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Physical Activity Patterns and Associated Factors Among First-Year Female University Students in Saudi Arabia: A Cross-Sectional Study​.

The World Health Organization (WHO) recommends at least 150 min of moderate-intensity or 75 min of vigorous-intensity physical activity (PA) per week for adults. In Saudi Arabia, over 70% of young adults are physically inactive. This study aimed to describe PA patterns among first-year Saudi female university students and determine factors that are associated with weekly participation in vigorous PA using convenience sampling. Participants completed an anonymous online survey after providing their informed consent. The survey comprised: i) demographic information, ii) PA level assessment using

Long-Term Effect of Intensive Education in Patients With First-Ever Ischemic Stroke.

BACKGROUND: This study evaluated the long-term effects of intensive education on functional recovery and quality of life in patients with first-ever mild ischemic stroke. METHODS: This propensity score-matched cohort study was conducted within the KOSCO (Korean Stroke Cohort for Functioning and Rehabilitation). Four of 9 institutions participated in the educational intervention substudy, recruiting patients between November 2016 and January 2020. Eligible participants were adults aged 19 to 74 years hospitalized within 7 days of a first-ever ischemic stroke, with mild neurological deficits (K

Effects of ketogenic diet therapy in outpatient anti epileptic drug cost reduction and parental satisfaction among children with intractable epilepsy.

INTRODUCTION: Epilepsy is a global neurological disorder that contributes to a significant disease burden in children and adolescents. About 11 million children worldwide suffer from epilepsy. Most children with epilepsy respond to anti-epileptic drugs and have controlled symptoms. However, drug-resistant epilepsy (DRE) happens in some children which presents a lot of challenges to their quality of life and development. Alternative treatment for DRE is ketogenic diet therapy (KDT) which is also given alongside the regiment. METHODS: This study aims to compare the prescribed anti-epileptic dru

The moderating effect of child abuse on the association between domestic violence and suicidal ideation/self-harm among Lebanese women.

Violence and abuse against women and children remain prominent issues in Lebanon, resulting in dire psychological consequences. The aims of the current study are to evaluate the moderating role of child abuse in the relationship between (1) domestic violence and suicidal ideation, and (2) domestic violence and self-harm. This cross-sectional study was conducted between January and May 2023. Women between the ages of 18 and 50 were recruited to participate using a snowball sampling technique. 915 women consented to take an online questionnaire that collected information about sociodemographic c

Influence of ginger root extract supplementation on the microbiota-gut-brain axis in individuals with sciatica: Study protocol for a double-blind, placebo-controlled randomized trial.

Neuropathic pain (NP) is caused by damage to the peripheral or central nervous system and is associated with adverse complex sensory and affective symptoms. There are few current treatment options for NP, and opioid analgesics have severe side effects which can lead to opioid abuse. Therefore, the development of innovative, effective, and safe alternatives is urgently needed. This study will assess the effects of ginger root extract's anti-inflammatory and anti-oxidant properties on individuals with sciatica via the microbiome-gut-brain axis. Eighty participants (18-85 years) with chronic scia

Изучение психологического воздействия и опыта в области здравоохранения пациентов, живущих с рефрактом тройного класса, множественным миеломой: исследование интерпретирующих феноменологических исследований.

Множественная миелома (ММ) — хроническая гематологическая порча, вызванная распространением злокачественных плазменных клеток в костном мозге и перепроизводством моноклонных антител. Несмотря на отсутствие лекарств, лечение направлено на борьбу с этим заболеванием и на ремиссию пациентов. Эти исследования были направлены на изучение психологических последствий и опыта в области здравоохранения пациентов, страдающих от трехклассной рефрактуальной (TCR) MM. Это исследование стало частью более широкого качественного исследования, в ходе которого был изучен опыт вновь диагностированных пациентов,

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… Interested individuals emailed the recruiters, Just Worldwide, who shared the participant information sheet, consent forms and organised a call to assess eligibility according to the inclusion criteria. … forms were reviewed and revised through engagement with Myeloma UK’s Patient and Carer Research Panel, consisting of volunteer patients and carers who provide opinions on research. …

Assessing Sleep Quality and Influencing Factors Among Medical Undergraduates: A Cross-Sectional Study.

BACKGROUND: Sleep is a biological process that is essential for life. Sleep quality refers to an individual's overall satisfaction with their sleep experience, encompassing factors such as ease of falling asleep, ability to stay asleep, total sleep duration, and the sense of refreshment upon waking. Undergraduate medical students frequently struggle with good-quality sleep. Poor sleep quality negatively impacts academic performance, behavioural issues, emotional issues, bad emotional status, and also increases the risk of alcohol, smoking habits and psychiatric disorders. OBJECTIVE: This stud

Feasibility study protocol: implementing consultation-based high-quality palliative care services in intensive care units.

INTRODUCTION: Critically ill patients in intensive care units (ICUs) receive life-sustaining treatments aimed at restoring or maintaining organ function. ICU admission often involves substantial multidimensional suffering that can burden patients, their families and surrogates. Multidisciplinary palliative care support can help alleviate their sufferings. In South Korea, however, palliative care has not yet been integrated into critical care settings, highlighting the need to explore the feasibility of its implementation within the ICU. METHODS AND ANALYSIS: This study aims to test the feasib

Oropharyngeal dysphagia management and informed consent: a survey of speech-language pathologists' practice patterns when recommending modified texture diets.

PURPOSE: The modification of diet textures and liquid viscosity represents the primary form of management of oropharyngeal dysphagia (OD) by speech-language pathologists (SLPs). Despite the ubiquitous use of modified texture diets (MTDs) to prevent aspiration in an attempt to prevent pneumonia, there is no convincing evidence that consumption of MTDs protects individuals with dysphagia from developing pneumonia. Furthermore, informed consent is required for the prescription of MTDs. To date, no study has investigated if practicing SLPs know the risks associated with MTDs, consider the risks wh

Enteric-coated Mycophenolate Sodium plus hydroxychloroquine therApy versus hydroxychloroquine for the Remission of Proteinuria in IgA Nephropathy (EMSAR-IgAN trial): study protocol for a randomised trial.

INTRODUCTION: The management of immunoglobulin A (IgA) nephropathy remains a topic of debate. Hydroxychloroquine and mycophenolate mofetil (MMF) are two immunosuppressive agents that have recently garnered increased attention among patients with IgA nephropathy in China. Several studies have shown the comparable efficacy between MMF and enteric-coated mycophenolate sodium (EC-MPS), with lower adverse event rates for EC-MPS. The present study aims to evaluate the efficacy and safety of EC-MPS combined with hydroxychloroquine as an immunosuppressive regimen for patients with high-risk progressiv

The CHILL BONES (combining high-intensity impact loading and lifting with mind-body exercise for optimisation of nervous system and skeletal health) trial: protocol for a parallel-group, semi-randomised controlled trial.

INTRODUCTION: Animal studies suggest that elevated sympathetic nervous system (SNS) activity can accelerate bone loss. However, this area has not been well researched in humans. High-intensity Resistance and Impact Training (HiRIT) is recognised as an effective treatment for osteoporosis and osteopenia. Alternate forms of exercise such as mind-body exercise may be used to modulate sympathetic activity, which could have an additive benefit for skeletal adaptation when used in conjunction with HiRIT. The aim of this study is to investigate whether the combination of mind-body exercise (Tai Chi)

Prevalence of Helicobacter pylori and intestinal parasitic coinfections among patients with gastrointestinal complaints in a Rwandan Teaching Hospital.

BACKGROUND: Intestinal parasitic infections and Helicobacter pylori (H. pylori) constitute a global health challenge especially in low-income countries. In Rwanda, documentation about their co-infection is scarce. The aim of the present study was to determine the prevalence of co-infection with intestinal parasites and H. pylori and their association with gastrointestinal symptoms among patients attending the University Teaching Hospital of Butare (CHUB) in Rwanda. METHODS AND MATERIAL: A cross-sectional study was carried out on a total number of 356 patients after signing the consent form. A

Обследование методов диагностики и лечения множественных склерозов в Турции.

ВВЕДЕНИЕ: Множественный склероз (МС) представляет собой динамическое терапевтическое поле, в котором с течением времени меняются процессы диагностики и лечения. В последние годы происходят изменения в области индивидуального диагностики и лечения. Цель этого исследования заключается в том, чтобы понять методы управления, используемые неврологами, работающими в области диагностики, последующей деятельности и лечения множественных склерозов в Турции. МАТЕРИАЛЫ И МЕТОДЫ: Был подготовлен вопросник, в котором участники могли бы участвовать в онлайновом режиме. Были заданы многочисленные вопросы о д

Навигация потерь и рост хронических заболеваний: исследование по вопросу о физической активности и благополучии.

В этом исследовании изучается живой опыт пациентов с хроническими заболеваниями, с тем чтобы понять, каким образом значения, приписываемые хроническим заболеваниям, физической активности и благополучию, переплетаются. Это понимание имеет решающее значение для практики ухода, направленной на поддержку и повышение благосостояния. МЕТОДОЛОГИЧЕСКАЯ ДЕСИГН: Мы провели качественное исследование, основанное на герменевическо-феноменологии, с тем чтобы отразить жизненный опыт участников в описательной форме. В качестве руководящего принципа отчетности используется COREQ. ЭТИЧЕСКИЕ ВОПРОСЫ И УТВЕРЖДЕНИ

Correlating dermatoscopic features with immunohistochemical markers in basal cell carcinoma: a comprehensive analysis of 100 cases in Caucasian population.

BACKGROUND: Basal Cell Carcinoma (BCC) is the most common form of skin cancer, characterized by its low metastatic potential yet considerable diversity in clinical and dermatoscopic presentation. Advances in dermatoscopy have significantly improved the early detection of BCC, revealing specific patterns that guide diagnosis and management. Parallelly, immunohistochemical markers have been explored for their potential to elucidate the underlying tumor biology and prognosis, with particular focus on angiogenesis, melanocytic activity, and lymphangiogenesis. OBJECTIVE: This study aims to investi

Thoracentesis to alleviate pleural effusion in acute heart failure: study protocol for the multicentre, open-label, randomised controlled TAP-IT trial.

INTRODUCTION: Pleural effusion is present in half of the patients hospitalised with acute heart failure. The condition is treated with diuretics and/or therapeutic thoracentesis for larger effusions. No evidence from randomised trials or guidelines supports thoracentesis to alleviate pleural effusion due to acute heart failure. The Thoracentesis to Alleviate cardiac Pleural effusion Interventional Trial (TAP-IT) will investigate if a strategy of referring patients with acute heart failure and pleural effusion to up-front thoracentesis by pleural pigtail catheter insertion in addition to pharma

Digital thErapy For Improved tiNnitus carE Study (DEFINE): Protocol for a randomised controlled trial.

Tinnitus is a common health condition, affecting approximately 15% of the UK population. The tinnitus treatment with the strongest evidence base is Cognitive Behavioural Therapy (CBT), with standard tinnitus therapy typically augmented with education, relaxation and other techniques. Availability of CBT and conventional tinnitus therapy more broadly is limited for tinnitus sufferers. The DEFINE trial aims to assess whether smartphone-delivered tinnitus therapy, the Oto app, is as effective as current standard care, one-to-one therapist-delivered tinnitus treatment for the treatment of tinnitus

Health-Related Quality of Life and its Determinants among School-going Adolescents: A Cross-sectional Study.

BACKGROUND: Adolescents experience rapid physical, cognitive, and psychosocial growth in their transition from childhood to adulthood, affecting health outcomes and well-being. Health-related quality of life (HRQoL) is a useful indicator of health outcomes, assessed in the current study along with associated determinants. METHODS: A cross-sectional study was conducted among 634 randomly selected adolescents from 13 randomly selected schools in Gharwal division, Uttarakhand, India, from August 2019 to September 2020. The students studying in the 8th-11th standard and those providing assent and

Kinesophobia and its related factors in patients after percutaneous coronary intervention: A cross-sectional study.

OBJECTIVES: To explore the postoperative kinesophobia of patients after percutaneous coronary intervention (PCI) and its related factors. BACKGROUND: Percutaneous coronary intervention is an effective method to treat coronary heart disease (CHD), and cardiac rehabilitation is an important auxiliary method after PCI. However, the compliance of patients with cardiac rehabilitation after PCI is not good, among which kinesophobia is an important influencing factor. DESIGN: A descriptive cross-sectional design was implemented, and the high-quality reporting of the study adhered to the Strengtheni

Barriers to Recruitment and Retention Among Underrepresented Populations in Cancer Clinical Trials: A Qualitative Study of the Perspectives of Clinical Trial Research Coordinating Staff at a Cancer Center.

BackgroundAlthough US research agencies have instituted peer review processes to require participant diversity in clinical trials before funding decisions are made, the underrepresentation of certain populations (eg, racial and ethnic minorities) in clinical trials remains a persistent challenge in biomedical research. This issue has the potential to affect the generalizability of findings and impede efforts to ensure the provision of high-quality healthcare across all populations. In this study, we examined barriers to the recruitment and retention of underrepresented populations in cancer cl

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… Data were also obtained on whether the trials offered informed consent forms in languages other than English and offered any incentives or reimbursements for patients. … The OnCore system also included information on availability of informed consent forms in languages other than English, as well as the availability of incentives and reimbursements for participants. …