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Deciding on thresholds for clinical relevance of PROMIS-upper extremity v2.0 in patients with upper extremity injury.

PURPOSE: In this study we focused on gaining better interpretation of the PROMIS-Upper-Extremity v2.0 (PROMIS-UE v2.0) T-score scale for measuring upper extremity function in patients with upper extremity injuries (UEIs). This is fundamental in order to clearly understand the clinical relevance of these outcomes. The aim of this study was to identify interpretive thresholds for mild, moderate and severe upper extremity function problems for PROMIS-UE v2.0 T-scores, in patients with UEIs, by performing a vignettes study. METHODS: A qualitative vignette study, based on the PROMIS-UE v2.0 and it…

18F‑FDG PET/CT in metastatic chordoma: a retrospective analysis of imaging features and potential clinical relevance.

BACKGROUND: Systematic data on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in metastatic chordo … oma, enabling the detection of occult metastases and revealing metabolic heterogeneity of potential clinical relevance. These hypothesis-generating findings suggest a potential role in surveillance and personalized management, warranting further prospective validation before clinical implementation.

Renin-Angiotensin-Aldosterone System (RAAS) in Pig-to-Baboon Kidney Xenotransplantation-Relevance to Clinical Pig Kidney Xenotransplantation.

BACKGROUND: Pig-to-human kidney xenotransplantation offers a potential solution to the organ shortage. However, the ability of the transplanted pig kidney to regulate blood pressure and fluid balance remains uncertain. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in these functions, but species differences may impair its effectiveness in xenotransplantation. METHODS: Gene-edited pig kidneys were transplanted into six immunosuppressed baboons. Group A (n = 2) underwent bilateral native nephrectomy, while Group B (n = 4) had unilateral nephrectomy with one native kidney

Clinical Relevance of Early Cranial Computed Tomography-Imaging After Elective Brain Tumor Surgery in Children and Adolescents.

BACKGROUND AND OBJECTIVES: This retrospective single-center cohort study evaluated the role of early postoperative computed tomography (EPOCT) after pediatric intracranial tumor resection, a practice that remains controversial. Although EPOCT is frequently used to detect early postoperative complications, evidence supporting its routine use in neurologically stable children is limited, and concerns regarding radiation exposure persist. The aim of this study was to assess the clinical relevance of routine EPOCT after elective intracranial tumor surgery in children and adolescents and to identif…

Clinical Implementation and Oncological Relevance of Molecular Profiling in Brain Metastases Patients-A Multicenter Retrospective Cohort Study.

Brain metastases (BM) require a multidisciplinary treatment approach combining surgery, radiotherapy, and systemic therapy. While current guidelines recommend the analysis of established cancer driver genes in BM tissue, little is known about its real-life implementation and relevance on oncological treatment strategies. This retrospective multicenter study includes patients with BM from melanoma, lung and breast cancer operated between 2010 and 2022. Clinical records were evaluated for BM molecular analyses of predefined cancer drivers and their discordance to extracranial tumor sites, that i

Clinical Relevance of Calcifications in Osteosarcoma Lung Metastases: Correlations Among Radiological Patterns, Histological Subtypes, and Chemotherapy Responses.

Background/Objectives: Osteosarcoma is a rare malignancy and the most common primary malignant bone tumor. Metastases commonly affect the lungs and are associated with reduced life expectancy. Calcifications can be present within a metastatic nodule at baseline or can appear during follow-up. We aimed to assess the clinical significance of calcifications in lung metastases, particularly in relation to radiological pattern, histopathological subtype, and treatment response. Methods: A retrospective cohort of patients with osteosarcoma and lung metastases at diagnosis was evaluated for the perio

Оценка клинической значимости анализатора растворимой крови на миелоидных клетках 2 в неврологических болезнях.

Преобразование рецептора, выраженного на миелиоидных клетках 2 (TREM2), является одним из ключевых регуляторов микроглиальной и периферической функции миелиоидных клеток, причем его растворимая форма (STREM2) становится биомаркером нейроинфламмации. Хотя цереброспинная жидкость (CSF) sTREM2 постоянно повышается в нейродегенеративных болезнях, клиническая значимость sTREM2 крови остается неясной. Мы провели ретроспективное исследование, в котором приняли участие 547 человек: болезнь Альцгеймера (AD, n = 142), слабое когнитивное расстройство (MCI, n = 42), множественный склероз (MS, n = 105), на

Совпадение в аннотации оригинала
Triggering receptor expressed on myeloid cells 2 (TREM2) is a key regulator of microglial and peripheral myeloid cell function, with its soluble form (sTREM2) emerging as a biomarker of neuroinflammation. Although cerebrospinal fluid (CSF) sTREM2 is consistently elevated in neurodegenerative diseases, the clinical relevance of blood sTREM2 remains unclear. W…

Clinical Relevance and Follow-Up of Incidental CT Imaging Findings for COVID-19 Diagnosis: A Retrospective Analysis.

Background/Objectives: The aim of this study was to evaluate the prevalence of incidental findings in thoracic computed tomography (CT) performed because of COVID-19 and their potential impact on patient management. Methods: This retrospective analysis included 683 CT scans from 327 patients who underwent CT imaging of the thorax with or without the application of intravenous contrast-agents because of the primary indication of COVID-19. Radiological findings were categorized according to the COVID-19 Pneumonia Imaging Classification by four independent readers. Incidental findings were catego

Global dissemination of Klebsiella pneumoniae in surface waters: Genomic insights into drug resistance, virulence, and clinical relevance.

The aquatic environment is a major pathway for the spread of antibiotic resistance (AR) among microorganisms. Among these, Klebsiella pneumoniae reveals high genome plasticity, adaptability, and the ability to colonize humans, animals, and the natural environment, awarding it a significant role in the spread of AR. This work presents an in-depth analysis of the whole sequences of 149 K. pneumoniae genomes isolated from surface waters available in databases. The sequences were obtained from 20 countries in five continents. The analyses showed a high genomic diversity of isolates, classifying th

Assessment of Donor-Specific Human Leukocyte Antigen Antibodies Following Pediatric Liver Transplantation: Predictors, Protectors, and Clinical Relevance.

BACKGROUND: Following pediatric liver transplantation (pLT), the significance and management of donor-specific antibodies (DSA) against human leukocyte antigen (HLA) remain undefined. The aim of this single-center study was to investigate the occurrence of DSA, their clinical impact on predictors for and protectors against DSA. PATIENTS AND METHODS: We compared anti-HLA DSA (cutoff for mean fluorescence intensity (MFI) ≥ 1000), clinical and laboratory results and outcome in a routine (RG, n = 142, standard DSA testing) and a hepatopathy group (HG, n = 19, DSA testing following indeterminate h

Influence of Immune Cells on Corneal Nerve Morphological Analysis and Clinical Relevance in Diabetes-Related Dry Eye.

PURPOSE: Corneal nerve morphology and immune cells are critical biomarkers in the ocular surface. This study aimed to investigate the influence of immune cells on corneal nerve morphology and the clinical significance in diabetes-related dry eye disease (DED). METHODS: In the first part, 1075 in vivo confocal microscopy images containing dendritic cells or round cells were included as system validation. Key morphological parameters, including corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), tortuosity, and box-count fractal dimension (Boxdim), were measured before and

Translational Anatomy of the Sinoatrial Node: Myoarchitecture and its Relevance for Catheter Ablation: Part II: Clinical Applications.

ANATOMY: Clinical applications relevant to the sinoatrial node anatomy for interventional electrophysiology procedures are reviewed. PATHOLOGY: Inappropriate sinus tachycardia, atrial tachycardia, and superior vena cava triggers for atrial fibrillation. IMAGING CORRELATION: Three-dimensional electroanatomic mapping, intracardiac echocardiography. TREATMENT: Ablation guided by activation mapping and intracardiac electrograms. TAKE-HOME MESSAGE: Understanding the anatomy of the sinoatrial node and the perinodal region provides key anatomic concepts to safely and effectively guide ablation pr

Reduced CD37 expression in B cell subsets after stimulation and its clinical relevance in primary Sjögren's syndrome.

OBJECTIVE: This study aims to analyse the expression of CD37 in different B cell subsets from human peripheral blood, exploring changes in CD37 expression in B cells of patients with primary Sjögren's syndrome (pSS) and assessing their clinical relevance. METHODS: A total of 32 pSS patients and age- and sex-matched healthy controls were included. Peripheral blood mononuclear cells (PBMCs) were isolated, and B cells were classified into five subsets using flow cytometry based on CD24 and CD38 expression. CD37 expression was evaluated, and functional differences between CD37+ and CD37- B cells …

Sensory Dysfunction in ALS and Other Motor Neuron Diseases: Clinical Relevance, Histopathology, Neurophysiology, and Insights from Neuroimaging.

Background: The clinical profiles of MNDs are dominated by inexorable motor decline, but subclinical proprioceptive, nociceptive and somatosensory deficits may also exacerbate mobility, dexterity, and bulbar function. While extra-motor pathology and frontotemporal involvement are widely recognised in motor neuron diseases (MNDs), reports of sensory involvement are conflicting. The potential contribution of sensory deficits to clinical disability is not firmly established and the spectrum of sensory manifestations is poorly characterised. Methods: A systematic review was conducted to examine th

[Clinical Characteristics and Prognostic Relevance of Co-Mutated Genes in Acute Myeloid Leukemia Patients with FLT3 Mutations].

OBJECTIVE: To investigate the clinical characteristics and influence of co-mutated gene on acute myeloid leukemia patients (AML) with FMS-like tyrosine kinase-3 (FLT3) mutations. METHODS: A total of 273 FLT3+ AML patients were enrolled, and the co-mutation gene data of the patients were collected to further analyze the prognosis of the patients. FLT3 and other common mutations were quantified by PCR amplification products direct sequencing and second-generation sequencing (NGS). RESULTS: When patients were divided into FLT3- ITD +, FLT3- TKD +, FLT3- ITD ++TKD + and FLT3- ITD -+TKD - group a

Ocular Tuberculosis Diagnosis Through Biomarkers: Clinical Relevance of Serum C1q and Whole Blood Interferon Gene Signature Score.

PURPOSE: To assess the clinical relevance of pathophysiology-based biomarkers, specifically serum C1q and whole blood interferon gene signature score (IGSS), in ocular tuberculosis (OTB) diagnosis by conducting an integrative analysis of clinical presentations and treatment response. METHODS: This retrospective cohort study analysed data from 70 patients with suspected OTB at a tertiary care uveitis practice in Indonesia. Serum C1q levels and whole blood IGSS were quantified. Patients were categorized into four quadrants based on their biomarker profiles: quadrant 1 (high C1q & low IGSS), qua…

High prevalence but no current clinical relevance of methyldibromo glutaronitrile since its ban in Turkey in 2015.

BACKGROUND: Regulatory actions significantly reduced methyldibromo glutaronitrile (MDBGN)-induced allergic contact dermatitis (ACD) from cos … D was rare (21.1%), occurring mainly in hairdressers from hair gel. Positive reactions with current clinical relevance dropped from 48.3% (1996-2014) to zero after 2015 (p < 0.001). CONCLUSIONS: The ban effectively reduced MDBGN-induced ACD in Turkey, yet the prevalence of positive patch test reactions remains high, likely due to past exposures or other undisclosed …

Clinical Relevance of Oxidative Stress Biomarkers in Human Flavivirus Infections as Predictors of Disease Progression and Severity.

Several Flaviviridae constitute an emerging threat to global health because of their continuing spread and the expansion of vector habitats, largely driven by climate change and intensified global travel. Infections can result in severe neurological or visceral pathologies. The relationship between oxidative stress (OS), an imbalance between generated reactive oxygen species and the antioxidant defences of the host, and flavivirus infection has been repeatedly demonstrated in in vitro and animal studies, but measuring biomarkers of oxidative stress in vivo could prove useful in clinical patien

Three-Dimensional (3D) Analysis of Orbital Morphometry in Healthy Anatolian Adults: Sex, Side Discrepancies, and Clinical Relevance.

Background and objective The complex structural integrity of the orbit is crucial for visual functions. Three-dimensional (3D) reconstructions from radiological images have revolutionized anatomical understanding, eliminating the limitations of two-dimensional (2D) imaging and offering intricate spatial details for complex structures. The aim of this study was to analyze the detailed morphometry of the orbit in healthy Anatolian adults, considering sex, side discrepancies, and clinical relevance using 3D models reconstructed from multidetector computed tomography (MDCT) images. Materials and m…