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Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy.

Prenatal exposure to the herbicide linuron, a weak androgen receptor antagonist, has been shown to perturb androgen-dependent male rat repro … nimals. Approximately 25 and 60% of the male offspring that had malformations of the epididymis and vas deferens did not exhibit either areolae on PND 13 or nipples at necropsy, respectively. These data indicate that in utero linuron exposure to 50 mg/kg/day results in permanent changes in AGD and nipple retention in male rats. Moreover, these findings indicat …

Laparoscopic radical prostatectomy with the Heilbronn technique: an analysis of the first 180 cases.

PURPOSE: In 1998 Guillonneau and Vallancien introduced laparoscopic radical prostatectomy with primary access to the seminal vesicle. In 199 … pex is then pulled ventrally followed with incision at the bladder neck, and transvesical access to vas deferens and seminal vesicle. After completing the posterior wall of the urethrovesical anastomosis with 5 interrupted endoscopic sutures, the Foley catheter is placed, bladder neck closed and specimen extracted via the umbilical incision. From March 1999 to …

The effect of Vigabatrin, Lamotrigine and Gabapentin on the fertility, weights, sex hormones and biochemical profiles of male rats.

PURPOSE: A case control study was conducted to assess the effect of Sabril (Vigabatrin), Lamictal (Lamotrigine) and Neurontin (Gabapentin) o … n the body weight and the weight of the testes, epididymis, seminal vesicles, ventral prostate, and vas deferens in the antiepileptic fed male rats in comparison to the control group (p > 0.001). There was significant reduction in testicular cells population dynamics including both germinal cell types and interstitial cell types in the antiepileptic fed male r …

A comparison of laparoscopic-assisted (LAARP) and posterior sagittal (PSARP) anorectoplasty in the outcome of intermediate and high anorectal malformations.

INTRODUCTION: Laparoscopic-assisted ano-rectoplasty (LAARP) has gained popularity since its introduction in 2000. Further evidence is needed … by PSARP. There were slightly more complications in the LAARP group; intra-operative injury to the vas deferens and urethra occurred once each. Post-operatively, 2 port-site hernias and 1 case of pelvic sepsis occurred. A poorly sited colostomy caused difficulty in 2 patients. Two patients were converted to laparatomy: severe adhesions in one and a poorly sit …

Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.

The development of buprenorphine as a treatment for opiate abuse and dependence has drawn attention to opioid ligands that have agonist actions followed by long-lasting antagonist actions. In a search for alternatives to buprenorphine, we discovered a bridged pyrrolidinomorphinan (BU72). In vitro, BU72 displayed high affinity and efficacy for mu-opioid receptors, but was also a partial delta-opioid receptor agonist and a full kappa-opioid receptor agonist. BU72 was a highly potent and long-lasting antinociceptive agent against both thermal and chemical nociception in the mouse and against ther

Ultrasound of the male genital tract in relation to male reproductive health.

BACKGROUND: Infertility affects ∼7% of all men. Despite much progress, mainly in genetics, its etiology remains obscure in ∼50% of cases. To … . Scrotal and transrectal US (TRUS) are useful in detecting congenital uni- or bilateral absence of vas deferens (CBAVD), which may be associated with epididymis, seminal vesicles (SV) or kidney abnormalities/agenesis. TRUS plays a key role in assessing obstructive azoospermia and detecting distal CBAVD or anomalies related to ejaculatory ducts obstruction, su …

Dietary arginine modulates growth performance and testicular development across life stages in male swimming crab (Portunus trituberculatus).

This study evaluated the effects of dietary arginine (Arg) on growth performance, testicular development, and apoptosis in juvenile and adul … dult stage, crabs fed 2.27% and 2.65% Arg diets showed higher gonadosomatic index, testis index and vas deferens index than those fed other diets (P < 0.05). In the hemolymph, the activities of adenylate kinase (AK) and neuronal nitric oxide synthase (n-NOS), as well as nitric oxide (NO) content, were significantly increased in the 2.65% Arg group (P < 0.05), …

Four laparoscopic surgical strategies for pediatric direct inguinal hernia: a retrospective single-center case series of six male children.

OBJECTIVE: Pediatric direct inguinal hernia is a rare subtype of inguinal hernia, characterized by protrusion of abdominal viscera through t … re completed successfully with minimal intraoperative blood loss. No intraoperative injuries to the vas deferens, spermatic vessels, testis, bowel, urinary bladder, external iliac vessels or nerves were identified. Oral liquid diet was resumed 6 to 8 h after surgery, and daily activities were restored within 24 h postoperatively. No short-term complications su …

Description of Surgical Technique and Oncologic and Functional Outcomes of the Precision Prostatectomy Procedure (IDEAL Stage 1-2b Study).

BACKGROUND: The existing treatment options for men with intermediate- or high-volume low-risk prostate cancer (PCa) are associated with a substantial risk of over- or undertreatment. The development of risk-adjusted therapies is an unmet need for these patients. OBJECTIVE: To describe our novel technique of precision prostatectomy, a form of surgical focal therapy that allows radical excision of the index PCa lesion along with >90% prostatic tissue extirpation while preserving the prostatic capsule and seminal vesicle/vas deferens complex on the side contralateral to the dominant cancer lesio…

General pharmacology of the new antimuscarinic compound vamicamide.

The general pharmacology of the new antimuscarinic compound vamicamide (FK176, (+/-)-(2R*, 4R*)-4-dimethylamino-2-phenyl-2- (2-pyridyl)valer … . Vamicamide on the highest concentration of 1 x 10(-4) g/ml augmented contractions of isolated rat vas deferens induced by noradrenaline, resting tonus of the isolated guinea pig trachea, and contractile force of spontaneous movement of the isolated rat nonpregnant uterus. The compound at 1 x 10(-4) g/ml had no significant effects on KCl-induced contraction o …

Clinical review 100: Evaluation and treatment of the infertile couple.

Infertility by itself does not threaten physical health but has a strong impact on the psychological and social well-being of couples. In th … fibrosis gene mutations should also be performed in azoospermia caused by congenital absence of the vas deferens and seminal vesicles. Appropriate genetic counseling should be made available to all ICSI couples whenever a gene or chromosomal anomaly has been identified. With most ARTs the average delivery rate per cycle is approximately 15% and the cumulative …

Представление результатов анализа диабетических осложнений с головы до ног: всеобъемлющий радиологический обзор.

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… Calcification of the Vas Deferens b CT, c CT (air window). CT demonstrates bilateral linear calcifications along the vas deferens, a characteristic and benign finding in patients with long-standing diabetes ( b – c ; arrow). … Vas deferens calcification (combined figure) (Fig.  15 ) Vas deferens calcification is an uncommon but characteristic imaging finding that is frequently observed in patients with long-standing DM [ 55 ]. …

Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model.

STUDY QUESTION: Can dexamethasone improve infertility-related cauda epididymidal tissue damage caused by bacterial epididymitis? SUMMARY AN … otecting effect of the combined treatment were not possible in the experimental animals because the vas deferens was ligated (model specific). WIDER IMPLICATIONS OF THE FINDINGS: Whereas innate immunity is necessary and involved in acute bacterial clearance, adaptive immunity seems to be responsible for long-term, subclinical immunological activities that may …

[Distribution pattern of the rectal circumferential fascia and its clinical significance: An anatomical study].

Objective: To investigate the pattern of distribution of the circumferential fascia of the rectum and elucidate its clinical implications. M … ttachment of Denonvilliers' fascia is at the angle between the seminal vesicles, the ampulla of the vas deferens, and the prostate. It adheres tightly to the prostatic capsule and vascular bundles pass through its cephalic side. (3) The pre-hypogastric fascia transitions laterally to merge with Denonvilliers' fascia; its middle part being inseparable from the …

[Mutations and polymorphisms in CFTR genes in infertile men with oligospermia or azoospermia].

INTRODUCTION: Impaired infertility of the male partner is causative or contributOry to in up to one half of all couples unable to conceive spontaneously. A considerable number of genes are now known that have an essential function in human reproduction and which, when deleted or mutated, can cause pathologic changes in the male reproductive system. Congenital bilateral absence of the vas deferens (CBAVD) is an important cause of obstructive azoospermia in otherwise healthy men. It is also present in 95% of men with an autosomal recessive systematic disease--cystic fibrosis. However, clinically…

Экспериментальные и клинические исследования фармакологических действий рода ахиллия: всеобъемлющий и обновленный обзор.

ЦЕЛЬ: Виды рода Ахиллеа (от семейства Compositae или Asteraceae) широко используются для их многочисленных фармакологических свойств. В настоящем документе рассматриваются фармакологические действия и их возможные основополагающие молекулярные механизмы, о которых сообщается в отношении различных видов ахиллы. МАТЕРИАЛЫ И МЕТОДЫ: использовались различные базы данных, включая PubMed, Science Direct и Scopus. Результаты: Для этих растений были продемонстрированы эффекты иммуноспрепрессии, против воспламенения и против окислителей. Кроме того, было продемонстрировано, что эти растения оказывают н

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… They also decreased the smooth muscle tone of the main pulmonary artery and trachea of the guinea pig, and the uterus and vas deferens of the rat (Abdalla et al., 1989; Rojas et al., 1996; Van Den Broucke and Lemli, 1983). … In different studies, the relaxation of guinea pig TSM and main pulmonary artery, and rat uterus and vas deferens was also observed for various plants (Abdalla et al., 1989; Rojas et al., 1996; Van Den Broucke and Lemli, 1983). …

New understanding of the damage of SARS-CoV-2 infection outside the respiratory system.

Since early December 2019, a number of pneumonia cases associated with unknown coronavirus infection were identified in Wuhan, China, and many additional cases were identified in other regions of China and in other countries within 3 months. Currently, more than 80,000 cases have been diagnosed in China, including more than 3000 deaths. The epidemic is spreading to the rest of the world, posing a grave challenge to prevention and control. On February 12, 2020, the International Committee on Taxonomy of Viruses and the World Health Organization officially named the novel coronavirus and associa

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… The results showed that ACE2 is highly expressed in renal tubular cells, mesenchymal cells, and testicular and vas deferens cells. Surprisingly, ACE2 mRNA and protein levels are higher in testis than in any other organ. …

Оценка и лечение мужской сексуальной дисфункции в болезни Паркинсона: клиническая дорожная карта.

Болезнь Паркинсона (PD) является прогрессивным нейродегенеративным заболеванием с множественными проявлениями, включая как моторные, так и немоторные симптомы. Одним из проявлений PD, который часто игнорируется, является сексуальная дисфункция (SD), которую могут испытывать пациенты. У лиц с ОВП могут быть дефекты сексуального желания, возбуждения или смазки, оргазма, эякуляции, боли и физических аспектов близости. Цель этой статьи состоит в том, чтобы дать общее представление о нынешней практике оценки и лечения сексуальной дисфункции у мужчин в контексте ПР. Следует отметить, что в этой стат

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… Sperm are transported from the testicles and into the pelvis through the vas deferens where they ultimately meet with the prostate and seminal vesicles at the level of the ejaculatory duct. …

Immunodeficiencies and CFTR dysfunction: results from a systematic screening in a cohort of adults with cystic fibrosis and CFTR-related disorders.

BackgroundImmunodeficiencies (IDs) are conditions caused by immune system dysfunctions which predispose to chronic infections. Cystic fibrosis (CF) patients are characterized by the presence of bronchiectasis filled with hyper-viscous secretions that constitute the ideal environment for infections. Although CF and IDs might share similarities in the pathophysiological mechanism of bronchiectasis development, they each offer different treatment options. We hypothesize that the introduction of a bundle of tests would increase the number of ID diagnoses among adults with Cystic Fibrosis Transmemb

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… The CFTR-RD cohort was characterized by the presence of bronchiectasis in 18 (85.7%) patients, recurrent pancreatitis in 2 (9.5%) patients, and congenital bilateral absence of the vas deferens in 1 (4.8%) patient. …

Significance of the sexual openings and supplementary structures on the phylogeny of brachyuran crabs (Crustacea, Decapoda, Brachyura), with new nomina for higher-ranked podotreme taxa.

The patterns of complexity of the male and female sexual openings in Brachyura, which have been the source of uncertainties and conflicting … racotreme). The heterotreme-thoracotreme distinction results from two different trajectories of the vas deferens and its ejaculatory duct via the P5 coxa (Heterotremata) or through the thoracic sternum (Thoracotremata). Dissections of males of several families have demonstrated that this major difference not only affects the external surface (perforation of th …