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Nurse-delivered sleep restriction therapy to improve insomnia disorder in primary care: the HABIT RCT.

BACKGROUND: Insomnia is a prevalent and distressing sleep disorder. Multicomponent cognitive-behavioural therapy is the recommended first-li … quality of life, depressive symptoms, work productivity and activity impairment, self-reported and actigraphy-defined sleep, and hypnotic medication use. Cost-effectiveness was evaluated using the incremental cost per quality-adjusted life-year. For the process evaluation, semistructured interviews were carried out with participants, nurses and practice man …

Wearable activity monitors in oncology trials: Current use of an emerging technology.

BackgroundPhysical activity is an important outcome in oncology trials. Physical activity is commonly assessed using self-reported questionnaires, which are limited by recall and response biases. Recent advancements in wearable technology have provided oncologists with new opportunities to obtain real-time, objective physical activity data. The purpose of this review was to describe current uses of wearable activity monitors in oncology trials.MethodsWe searched Pubmed, Embase, and the Cochrane Central Register of Controlled Trials for oncology trials involving wearable activity monitors publi

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… A detailed description of how missing actigraphy data were handled was provided in only one trial [ 18 ]. In most trials, methods for handling nonwear time and missing data were unclear. … Objective monitoring of sleep, using actigraphy, has allowed for investigators to objectively measure sleep duration, sleep latency, number of awakenings, and sleep efficiency within their own home environment. …

Количественная оценка резерва движения в множестве склероза с помощью дневных квантовой активности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Обычные клинические оценки по множественным склерозам (МС), таким, как расширенная шкала взносов для инвалидов (EDSS), часто не учитывают тонкие функциональные изменения. Хотя акселерометрия является объективным показателем реальной моторной активности, большинство ежедневных сводок концентрируются на средних значениях, игнорируя как пиковые характеристики, так и их изменчивость в течение дня. Эта дневная максимальная изменчивость показателей может отражать способность человека поддерживать высокую активность, несмотря на усталость, явление, которое мы называем наблюдаем

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… Methods HEAL-MS study We analyzed baseline data from the Home-based Evaluation of Actigraphy to Predict Longitudinal Function in MS (HEAL-MS) observational cohort, recruited at Johns Hopkins University between January 2021 and March 2023 ( Tian et al., 2020 ; Bou Rjeily et al., 2025 ). …

Повреждения сна в образце пациентов с множественным склерозом педиатрии: сосредоточьтесь на синдроме беспокойных ног.

Фон/цели: Согласно сообщениям, нарушения сна (SD) и синдром нержавеющих ног (RLS) широко распространены в случае множественного склероза (MS), однако данные о педиатрии-понтере MS (POMS) являются ограниченными. Целью этого исследования является оценка распространенности УР, в частности РСТ, в группе ПОМС и изучение сопутствующих клинических особенностей. Методы: Мы наняли пациентов ПОМС, которые посещали Центр ПОМС при Детской больнице Бамбино-Гессе в период с сентября 2021 и февраль 2023; они были оценены на предмет УР с использованием индекса качества сна Питтсбурга (PSQI) или шкалы неустойч

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… Similarly, Stephens et al. [ 33 ], using actigraphy, reported no differences in sleep parameters such as sleep time, sleep efficiency, number of awakenings, number of minutes awake after sleep onset, sleep latency, or time in bed between these groups. … The lack of objective tools, such as polysomnography or actigraphy, to assess sleep disorders is another limitation that could have reduced the accuracy of diagnosing certain conditions. …

Study Design and Rationale for The Breathe Easier With Tadalafil Therapy for Exercise-Related Dyspnea in COPD-PH (BETTER COPD-PH).

Dyspnea, a debilitating symptom of COPD, worsens health-related quality of life (HRQL), reduces daily physical activity, increases health care utilization, and is more closely associated with survival than airflow limitation. Thus, having treatments that reduce dyspnea in COPD is important. Pulmonary hypertension (PH) is a common complication of COPD that is associated with severe dyspnea, more frequent COPD exacerbations, and increased mortality. Multiple causes of PH, including a reduction in bioavailable vasodilator nitric oxide (NO), are associated with COPD (COPD-PH). Phosphodiesterase ty

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… Secondary outcomes include: physical activity measured as daily step count using actigraphy, exercise capacity as measured by 6MWD, and clinically important deterioration, a validated composite outcome defined as an increase of at least 4 units in the St. … Finally, this study was designed to be able to assess multiple patient‐centered outcomes remotely if necessary: the primary outcome (UCSD SOBQ) and several secondary outcomes (COPD exacerbations, SGRQ total score, and actigraphy). …

Качество сна и сон у взрослых с множественной миеломой. Возможно ли лечение мелатонина?

Нездоровые сны оказывают значительное воздействие на качество жизни больных раком, однако они по-прежнему плохо характеризуются множественной миеломой (ММ). Цель этого исследования состояла в том, чтобы охарактеризовать профили сна у пациентов из числа ММ и оценить терапевтический потенциал внешнего мелатонина. Мы оценили 46 Пациенты ММ и 64 :: возрастной контроль с использованием индекса качества сна Питтсбурга (PSQI) и шкалы сна Epworth (ESS). Данные показали значительно более низкое качество сна у пациентов с ОМ по сравнению с контрольными показателями (глобальная PSQI: U = 1126; p = 0.034)

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… A novel approach using actigraphy to quantify the level of disruption of sleep by in‐home polysomnography: The MrOS Sleep Study. Sleep Medicine, 32, 97–104. 10.1016/j.sleep.2016.11.019 Bonnet, M. H. , & Arand, D. L. (2003). Clinical effects of sleep fragmentation versus sleep deprivation. …

Non-invasive electrical stimulation for sleep disturbances in adults: protocol for an evidence-mapping umbrella review of systematic reviews and meta-analyses with subgroup analysis by intervention type and population.

BackgroundSleep disturbances affect 10%-30% of adults worldwide. Non-invasive electrical stimulation (e.g., transcranial electrical stimulation) has emerged as a promising non-pharmacological intervention. Although numerous systematic reviews and meta-analyses have been published, they vary considerably in methodological quality, populations, intervention types, and conclusions. No umbrella review has yet synthesised the evidence across different modalities and populations. This evidence mapping umbrella review aims to systematically chart the existing systematic reviews, assess methodological

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… Secondary outcomes: (1) Total sleep time (TST), measured by polysomnography (PSG), actigraphy, or validated sleep diaries. …

Sleep quality following hematopoietic stem cell transplantation: longitudinal trajectories and biobehavioral correlates.

The present study examined changes in sleep quality following hematopoietic stem cell transplantation (HSCT) and investigated associations with biobehavioral factors. Individuals undergoing HSCT for hematologic malignancies (N=228) completed measures of sleep quality and psychological symptoms pre-transplant and 1, 3, 6 and 12 months post transplant. Circulating inflammatory cytokines (IL-6, TNF-α) were also assessed. Sleep quality was poorest at 1 month post transplant, improving and remaining relatively stable after 3 months post transplant. However, approximately half of participants contin

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… Future studies should also consider other measures of sleep-wake disturbance, such as wrist actigraphy or polysomnography. In addition, our capacity to generalize the conclusions to other populations is limited. …

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer.

Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associate

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… Studies utilizing actigraphy measurement (a wrist-worn device that measures locomotor activity counts) showed that chemotherapy disrupts sleep-wake cycles as early as the first cycle 11 and that these disruptions tend to worsen as chemotherapy continues. 31 Studies that have used the gold standard of … have suggested that administering CBT-I or its variant to participants stabilizes or improves various sleep parameters. 102 – 113 Recent randomized controlled trials investigating the efficacy of CBT-I in breast cancer survivors have shown statistically significant improvements in both objective (ie, actigraphy …

The Potential of Chronotherapy and Nanotherapy-Based Strategies for Glioblastoma Treatment.

Glioblastoma is the most common and aggressive brain tumour in adults, and despite ongoing efforts, effective treatment remains limited. Standard therapies often face challenges because of the tumour's specific biology, its aggressive nature, and the presence of certain physiological barriers in the brain that impede chemotherapeutics from reaching their target. Emerging research in circadian biology highlights the role of the internal circadian clock in tumour progression and treatment response. Evidence suggests that aligning therapy to patients' chronotypes could potentially improve treatme

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… Identification and validation of circadian biomarkers, including clock gene expression profiles, melatonin rhythms, and actigraphy-based measurements, will be essential to stratify patients and personalise treatment schedules [ 56 ]. … artificial intelligence models (including deep learning, machine learning, and hybrid mechanistic-data approaches) have been applied to analyse real-time rhythmic phase shifts, circadian biomarkers, amplitude reductions, and desynchronizations using large datasets from wearable sensors, genetic research, actigraphy …

beta Testing a Medical Symptom Management для людей с продвинутым раком: Исследование одноразовой осуществимости и приемлемости.

КОЛИЧЕСТВО: Люди, страдающие раком, имеют более частые и серьезные симптомы, чем лица, страдающие ранней стадией заболевания. Обычные, тревожные симптомы включают трудности со сном, беспокойство и неуверенность, усталость и депрессию. Когнитивная поведенческая терапия (КБТ) и терапия принятия и принятия обязательств (АКТ) эффективно устраняют эти симптомы, но зачастую они являются слишком продолжительными для пациентов с несколькими назначениями, ограниченной энергией и конкурирующими приоритетами. Кратко говоря, мобильные медицинские услуги (медицинское обслуживание) являются доступной альтер

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… We conducted a pilot randomized controlled trial with people with advanced cancer, and the results demonstrated improved sleep on both self-report [ 17 ] and physiological measures (ie, actigraphy) [ 18 ] and moderate to strong improvements in worry, depression, and fatigue interference. … While the focus at this stage of app development was app user experience, including app-based sleep diary development, we recognize this as a limitation and plan to use objective sleep monitoring devices (ie, actigraphy watches) in our larger randomized clinical trial. …

Частота и факторы риска возникновения проблем со сном у египетских пациентов с множественным склерозом.

КОЛИЧЕСТВО: Проблемы со сном затрагивают более 65% пациентов с множественным склерозом (МС), что значительно выше, чем в целом по населению. Цель этого исследования заключалась в оценке частотности и связанных с риском факторов проблем со сном в большой группе MS и в оценке их воздействия на качество жизни (QoL). В исследовании приняли участие 103 участника, в том числе MS на различных этапах заболевания и 62 специалиста по контролю за состоянием здоровья. Инструменты оценки включали в себя Расширенную шкалу взносов для инвалидов (EDSS), Индекс качества сна Питтсбурга (PSQI), шкалу показателей

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… Previous studies that found stronger correlations between sleep and cognition often included objective measures such as polysomnography (PSG) or actigraphy, which assess sleep architecture, sleep fragmentation, and specific sleep stages (e.g., slow-wave sleep, REM sleep). …

IMPROVE-BMT: a protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients.

IntroductionHaematopoietic stem cell transplant (HSCT) in adults is an intensive medical procedure for a variety of haematological malignancies. Although there is a large body of evidence demonstrating the negative effects of HSCT on physical function and psychosocial parameters, there is limited evidence on the impact of HSCT on body composition and bone health. Further, aerobic and resistance-training exercise interventions aimed at improving physical function and patient-reported outcomes largely take place during the peritransplant and post-transplant period. Prehabilitative exercise, or e

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… activity, leisure time activities such as cycling, walking and sports, household and occupational activity will be assessed via the Short QUestionnaire to ASsess Health-enhancing Physical Activity (SQUASH). 63 64 The SQUASH has been reported to be reliable (r=0.45–0.90) and correlated with free-living actigraphy …

Non-pharmacological interventions for sleep promotion in hospitalized children.

BACKGROUND: Healthy sleep is an important component of childhood development. Changes in sleep architecture, including sleep stage compositi … d highly reliable sleep assessment tools, including objective measures, such as polysomnography and actigraphy.

Pharmacotherapies for sleep disturbances in dementia.

BACKGROUND: Sleep disturbances, including reduced nocturnal sleep time, sleep fragmentation, nocturnal wandering, and daytime sleepiness are … ants had a variety of common sleep problems at baseline. Primary sleep outcomes were measured using actigraphy or polysomnography. In one study, melatonin treatment was combined with light therapy. Only four studies systematically assessed adverse effects. Overall, we considered the studies to be at low or unclear risk of bias. We found low-certainty evidenc …

Take the reins: a study protocol of a randomized controlled trial testing the effects of time-restricted eating vs. nutrition control on cancer-related fatigue among survivors of hematological malignancies.

BACKGROUND: Cancer-related fatigue is one of the most common and debilitating side effects of cancer and its treatments. Fatigue may stem from disruptions in circadian rhythms and dysregulation of glucose metabolism, which can be improved through time-restricted eating. Time-restricted eating is a daily eating pattern that entails consuming food within a defined, consistent window (e.g., 10 h) every day. When the eating window aligns with the daylight hours, it can entrain circadian processes and modulate physiological regulation of whole-body metabolism. It is hypothesized that time-restricte

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… participants are asked to complete questionnaires that probe fatigue (e.g., [ 39 ]), behaviors that correlate with fatigue (e.g., physical activity [ 40 ]), and related symptoms; log their food with time stamps via the myCircadianClock smartphone application (Salk Institute, La Jolla, CA, USA [ 41 ]); wear an actigraphy … Participants then return the actigraphy watch and glucose monitor reader to the lab via a postage-paid USPS box for data extraction. After baseline assessments, participants are randomized 1:1 to the TRE group (intervention) or the unrestricted eating group (control). …

The use of smart technologies for enhancing palliative care: A systematic review.

IntroductionWith the rapid advancement of technology, smart technologies have permeated various sectors, including palliative care in healthcare. Based on the available literature, similar studies have elucidated the application of individual and isolated smart technologies in palliative care, with their benefits, and limitations. This research, therefore, focuses on the conceptualisation of various smart technologies and makes holistic recommendations on the effective and efficient use of smart technologies in healthcare to enhance palliative care.PurposeThe purpose of this study is to system

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… . | Breast cancer | Taiwan | Qualitative using observations | Wearable devices | Potential outcomes such as end-of-life admission in cancer patients receiving palliative care could be predicted by wrist actigraphy. …

Lifestyle considerations in multiple myeloma.

As the prognosis for multiple myeloma (MM) has significantly improved and patients remain on therapy longer, there is a need for supportive care interventions to optimize patient quality of life (QOL) and functional status over the course of cancer treatment. MM is characterized by a significant symptom burden and a relatively lower QOL compared to other cancers. This review evaluates the role of healthy lifestyle behaviors in improving both the physical functioning and psychological well-being of the MM population. We (1) describe the current literature on physical activity, weight management

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… Sleep measures, both objective (e.g. polysomnography, actigraphy, bispectral index) and subjective (e.g. Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, Consensus Sleep Diary), need to be included in studies [ 66 ]. …

Краткосрочные изменения в объективно измеряемой активности предсказывают атрофию мозга и развитие инвалидности при множественном склерозе.

ЦЕЛЬ: Оценка того, как изменения в структуре акселерометрической активности внутри человека приводят к атрофии мозга и ухудшению инвалидности у людей с множественным склерозом (PwMS). Мы включили PwMS в возрастную группу ≥40 годами с приблизительно годовым МРТ мозга, который носил акселерометры GT9X Actigraph three месяцев сверх three Годы. Индексы, полученные на основе акселерометрии, включали в себя общие и 2-hour Специфическая активность, оседлое время и параметры циркадианского ритма. Подтвержденное ухудшение ситуации с инвалидностью было характерно для комплексной расширенной шкалы взносо

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… Materials and Methods Study population We included participants from the Home-based Evaluation of Actigraphy to predict Longitudinal Function in MS (HEAL-MS) cohort, as described previously. …

ASENT 2022 Annual Meeting.

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… Methods include chronic drug dosing, testing susceptibility to audiogenic-induced seizures and assessment of hyperactivity by 24/7 actigraphy monitoring. Results indicate partial rescue of seizures in males with the ketone beta-hydroxybutyrate but no rescue with the glucose analog 2-deoxyglucose. … Testing of tributyrin and actigraphy are in progress. We conclude that the ketogenic diet is highly effective in reducing seizures and hyperactivity in male Fmr1KO mice. Treatment with a single ketone, beta-hydroxybutyrate, partially recapitulates efficacy. …