Результаты поиска

Targeting Cancer Stem Cell Markers or Pathways: A Potential Therapeutic Strategy for Oral Cancer Treatment.

Cancer stem cells (CSCs) are a small subset of cancer cells with stem cell-like properties, self-renewal potential, and differentiation capacity into multiple cell types. Critical genetic alterations or aberrantly activated signaling pathways associated with drug resistance and recurrence have been observed in multiple types of CSCs. In this context, CSCs are considered to be responsible for tumor initiation, growth, progression, therapeutic resistance, and metastasis. Therefore, to effectively eradicate CSCs, tremendous efforts have been devoted to identify specific target molecules that play

Совпадение в полном тексте источника
… Clay MR, Tabor M, Owen JH, Carey TE, Bradford CR, Wolf GT, Wicha MS, Prince ME. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck. 2010;32:1195–1201. doi: 10.1002/hed.21315. 54. …

The CoV-2 outbreak: how hematologists could help to fight Covid-19.

COVID-19 is a medical emergency, with 20 % of patients presenting with severe clinical manifestations. From the pathogenetic point of view, COVID-19 mimics two other well-known diseases characterized by cytokine storm and hyper-activation of the immune response, with consequent organ damage: acute graft-versus-host disease (aGVHD) and macrophage activation syndrome (MAS). Hematologists are confident with these situations requiring a prompt therapeutic approach for switching off the uncontrolled cytokine release; here, we discuss pros and cons of drugs that are already employed in hematology in

Совпадение в полном тексте источника
… Ernst M., Inglese M., Scholz G.M., Harder K.W., Clay F.J., Bozinovski S. Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. J. Exp. Med. 2002;196(5):589–604. doi: 10.1084/jem.20020873. PMID:12208875. 40. …

TECH-VER: A Verification Checklist to Reduce Errors in Models and Improve Their Credibility.

BackgroundIn health economic literature, checklists or best practice recommendations on model validation/credibility always declare verification of the programmed model as a fundamental step, such as 'is the model implemented correctly and does the implementation accurately represent the conceptual model?' However, to date, little operational guidance for the model verification process has been given. In this study, we aimed to create an operational checklist for model users or reviewers to verify the technical implementation of health economic decision analytical models and document their ver

Совпадение в полном тексте источника
… Büyükkaramikli NC Blommestein HM Riemsma R Armstrong N Clay FJ Ross J Ramucirumab for treating advanced gastric cancer or gastro-oesophageal junction adenocarcinoma previously treated with chemotherapy: an evidence review group perspective of a NICE single technology appraisal PharmacoEconomics. 2017 …

Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue.

In most clinical trials, thiazolidinediones do not show any relevant anti-cancer activity when used as mono-therapy. Clinical inefficacy contrasts ambiguous pre-clinical data either favoring anti-tumor activity or tumor promotion. However, if thiazolidinediones are combined with additional regulatory active drugs, so-called 'master modulators' of tumors, i.e., transcriptional modulators, metronomic low-dose chemotherapy, epigenetically modifying agents, protein binding pro-anakoinotic drugs, such as COX-2 inhibitors, IMiDs, etc., the results indicate clinically relevant communicative reprogram

Совпадение в полном тексте источника
… Clay C.E., Namen A.M., Atsumi G., Willingham M.C., High K.P., Kute T.E., Trimboli A.J., Fonteh A.N., Dawson P.A., Chilton F.H. Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. Carcinogenesis. 1999;20:1905–1911. doi: 10.1093/carcin/20.10.1905. 35. …

Exploring microRNA targeting as a promising approach for solid tumor treatment.

The discovery of microRNAs (miRNAs) and their pivotal role in gene regulation has opened up new avenues for innovative cancer treatments. Recent years have witnessed extensive research into the intricate mechanisms of miRNAs and their impact on solid tumors. These small non-coding RNA molecules are central to gene regulation and are frequently dysregulated in various cancers, particularly solid tumors. Dysregulation of specific miRNAs can initiate, progress, and metastasize tumors, making them appealing targets in cancer therapy. This article explores recent studies on identifying specific miR

Совпадение в полном тексте источника
… Nat Commun . ( 2018 ) 9 : 771 . doi: 10.1038/s41467-018-03224-w , PMID: 29472616 PMC5823939 79 Graff JW Dickson AM Clay G McCaffrey AP Wilson ME . Identifying functional microRNAs in macrophages with polarized phenotypes . …

Exosomal delivery of TRAIL and miR‑335 for the treatment of hepatocellular carcinoma (Review).

Liver cancer is the sixth most prevalent type of cancer worldwide and accounts for the third most frequent cause of cancer‑associated mortality. Conventional anticancer drugs display limited efficacy owing to their short half‑life, poor solubility and inefficient drug delivery. Despite advancements being made in drug discovery and development for the treatment of hepatocellular carcinoma (HCC), drug inefficacy and drug continue to pose significant obstacles to effective treatment. Therefore, it is imperative that novel treatment strategies be developed with the aim of developing anticancer tre

Совпадение в полном тексте источника
… Novault S Flament C Leboulaire C Borg C Amigorena S Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of thefirst phase I clinical trial J Transl Med 3 10 2005 10.1186/1479-5876-3-10 15740633 PMC554765 114 Morse MA Garst J Osada T Khan S Hobeika A Clay …

An Individualized Exercise Intervention for People with Multiple Myeloma-Study Protocol of a Randomized Waitlist-Controlled Trial.

People with multiple myeloma (MM) are second only to people with lung cancer for the poorest reported health-related quality of life (HRQoL) of all cancer types. Whether exercise can improve HRQoL in MM, where bone pain and lesions are common, requires investigation. This trial aims to evaluate the efficacy of an exercise intervention compared with control on HRQoL in people with MM. Following baseline testing, people with MM (n = 60) will be randomized to an exercise (EX) or waitlist control (WT) group. EX will complete 12-weeks of supervised (24 sessions) and unsupervised (12 sessions) indiv

Совпадение в полном тексте источника
… Hart N.H., Galvao D.A., Saunders C., Taaffe D.R., Feeney K.T., Spry N.A., Tsoi D., Martin H., Chee R., Clay T., et al. …

The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults.

Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing

Совпадение в полном тексте источника
… Dioctahedral Smectite or Diosmectite Diosmectite (DS) is a medicinal clay and a product frequently recommended over-the-counter in Eastern European countries [ 98 ], France [ 99 ], and China [ 100 ] as an adjuvant therapy in children and adults with acute diarrhea. …

Mechanical suppression of osteolytic bone metastases in advanced breast cancer patients: a randomised controlled study protocol evaluating safety, feasibility and preliminary efficacy of exercise as a targeted medicine.

BACKGROUND: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80% of patients with advanced breast cancer. Preclinical models have demonstrated the ability of mechanical stimulation to suppress tumour formation and promote skeletal preservation at bone sites with osteolytic lesions, generating modulatory interference of tumour-driven bone remodelling. Preclinical studies have also demonstrated anti-cancer e

Совпадение в полном тексте источника
… maximum Robert U Newton Sir Charles Gairdner Osborne Park Health Group Short Form, Module 36 Spinal isometric training St John of God Hospital Suzanne K Chambers Statistical Package for the Social Sciences Stress-Strain Index Polar Trabecular area Trabecular volumetric bone mineral density Tim Clay …

Resveratrol Nanoformulations for Cancer Management: A Comprehensive Review of Disease-Specific Strategies and Clinical Translational Barriers.

Cancer remains a leading cause of mortality worldwide, highlighting the need for therapeutic strategies that reduce systemic toxicity and drug resistance. Resveratrol (RES), a natural polyphenolic stilbenoid, possesses antioxidant, anti-inflammatory, pro-apoptotic, anti-metastatic, and chemosensitizing activities. However, its clinical translation is limited by poor aqueous solubility, chemical instability, rapid metabolic clearance, and consequently low systemic bioavailability. Nanotechnology-based drug delivery systems provide a promising strategy to address these limitations. This review s

Proceedings from the First Onco Summit: LATAM Chapter, 19-20 May 2023, Rio de Janeiro, Brazil.

The Onco Summit 2023: The Latin American (LATAM) Chapter took place over two days, from 19-20 May 2023, in Brazil. The event aimed to share the latest updates across various oncology disciplines, address critical clinical challenges, and exchange best practices to ensure optimal patient treatment. More than 30 international and regional speakers and more than 300 oncology specialists participated in the Summit. The Summit discussions centered on common challenges and therapeutic advances in cancer care, with a specific focus on the unique obstacles faced in LATAM and examples of adaptable stra

Совпадение в полном тексте источника
… Clay T.D., Majem M., Felip E., Doger B., Costa E.C., Forster M., Krebs M., Peguero J.A., Mueller C., Triebel F. Results from a phase II study of eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab in patients with PD-L1 unselected metastatic non-small cell lung carcinoma. J. Clin. …

S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction.

The aberrant activity of Wnt signaling is an early step in the transformation of normal intestinal cells to malignant tissue, leading to more aggressive tumors, and eventually metastases. In colorectal cancer (CRC), metastasis accounts for about 90% of patient deaths, representing the most lethal event during the course of the disease and is directly linked to patient survival, critically limiting successful therapy. This review focuses on our studies of the metastasis-inducing gene S100A4, which we identified as transcriptional target of β-catenin. S100A4 increased migration and invasion in v

Совпадение в полном тексте источника
… Clay T.M. Chen W. Morse M.A. Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations Cancer Res. 2011 71 4172 4182 10.1158/0008-5472.CAN-10-3978 21531761 PMC3117125 118. Tomizawa M. Shinozaki F. Motoyoshi Y. Sugiyama T. …

The genetic architecture of bone metastases: unveiling the role of epigenetic and genetic modifications in drug resistance.

Bone metastases represent frequent and severe complications in various cancers, notably impacting prognosis and quality of life. This review article delves into the genetic and epigenetic mechanisms underpinning drug resistance in bone metastases, a key challenge in effective cancer treatment. The development of drug resistance in cancer can manifest as either intrinsic or acquired, with genetic heterogeneity playing a pivotal role. Intrinsic resistance is often due to pre-existing mutations, while acquired resistance evolves through genetic and epigenetic alterations during treatment. These a

Совпадение в полном тексте источника
… A study using a 3D in vitro model with nano clay-based scaffolds, osteogenically differentiated MSCs, and breast cancer cells (MCF-7, MDA-MB-231) showed increased expression of Wnt components (Wnt-5a, β-catenin, AXIN2, LRP5) in MSCs cultured with MCF-7 compared to MDA-MB-231. …

γδ T Cells: Game Changers in Immune Cell Therapy for Cancer.

Gamma delta (γδ) T cells are a unique subset of T lymphocytes with distinctive features that make them highly promising candidates for cancer therapy. Their MHC-independent recognition of tumor antigens, ability to mediate direct cytotoxicity, and role in modulating the tumor microenvironment position them as versatile agents in cancer immunotherapy. This review integrates and synthesizes the existing data on γδ T cells, with an emphasis on the development and optimization of in vitro expansion protocols. Critical aspects are detailed such as activation strategies, co-culture systems, cytokine

Совпадение в полном тексте источника
… Edelblum K.L., Shen L., Weber C.R., Marchiando A.M., Clay B.S., Wang Y., Prinz I., Malissen B., Sperling A.I., Turner J.R. Dynamic Migration of Γδ Intraepithelial Lymphocytes Requires Occludin. Proc. Natl. Acad. Sci. USA. 2012;109:7097–7102. doi: 10.1073/pnas.1112519109. 4. …

Targeted Delivery Strategies for Multiple Myeloma and Their Adverse Drug Reactions.

Currently, multiple myeloma (MM) is a prevalent hematopoietic system malignancy, known for its insidious onset and unfavorable prognosis. Recently developed chemotherapy drugs for MM have exhibited promising therapeutic outcomes. Nevertheless, to overcome the shortcomings of traditional clinical drug treatment, such as off-target effects, multiple drug resistance, and systemic toxicity, targeted drug delivery systems are optimizing the conventional pharmaceuticals for precise delivery to designated sites at controlled rates, striving for maximal efficacy and safety, presenting a promising appr

Совпадение в полном тексте источника
… Smadja-Joffe F., Legras S., Girard N., Li Y., Delpech B., Bloget F., Morimoto K., Le Bousse-Kerdiles C., Clay D., Jasmin C., et al. CD44 and hyaluronan binding by human myeloid cells. Leuk. Lymphoma. 1996;21:407–420, color plates following 528. doi: 10.3109/10428199609093438. 86. …

Targeting the DNA Damage Response for Cancer Therapy.

Over the course of long-term evolution, cells have developed intricate defense mechanisms in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic stability. Defects in the DNA damage response pathways can give rise to various diseases, including cancer. The DNA damage response (DDR) system is instrumental in safeguarding genomic stability. The accumulation of DNA damage and the weakening of DDR function both promote the initiation and progression of tumors. Simultaneously, they offer opportunities and targets for cancer therapeutics. This article primarily elucid

Совпадение в полном тексте источника
… Clay-Farrace L. Fiegler H. Carr P. Von Zglinicki T. Saretzki G. Carter N.P. Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence Nature 2003 426 194 198 10.1038/nature02118 14608368 17. Kang C. Xu Q. Martin T.D. Li M.Z. Demaria M. Aron L. Lu T. Yankner B.A. Campisi J. …

Систематический обзор потенциального ускорения нееврокогнитивного старения пожилых лиц, переживших рак.

По мере роста показателей выживаемости больше внимания стало уделяться возможным когнитивным сиквелам у пожилых больных раком, что можно объяснить ускоренным старением мозга. В этом обзоре мы представляем полный обзор исследований, посвященных нейроимации, нейрокогнитивным и нейродегенеративным расстройствам у пожилых выживших жертв рака (см.>65 лет), на основе three базы данных (Pubmed, Web of Science and Medline). Ninety-six В него были включены исследования. Были обнаружены данные о функциональных и структурных изменениях в мозге (фронтальные области, базальная ганглиа, серые и белые вещест

Совпадение в полном тексте источника
… Kvale E.A., Clay O.J., Ross-Meadows L.A., McGee J.S., Edwards J.D., Unverzagt F.W., Ritchie C.S., Ball K.K. Cognitive Speed of Processing and Functional Declines in Older Cancer Survivors: An Analysis of Data from the ACTIVE Trial. Eur. J. …

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach.

A brain tumor (BT) is a condition in which there is growth or uncontrolled development of the brain cells, which usually goes unrecognized or is diagnosed at the later stages. Since the mechanism behind BT is not clear, and the various physiological conditions are difficult to diagnose, the success rate of BT is not very high. This is the central issue faced during drug development and clinical trials with almost all types of neurodegenerative disorders. In the first part of this review, we focus on the concept of brain tumors, their barriers, and the types of delivery possible to target the b

Совпадение в полном тексте источника
… Recent Advances in the Design of Inorganic and Nano-Clay Particles for the Treatment of Brain Disorders. J. Mater. Chem. B. 2021;9:2756–2784. doi: 10.1039/D0TB02957B. 139. Nsairat H., Khater D., Odeh F., Al-Adaileh F., Al-Taher S., Jaber A.M., Alshaer W., Al Bawab A., Mubarak M.S. …

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. Tumorigenesis, tumor progression and therapeutic response have all been shown to be impacted by the Shh signaling pathway. Downstream effectors of the Shh pathway include smoothened (SMO) and glioma-associated oncogene homolog (GLI) family of zinc

Совпадение в полном тексте источника
… Clay J.M. Lobb K.L. Sall D.J. Abstract 2819: Identification and characterization of a novel smoothened antagonist for the treatment of cancer with deregulated hedgehog signaling Cancer Res. 2011 71 2819 10.1158/1538-7445.AM2011-2819 109. Wang C. Wu H. Katritch V. Han G.W. Huang X.-P. Liu W. …

Emerging Frontiers in Colorectal Cancer Therapy: From Targeted Molecules to Immunomodulatory Breakthroughs and Cell-Based Approaches.

Colorectal cancer (CRC) is ranked as the second leading cause of cancer-related deaths globally, necessitating urgent advancements in therapeutic approaches. The emergence of groundbreaking therapies, including chimeric antigen receptor-T (CAR-T) cell therapies, oncolytic viruses, and immune checkpoint inhibitors, marks a transformative era in oncology. These innovative modalities, tailored to individual genetic and molecular profiles, hold the promise of significantly enhancing patient outcomes. This comprehensive review explores the latest clinical trials and advancements, encompassing targe

Совпадение в полном тексте источника
… Morse MA, Chaudhry A, Gabitzsch ES, Hobeika AC, Osada T, Clay TM et al. Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients. Cancer Immunol Immunother 2013;62:1293–1301. 10.1007/s00262-013-1400-3. 72. …