Результаты поиска

Toxic Epidermal Necrolysis Mimicking Severe Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Diagnostic Challenge.

Background: Toxic epidermal necrolysis (TEN) is a rare but life-threatening complication that may occur in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in the context of extensive drug exposure. In this population, TEN can closely resemble severe acute graft-versus-host disease (GVHD), making diagnosis and management challenging. Case presentation: We report the clinical course of an allo-HSCT recipient who developed a rapidly progressive skin rash early after transplantation, and we analyzed the clinical features, histopathology, treatment and ou

Совпадение в полном тексте источника
… Outcome Hilgendorf et al., 2007 [ 12 ] | - | Multiple myeloma | MUD (HLA-matched) | No active GVHD reported | TMP-SMX, levofloxacin, amoxicillin/clavulanate | Steroids, IVIG, supportive care | Recovered Macedo et al., 2014 [ 20 ] | 23/F | T-cell lymphoma | Mismatched unrelated donor | Grade IV GI GVHD | Cefepime …

Duration of Hospitalization is Associated with the Gut Microbiome in Patients Undergoing Hematopoietic Stem Cell Transplantation: Early Results from a Randomized Trial of Home Versus Hospital Transplantation.

Home-based hematopoietic stem cell transplantation (HCT) is an innovative care model with growing interest, but its impact on the gut microbiome remains unexplored in a randomized setting. We present interim results from the first randomized controlled trials (RCT) evaluating the effect of HCT location-home versus hospital-on gut microbial diversity and antimicrobial resistance (AMR) gene carriage. We hypothesize that patients randomized to undergo home HCT would have higher gut taxonomic diversity and lower AMR gene abundance compared to those undergoing standard hospital HCT. We analyzed sto

Совпадение в полном тексте источника
… Table 1 Demographics and transplant characteristics of patients included, comparing patients randomized to home and hospital HCT. 1 One patient in the Hospital HCT group with unknown ethnicity. 2 Includes ceftriaxone, ceftazidime, cefepime, piperacillin-tazobactam, meropenem, aztreonam. 3 Includes piperacillin-tazobactam …

Review of Hematology-Oncology Emergencies for Internal Medicine Residents.

The prevalence of cancer continues to grow globally every year. With therapeutic advances over the recent decades, the prevalence of individuals living with cancer continues to increase. Internal medicine residents can see patients admitted to the hospital for cancer-related emergencies. Early identification and appropriate management of these emergencies have been shown to improve mortality and morbidity. In this article, we aim to review the recent updates in the management of commonly encountered oncologic emergencies in the practice of internal medicine residents. This review will cover sp

Совпадение в полном тексте источника
… Ideally, treatment should be started within one hour of presentation with intravenous broad-spectrum antibiotics with pseudomonal coverage (cefepime, piperacillin-tazobactam, and meropenem), even if risk stratification has not been completed [ 41 ]. …

COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO).

In the COVID-19 scenario, patients undergoing hematopoietic stem cell transplantation (HSCT) infected with SARS-CoV-2 may have an increased risk of death. Through a national multicenter study, we aimed to describe the impact of COVID-19 on the survival of HSCT recipients in Brazil. Eighty-six patients with a confirmed diagnosis of SARS-CoV-2 (92% by RT-PCR) were included. There were 24 children and 62 adults receiving an autologous (n = 25) and allogeneic (n = 61) HSCT for malignant (n = 72) and non-malignant (n = 14) disorders. Twenty-six patients died, (10 on autologous (38%) and 16 patients

Совпадение в полном тексте источника
… No patient received the drug Remdesivir despite its approval and use in other countries during the period of observation. 43 (50%) patients were treated with antibiotics (azithromycin, amoxicillin, cefepime). …

Ceftazidime-Avibactam Improves Outcomes in High-Risk Neutropenic Patients with Klebsiella pneumoniae Carbapenemase-Producing Enterobacterales Bacteremia.

Few studies have evaluated the efficacy of ceftazidime-avibactam (CA) for Klebsiella pneumoniae carbapenemase-producing Enterobacterales bacteremia (KPC-PEB) in high-risk neutropenic patients. This is a prospective multicenter observational study in high-risk neutropenic patients with multi-drug resistant Enterobacterales bacteremia. They were compared according to the resistance mechanism and definitive treatment provided: KPC-CPE treated with CA (G1), KPC-CPE treated with other antibiotics (G2), and patients with ESBL-producing Enterobacterales bacteremia who received appropriate definitive

Совпадение в полном тексте источника
… In patients with ESBL-producing Enterobacterales, empirical or definitive antibiotic therapy with piperacillin/tazobactam or cefepime monotherapy was considered inappropriate [ 29 ]. …

Evaluation of bloodstream infections in febrile neutropenic patients with hematological malignancy: a retrospective cohort study.

BACKGROUND: Patients with hematological malignancies (HMs) are at high risk of bloodstream infections (BSIs) during episodes of febrile neutropenia (FN). However, empirical treatment initiated before isolation of the causative agent from blood cultures is crucial. The aim of this study was to determine the distribution and antimicrobial resistance profile of microorganisms isolated from BSIs in patients with HMs, and to evaluate the association with the need for intensive care unit (ICU) and mortality at 30 days. METHODS: Single-centre data from patients with HMs who were admitted to the hema

Совпадение в полном тексте источника
… Piperacillin-tazobactam was the most frequently initiated empirically therapy, used in 39.0% of BSI episodes, followed by cefepime (15.9%), meropenem (15.2%), and meropenem plus vancomycin (12.8%). …

Acute kidney injury in cancer patients: A nationwide survey in China.

Cancer patients have a high risk for acute kidney injury (AKI); however, the incidence, severity, and risk factors of malignancy-related AKI (MR-AKI) are unclear. This study aimed to assess MR-AKI risk factors and provide reliable data for AKI prevention, diagnosis, and management in China. This cross-sectional study analysed data from 44 academic and local hospitals in China. AKI patients were identified based on 2 screening criteria: the 2012 Kidney Disease: Improving Global Outcomes-AKI definition and the expanded screening criteria for patients with no repeated serum creatinine (SCr) test

Совпадение в полном тексте источника
… Acute Kidney Injury in Hematopoietic Cell Transplantation Patients Receiving Vancomycin and Piperacillin/Tazobactam Versus Vancomycin and Cefepime. …

Selinexor, a selective inhibitor of nuclear export, shows anti-proliferative and anti-migratory effects on male germ cells in vitro.

BackgroundSelinexor (SLX), a selective inhibitor of nuclear export (SINE), has been shown to interfere with nuclear export mechanisms and to exert antitumor effects in a variety of cancer cell types. It is known to regulate multiple fundamental cellular processes, including the DNA damage response, cell proliferation, and stress signaling pathways. Nevertheless, its potential effects on reproductive cells remain inadequately characterized. The present study was aimed to investigate the cytotoxic, apoptotic, anti-proliferative and anti-migratory effects of SLX on GC1 (spermatogonia) and GC2 (sp

Совпадение в полном тексте источника
… Cefepime, a cephalosporin, induces the apoptosis and oxidative stress in NB2a neuroblastoma cells. Euroasia J Math Eng Nat Med Sci. 2022;9(21):79–86. 10.38065/euroasiaorg.962. 27. Algaidi SA, Eldomiaty MA, Elbastwisy YM, Almasry SM, Desouky MK, Elnaggar AM. …

A Focus on CAR T-Cell Therapy and Bispecific Antibodies in Multiple Myeloma.

Significant strides have been made in the management of patients living with myeloma. However, patients with multiply relapsed or refractory multiple myeloma (MM) have a shorter overall survival; therefore, new treatments with novel mechanisms of action are needed in this patient population. Patients with relapsing disease require a full restaging workup, including whole body imaging to evaluate for extramedullary disease and lytic bone lesions, as well as bone marrow biopsy with fluorescence in situ hybridization to determine if the patient has any new chromosomal changes that are present. Th

Совпадение в полном тексте источника
… He was also started on antibiotics with vancomycin and cefepime. Cultures were obtained, and a chest x-ray showed no consolidation. He received a dose of tocilizumab once. CT chest on day 2 revealed new opacities in the right lower lobe. …

Epidemiology, Risk Factors, and Outcomes of Neutropenic Enterocolitis in Onco-Hematological Patients According to Chemotherapy Regimen.

BackgroundWhile neutropenic enterocolitis (NEC) is a well-known life-threatening complication during intensive chemotherapy, its incidence, impact, and outcome on specific at-risk populations remain ill defined.MethodsWe report 178 NEC episodes during 1963 myeloablative chemotherapy courses among 1259 adult patients with acute myeloid (AML) or lymphoblastic (ALL) leukemia or receiving autologous hematopoietic stem cell transplantation (auto-HCT) for lymphoma or multiple myeloma. Risk factors were assessed by multivariate logistic regression models.ResultsMost NEC cases (93.3%) occurred during

Совпадение в полном тексте источника
… Broad-spectrum empiric antibiotic therapy (cefepime +/− metronidazole or piperacillin-tazobactam) is promptly started after microbiological sampling at each episode of FN. Antifungal prophylaxis during neutropenia was prescribed according to international recommendations [ 10 , 27 ]. …

Gut Microbiota Dysbiosis and Dietary Interventions in Non-Hodgkin B-Cell Lymphomas: Implications for Treatment Response.

Non-Hodgkin B-cell lymphomas are a heterogeneous group of lymphoid malignancies with variable biological behavior, clinical presentation and treatment response. While chemoimmunotherapy remains the cornerstone of their management, growing evidence implicates the gut microbiota as a critical modulator of both lymphomagenesis and therapeutic efficacy. Gut microbiota dysbiosis, characterized by reduced microbial diversity and pathogenic taxonomic shifts, has been observed also in newly diagnosed patients and not just after therapy. This microbial imbalance contributes to mucosal barrier disruptio

Совпадение в полном тексте источника
… In patients with non-Hodgkin B-cell lymphoma, those who received high-risk antibiotics such as meropenem, cefepime, ceftazidime, and piperacillin–tazobactam during therapy exhibited poorer treatment responses. …

Fluoroquinolone Prophylaxis Uncovers High Prevalence Rates of Fluoroquinolone-Resistant Enterobacterales Colonization in Multiple Myeloma Autologous Transplant Patients: A Prospective Cohort Study.

Background: Fluoroquinolone prophylaxis during autologous stem cell transplantation (aSCT) reduces the risk of fever but raises the risk of bloodstream infection (BSI) with fluoroquinolone-resistant Enterobacterales (FRE). We performed a prospective cohort study to detect the presence and potential gain or loss of colonic FRE colonization using serial sampling before and after aSCT in a uniform population of patients with a diagnosis of multiple myeloma. Methods: Eligible subjects underwent aSCT after conditioning with dose-intense melphalan, 200 mg/m2. Peri-anal swabs were obtained before aSC

Совпадение в полном тексте источника
… The prophylactic FQ (or other antibiotic) was discontinued and empiric treatment with cefepime 2 gm IV q8 h (or aztreonam 2 gm IV q8 h with vancomycin 15 mg/kg (ABW) IV q12 h for subjects with penicillin allergy) was initiated. …

A Literature Review on the Impact of the Gut Microbiome on Cancer Treatment Efficacy, Disease Evolution and Toxicity: The Implications for Hematological Malignancies.

The gut microbiome plays a crucial role in modulating the efficacy and toxicity of cancer therapies, particularly in hematological malignancies. This review examines the dynamic interplay between gut microbiota and cancer treatments, such as chemotherapy, immunotherapy, and hematopoietic stem cell transplantation (HSCT). Disruptions in the gut microbiome, known as dysbiosis, are associated with adverse effects like gastrointestinal toxicity, neutropenia and cardiotoxicity during chemotherapy. Conversely, the supplementation of probiotics has shown potential in mitigating these side effects by

Совпадение в полном тексте источника
… It was found that patients who received high-risk antibiotics, such as meropenem, cefepime, ceftazidime, and piperacillin–tazobactam, during therapy exhibited higher levels of Prevotella , Veillonella and Enterococcus species, which were associated with poorer treatment responses. …

Epidemiology and Factors Associated with Treatment Success of Invasive Fungal Infections Among Newly Hematologic Malignancy Patients Receiving Chemotherapy or Hematopoietic Stem Cell Transplant in Thailand.

PurposeInvasive fungal infection (IFI) causes disability/death in patients with hematologic malignancy (HM) receiving chemotherapy or hematopoietic stem cell transplant (HSCT). There is limited epidemiological data, treatment outcomes, and factors associated with IFI treatment success in Thailand. This study aimed to identify factors associated with IFI treatment success among new HM patients receiving chemotherapy or HSCT, determine IFI incidence among HM patients receiving chemotherapy or HSCT, and the IFI incidence of a breakthrough in patients receiving primary antifungal prophylaxis, and

Совпадение в полном тексте источника
… The management of febrile neutropenia was as follows: broad-spectrum antimicrobial drugs (eg, ceftazidime, cefepime, piperacillin–tazobactam) were first administered, followed by escalation to carbapenems if indicated. …

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… May send home with follow-up high risk —admit for intravenous antibiotics first line —one of imipenem 500 mg IV q6 h, meropenem 2 g IV q8h, ceftazidime 2 g IV q8h, cefepime 2 g IV q8h, piperacillin/tazobactam 4.5 g IV q8h, piperacillin 3 g IV q4h plus tobramycin 2–2.5 mg/kg IV q8h, clindamycin 600 … Cefoxitin 1–2 g IV q6–8 h | Bactericidal, cell wall synthesis inhibition and lysis | +++ | +++ | ++ | | Yes (interval) Cefotaxime 1–2 g IV q6–8 h | | +++ | +++ | | | Yes (interval) Ceftriaxone 1–2 g IV q24h | | +++ | +++ | | | No Ceftazidime 1 g IV q8–12 h | | +++ | +++Pseudo | | | Yes (interval) Cefepime …

Neurotoxicity of Immunotherapy: Immune Checkpoint Inhibitor-Related Encephalitis vs. Immune Effector Cell-Associated Neurotoxicity Syndrome.

Immune checkpoint inhibitors and engineered T-cell therapies such as chimeric antigen receptor T-cell (CAR-T) cells and bispecific T-cell engagers (BiTEs) have revolutionized oncology care, and with them came two neurologic syndromes that look deceptively alike at the bedside with confusion, seizures, and encephalopathy: immune checkpoint inhibitor-related encephalitis (irEncephalitis) and immune effector cell-associated neurotoxicity syndrome (ICANS). Several differential observations between the two syndromes motivated this review: 1) although loss of immune tolerance likely drives irEncepha

Совпадение в полном тексте источника
… nodular parenchymal or linear leptomeningeal enhancement and malignant cells on CSF cytology when positive [ 75 ]. 4) Metabolic/toxic encephalopathy is suggested by fluctuating attention, asterixis/myoclonus, triphasic electroencephalograph (EEG) waves, normal CSF, and drug triggers (e.g., opioids, cefepime …

Management of chimeric antigen receptor T (CAR-T) cell-associated toxicities.

The use of chimeric antigen receptor T (CAR-T) cells is a significant therapeutic improvement increasing the prognosis for patients with a variety of hematological malignancies. However, this therapy has also sometimes life-threatening, complications. Therefore, knowledge of the treatment and management of these complications, especially in treatment centers and intensive care units, respectively, is of outstanding importance. This review provides recommendations for the diagnosis, management, and treatment of CAR-T cell-associated complications such as cytokine release syndrome, immune effect

Совпадение в полном тексте источника
… If the focus is unclear, a Pseudomonas-effective antibiotic (piperacillin/tazobactam, imipenem, meropenem, cefepime, or ceftazidime) must be initiated within one hour [ 21 ]. …

36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.

P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, … . M. Janssen, C. S. Bouman, R. A. Mathôt, M. D. De Jong, R. M. Van Hest P106 - Systematic review of cefepime induced neurotoxicity L. Payne, G. L. Fraser P107 - Unasyn® causes QT prolongation during treatment of intensive care patients B. Tudor, M. Lahner, G. Roth, C. Krenn P108 - Comparative study between teicoplanin and vancomycin in methicillin-resistan …

Применение искусственного интеллекта в перипостетической суставной инфекции.

Перипростетическая суставная инфекция (ПСО) представляет собой one Из наиболее разрушительных осложнений, вызванных общей совместной артропластикой, часто требующих дополнительных операций и антимикробной терапии, и потенциально ведущих к инвалидности. Это значительно увеличивает нагрузку как на пациентов, так и на систему здравоохранения. С учетом значительных страданий, причиняемых ПСО, его профилактика и лечение уже давно являются ключевыми факторами, вызывающими озабоченность. Вместе с тем сохраняются проблемы, связанные с точной оценкой индивидуального риска, предотвращением инфекции, сов

Совпадение в полном тексте источника
… First author Algorithm Target microorganism Target antibiotic Strengths Limitations Isolated strains/ mass spectra Gerada [174] CNN Gram-negative Enterobacterales bacterial strains amikacin, chloramphenicol, ciprofloxacin, gentamicin, meropenem, amoxicillin, amoxicillin/clavulanic acid, cefepime, ceftazidime … author | Algorithm | Target microorganism | Target antibiotic | Strengths | Limitations | Isolated strains/ mass spectra Gerada [174] | CNN | Gram-negative Enterobacterales bacterial strains | amikacin, chloramphenicol, ciprofloxacin, gentamicin, meropenem, amoxicillin, amoxicillin/clavulanic acid, cefepime …

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review.

During the COVID-19 pandemic, elderly patients with underlying condition, such as tumors, had poor prognoses after progressing to severe pneumonia and often had poor response to standard treatment. Mesenchymal stem cells (MSCs) may be a promising treatment for patients with severe pneumonia, but MSCs are rarely used for patients with carcinoma. Here, we reported a 67-year-old female patient with lung adenocarcinoma who underwent osimertinib and radiotherapy and suffered from radiation pneumonitis. Unfortunately, she contracted COVID-19 and that rapidly progressed to severe pneumonia. She respo

Совпадение в полном тексте источника
… Remdesivir, Dexamethasone, Convalescent Serum | PLX-PAD | 300×10 6 /L IM×15 | Remission | Died of a bacterial infection on day 140 Kim 2022 ( 94 ) | Korea | M | 73 | Diabetes, Hypertension, cerebral infarction, Hyperlipidemia | No | Chloroquine, Lopinavir/Ritonavir, Inotropic agent, Immunoglobulin, Cefepime …