-Center Experience.

BACKGROUND: Small bowel mass lesions (SBMLs) are rare, span a range of different histologies and phenotypes, and our understanding of them i … s had symptoms for more than a year prior to their diagnosis. Most patients (71.6%) underwent video capsule endoscopy (VCE) prior to DAE and 84% of these exams showed the lesion. The lesion was seen less frequently (48.9%) on computed tomography (CT) scan performed prior to DAE. The majority of lesions were found on antegrade (56%) or retrograde (29.8%) double-ball …

Fallopian tube cancer with inguinal lymph node metastasis as the first symptom: A case study and review of the literature.

INTRODUCTION AND IMPORTANCE: Fallopian tube cancer that is characterized only by inguinal lymph node metastasis without intra-abdominal widespread is rare. Here we report a patient with primary Fallopian tube cancer with bilateral inguinal metastases as the first symptom. CASE PRESENTATION: A 68-year-old patient with primary Fallopian tube cancer, with painless bilateral inguinal enlargement (7 × 6 cm on the right side, 3 × 2 cm on the left side) as the only manifestation, was confirmed by preoperative biopsy as metastatic high-grade serous denocarcinoma, consider the adnexal or peritoneal so

A new, practical, low-dose 14C-urea breath test for the diagnosis of Helicobacter pylori infection: clinical validation and comparison with the standard method.

The carbon-14 urea breath test (UBT) is a reliable and non-invasive technique for the diagnosis of Helicobacter pylori (HP) infection. In this study we evaluated the diagnostic performance of a new, practical and low-dose (14)C-UBT system for the diagnosis of HP and compared the results with those obtained using the standard method. Seventy-five patients (56 female, 19 male) with dyspepsia underwent (14)C-UBT and endoscopy with antral biopsies for histological analysis. The rapid urease test (CLO test) was applied to 50 of these patients. After a 6-h fasting period, a 37-kBq (14)C-urea capsule

A smart ingestible capsule for real-time monitoring of stimuli-responsive polymer dissolution kinetics and oral drug release in the gastrointestinal tract.

Oral drug delivery relies on precise, site-specific release within the gastrointestinal (GI) tract, commonly achieved using stimuli-responsive polymer (SRP) coatings that regulate dissolution under varying physiological conditions to maximize therapeutic efficacy. Continuous advancements in polymer chemistry and composite formulations have enabled increasingly sophisticated control over drug release profiles. However, a critical challenge remains in accurately assessing how these materials degrade, dissolve, and perform under true in vivo GI conditions. While numerous in vitro models have been

Current Status of Colorectal Cancer Screenings: Tailoring Them to Mississippi's Rural Geography, Demographics, Infrastructure and Community Needs.

Colorectal cancer (CRC) is a major cancer problem not only in western nations, but also now even in the developing world such as the Global … ation (colonoscopy and sigmoidoscopy), non-invasive direct visualization (CT colonography and colon capsule endoscopy), and stool- and blood-based screening, are detailed, highlighting relative advantages, limitations, and optimal use scenarios. Using insights from simulation models and population-level studies, the cost-effectiveness and clinical outcomes of 13 di …

Gastrointestinal bleeding as initial presentation of extramedullary plasma cell neoplasms: A case report and review of the literature.

BackgroundPlasma-cell neoplasms rarely involve the gastrointestinal tract and manifest as gastrointestinal bleeding. Plasmablastic myeloma is an aggressive plasma cell neoplasm associated with poor outcomes. A small number of cases with gastrointestinal involvement is reported in the literature and therefore high index of suspicion is essential for avoiding delays in diagnosis and treatment.Case summaryOur aim is to present our experience of a 70-year-old patient with a secondary presentation of plasmablastic myeloma manifesting as unstable upper gastrointestinal bleeding and to review the lit

Совпадение в полном тексте источника
… Figure 1 Images from small bowel capsule endoscopy. … For lesions located in jejunum and ileum, where Oesophagogastroscopy was not diagnostic further investigations (small bowel capsule endoscopy, CT angiogram, laparotomy) were used. …

UEG Week 2015 Poster Presentations

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Свет в диагностике, терапии и хирургии.

Легкие и оптические методы оказывают глубокое воздействие на современную медицину, и в настоящее время в клинической практике используются многочисленные лазеры и оптические устройства для оценки состояния здоровья и лечения заболеваний. Последние достижения в области биомедицинской оптики позволили использовать все более сложные технологии, в частности технологии, которые объединяют фотонику с нанотехнологией, биоматериалами и генной инженерией. В настоящем Обзоре мы вновь обращаемся к основам взаимодействия легкой материи, описываем применение света в визуализации, диагностике, терапии и хир

Совпадение в полном тексте источника
… Capsule endoscopy Over the past decade, wireless video capsule endoscopy has become an increasingly popular non-invasive tool for the diagnosis of small bowel disorders 108 . … endoscopy Nature 405 417 2000 10.1038/35013140 10839527 109 Liao Z Gao R Xu C Li ZS Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review Gastrointest Endosc 71 280 286 2010 20152309 10.1016/j.gie.2009.09.031 110 Drexler W Fujimoto JG State-of-the-art …

Endoscopic Flexor Hallucis Longus Tendon Transfer for the Treatment of Chronic Achilles Tendon Defects.

BACKGROUND: An all-inside endoscopic flexor hallucis longus (FHL) tendon transfer is indicated for the treatment of chronic, full-thickness Achilles tendon defects. The aim of this procedure is to restore function of the gastrocnemius-soleus complex while avoiding the wound complications associated with open procedures. DESCRIPTION: This procedure can be performed through 2 endoscopic portals, a posteromedial portal (the working portal) and a posterolateral portal (the visualization portal). The FHL tendon is identified, and the joint capsule is debrided to identify the subtalar joint. A shav

Monitoring nonresponsive patients who have celiac disease.

Because of the wide variations in the clinical presentation of celiac disease and because treatment exists that is effective in most cases, … overt lymphoma is suspected, upper and lower endoscopy, an ear, nose, and throat work-up, CT scan, capsule endoscopy, and possibly double-balloon enteroscopy should be performed. Most reports of the difficulties in treating patients who have true RCE are casereports. Turner and colleagues [28] reported on an induction of remission by useof the anti-TNF-alpha antib …

Heyde Syndrome Unveiled: A Case Report with Current Literature Review and Molecular Insights.

Heyde syndrome, marked by aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome, is often underreported. Shear stress from a narrowed aortic valve degrades von Willebrand factor multimers, leading to angiodysplasia formation and von Willebrand factor deficiency. This case report aims to raise clinician awareness of Heyde syndrome, its complexity, and the need for a multidisciplinary approach. We present a 75-year-old man with aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome type 2A. The patient w

Совпадение в полном тексте источника
… Upper and lower endoscopy are the primary diagnostic tools for angiodysplasia, with capsule endoscopy serving as an advanced and efficient option in detecting small bowel angiodysplasias. … Convolutional neural network-based segmentation network applied to image recognition of angiodysplasias lesion under capsule endoscopy. World J. …

Неделя ГЭЭ 2017 Презентации на плакате

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Неделя ГЭЭ 2018 Презентации на плакате

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Curcumin in Autoimmune and Rheumatic Diseases.

Over recent decades, many clinical trials on curcumin supplementation have been conducted on various autoimmune diseases including osteoarthritis, type 2 diabetes, and ulcerative colitis patients. This review attempts to summarize the highlights from these clinical trials. The efficacy of curcumin either alone or in conjunction with existing treatment was evaluated. Sixteen clinical trials have been conducted in osteoarthritis, 14 of which yielded significant improvements in multiple disease parameters. Eight trials have been conducted in type 2 diabetes, all yielding significant improvement i

Stereotactic Navigation-Guided Biportal Endoscopic Transforaminal Lumbar Interbody Fusion for Degenerative Lumbar Spondylolisthesis.

BACKGROUND: In spine surgery, biportal endoscopy (BE) is a minimally invasive approach for addressing a range of degenerative lumbar pathologies, including degenerative lumbar spondylolisthesis. The biportal technique benefits from the separation of the endoscopic viewing portal and the working portal for surgical tools, which facilitates an expanded visual field and greater operative flexibility1-3. BE enables both decompression and transforaminal lumbar interbody fusion (TLIF) within a single procedure4. Furthermore, integrating stereotactic navigation with BE enhances the precision of pedic

Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist's perspective.

Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is an autosomal dominant disorder that causes abnormal blood vessel formation. The diagnosis of hereditary hemorrhagic telangiectasia is clinical, based on the Curaçao criteria. Genetic mutations that have been identified include ENG, ACVRL1/ALK1, and MADH4/SMAD4, among others. Patients with HHT may have telangiectasias and arteriovenous malformations in various organs and suffer from many complications including bleeding, anemia, iron deficiency, and high-output heart failure. Families with the same mutatio

Emerging insights into the gut microbiota as a key regulator of immunity and response to immunotherapy in hepatocellular carcinoma.

The gut microbiota, a complex microbial ecosystem closely connected to the liver via the portal vein, has emerged as a critical regulator of liver health and disease. Numerous studies have underscored its role in the onset and progression of liver disorders, including alcoholic liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This review provides a comprehensive overview of current insights into the influence of the gut microbiota on HCC progre