Результаты поиска

Neurobiology of Cancer: Introduction of New Drugs in the Treatment and Prevention of Cancer.

Research on the neurobiology of cancer, which lies at the border of neuroscience and oncology, has elucidated the mechanisms and pathways that enable the nervous system to modulate processes associated with cancer initiation and progression. This research has also shown that several drugs which modulate interactions between the nervous system and the tumor micro- and macroenvironments significantly reduced the progression of cancer in animal models. Encouraging results were also provided by prospective clinical trials investigating the effect of drugs that reduce adrenergic signaling on the co

Совпадение в полном тексте источника
… Chemical sympathectomy suppresses fibrosarcoma development and improves survival of tumor-bearing rats Neoplasma 2011 58 424 429 10.4149/neo_2011_05_424 21744996 28. Lucido C.T. Callejas-Valera J.L. Colbert P.L. Vermeer D.W. Miskimins W.K. Spanos W.C. …

The Reversal of Immune Exclusion Mediated by Tadalafil and an Anti-tumor Vaccine Also Induces PDL1 Upregulation in Recurrent Head and Neck Squamous Cell Carcinoma: Interim Analysis of a Phase I Clinical Trial.

Myeloid Derived suppressor cells (MDSCs) play a key role in the progression and recurrence of human malignancies and in restraining the efficacy of adjuvant therapies. We have previously shown that Tadalafil lowers MDSCs and regulatory T cells (Treg) in the blood and in the tumor, primes a tumor specific immune response, and increases the number of activated intratumoral CD8+T cells in patients with primary Head and Neck Squamous Cell Carcinoma (HNSCC). However, despite these important immune modulatory actions, to date no clinically significant effects have been reported following PDE5 inhibi

Совпадение в полном тексте источника
… In our original preclinical works, we showed that the PDE5 inhibitor sildenafil effectively inhibits MDSCs by increasing cGMP and reducing their expression of arginase 1, Nitric oxide synthase 2, and IL4Rα in mouse models of mammary carcinoma, colon cancer, and fibrosarcoma ( 26 ). …

The role of interleukin 17 in tumour proliferation, angiogenesis, and metastasis.

With 7.6 million deaths globally, cancer according to the World Health Organisation is still one of the leading causes of death worldwide. Interleukin 17 (IL-17) is a cytokine produced by Th17 cells, a T helper cell subset developed from an activated CD4+ T-cell. Whilst the importance of IL-17 in human autoimmune disease, inflammation, and pathogen defence reactions has already been established, its potential role in cancer progression still needs to be updated. Interestingly studies have demonstrated that IL-17 plays an intricate role in the pathophysiology of cancer, from tumorigenesis, prol

Совпадение в полном тексте источника
… Animal models echoed these findings; for example, increased expression of IL-17 in mice transfected with fibrosarcoma cells was associated with tumours exhibiting higher MVD through upregulation of VEGF, keratinocyte-derived chemokine (KC or CXCL1 and CXCL 2), macrophage inflammatory protein-2 (MIP-2 …

From post-war reconstruction to the twenty-first century - ophthalmic pathology in Freiburg 1945-2015. Part 2: review of 43,169 histological diagnoses from 39,256 specimens collected over 71 years at a large German tertiary eye care centre.

BACKGROUND: Ophthalmic pathology is essential for diagnosing ocular diseases, correlating clinical and histopathological findings, and advancing research. The Eye Center at the University of Freiburg, Germany, has archived histopathological specimens since 1945, offering a unique resource to analyse long-term diagnostic trends. This study examines 43,169 diagnoses from 39,256 specimens over 71 years (1945–2015), providing insights into the evolution of ophthalmic pathology at a major tertiary care centre. METHODS: We performed a retrospective analysis of all archived ophthalmic pathology repor

Совпадение в полном тексте источника
… 22%) | Iris nevus | 3 (7.5%) | Ciliary body melanoma | 2 (9.5%) | Iris melanoma | 10 (17%) | Normal iris | 7 (17%) | Iris nevus | 3 (17%) | Iritis | 2 (17%) | Iris cyst | 4 (15%) | Normal choroid | 3 (7.5%) | Iris melanoma | 2 (9.5%) | Ciliary body melanoma | 7 (12%) | Iritis | 7 (17%) | Choroidal fibrosarcoma … The proportion of malignant tumours from all uveal tissue increased from 11% (including one choroidal fibrosarcoma and one iris melanoma) and 17% (two iris melanomas) in the first two intervals to 28% (comprising ten iris melanomas and seven ciliary body melanomas) and 33% (consisting of eight iris melanomas …

The War Is on: The Immune System against Glioblastoma-How Can NK Cells Drive This Battle?

Natural killer (NK) cells are innate lymphocytes that play an important role in immunosurveillance, acting alongside other immune cells in the response against various types of malignant tumors and the prevention of metastasis. Since their discovery in the 1970s, they have been thoroughly studied for their capacity to kill neoplastic cells without the need for previous sensitization, executing rapid and robust cytotoxic activity, but also helper functions. In agreement with this, NK cells are being exploited in many ways to treat cancer. The broad arsenal of NK-based therapies includes adoptiv

Совпадение в полном тексте источника
… Likewise, and pointing more specifically to NK cells, their depletion by treatment with monoclonal antibodies to asialo-GM1 or NK1.1 increases the susceptibility of mice to chemically induced fibrosarcomas [ 92 ]. …

Unraveling the Anticancer Effect of Curcumin and Resveratrol.

Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unr

Совпадение в полном тексте источника
… Park and colleagues have demonstrated the anti-metastatic activity of resveratrol in human fibrosarcoma cells. … Several in vitro and in vivo studies have reported the anti-metastatic activity of resveratrol through downregulation of MAPK pathways against cancers, such as ovarian [ 213 , 214 ], oral [ 215 ], breast [ 216 , 217 ], fibrosarcoma [ 218 ], hepatocellular carcinoma [ 219 ] and osteosarcoma [ 220 ]. …

Mutual connected IL-6, EGFR and LIN28/Let7-related mechanisms modulate PD-L1 and IGF upregulation in HNSCC using immunotherapy

The development of techniques and immunotherapies are widely applied in cancer treatment such as checkpoint inhibitors, adoptive cell therapy, and cancer vaccines apart from radiation therapy, surgery, and chemotherapy give enduring anti-tumor effects. Minority people utilize single-agent immunotherapy, and most people adopt multiple-agent immunotherapy. The difficulties are resolved by including the biomarkers to choose the non-responders’ and responders’ potentials. The possibility of the potential complications and side effects are examined to improve cancer therapy effects. The Head and Ne

Совпадение в полном тексте источника
… -bisphosphate PIP3 | Phosphatidylinosito 3,4,5-trisphosphate PKM2 | Pyruvate kinase M2 PDLIM2 | PDZ-LIM domain-containing protein 2 PP2A | protein phosphatase 2A PTEN | phosphatase and tensin homologue deleted on chromosome 10 PTPRs | protein tyrosine phosphatase receptors Raf | rapidly accelerated fibrosarcoma …

Selinexor: Targeting a novel pathway in multiple myeloma.

Selinexor is an orally bioavailable selective inhibitor of nuclear export compound that inhibits exportin-1 (XPO1), a novel therapeutic target that is overexpressed in multiple myeloma (MM) and is responsible for the transport of ∼220 nuclear proteins to the cytoplasm, including tumour suppressor proteins. Inhibition of this process has demonstrated substantial antimyeloma activity in preclinical studies, both alone and in combination with established MM therapeutics. Based on a clinical trial programme encompassing multiple combination regimens, selinexor-based therapy has been approved for t

Совпадение в полном тексте источника
… selinexor plus pomalidomide [ 40 ], the conventional MM chemotherapy drugs melphalan [ 46 ] and doxorubicin [ 47 ], the latter mediated through inhibition of nuclear export of topoisomerase II alpha and the resultant doxorubicin‐induced DNA damage, and the investigational pan‐RAF (rapidly accelerated fibrosarcoma …

Beyond Formulation: Contributions of Nanotechnology for Translation of Anticancer Natural Products into New Drugs.

Nature is the largest pharmacy in the world. Doxorubicin (DOX) and paclitaxel (PTX) are two examples of natural-product-derived drugs employed as first-line treatment of various cancer types due to their broad mechanisms of action. These drugs are marketed as conventional and nanotechnology-based formulations, which is quite curious since the research and development (R&D) course of nanoformulations are even more expensive and prone to failure than the conventional ones. Nonetheless, nanosystems are cost-effective and represent both novel and safer dosage forms with fewer side effects due to m

Совпадение в полном тексте источника
… Lipodox® (generic doxorubicin hydrochloride liposome injection): In vivo efficacy and bioequivalence versus Caelyx® (doxorubicin hydrochloride liposome injection) in human mammary carcinoma (MX-1) xenograft and syngeneic fibrosarcoma (WEHI 164) mouse models. …

Therapeutic Potential of Antibody-Drug Conjugate-Based Therapy in Head and Neck Cancer: A Systematic Review.

BackgroundAntibody-drug conjugates (ADCs) are designed to deliver potent cytotoxic agents into tumor tissues. During the last two decades, a plethora of ADCs have been successfully developed and used for several indications, including hematologic and solid tumors. In this work, we systematically reviewed the progress in ADC development for the treatment of HNC.MethodsThis review was registered in PROSPERO database. A comprehensive search was conducted following PRISMA guidelines and using PubMed, Scopus and Web of Science database.ResultsIn total, 19 studies were included. Due to the significa

Совпадение в полном тексте источника
… propionate (SPDP) | Nasopharyngeal cancer | HNC cell lines: HNE2 and HNE2/LMP1 transfected, HNC xenograft models: HNE2/LMP1 transfected | // | Chen 2012 [ 52 ] | FAP5-SPP-DM1, FAP5-SPDB-DM4, FAP5-SMCC-DM1 | FAPα | Maytansinoids DM1/DM4 | Cleavable SPP, Cleavable SPDB, Non cleavable SMCC | Colon cancer, fibrosarcoma …

Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations.

Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA damage and other effects important in cancer transformation. Dietary vitamin C from natural sources is taken with other compounds affecting its bioavailability and biological effects. High pharmacological doses of vitamin C may induce prooxidant effects, detrimental for cancer cells. An oxidized form of vitamin C, dehydroascorbate, is transported through glucose transporters, and cancer cells switch from oxidative phosphorylation to glycolysis in energy production so an excess of vitamin C may limit glucose tr

Совпадение в полном тексте источника
… Vitamin C and its four derivatives, Asc-6-O-palmitate (Asc6Plm), Asc-2-O-phosphate (Asc2P), Asc-2-O-phosphate-6-O-palmitate (Asc2P6Plm), and Asc-5,6-benzylidene (Asc5,6Bz), inhibited the invasion of the human fibrosarcoma HT-1080 cells [ 136 ]. …

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review.

Cancer is the second biggest cause of death worldwide. Despite a number of studies being conducted, the effective mechanism for treating cancer has not yet been fully understood. The tumor-microenvironment such as hypoxia, low nutrients could disturb function of endoplasmic reticulum (ER) to maintain cellular homeostasis, ultimately leading to the accumulation of unfolded proteins in ER, so-called ER stress. The ER stress has a close relation with cancer. ER stress initiates unfolded protein response (UPR) to re-establish ER homeostasis as an adaptive pathway in cancer. However, persistent ER

Совпадение в полном тексте источника
… Inhibition of tumor progression by suppression of stress protein GRP78/BIP induction in fibrosarcoma B/C10ME Proc. Natl. Acad. Sci. USA 1996 93 7690 7694 10.1073/pnas.93.15.7690 8755537 PMC38808 17. Bi M. Naczki C. Koritzinsky M. Fels D. Blais J. Hu N. Harding H. Novoa I. Varia M. Raleigh J. …

Декодирование GPCR, сигнализирующее перепрограммирование рака: молекулярные механизмы и терапевтические последствия.

G белковые рецепторы (GPCR) представляют собой крупнейшую мембранную группу рецепторов в геноме человека и служат ключевыми регуляторами клеточного сигнала, гомеостаза и фармакологической реакции. Помимо их классической роли в посредничестве внеклеточной стимуляции по зависящим от G-протеина и независимым путям, которые играют ключевую роль при помощи GPCR сигнальных путей, включая CAMP-PKA/EPAC, IP3/PLC, PI3K/Akt/mTOR и ERK/MAPK cascades, в вождении онкогенного распространения, апоптоза и метастаза. Кроме того, ГПХР замешаны в опухоли с помощью различных молекулярных механизмов, в рамках кото

Selinexor in acute myeloid leukemia: therapeutic applications and current challenges.

This article aims to review the current application status and research advancements of selinexor in the treatment of acute myeloid leukemia (AML). Selinexor, as the first oral selective inhibitor of nuclear export protein Exportin-1 (XPO1), inhibits the abnormal nuclear export of tumor suppressor proteins by blocking XPO1, thereby restoring their activity and exerting antitumor effects. Clinical studies have shown that selinexor monotherapy or combination therapy has demonstrated good anti-leukemia effects in AML, especially in patients with relapsed/refractory AML. In addition, the combinati

Совпадение в полном тексте источника
… The above symptoms still need to be closely monitored and detected in subsequent studies. 4.2 Resistance to selinexor In experiments probing the resistance mechanism of selinexor, human fibrosarcoma HT1080 cell lines were subjected to gradually increasing concentrations of KPT-185 (an early analog …

Mucin1 as a potential molecule for cancer immunotherapy and targeted therapy.

Mucin1 is a highly glycosylated type 1 transmembrane mucin that ranks second among 75 tumor-related antigens published by the National Cancer Institute, and has been identified as a possible therapeutic target over the past 30 years. MUC1 plays an important role in malignant transformation and disease evolution, including cell proliferation, survival, self-renewal, and metastatic invasion. MUC1 has been shown to interact with diverse effectors such as β-catenin, receptor tyrosine kinases, and cellular-abelsongene, which are of importance in the pathogenesis of various malignant tumors. Targeti

Совпадение в полном тексте источника
… kinase zinc finger E-box binding homolobox 1 vascular endothelial growth factor neuropilin-1 mitogen-activated protein kinase Janus Kinase Signal Transducers and Activators of Transcription mammalian target of rapamycin extracellular regulated protein kinases rat sarcoma rapidly accelerated fibrosarcoma …

A review of feline infectious peritonitis virus infection.

Feline infectious peritonitis (FIP) is an infectious disease characterized by non-specific laboratory changes and clinical signs. Clinical symptoms include anorexia, jaundice, fever, and weight loss. Moreover, some lesions are found in the digestive and respiratory systems. FIP, whose virulence varies, cannot be distinguished using several diagnostic methods. Moreover, feline coronaviruses (FCoVs) can be classified into two serotypes based on differences in their amino acid sequences, spike (S) protein sequences, and antibody (Ab) neutralization. There are two pathotypes, namely those caused b

Совпадение в полном тексте источника
… Biological behavior of tumors and associated retroviremia in cats inoculated with Snyder-Theilen fibrosarcoma virus and the phenomenon of tumor recurrence after primary regression. Infect. Immun. 1984;43(2):631–636. doi: 10.1128/iai.43.2.631-636.1984. 13. Kennedy M, Boedeker N, Gibbs P, Kania S. …

Osteoprotective Roles of Green Tea Catechins.

Osteoporosis is the second most common disease only secondary to cardiovascular disease, with the risk of fracture increasing with age. Osteoporosis is caused by an imbalance between osteoblastogenesis and osteoclastogenesis processes. Osteoclastogenesis may be enhanced, osteoblastogenesis may be reduced, or both may be evident. Inflammation and high reactive oxygen enhance osteoclastogenesis while reducing osteoblastogenesis by inducing osteoblast apoptosis and suppressing osteoblastic proliferation and differentiation. Catechins, the main polyphenols found in green tea with potent anti-oxida

Совпадение в полном тексте источника
… Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cells J. Cell Biol. 1983 96 1475 1479 10.1083/jcb.96.5.1475 6302102 PMC2112662 82. Lesot H. Kuhl U. Mark K. …

Repurposing drugs in oncology (ReDO)-selective PDE5 inhibitors as anti-cancer agents.

Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension. They are also well-known as examples of successful drug repurposing in that they were initially developed for angina and only later developed for erectile dysfunction. However, these drugs may also be effective cancer treatments. A range of evidentiary sources are assessed in this paper and the case made that there is pre-clinical and clinical evidence that these drugs may offer clinical benefit in a range of can

Совпадение в полном тексте источника
… BALB/c mice were challenged with CT26WT (colon carcinoma), C26GM (a more aggressive variant of CT26WT) or TS/A (mammary adenocarcinoma) and C57BL/6 with MCA203 (murine fibrosarcoma) cell lines and then treated with the PDE5 inhibitors, starting on the day of inoculation. …

Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.

Experimental data indicate that several pharmacological agents that have long been used for the management of various diseases unrelated to cancer exhibit profound in vitro and in vivo anticancer activity. This is of major clinical importance, since it would possibly aid in reassessing the therapeutic use of currently used agents for which clinicians already have experience. Further, this would obviate the time-consuming process required for the development and the approval of novel antineoplastic drugs. Herein, both pre-clinical and clinical data concerning the antineoplastic function of dist

Совпадение в полном тексте источника
… In this way, captopril suppresses the invasiveness of HT1080 fibrosarcoma cells and T98G glioma cells in vitro and impedes the growth of human gastric adenocarcinoma cells in a mouse xenograft model, either when it is administered alone or in synergy with cisplatin. 100 , 101 A short-term clinically …

Emerging strategies and therapies for treatment of Paget's disease of bone.

Paget's disease of bone (PDB) is a progressive monostotic or polyostotic metabolic bone disease characterized by focal abnormal bone remodeling, with increased bone resorption and excessive, disorganized, new bone formation. PDB rarely occurs before middle age, and it is the second most frequent metabolic bone disorder after osteoporosis, affecting up to 3% of adults over 55 years of age. One of the most striking and intriguing clinical features is the focal nature of the disorder, in that once the disease is established within a bone, there is only local spread within that bone and no systemi

Совпадение в полном тексте источника
… apoptosis-related cysteine peptidase | Osteoclast * | 154 CTSK | Cathepsin K | Osteoclast * | 154 FLJ23191 | Chromosome 4 open reading frame 31 | Osteoblast | 2 GCA | Grancalcin, EF-hand calcium binding protein | Osteoblast | 2 GLRB | Glycine receptor, beta | Osteoblast | 2 MAFB | V-maf musculoaponeurotic fibrosarcoma …