Результаты поиска

Ventricular structure and function in hypertensive participants with heart failure and a normal ejection fraction: the Cardiovascular Health Study.

OBJECTIVES: The purpose of this study was to evaluate left ventricular (LV) size and structure in elderly subjects with hypertension (HTN) and heart failure who have a normal ejection fraction (HFNEF) in a large population-based sample. BACKGROUND: The pathophysiology of HFNEF is incompletely understood but is generally attributed to LV diastolic dysfunction with normal or reduced LV diastolic chamber size despite greater than normal filling pressures. METHODS: In the Cardiovascular Health Study (n = 5,888), demographic and clinical characteristics and ventricular structure and function were

Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains.

BACKGROUND: The detection of monoclonal free light chains (FLCs) is an important diagnostic aid for a variety of monoclonal gammopathies and … parent change for those >80 years. This trend was lost when the FLC concentration was normalized to cystatin C concentration. The ratio of kappa FLC to lambda FLC (FLC K/L) did not exhibit an age-dependent trend. The diagnostic interval for FLC K/L was 0.26-1.65. The 95% reference interval for kappa FLC was 3.3-19.4 mg/L, and that for lambda FLC was 5.7-26.3 …

Multimodal Computational Approach for Forecasting Cardiovascular Aging Based on Immune and Clinical-Biochemical Parameters.

Background: This study presents an innovative approach to cardiovascular disease (CVD) risk prediction based on a comprehensive analysis of … as well as indices of liver function, kidney function, oxidative stress and heart failure (albumin, cystatin C, N-terminal pro B-type natriuretic peptide (NT-proBNP), superoxide dismutase (SOD), C-reactive protein (CRP), cholinesterase (ChE), cholesterol, and glomerular filtration rate (GFR)). Clinical and behavioural risk factors were also considered: arter …

Risk factors for brain injury in patients with exertional heatstroke: A 5-year experience.

PURPOSE: Minimal data exist on brain injury in patients with exertional heatstroke (EHS) in developing country. In this study, we explored t … , platelet counts, procalcitonin, alanine aminotransferase, aspartate aminotransferase, creatinine, cystatin C, coagulation parameters, international normalized ratio, acute physiology and chronic health evaluation II scores, sequential organ failure assessment (SOFA) scores, and Glasgow coma scale scores (all p < 0.05). Multivariate logistic regression show …

Effect of Omega-3 Fatty Acid Supplementation on Plasma Fibroblast Growth Factor 23 Levels in Post-Myocardial Infarction Patients with Chronic Kidney Disease: The Alpha Omega Trial.

Fibroblast growth factor 23 (FGF23) is an independent risk factor for cardiovascular mortality in chronic kidney disease. Omega-3 (n-3) fatt … placebo for 41 months. In a subcohort of 336 patients with an eGFR < 60 mL/min/1.73 m² (creatinine-cystatin C-based CKD-EPI formula), plasma C-terminal FGF23 was measured by ELISA at baseline and end of follow-up. We used analysis of covariance to examine treatment effects on FGF23 levels adjusted for baseline FGF23. Patients consumed 19.8 g margarine/day o …

Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults.

BACKGROUND: Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations be … ulse rate -0.00194 (95% CI -0.00317--0.000705), C-reactive protein -0.0363 (95% CI 0.0601--0.0124), cystatin C -0.0391 (95% CI -0.0772--0.00107). When using clinical cut-points we additionally found associations between LTL and insulin resistance -0.0412 (95% CI -0.0685--0.0139), systolic blood pressure 0.0455 (95% CI 0.00137-0.0897), and diastolic blood pre …

Assessment of biomarkers and predictive model for short-term prospective abdominal aortic aneurysm growth-A pilot study.

BACKGROUND: Abdominal aortic aneurysms (AAAs) are currently followed with serial ultrasound or computed tomography scanning diameter measure … eter, prospective 1-year AAA growth, and the concentration of metalloprotease-2, metalloprotease-9, cystatin C, α1-antitrypsin, myeloperoxidase, monocyte chemoattractant protein-1, homocysteine, D-dimer, plasmin-antiplasmin complex (PAP), and C-reactive protein in peripheral blood at the time of baseline assessment. With all these data, we elaborated predict …

How to estimate renal function in patients with liver disease: choosing the most suitable equation.

BACKGROUND: Hepatitis B virus (HBV) infection is a public health challenge, especially in China. In clinical practice, HBV infection is asso … ) (p = 0.009), creatinine (p = 0.006), urine N-acetyl-β-glucosaminidase (NAG) (p = 0.001) and serum cystatin C (CysC) (p = 0.044). CONCLUSION: The CHINAcr-cys equation may be more suitable for the estimation of GFR in Chinese patients with CHB or compensated cirrhosis. INR, creatinine, NAG, and CysC are proper biomarkers for screening renal dysfunction in C …

Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy).

PURPOSE OF REVIEW: The purpose of this study was to investigate the association of 26 inflammatory biomarkers (acute phase proteins, cytokines, chemokines) and renal markers with coronary lipid core burden index (LCBI) assessed by near-infrared spectroscopy (NIRS) imaging, as well as the association of these biomarkers with long-term cardiovascular outcome. RECENT FINDINGS: NIRS-derived LCBI has recently been shown to be an independent predictor of major adverse cardiac events (MACE). However, studies on the association between circulating biomarkers and NIRS-derived characteristics have not

Measuring and Assessing Kidney Function.

Assessment of kidney function is important for the detection and management of chronic kidney disease. The glomerular filtration rate (GFR) and level of albuminuria are two frequently used indices of kidney function assessment. Administration of an exogenous filtration marker to measure GFR and collection of urine for 24 hours to measure albumin excretion generally are considered the gold standard for GFR and albuminuria, respectively, but they are time consuming and onerous for the patient. Thus, in routine clinical practice, other methods are used more frequently to assess GFR and albuminuri

Acute Kidney Injury in Cirrhosis.

Acute kidney injury (AKI) is a frequent complication of end-stage liver disease, especially in those with acute-on-chronic liver failure, occurring in up to 50% of hospitalized patients with cirrhosis. There is no specific blood or urine biomarker that can reliably identify the cause of AKI in cirrhotic patients. This review examines studies used to assess renal dysfunction in cirrhotic patients including new diagnostic criteria and potential novel biomarkers. Although biomarker development to differentiate the cause of AKI in cirrhosis has promise, the utility of biomarkers to determine irrev

The cardiorenal problem.

Cardiorenal syndrome (CRS) describes the reciprocally detrimental interaction between both acute and chronic cardiac and renal dysfunction. The syndrome is prevalent and carries a high mortality. CRS has five clinical subtypes, which share common pathogenetic mechanisms including neurohumoral and haemodynamic derangements. We describe several serum markers that offer improvements over traditional measurement of serum creatinine for the diagnosis of CRS. The mainstay of therapy of CRS is loop diuretics in the acute setting and ACE-inhibition in the chronic setting, the latter should in most cas

Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors.

BACKGROUND: Folate deficiency has serious consequences for the fetus. Folic acid fortification of food addresses this problem. However, clinical consequences of vitamin B-12 deficiency may be worsened by high folic acid intakes, perhaps as a direct result of unmetabolized folic acid, which does not occur naturally in body tissues. OBJECTIVE: We attempted to attribute associations that we previously found between higher folate status and anemia and cognitive test performance to circulating unmetabolized folic acid or 5-methyltetrahydrofolate (5MeTHF). DESIGN: The subjects (n = 1858) were seni

The Solitary Functioning Kidney: From Pathophysiology to Long-Term Management.

Solitary functioning kidney (SFK) is a clinical condition characterized by the presence of a single functioning kidney, arising from either … of renal function and emerging biomarkers, including neutrophil gelatinase-associated lipocalin and cystatin C. Prognostic evaluation of patients with SFK should comprehensively consider etiology, age, compensatory renal growth, associated urinary tract anomalies, comorbidities, and markers of kidney injury. Effective long-term management is essential to pre …

Dynamics in kidney function markers as predictors of post-ICU survival: an innovative approach to enhance marker accuracy.

INTRODUCTION AND AIMS: The variability of physiological biomarkers is emerging as an independent indicator of health across various contexts … a weak association with short-term post-ICU survival. In contrast, urine peptidome score CKD273 and cystatin C levels measured at ICU discharge were strongly associated with one-month survival. The differences in CKD273, Galectin-3, and plasma neutrophil gelatinase-associated lipocalin (NGAL) between admission and discharge were the most predictive of one-mo …

Life-Course Fertility and Cardio-Kidney-Metabolic Health in Chinese Middle-Aged and Older Women: A Cross-Sectional CHARLS Study.

BACKGROUND: The cardio-kidney-metabolic (CKM) syndrome, recently conceptualized by the American Heart Association (AHA) in 2023, integrates … itudinal Study (CHARLS, 2011-2018). CKM stages were classified using objective biomarkers including cystatin C-based estimated glomerular filtration rate (eGFR). Parity was categorized as 0, 1, 2 (reference), 3, 4-5, and 6 or more. Poisson regression with robust standard errors estimated adjusted prevalence ratios (aPR). Restricted cubic splines (RCS) assess …

Integrating Mendelian Randomization and Epithelial Barrier Assays Reveals Protective Effects of Acetate and Histidine Against Cholesterol Depletion-Induced Esophageal Dysfunction in GERD.

OBJECTIVE: This study aims to evaluate the causal relationship between serum biomarkers and gastroesophageal reflux disease (GERD) using Men … ive effects, reducing GERD risk by 15% (OR: 0.85, 95% CI: 0.72-1.00, p=0.047). Conversely, elevated Cystatin C levels were linked to a 32% increased GERD risk (OR: 1.32, 95% CI: 1.10-1.73, p=0.0105). In vitro validation demonstrated that MβCD-induced cholesterol depletion disrupted epithelial barrier function, reducing TEER by 30% and doubling FITC-dextran f …

N-propargylglycine restores survival by preventing calcium oxalate stone formation, tubular injury, and kidney dysfunction in a lethal mouse model of primary hyperoxaluria type 2.

INTRODUCTION: New therapeutics are needed to address the rapid progression of calcium oxalate (CaOx) nephrolithiasis and life-threatening ki … glycine (N-PPG) as a preclinical candidate for PH2, measuring oxalate levels, CaOx stone formation, Cystatin C levels, albumin/creatinine ratio, kidney tubule damage by kidney injury molecule-1 and Lotus Tetragonolobus lectin immunohistochemistry, metabolites, weight, and lifespan. RESULTS: Oral administration of N-PPG, a well-tolerated small-molecule inhib …

Efficacy and safety of flexible ureteroscopy assisted by a flexible-tip negative pressure suction sheath for 2-4 cm renal calculi.

OBJECTIVE: To investigate the efficacy and safety of flexible ureteroscopy assisted by a flexible-tip negative-pressure suction sheath for t … ble-tip suction sheath group (all P < 0.05). In addition, postoperative levels of serum creatinine, cystatin C, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin, as well as 6-month postoperative quality-of-life scores, were significantly better in the flexible-tip suction sheath group than in the conventional sheath group (all P < 0.05). …

Кассетная нефропатия в СИС: Раннее признание и экстракорпоральные стратегии улучшения результатов.

Острая почечная травма (АКИ), вызванная кастами, является частой, но недостаточно признанной причиной дисфункции почек в отделении интенсивной терапии. Она возникает, когда фильтрованные белки или пигменты - свободные световые цепи (ФЛК) в множестве миеломы, миоглобин в хабдомиолизе, билирубин в тяжелом холестазе или гемоглобин в внутриваскулярном гемолизе - возникают внутри почечных трубок, образуя обструктивные касты и вызывая окислительные и подстрекательские травмы. Раннее распознавание имеет важное значение, поскольку традиционные маркеры (кротинин, мочи) задерживаются. Формирующиеся биом

Совпадение в аннотации оригинала
Cast-induced acute kidney injury (AKI) is a frequent yet under-recognized cause of kidney dysfunction in the intensive care unit. It arises … utput) rise late. Emerging biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, and the tissue inhibitor of metalloproteinases-2 · insulin-like growth factor binding protein-7 ([TIMP-2]·[IGFBP7]) panel, detect tubular stress earlier and can guide timely intervention. This narrative review summarizes pathophysiology, diagnostic …