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Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… fluvoxamine”, “sertraline”, “desvenlafaxine”, “duloxetine”, “levomilnacipran”, “milnacipran”, “tofenacin”, “venlafaxine”, “vilazodone”, “vortioxetine”, “etoperidone”, “trazodone”, “nefazodone”, “reboxetine”, “viloxazine”, “amitriptyline”, “butriptyline”, “clomipramine”, “desipramine”, “dosulepin”, “imipramine …

Chronic Psychological Stress in Oncogenesis: Multisystem Crosstalk and Multimodal Interventions.

Malignant tumors constitute a major global public health burden. Chronic psychological stress (CPS) manifests as sustained dysregulation arising from prolonged adaptive responses to chronic endogenous and exogenous stimuli. Clinical evidence indicates that CPS markedly influences cancer progression, with most oncology patients developing detectable stress-related psychological disorders during disease management. This review synthesizes recent advances in understanding CPS-mediated oncogenic mechanisms and evaluates current intervention approaches. Mechanistically, CPS compromises immune surve

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… Tricyclic antidepressants also exhibit unique mechanisms: imipramine overcomes therapy resistance by dually blocking cell cycle progression and DNA repair pathways in breast cancer, enhancing PARP inhibitor efficacy in preclinical models [ 140 ]; amitriptyline regulates tryptophan metabolism by antagonizing … The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events. Cancer Lett. 2022;540: Article 215717. 141. Li J, Mei B, Feng L, Wang X, Wang D, Huang J, Zhang G. …

The erectile and ejaculatory implications of the surgical management of rectal cancer.

Colorectal cancer is a significant cause of cancer-related deaths worldwide. Although advances in surgical technology and technique have decreased mortality rates, surviving patients often experience sexual dysfunction as a common complication. The development of the lower anterior resection has greatly decreased the use of the radical abdominoperineal resection surgery, but even the less radical surgery can result in sexual dysfunction, including erectile and ejaculatory dysfunction. Improving the knowledge of the underlying causes of sexual dysfunction in this context and developing effectiv

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… Concentration: 1–2 h, Half‐life: 5–20 h | Nasal decongestion, anejaculation | Hypersensitivity, severe hypertension, tachycardia, arrhythmia, coronary artery disease, angina, hyperthyroidism, glaucoma, diabetes, pheochromocytoma, prostatic hypertrophy | Headache, dry mouth, shortness of breath, arrhythmia Imipramine …

Non-diabetic hypoglycemia: bridging gaps in diagnosis and treatment: a position statement report by the Arabic Association for the Study of Diabetes and Metabolism (AASD).

BACKGROUND: Non-diabetic hypoglycemia presents a substantial diagnostic challenge due to its diverse and often nonspecific symptomatology. The resultant delay in diagnosis can lead to a myriad of misdiagnoses. This misidentification not only prolongs patient suffering but also elevates the risk of severe complications, such as permanent neurologic damage and mortality. Recognizing the clinical nuances of non-diabetic hypoglycemia is paramount for timely and accurate diagnosis, which ultimately enhances patient outcomes and safety. MAIN BODY: A position statement has been formulated by the Ara

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… Table 1 Medications associated with non-diabetic hypoglycemia Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen) Indomethacin: analgesic Tricyclic antidepressants (TCAs): (e.g., doxepin, imipramine, nortriptyline) Antidepressant of selective serotonin re-uptake inhibitors (SSRIs …

The BE (2)-M17 neuroblastoma cell line: revealing its potential as a cellular model for Parkinson's disease.

Parkinson's disease is a pathology with a wide range of in vivo and in vitro models available. Among these, the SH-SY5Y neuroblastoma cell line is one of the most employed. This model expresses catecholaminergic markers and can differentiate and acquire various neuronal phenotypes. However, challenges persist, primarily concerning the variability of growth media, expression of dopaminergic markers, and a wide variety of differentiation protocols have been reported in the literature without direct comparison between them. This lack of standardized differentiation conditions impacts result repro

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… Tricyclic and tetracyclic antidepressants, such as amitriptyline, desipramine, imipramine, protriptyline among others, have shown significant upregulation of VMAT2 activity. …

Managing treatment-related peripheral neuropathy in patients with multiple myeloma.

Peripheral neuropathy is one of the most important complications of multiple myeloma treatment. Neurological damage can be observed at the onset of the disease, due to the effect of monoclonal protein or radicular compression, but more often is treatment related. Vinca alkaloids in the past era, and more recently, thalidomide and bortezomib are mainly responsible. Degeneration of dorsal root ganglion is common, prevalently related to angiogenesis inhibition and cytokine modulation in the case of thalidomide and inhibition of the ubiquitin proteasome system in the case of bortezomib. Sensory ne

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… The drugs to alleviate BiPN include gabapentin or pregabalin; tricyclic antidepressants such as amitriptyline, nortriptyline, and imipramine; serotonin and norepinephrine reuptake inhibitors; carbamazepine; and opioid-type analgesics. …

Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study.

Bortezomib is a pivotal drug for the management of multiple myeloma. However, bortezomib is a neurotoxic anticancer drug responsible for chemotherapy-induced peripheral neuropathy (CIPN). CIPN is associated with psychological distress and a decrease of health-related quality of life (HRQoL), but little is known regarding bortezomib-related CIPN. This single center, cross-sectional study assessed the prevalence and severity of sensory/motor CIPN, neuropathic pain and ongoing pain medications, anxiety, depression, and HRQoL, in multiple myeloma patients after the end of bortezomib treatment. Pap

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… | 0 (0) | 0 (0) | 1 (12.5) Gabapentin | 1 (2.9) | 0 (0) | 1 (8.3) | 0 (0) | 1 (12.5) Amitriptyline | 1 (2.9) | 0 (0) | 1 (8.3) | 1 (3.7) | 0 (0) Codeine | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) Duloxetine | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) Dihydrocodeine | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) Imipramine …

Autophagy in tumor immune escape and immunotherapy.

The immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment; however, the challenge of immune resistance remains significant. Autophagy, a cellular response to various stressors, involves the degradation of damaged proteins and organelles via lysosomal pathways, maintaining cellular homeostasis. This process not only supports tumor cell survival but also profoundly impacts the efficacy of cancer immunotherapies. The modulation of autophagy in tumor cells or immune cells exerts dual effects on tumor immune escape and immunotherapy. However,

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… and HMGB1 release | immune activation | 103 Oncolytic Adenovirus With Temozolomide | Autophagy induction | Prostate cancer | elevated calreticulin, ATP, and HMGB1 release | immune activation | 104 Brucine | Autophagy inhibition | CRC | enhance calreticulin and HMGB1 release | immune activation | 105 Imipramine … Imipramine promotes T-cell recruitment by activating autophagy, and VEGF inhibitors provide a more suitable environment for T-cell activation; therefore, the combination of both can efficiently activate immunity and inhibit the growth of glioblastoma [ 106 ]. …

Belantamab Mafodotin for the Treatment of Multiple Myeloma: An Overview of the Clinical Efficacy and Safety.

Despite the introduction of immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and, more recently, monoclonal antibodies (mAbs), in the chemotherapy regimens for newly diagnosed (NDMM) and relapsed/refractory MM (RRMM), the occurrence of drug resistance remains a challenge in MM patients. This is mainly in the advanced stage of the disease when treatments are limited, and the prognosis is abysmal. Nevertheless, novel molecules and therapeutic approaches are rapidly moving through the several phases of drug development and could address the need for new treatment options. The recent i

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… Lin et al 84 studied imipramine as a new potential drug against micropinocytosis in cellular and biological systems, and it could be a new approach to fight against ocular toxicity of Belamaf. …

[Alpha-interferon and mental disorders].

UNLABELLED: The interferon alpha stands as a reference both in oncology and virology. But its efficiency is limited by frequent somatic as well as neuropsychic side effects. As a matter of fact, the reduction or the ending of a chemotherapy treatment come chiefly from the psychiatric complications caused by the use of interferon. For about 30% of patients, various psychic disorders are noticed: personality disorders, mood disorders, anxiety states, suicidal tendencies, manic and psychotic symptoms. We thus propose a review which shall be completed by a discussion on wether the interferon is re

Естественные соединения серы в состоянии психического здоровья и неврологических расстройств: наблюдения и исследования.

За прошедшие годы глобальное бремя неврологических и психических расстройств значительно возросло, в результате чего они стали одной из наиболее серьезных проблем и вызовов для здоровья человека. В рамках новых методов лечения от болезней и болезней все больше внимания уделяется вопросам питания и здравоохранения. Питание серы, главным образом полученное из различных природных источников, играет решающую роль в многочисленных физиологических процессах, включая функцию мозга. В настоящем обзоре содержится обзор химического состава ряда естественных источников таких богатых серой веществ, как из

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… A recent study found that administering DADS at doses of either 40 or 80 mg/kg produced therapeutic effects comparable to those of imipramine, a prescription antidepressant at a dose of 10 mg/kg, in treating mice with depression-like behaviors induced by LPS ( 160 ). …

Животные модели периферической нейропатии, вызванной химиотерапией, для гематологических заболеваний: обзор.

Химиотерапия это one основные виды лечения гематологовых магнестов. Однако периферическая нейропатия, вызванная химиотерапией (CIPN) one Наиболее часто встречающиеся долгосрочные токсичные реакции в химиотерапии, а также случаи CIPN влияют на качество жизни пациентов и могут приводить к прерыванию химиотерапии в тяжелых случаях, снижая тем самым эффективность химиотерапии. В настоящее время мы резюмируем существующие зверские модели CIPN, включая характеристики нескольких общих животных моделей, таких, как периферическая нейропатия, вызванная бортезомибами, периферическая нейропатия, вызванная

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… Currently, for the management of neuropathic pain, multimodal analgesia is recommended, including opioids (morphine or codeine, etc.), antiepileptic drugs (gabapentin, pregabalin, etc.) and some antidepressants (amitriptyline, venfalacine, or imipramine, etc.) 4 , 5 , 108 , 109 Traditional Chinese medicine …

The potential of dibenzazepine carboxamides in cancer therapy.

Cancer is a leading cause of mortality worldwide, with most conventional treatments lacking efficacy and having significant challenges like drug resistance. Finding new molecules is quite challenging in terms of cost, time and setbacks. Hence, drug repurposing is considered sensible for skipping the long process of drug development. Dibenzazepine carboxamides, as traditional anticonvulsants, primarily function by blocking voltage-gated sodium channels, which not only mitigate seizures but also influence mood disorders through modulation of serotonin and dopamine. Recent studies have uncovered

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… Its structure is quite similar to tricyclic antidepressants such as imipramine ( Al-Waili, 2000 ). CBZ was initially FDA-approved for trigeminal neuralgia in 1968 ( Blom, 1962 ). …

Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing.

Cancer persists as a global challenge necessitating continual innovation in treatment strategies. Despite significant advancements in comprehending the disease, cancer remains a leading cause of mortality worldwide, exerting substantial economic burdens on healthcare systems and societies. The emergence of drug resistance further complicates therapeutic efficacy, underscoring the urgent need for alternative approaches. Drug repurposing, characterized by the utilization of existing drugs for novel clinical applications, emerges as a promising avenue for addressing these challenges. Repurposed d

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… For instance, cimetidine, an anti-peptic ulcer drug, has shown promise for lung adenocarcinoma, while anti-psychotic imipramine has exhibited potential for glioblastoma [ 9 ]. …

Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder.

SYNOPSIS: Paroxetine is the first selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) to be approved for the treatment … compare the efficacy and tolerability of paroxetine with that of other tricyclic agents (especially Imipramine), high-potency benzodiazepines and monoamine oxidase inhibitors are needed, the drug appears to have the potential to become a first-line treatment for panic disorder. PHARMACODYNAMIC PROPERTIES: Paroxetine increases serotonergic neurotransmission …

Belantamab Mafodotin: From Clinical Trials Data to Real-Life Experiences.

Despite the recent approval of novel immunotherapies, such as immunomodulatory drugs, proteasome inhibitors and anti-CD38 monoclonal antibodies, Multiple Myeloma (MM) remains incurable, and the acquisition of triple-refractoriness leads to really dismal outcomes in even earlier lines of therapy. More recently, innovative therapeutic strategies targeting B cell maturation antigen (BCMA), highly expressed on the plasma cell surface, are drawing different future landscapes in terms of effectiveness and outcomes. Belantamab Mafodotin, a first-in-class anti-BCMA antibody-drug conjugate, demonstrate

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… Lin et al. [ 42 ] analyzed imipramine as a new potential drug against macropinocytosis in cellular and biological systems, so theoretically, the inhibition of belamaf macropinocytosis might reduce the occurrence of ocular toxicity, but the practical role of such inhibition is limited [ 44 ]. …

Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features.

The indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we conducted a review on the antitumor mechanisms of aminoquinolines, focusing on the responses and differences of tumor histological tissues and toxicity related to pharmacokinetics. This well-defined analysis shows similar mechanistic forms triggered by aminoquinolines in different histological tumor tissues and under coexposure conditions, although different pharmacological potencies also occur. These molecules are lysosomotropic amines th

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… Higher lysosomal pH was observed after 4 h of treatment with known alkalinizer drugs (fluoxetine, imipramine, dimebon, tamoxifen, chlorpromazine, amitriptyline, and verapamil), including chloroquine. …

Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents.

Neurodegenerative diseases (NDDs) represent a class of incurable and progressive disorders characterized by the gradual degeneration of the structure and function of the nervous system, particularly the brain and spinal cord. A range of innovative therapeutic approaches is currently under investigation, such as stem cell-based therapies, gene-editing platforms such as CRISPR, and immunotherapies directed at pathogenic proteins. Moreover, phytochemicals such as β-caryophyllene and xanthohumol have demonstrated significant neuroprotective potential in preclinical models. These natural agents exe

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… . | OLN-93 oligodendrocyte cells treated with LPS; BCP tested at low (0.2–1 μM) and high (10–50 μM) concentrations; effects on ROS, NO, TNF-α, GSH, and signaling pathways were measured; SMase inhibitors (imipramine, fluoxetine) tested for synergy. | The protective effects of BCP are mediated through …

Peripheral Neuropathy under Oncologic Therapies: A Literature Review on Pathogenetic Mechanisms.

Peripheral neurologic complications are frequent adverse events during oncologic treatments and often lead to dose reduction, administration delays with time elongation of the therapeutic plan and, not least, worsening of patients' quality of life. Experience skills are required to recognize symptoms and clinical evidences and the collaboration between different health professionals, in particular oncologists and hospital pharmacists, grants a correct management of this undesirable occurrence. Some classes of drugs (platinates, vinca alkaloids, taxanes) typically develop this kind of side effe

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… In the case of paraesthesia and pain, the patient should be treated with carbamazepine, imipramine or lignocaine [ 186 ]. 4.7. …

Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment.

Fibromyalgia syndrome is mainly characterized by pain, fatigue, and sleep disruption. The etiology of fibromyalgia is still unclear: if central sensitization is considered to be the main mechanism involved, then many other factors, genetic, immunological, and hormonal, may play an important role. The diagnosis is typically clinical (there are no laboratory abnormalities) and the physician must concentrate on pain and on its features. Additional symptoms (e.g., Raynaud's phenomenon, irritable bowel disease, and heat and cold intolerance) can be associated with this condition. A careful differen

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… 559 2-s2.0-0030959929 9058665 29 Yunus MB Dailey JW Aldag JC Masi AT Jobe PC Plasma tryptophan and other amino acids in primary fibromyalgia: a controlled study Journal of Rheumatology 1992 19 1 90 94 2-s2.0-0026503839 1556707 30 Hrycaj P Stratz T Muller W Russell IJ Vipraio GA Lopez Y Platelet 3H-imipramine …