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[Effect of opioid peptides on immunomodulation].

Activation of the opioid receptors by delta-agonist DSLET and by kappa-agonist rimorphin led to a significant inhibition of plaque-forming and rosette-forming cells in the CBA mice. On the other hand, mu-agonist DAGO stimulated the immune response on the 4th and 5th days after immunization with SRBC (5 x 10(8)). Lesion of the hypothalamo-hypophyseal connection prevented immuno-stimulating as well as immuno-depressive effects. The latter seems to be due to an interaction with the serotoninergic system, whereas immuno-stimulating effect involves the dopaminergic system.

[Protective effect of Liujing Toutong Tablets on rats with permanent cerebral ischemia via NF-κB signaling pathway].

This study investigated the neuroprotective effects and underlying mechanism of Liujing Toutong Tablets(LJTT) on a rat model of permanent middle cerebral artery occlusion(pMCAO). The pMCAO model was established using the suture method. Eighty-four male SPF-grade SD rats were randomly divided into a sham operation group, a model group, a nimodipine group(0.020 g·kg~(-1)), and high-, medium-, and low-dose LJTT groups(2.8, 1.4, and 0.7 g·kg~(-1)). The Longa score, adhesive removal test and laser speckle contrast imaging technique were used to evaluate the degree of neurological functional impairm

The Effect of Laughter Yoga on Chemotherapy-Induced Symptoms and Sleep Quality in Patients with Haematologic Cancer.

There are international studies that examine the effects of laughter yoga on the symptoms and quality of life of cancer patients as a complementary therapeutic method.AimThis study aims to examine the effect of laughter yoga on chemotherapy-induced symptoms and sleep quality in patients with haematologic cancer.Materials and methodsThis study was conducted as a randomised controlled trial with two parallel treatment arms. The study was between November 2020 and December 2021. The sample was calculated with 60 patients including in the study. A total of 4 sessions of laughter yoga were applied

Acupuncture as a Complementary Method of Traditional Psoriasis Treatment: Myth or Reality?

Dear Editor, the practitioners of traditional Chinese medicine described psoriasis some 2000 years ago (1). Psoriasis vulgaris is a common, … re, hair-thin needles are inserted into the skin, releasing natural pain killers such as adenosine, endorphins, and serotonin into the body. It is known that patients with psoriatic arthritis can benefit from the treatment. Some patients may be concerned that acupuncture needles could worsen a skin flare-up but an acupuncturist uses sterile needles to preven …

Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.

The opioid receptors involved in the mediation of gastric acid secretory effects were studied in the pylorus-ligated rat. The effects of i.c.v. and i.v. administration of morphine and mu ([D-Ala2, NMePhe4, Gly5-ol]enkephalin and Tyr-Pro-NMePheD-Pro-NH2)-, delta ([D-Pen2,D-Pen5]enkephalin)- and kappa-selective [trans-3,4-dichloro-N-methyl-N-[2-91-pyrrolidinyl)-cyclohexyl]- benzeneacetamide methanesulfonate (U-50,488H), dynorphin-(1-9), dynorphin-(1-17), nalorphine, alpha-neoendorphin and ethyl-ketocyclazocine) opioid receptor agonists on gastric volume and acid output were examined. Morphine, [

Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.

We studied adaptations to acute precipitated opioid withdrawal of spinal μ-opioid receptor (MOR)-coupled regulation of the release of endomorphin 2 (EM2). The release of this highly MOR-selective endogenous opioid from opioid-naive spinal tissue of male rats is subjected to MOR-coupled positive as well as negative modulation via cholera toxin-sensitive G(s) and pertussis toxin-sensitive G(i)/G(o), respectively. The net effect of this concomitant bidirectional modulation is inhibitory. MOR-coupled pleiotropic regulation of EM2 release is retained in opioid-withdrawn spinal tissue of male rats,

mu-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurons.

Whole-cell patch-clamp recordings were used to characterize calcium channel types that are modulated by mu-opioid receptor activation in rat dorsal root ganglion (DRG) neurons. Five distinct components of high-threshold calcium current were isolated on the basis of their sensitivity to the selective channel blockers omega-conotoxin GVIA, nifedipine, omega-conotoxin MVIIC, or omega-agatoxin IVA. The mu-opioid selective agonist Tyr-Pro-NMePhe-D-Pro-NH2 (PLO17) routinely suppressed high-threshold currents and this effect was always reduced by omega-conotoxin GVIA. A fraction of PLO17-sensitive cu

Human fetal adrenal transplant: a possible role in relieving intractable pain in advanced rheumatoid arthritis.

BACKGROUND: The art of transplant surgery has gone a long way in establishing itself as an important discipline in medicine with the support of molecular biology, immunology, biochemistry, etc., as the ultimate treatment for the restoration of function of a failing organ. With the progressive increase in the life expectancy of human beings, there is an increasing discrepancy in the demand and supply of organ grafts. A less efficient alternative could be synthetic or mechanical grafts. Nucleated cell therapy, that is, cellular transplant, is a promising new area of study with its proven efficac

Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study.

BackgroundThis single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.MethodsPatients with neuropathy ≥ grade 2 received 20 acupuncture treatments over 9 weeks.ResultsFor the 19 evaluable patients, Functional Assessment of Cancer Therapy/Gynecological Oncology Group-Neurotoxicity (FACT/GOG/NTX) mean (SD) scores improved significantly between baseline and week 13 (20.8 [9.6] vs 13.2 [8.5], p = 0.0002). Moderate effect size differences began on week 4, with t

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… For example, a frequency of 2 Hz induces the gene expression of endorphins in the diencephalons, 2–15 Hz causes the release of endorphins and enkephalin in the brain and dynorphin in the spinal cord, and a frequency of 100 Hz causes the release of dynorphin in the spinal cord alone [ 30 ]. … Acupuncture and endorphins. Neurosci Lett. 2004;361(1–3):258–261. doi: 10.1016/j.neulet.2003.12.019. Mittleman E, Gaynor JS. A brief overview of the analgesic and immunologic effects of acupuncture in domestic animals. J Am Vet Med Assoc. 2000;217(8):1201–1205. doi: 10.2460/javma.2000.217.1201. …

The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy.

As the number of cancer patients and survivors increases, we face a rising challenge: the long-term impact of the adverse effects of cancer treatment. One of the known adverse effects is chemotherapy-induced peripheral neuropathy (CIPN), which courses with pain complaints. The treatments of CIPN have reduced efficacy. The neurobiological causes of CIPN have been mainly ascribed to peripheral nerve damage, but recent studies show effects in the brain, namely in the descending pain modulatory systems. Physical exercise seems to be associated with better outcomes in CIPN patients, but the mechani

Acupuncture for cancer-induced bone pain?

Bone pain is the most common type of pain in cancer. Bony metastases are common in advanced cancers, particularly in multiple myeloma, breast, prostate or lung cancer. Current pain-relieving strategies include the use of opioid-based analgesia, bisphosphonates and radiotherapy. Although patients experience some pain relief, these interventions may produce unacceptable side-effects which inevitably affect the quality of life. Acupuncture may represent a potentially valuable adjunct to existing strategies for pain relief and it is known to be relatively free of harmful side-effects. Although acu

The delta-opioid receptor participates in T-cell development by promoting negative selection.

The delta-opioid receptor-1 (DOR-1) as well as delta-opioid enkephalin peptides are expressed during maturation of T cells, although the functional significance of their expression remains unclear. Based on results which show that the administration of the highly selective delta-opioid agonist D-Pen2, D-Pen5]enkephalin (DPDPE) induces an altered pattern of T-cell differentiation in fetal thymic organ culture (FTOC), we hypothesized that DOR-1 is involved in the negative selection process. Our results show that superantigen-induced clonal deletion is promoted by DPDPE and significantly impaired

Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells.

The cardiac differentiation of embryonic stem (ES) cells was found to involve prodynorphin gene and dynorphin B expression and was associated with the interaction of secreted dynorphin B with cell surface opioid receptors coupled with protein kinase C (PKC) signaling and complex subcellular redistribution patterning of selected PKC isozymes. Here, confocal microscopy revealed the presence of immunoreactive dynorphin B-like material in GTR1 ES cells, suggesting that dynorphin peptides may also act intracellularly. Opioid binding sites were identified in ES cell nuclei, with a single dissociatio

Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update.

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were influenced for each individual solute or group of solutes, with some impacting up to 7 different biolo

Acupuncture treatment for bortezomib-induced peripheral neuropathy: a case report.

Peripheral neuropathy is a common and severe dose-limiting side effect of the chemotherapy agent, bortezomib, in multiple myeloma patients. Treatment with narcotics, antidepressants, and anticonvulsants has limited response and potential significant side effects. Acupuncture has been reported to be effective in treating diabetic neuropathy and chemo-induced peripheral neuropathy. There has not been report on the effect of acupuncture in treating bortezomib-induced peripheral neuropathy specifically. Here, we report a successful case of using acupuncture to relieve bortezomib-induced peripheral

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… Animal research suggests that acupuncture accomplishes its anesthesia effect by stimulating nerves in the muscle, which then relay the signal to the spinal cord, midbrain, and hypothalamus-pituitary system, which then lead to the release of neurotransmitters and hormones, that is, endorphins and enkephalins … It is perceivable that acupuncture reduces BIPN symptoms by suppressing activities of glial cell and stimulating neurohormonal pathways, which increases endorphins release and reduces proinflammatory cytokines. …

Prognostic value of CA15-3, CA125, CEA in breast cancer patients undergoing chemotherapy.

BackgroundTo explore the prognostic value of cancer antigen 15-3 (CA15-3), Carbohydrate antigen 125 (CA125), and carcino-embryonic antigen (CEA) in breast cancer patients undergoing chemotherapy.MethodsThe data of 100 patients with breast cancer who received chemotherapy in a hospital from May 2022 to May 2024 were selected. Patients were divided into control and test groups based on different intervention methods and hospital stays. The control group receives routine nursing interventions. The test group implements exercise intervention under planned behaviour planning, with 50 cases in each

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… Moderate and regular exercise can stimulate the brain to release neurotransmitters such as dopamine [27] , endorphins [28] , and serotonin [29] . The secretion of these substances can improve the patient’s mood and alleviate anxiety and depression. … Prior studies suggest that moderate, regular exercise stimulates the release of neurotransmitters like dopamine, endorphins, and serotonin, which help improve mood, reduce anxiety, and combat fatigue. …

β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties.

Natural bicyclic sesquiterpenes, β-caryophyllene (BCP) and β-caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of numerous cancer cells. Nevertheless, their antineoplastic effects have hardly been investigated in vivo. In addition, both compounds potentiate the classical drug efficacy by augmenting their concentrations inside the cells. The mechanisms underlying the anticancer activities of these sesquiterpenes are poorly described. BCP is a phytocannabinoid wit

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… The literature data indicate that CB 2 ‐selective agonists stimulate peripheral release of endogenous opioids such as β ‐endorphins, which activates μ ‐opioid receptors on primary afferent neurons 65 . … Another possible mechanism of BCP pain modulation may be related to peripheral CB 2 simulation and β ‐endorphin release from keratinocytes, which was noted after local and intraplantar injections of BCP in response to capsaicin‐induced nociception. …

Нейрофизиологические, радиологические и молекулярные биомаркеры условий, связанных с болью: обзор " Umbrella " .

Справочная информация/цели: Боль и условия, связанные с болью, считаются глобальным медико-санитарным и финансовым бременем. В целях совершенствования методов обезболивания, оценки болеутоляющей силы и диагностики боли были предложены различные биомаркеры. Поскольку их клиническая полезность еще не доказана, цель этого зонтичного обзора заключается в обобщении имеющихся данных о всех видах обезболивающих биомаркеров. Методы: Систематические обыски проводились в Пуббмеде, Скопусе и Кокрейнской библиотеке с момента их создания 2 Июнь 2025. Приемлемыми исследованиями были систематические обзоры и

The role of complementary and alternative methods in the treatment of pain in patients with cancer - current evidence and clinical practice: a narrative review.

IntroductionPain related to cancer, despite the numerous treatment options available, is still a challenge in contemporary pain medicine. The unsatisfactory treatment of cancer pain is one of the main reasons why patients seek complementary and alternative methods (CAM) and a more integrative/holistic approach to pain management. The popularity of CAM forces healthcare professionals to provide patients with current and evidence-based information on the effectiveness and safety of CAM. The aim of the paper is to present current evidence and limitations regarding CAM commonly used in the pain ma

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… several centres in the central nervous system (CNS) (among others periaqueductal grey matter, locus coeruleus, nuclei raphe magnus, rostral ventromedial medulla), resulting in activation of pain inhibition mechanisms and subsequent release of endogenous antinociceptive neurotransmitters, including endorphins … Naloxone blockade of acupuncture analgesia: endorphin implicated. Life Sci 1976; 11: 1757-1762. 18. Han JS. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci 2003;1: 17-22. 19. Silberstein M. Is acupuncture “stimulation” a misnomer? …