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Surveillance for Violent Deaths - National Violent Death Reporting System, 39 States, the District of Columbia, and Puerto Rico, 2018.

PROBLEM/CONDITION: In 2018, approximately 68,000 persons died of violence-related injuries in the United States. This report summarizes data … 36 states with statewide data (Alabama, Alaska, Arizona, Colorado, Connecticut, Delaware, Georgia, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont …

Oncolytic Viruses for Cancer Therapy in Dogs.

Cancer remains the leading cause of death in domestic dogs. Conventional therapeutic approaches, including surgery, chemotherapy, and radiotherapy, frequently fail to achieve sustained remission or stabilization. Oncolytic virotherapy, a rapidly advancing therapeutic modality in human oncology, is emerging as a novel strategy in veterinary medicine. This systematic review summarizes current knowledge on the application of oncolytic viruses (OVs) in canine cancer treatment, focusing on their mechanisms of action, safety profiles, and clinical efficacy. We evaluate diverse OV platforms, includin

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… Two serotypes—Indiana and New Jersey— predominate. VSV exhibits high transmissibility among ungulate species, producing characteristic blisters in the oral cavity, and on the udder and hooves. … Clinical and serological response to laboratory-acquired human infection by Indiana type vesicular stomatitis virus (VSV) Am. J. Trop. Med. Hyg. 1966 15 244 246 10.4269/ajtmh.1966.15.244 4286381 70. Hastie E. Cataldi M. Marriott I. Grdzelishvili V.Z. …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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Hybrid Fixation Technique for Femoral Stem Revision in B3 Periprosthetic Fractures: A Report of Two Cases.

Periprosthetic femoral fractures (PPFs) are challenging complications following total hip arthroplasty, especially in cases with compromised bone stock. We present 2 cases of Vancouver Type B3 PPF treated with a monoblock cementless long-stem prosthesis, using cement only for distal fixation. This technique provided initial stability, allowing early mobilization and eventual fracture healing with bony ingrowth. Radiographic follow-up demonstrated successful outcomes with no significant complications. Our results support the potential of this method for treating complex PPF cases, offering a so

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… A 47-mm cemented ZCA All-Poly acetabular cup (Zimmer, Warsaw, Indiana) was implanted. The cement mantle and femoral stem were removed through the PPF site. To prevent fracture propagation during reaming and stem impaction, a prophylactic cerclage wire was placed 1 cm distal to the PPF site. …

Oral cancer therapy: policy implications for the uninsured and underinsured populations.

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… A total of 26 states have enacted oral chemotherapy access laws: Oregon (2008), Indiana (2009), Iowa (2009), Hawaii (2009), District of Columbia (2009), Vermont (2010), Connecticut (2010), Kansas (2010), Colorado (2010), Minnesota (2010), Illinois (2011), New Mexico (2011), Texas (2011), New York (2011 …

Наблюдение за финансовыми трудностями пациентов с множественной миеломой и хронической лимфоцитической лейкемией, проходящих лечение в онкологических клиниках США (Alliance A231602CD).

ЦЕЛИ: Оценка доли и корреляции финансовых трудностей, о которых сообщают сами пациенты с множественной миеломой (ММ) или хронической лимфоцитической лейкемией (КЛ). Вечеринка: Sixty-six Общинная практика США и практики меньшинств в области онкологии связана с Программой общинных онкологических исследований Национального института раковых заболеваний (НКОРП). Участники: в целом 521 (больные)≥18 С согласия MM или CLL и 416 :: ответы на опрос (процент завершения)79.8%). Респонденты имели диагноз MM (MM-диагностика)74.0%), степень бакалавра или выше (53.4%), белые (или белые).89.2%), застрахованны

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… . § Geographic Regions were divided according to the United States census divisions and regions: Northeast: Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, Connecticut, New York, New Jersey and Pennsylvania; Midwest : Ohio, Michigan, Indiana, Wisconsin, Illinois, Minnesota, Iowa, Missouri … Hawaiian or other Pacific Islander, Unknown, Not reported. § Geographic Regions were divided according to the United States census divisions and regions: Northeast: Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, Connecticut, New York, New Jersey and Pennsylvania; Midwest : Ohio, Michigan, Indiana …

Use of Herbal Medicine Is Associated With Late-Stage Presentation in Tanzanian Patients With Cancer: A Survey to Assess the Utilization of and Reasons for the Use of Herbal Medicine.

PurposeIn Tanzania, patients with cancer present late with advanced stages. Among other reasons, the use of herbal medicine (HM) might contribute to delay in diagnosis and treatment. This study aims to understand the utilization of HM and the reasons for its' use.MethodsA semistructured 30-item questionnaire with closed- and open-ended questions was applied to a cohort of patients with cancer at Kilimanjaro Christian Medical Centre. Content analysis was performed for answers to open-ended questions.ResultsThree hundred two patients were interviewed, 50.9% males and 49.1% females. The mean age

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… Indiana University Press 2011 24. Engdal S Steinsbekk A Klepp O et al Herbal use among cancer patients during palliative or curative chemotherapy treatment in Norway Support Care Cancer 16 763 – 769 2008 18196289 10.1007/s00520-007-0371-3 25. …

Partial impairment of cytokine responses in Tyk2-deficient mice.

To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2-/- mice. In contrast to other Jaks, where inactivation leads to a complete loss of the respective cytokine receptor signal, Tyk2-/- mice display reduced responses to IFNalpha/beta and IL-12 and a selective deficiency in Stat3 activation in these pathways. Unexpectedly, IFNgamma signaling is also impaired in Tyk2-/- mice. Tyk2-/- macrophages fail to produce nitric oxide upon lipopolysaccharide induction. Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge.

Клиническая презентация и результаты нетрадиционных инфекций сальмонеллы у больных раком.

КОЛИЧЕСТВО: Считается, что инфекция сальмонеллы (NTS) является более острой у раковых больных, однако она не изучалась с момента разработки новых методов лечения рака, повышения сопротивляемости антибиотикам и введения новых антибиотиков. Мы пытались описать демографические характеристики, микробиологические результаты, клинические проявления и последствия инфекций НТС у раковых пациентов в нашем учреждении. Мы изучили данные микробиологических лабораторий и выявили пациентов с раком, у которых в период с января были обнаружены организмы NTS. 1, 2000 и декабрь 31, 2013, в центре рака в Хьюстон

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… Six of these patients (38%) had one or more urinary tract abnormalities or a foreign body, including nephrolithiasis (4), hydronephrosis (3), and one each with history of recurrent UTIs, urinary incontinence, vesicoureteral reflux, ureteral stent, and placement of an Indiana pouch. …

Hematology and Hemostasis

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… Nat Clin Pract Oncol. 2005;2:356–63. doi: 10.1038/ncponc0225. 1. http://www.med.unc.edu/isth/welcome ISTH 2. http://tollefsen.wustl.edu/projects/coagulation/coagulation.html Washington Univ 3. http://www.indstate.edu/thcme/mwking/blood-coagulation.html Indiana State Univ 4. http://www.nlm.nih.gov …

Intensive Care Outcomes of Patients after High Dose Chemotherapy and Subsequent Autologous Stem Cell Transplantation: A Retrospective, Single Centre Analysis.

High dose chemotherapy (HDT) followed by autologous peripheral blood stem cell transplantation (ASCT) is standard of care including a curative treatment option for several cancers. While much is known about the management of patients with allogenic SCT at the intensive care unit (ICU), data regarding incidence, clinical impact, and outcome of critical illness following ASCT are less reported. This study included 256 patients with different cancer entities. Median age was 56 years (interquartile ranges (IQR): 45-64), and 67% were male. One-year survival was 89%; 15 patients (6%) required treatm

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… High-Dose Chemotherapy and Autologous Peripheral-Blood Stem-Cell Transplantation for Relapsed Metastatic Germ Cell Tumors: The Indiana University Experience. J. Clin. Oncol. 2017;35:1096–1102. doi: 10.1200/JCO.2016.69.5395. 8. …

Towards a unified approach for multiple myeloma care in Kenya - proceedings of the Inaugural Multiple Myeloma Congress.

The rising burden of multiple myeloma in Kenya has not been met by a commensurate effort for control. Patients and practitioners struggle with unavailability and unaffordability of diagnostics, drugs and stem cell transplant leading to presentation at advanced stages and under-treatment with increased morbidities and mortality. A concerted effort among stakeholders is urgently needed to develop strategies for myeloma control. The scarcity of providers also carries grave consequences for Kenyan patients. The Academic Model Providing Access To Healthcare (AMPATH) multiple myeloma program organiz

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… | ScanLab | Pharmaceutical supplies, Kenya | | | Medipoint EA LTD | | Philips Pharmaceuticals Academia | Kenya | | | Moi University | | University of Nairobi | | Aga Khan University | | Maseno University | | Kenyatta University | | University of Kabianga | International | | | Indiana …

Geriatric assessments and frailty scores in multiple myeloma patients: a needed tool for individualized treatment?

PURPOSE OF REVIEW: Multiple myeloma is a disease of elderly adults. Improvement in survival has occurred because of biological insights and novel agents. Therapeutic options involve choices today, thus have become more complex. Demographics have led to an increased number of elderly patients and age may be associated with a poorer outcome but is not the only prognostic predictor today. RECENT FINDINGS: To evaluate patients' health status rather than their chronological age alone, frailty scores and functional geriatric assessments are used to identify prognostic groups, avoid adverse events,

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… Rd-R10 ( n = 98) in intermediate-fit | Randomized | Intermediate, not frail pts, R10 later rather than initially = upfront reduced Suvannasankha NCT04223661 | 44/Indiana/II | IMWG frailty score | Dara-Rd in fit: Len 10 mg → 15 mg Dara-Rd frail: Len 5 → 10 mg | Prospective data: intermediate/frail profit …

Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling.

Osteolytic destruction is a hallmark of multiple myeloma and impairs myeloma patients' quality of life. However, the molecular mechanism underlying the pathogenesis of myeloma-associated bone disease remains unclear. In this study, we demonstrate the role of myeloma cell-expressed integrin α6 in bone. Integrin α6 binds to laminin 8 and epidermal growth factor receptor on mesenchymal stem cells (MSCs) to form a trimer complex and upregulates the secretion of osteolytic cytokines from both myeloma cells and MSCs, leading to enhanced bone resorption and reduced bone formation. Thus, this study el

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… In Vivo Mouse Experiments, Measurement of Tumor Burden, Radiography, and Bone Histomorphometry CB.17 SCID mice purchased from Envigo (Indianapolis, Indiana, USA) were maintained in American Association of Laboratory Animal Care–accredited facilities. …

High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer.

Advanced head and neck cancer (HNC) can invade facial bone and cause bone pain, thus posing a significant challenge to the quality of life of patients presenting with advanced HNC. The present study was designed to investigate HNC bone pain (HNC‑BP) in an intratibial mouse xenograft model that utilized an HNC cell line (SAS cells). These mice develop HNC‑BP that is associated with an expression of phosphorylated ERK1/2 (pERK1/2), which is a molecular indicator of neuron excitation in dorsal root ganglia (DRG) sensory neurons. Our experiments demonstrated that the inhibition of high mobility gr

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… Bellido (Department of Anatomy and Cell Biology, School of Medicine, Indiana University, Indianapolis, IN, USA) and primary mouse osteoblast cells (OBC12) (Cosmo Bio, Tokyo) were cultured in α-MEM (minimal essential medium) containing 5% FBS. …

Symptomatic spinal epidural lipomatosis after combined hormonal and steroidal palliative therapy of prostate cancer.

To meet the demand for kidney transplants (KTx), organs are frequently retrieved not only from standard criteria donors (SCD; a donor who is aged <50 years and suffered brain death from any number of causes, such as traumatic injuries or a stroke) but also from expanded criteria donors (any donor aged >60 years or donors aged >50 years with two of the following: A history of high blood pressure, a creatinine serum level ≥1.5 mg/dl or death resulting from a stroke). This comes at the cost of a higher risk of primary non‑function (the permanent hyperkalemia, hyperuremia and fluid overload that r

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… | Course | Independent study | – | 1st-yr UG, 2nd or 3rd-yr UG, 4th-yr UG | University of Delaware | Course | Clinical immersion for engineers | – | 1st-yr UG, 2nd or 3rd-yr UG, 4th-yr UG,Other | 30 Case Western Reserve University | Program | BME summer immersion program | – | 2nd or 3rd-yr UG | Indiana …

Exercise facilitators and barriers following participation in a community-based exercise and education program for cancer survivors.

Cancer survivors participating in supervised exercise programs learn to exercise safely with oversight from care providers who monitor and facilitate their progress. This study investigated the long-term exercise participation levels and identified exercise barriers for graduates from a specialized cancer exercise and education program. Subjects were graduates from a 12-week supervised exercise program (www.canwellprogram.ca) who participated in a, prospective, long-term evaluation. Measures included: six-minute walk test (6-MWT), STEEP treadmill test, Functional Assessment Cancer Therapy-Gene

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… The University Information Technology Services Center for Statistical and Mathematical Computing, Indiana University. 2009 http://www.indiana.edu/~stat-math . …

Final report on North Central Cancer Treatment Group N0877 (alliance): A phase II randomized, placebo-controlled trial of chemoradiotherapy with or without dasatinib for glioblastoma.

BackgroundDasatinib is an oral inhibitor of the Src kinase family, with preclinical data indicating impact on gliomagenesis, tumor invasion, and radiosensitivity.MethodsNorth Central Cancer Treatment Group N0877 is a phase 1 dose escalation and phase II randomized study evaluating the maximum tolerated dose (MTD), safety, and efficacy of dasatinib with radiation and temozolomide (TMZ) for glioblastoma. Following identification of the MTD, adult patients with a histologic diagnosis of glioblastoma were randomized 2:1 between dasatinib given with standard concurrent and adjuvant TMZ, versus plac

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… Weckstein; New Mexico Minority Underserved NCORP, Albuquerque, NM; Zoneddy Ruiz Dayao; UG1CA189856; Northern Indiana Cancer Research Consortium, South Bend, IN; ProMedica Flower Hospital, Sylvania, OH; Saint Charles Hospital, Oregon, OH; Sanford NCI Community Oncology Research Program of the North Central …

Carbon fibre PEEK versus titanium cephalomedullary nails for management of oncological lesions of the femur: a retrospective cohort study.

BACKGROUND: Carbon fibre reinforced polyetheretherketone (CF-PEEK) intramedullary devices have been gaining traction in the field of orthopaedic oncology. We aim to investigate the safety and efficacy of this device. METHODS: A retrospective cohort study was performed. Our primary objectives were to compare all-cause revision and the incidence of postoperative complications between CF-PEEK nails (Group 1) to titanium alloy nails (Group 2) for management of oncological lesions of the femur. Secondary objectives were to compare estimated blood loss and all-cause mortality between the two groups

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… CarboFix Trochanteric (PF) Nail (CarboFix Orthopaedics Ltd, Herzeliya, Israel), whereas patients in Group 2 received either a Long Gamma Nail (Stryker GmbH, Selzach, Switzerland), TRIGEN META-TAN Trochanteric Antegrade Nail (Smith & Nephew Inc, Tennessee, USA) or AFFIXUS Hip Fracture Nail (Biomet Trauma, Indiana …

Use of therapeutic plasma exchange to treat nonsteroidal anti-inflammatory drug overdose in dogs.

BACKGROUND: Therapeutic plasma exchange (TPE) may be an effective technique for treatment of accidental nonsteroidal anti-inflammatory drug (NSAID) overdose, but information regarding the use of this technique in veterinary medicine is currently limited. OBJECTIVES: To evaluate the overall outcome for dogs with NSAID overdose treated with TPE and to determine if any presenting factors can predict or influence overall outcome. Secondary objectives included investigating TPE complications as well as the utility of other adjunctive treatments. ANIMALS: Eleven client-owned dogs presented for NSA

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… ibuprofen (multiple brands available including Motrin; Johnson & Johnson Consumer Inc, Fort Washington, Pennsylvania) in 6 dogs (54.5%), naproxen (multiple brands available including Aleve; Bayer Healthcare LLC, Morristown, New Jersey) in 4 dogs (36.4%), and deracoxib (Deramaxx; Elanco US Inc, Greenfield, Indiana …