Результаты поиска

[Jargon agraphia in a case with Broca aphasia: dissociation between language and writing dominancy].

A 69-year-old left-handed man developed Broca aphasia and jargon agraphia following a right cerebral infarction. He learned to write with his right hand. There is no family history of left-handedness. Neurological examination revealed hemiparesis, sensory impairment, and hyperreflexia with pathological reflexes on the left side. An MRI demonstrated lesions in the area including the pre- and post-central gyri, the posterior part of the middle and inferior frontal gyri, and inferior parietal lobule on the right side. Neuropsychologically he was alert and cooperative. He demonstrated severe Broca

Neural correlates of lexicon and grammar: evidence from the production, reading, and judgment of inflection in aphasia.

Are the linguistic forms that are memorized in the mental lexicon and those that are specified by the rules of grammar subserved by distinct neurocognitive systems or by a single computational system with relatively broad anatomic distribution? On a dual-system view, the productive -ed-suffixation of English regular past tense forms (e.g., look-looked) depends upon the mental grammar, whereas irregular forms (e.g., dig-dug) are retrieved from lexical memory. On a single-mechanism view, the computation of both past tense types depends on associative memory. Neurological double dissociations bet

Second Language Word Learning through Repetition and Imitation: Functional Networks as a Function of Learning Phase and Language Distance.

Introduction and Aim: Repetition and imitation are among the oldest second language (L2) teaching approaches and are frequently used in the context of L2 learning and language therapy, despite some heavy criticism. Current neuroimaging techniques allow the neural mechanisms underlying repetition and imitation to be examined. This fMRI study examines the influence of verbal repetition and imitation on network configuration. Integration changes within and between the cognitive control and language networks were studied, in a pair of linguistically close languages (Spanish and French), and compar

[Neurocognitive functioning after cognitive treatment in post-COVID].

BACKGROUND: Post-COVID is a post-infectious condition resulting from COVID-19 (SARS-CoV-2) that can cause a wide range of neurocognitive and … lyzed using Wilcoxon signed-rank tests. RESULTS: Of the 23 participants, 15 completed the program. Verbal learning improved significantly (p = 0.01). No significant changes were found in other neurocognitive domains. Psychological symptoms decreased significantly (p = 0.03). CONCLUSION: Despite the small sample size, several significant improvements were observ …

Machine Learning of Urine Cytology Highlights Increased Neutrophil Count in Muscle-Invasive Urothelial Carcinoma.

OBJECTIVE: This study conducted an unsupervised learning cluster analysis on urine cytological images of high-grade urothelial carcinoma to assess their explanatory potential. MATERIALS AND METHODS: A total of 124 urine cytology specimens of urothelial carcinoma, collected between December 2010 to December 2021 at Gunma University Hospital, were analyzed. Ten cytological image fields per specimen were captured, and pathological T factors were examined using principal component analysis and t-distributed stochastic neighbor embedding (t-SNE) with machine learning (ML) software. Common image fe

Neuropsychological and Emotional Functioning in Patients with Cushing's Syndrome.

Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with particular emphasis on complex attention and memory. In a clinical sample of 18 adults with CS referred for neuropsychological evaluation (age 41.6 ± 10.6, 72% Caucasian), patients' most common subjective complaints were in attention and increased irritability. On objective testing, pa

Naming and categorization in young children: v. manual sign training.

Following pre-training with everyday objects, 8 children aged from 2 to 4 years learned to produce one manual sign (fists placed one above the other, in front of body) to one stimulus and an alternative manual sign (shoulders touched with ipsilateral hands) to the other stimulus, with each of three pairs of different arbitrary wooden shapes (Set 1). The six stimuli then were presented in category match-to-sample tests, which all subjects passed. Three of the children were next trained to produce the manual signs (denoted as fist/shoulder) for an additional six arbitrary stimuli, Set 2. All 3 c

Specific language impairment in children with velocardiofacial syndrome: four case studies.

OBJECTIVE: To describe specific language impairment in four children with velocardiofacial syndrome (VCFS). DESIGN: A descriptive, retrospe … onse to therapy and did not develop language in accordance with their normal learning abilities (nonverbal learning capacities and language comprehension). Persistent hypernasal resonance and severe articulation problems remained in all four children. In two children the expressive language profile was also not in agreement with the nonverbal profile: they produc …

Recall for self and other in autism: children's memory for events experienced by themselves and their peers.

Research on memory processing suggests that memory for events that an individual experiences should be superior to that for similar events that someone else experiences (e.g., Baker-Ward et al., 1990). However, such predictions may not be applicable to individuals with autism. There are already suggestions that individuals with autism have specific difficulties in remembering (Boucher & Lewis, 1989). In addition, they are known to have more general difficulties involving processes related to the "self." If children with autism have difficulties in encoding information about themselves this cou

Neural Basis of Simple Arithmetic Processing in a Native and Second Language.

Typically, bilinguals learn multiplication facts in their native language (L1), resulting in a performance advantage for arithmetic in L1 compared to a second language (L2). This performance advantage has been shown to be greater for individuals with lower L2 proficiency, suggesting that an individual's language background may play a role in arithmetic processing. The current study aimed to determine whether adult learners of an L2 with limited L2 proficiency engage shared or separate cortical regions to process simple arithmetic across languages. Participants verified small (2 × 3) and large

Loss-of-function variant in spermidine/spermine N1-acetyl transferase like 1 (SATL1) gene as an underlying cause of autism spectrum disorder.

Autism spectrum disorder (ASD) is a complicated, lifelong neurodevelopmental disorder affecting verbal and non-verbal communication and social interactions. ASD signs and symptoms appear early in development before the age of 3 years. It is unlikely for a person to acquire autism after a period of normal development. However, we encountered an 8-year-old child who developed ASD later in life although his developmental milestones were normal at the beginning of life. Sequencing the complete coding part of the genome identified a hemizygous nonsense mutation (NM_001367857.2):c.1803C>G; (p.Tyr601

Neuropsychological Testing in Autoimmune Encephalitis: A Scoping Review.

BACKGROUND AND OBJECTIVES: Identifying optimal methods for evaluation and monitoring of cognitive outcomes in AE is important for clinical c … spanning all cognitive domains. The highest yield measures may include the tests of (1) visual and verbal learning/memory, (2) basic and sustained attention, (3) processing speed, and (4) executive functions.

Affective episodes in recently diagnosed patients with bipolar disorder associated with altered working memory-related prefrontal cortex activity: A longitudinal fMRI study.

INTRODUCTION: Bipolar disorder (BD) is often accompanied by trait-related cognitive impairments, but it is unclear which neurocircuitry abno … impaired cognitive function within attention and psychomotor speed, WM and executive function, and verbal learning and memory compared to controls at baseline. During the follow-up period, 26 patients experienced at least one affective episode (BD+), while 21 remained in remission (BD-). There was no deterioration in cognitive performance in BD+ compared to BD- …

Systemic Review and Meta-analysis of the Intellectual Integrity of Children with Neurofibromatosis Type 1.

BACKGROUND: Cognitive impairment is a common neurologic complication of neurofibromatosis type 1 (NF-1) in childhood. A great number of learning disabilities appear in 30%-65% of children with NF-1. The aim of the study is to compare intelligence quotient (IQ) scores between children with NF-1 and comparable control groups. METHODS: A literature review was conducted using the following databases: Cochrane, PubMed, Wiley, Microsoft Academic, and Google Scholar. We identified 180 papers. The pertinence of any study to the inclusion criteria was determined by assessing the title, key words, and

Is the construction of spatial models multimodal? New evidences towards sensory-motor information involvement from temporary blindness study.

Using new developments of interference paradigm, this paper addresses the raising question of the involvement of sensory-motor information in the construction of elaborate spatial models (Johnson-Laird in Mental models: towards a cognitive science of language, inference, and consciousness Cambridge University Press Cambridge, 1983). In two experiments, 112 participants had to explore and memorize the spatial arrangement of 12 objects, disposed on 3 tables. Participants were either sighted or blindfolded, leading to a visual or a more sensory-motor based exploration of the room. During explorat

Development of normative neuropsychological performance in Thailand for the assessment of HIV-associated neurocognitive disorders.

International studies of HIV-associated neurocognitive disorder (HAND) are needed to determine the viral and host factors associated with co … gical measures with the exception of verbal fluency. The Thai group performed better on measures of verbal learning (p < .001) and memory (p < .001) and measures of psychomotor speed (p < .001). Education was a more powerful predictor of performance in the Thai cohort than in the US group. These results highlight the continued need for the development of normativ …

Unrecognised cognitive impairment in hospice patients: a pilot study.

The presence of cognitive impairment in patients who are receiving hospice care can affect numerous practical, ethical and legal aspects of their healthcare. A number of factors can contribute to cognitive impairment in these patients. Prevalence rates of cognitive impairment vary widely, but it remains under-recognised and under-treated. The aims of this pilot study were to evaluate the presence and nature of cognitive deficits in patients receiving inpatient hospice care who did not have a known current or past diagnosis of a cognitive disorder or any obvious cognitive impairments. A conveni

Diagnostic Classification of Autism Spectrum Disorder in the Frequency Domain Using Resting-State fMRI.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with problems in social interactions, verbal and non-verbal communication, repetitive behaviors, and limited interests in a person. Considering the challenges in diagnosing ASD based on behavioral symptoms-such as subjectivity, variability among individuals, and overlap with other developmental conditions-it seems necessary to propose computer-aided diagnosis systems (CADS) for ASD. We proposed an age-dependent CADS based on functional connectivity (FC) in the frequency domain for ASD using resting-state functional magnetic resona

Влияние скорости обработки информации на процессы памяти пациентов с повторным излучением и первичным постепенным множественным склерозом.

Замедленная скорость обработки информации (IPS) является основным когнитивным расстройством у людей с множественным склерозом (pwMS). Хотя известно, что это влияет на процессы памяти, взаимосвязи между устным обучением (VL), устной памятью (VM) и IPS в различных фенотипах множественного склероза (MS) остаются недостаточно изученными. Цель этого бицентрического исследования состояла в подробном изучении IPS, VL и VM, а также взаимосвязей между этими когнитивными областями в обширной выборке из 92 PwMS (61 с ранним восстановлением эмиссий MS (pwRMS), 31 с первичным прогрессивным MS (pwPPMS)) и 6

Совпадение в аннотации оригинала
Slowed information processing speed (IPS) is the primary cognitive impairment in people with multiple sclerosis (pwMS). Although it is known to affect memory processes, the relationships between verbal learning (VL), verbal memory (VM) and IPS in different phenotypes of multiple sclerosis (MS) remain underexplored. This bicentric study aimed to investigate i…

Age-Related Dichotic Listening Skills in Impaired and Non-Impaired Readers: A Comparative Study.

Dichotic listening is the high-level auditory process which enables the perception of different verbal stimuli delivered simultaneously to the right and left ears (binaural integration), as well as the perception of a verbal stimulus presented to one ear while ignoring a different stimulus in the other ear (binaural separation). Deficits in central auditory processing have been reported in children with learning disabilities. The present study aimed to compare dichotic listening performances in right-handed impaired readers (IR) and non-impaired readers (non-IR) according to age. For this, a c