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Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates-Preliminary data: Medical ozone gas insufflation in treating ONJ lesions.

Osteonecrosis of the Jaw (ONJ) is an adverse event reported especially in patients receiving cancer treatments regimen, bisphosphonates (BPs), and denosumab. We performed an open-label, prospective study in patients treated with zoledronic acid who developed ONJ lesions >2.5 cm, and had no benefit after the treatment with the standard therapy, to evaluate the efficacy and tolerability of medical ozone (O3) treatment delivered as gas insufflations on each ONJ lesions. Twenty-four patients (mean age 62.5, range 41-80; 12 female) with bone metastases due to breast (11), prostate (4)and lung (4)ca

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… Indiana University School of Dentistry; Indianapolis: 2002. pp. 226–227. 16. Hoefert S., Schmitz I., Tannapfel A., Eufinger H. …

Attachment Styles and Sexual Function Among Survivors of Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study.

Background and Objectives: Autologous hematopoietic stem cell transplantation (AHSCT) offers life-saving treatment for hematologic malignancies but can result in persistent sexual dysfunction and relationship challenges. Attachment theory provides a valuable framework for understanding how enduring relational patterns influence sexual well-being. This study aimed to assess sexual function and attachment styles in AHSCT survivors and examine correlations between attachment and sexual health outcomes. Materials and Methods: A multicenter, cross-sectional study was conducted from December 2019 to

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… Indiana M.L. La Rosa V.L. Exploring the Association between Attachment Style, Psychological Well-Being, and Relationship Status in Young Adults and Adults-A Cross-Sectional Study Eur. J. Investig. Health Psychol. Educ. 2023 13 525 539 10.3390/ejihpe13030040 PMC10047625 36975392 45. Tsatsou I. …

A Systematic Review of Decision Aids in Hematologic Malignancies: What Are Currently Available and What Are We Missing?

BackgroundPatient decision aids (PDAs) are tools designed to facilitate decision-making. In this systematic review, we summarized existing studies on the development and evaluation of PDAs for patients with hematologic malignancies.Patients and methodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched for articles in PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. We included studies, abstracts, and clinical trial protocols available in English involving PDAs for patients ag

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… Other races represented included Black ( n = 20, 1.5%), Asian ( n = 1, 0.1%), Alaskan Indiana/Alaskan Native ( n = 1, 0.1%), and self-reported “non-white” ( n = 165, 12.2%). Randomized Trials Full texts for 2 of the 3 randomized control trials were available 23 , 24 . …

Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy Adult Subjects.

Avadomide (CC-122) is a novel immunomodulatory drug that binds to cereblon, a member of the Cullin 4-RING E3 ubiquitin ligase complex. Avadomide has multiple pharmacologic activities including potent immune modulation, antiangiogenic, antitumor, and antiproliferative activity and is being evaluated as an oncology treatment for hematologic malignancies and advanced solid tumors. In vitro study has indicated that cytochrome P450 (CYP) 3A and CYP1A2 appear to be the major enzymes involved in the oxidative metabolism of avadomide. The effects of CYP3A inhibition/induction and CYP1A2 inhibition on

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… Indiana University School of Medicine . Drug Interactions Flockhart Table. https://drug-interactions.medicine.iu.edu/Main-Table.aspx . Accessed March 3, 2019. 5. Gunes A, Dahl ML. …

Diagnostic Trends and Geographic Health Care Disparities Among Patients With Transthyretin Amyloid Cardiomyopathy.

BACKGROUND: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a rare, life-threatening form of restrictive cardiomyopathy. Access to cardiology providers and specialized amyloid centers may impact ATTR-CM diagnosis. We sought to elucidate diagnostic disparities of ATTR-CM through assessment of diagnostic trends and the geographic distribution of amyloid centers and cardiology providers in the United States. METHODS: This was a cross-sectional geospatial analysis of amyloid centers and cardiology providers and a retrospective cohort analysis of patients with ATTR-CM from the Komodo Healthcare

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… Geographically, the prevalence of ATTR‐CM was highest in the Northeast (Maine, 69.74 per 100 000 people; Massachusetts, 64.28; New York, 58.89; District of Columbia, 48.03; New Jersey, 47.18; Pennsylvania, 45.47; Connecticut, 44.06) but was lower in the Midwest (Iowa, 11.71; South Dakota, 14.12; Indiana …

Современные методы диагностики медицинских паразитов и артроподов

Обычные методы, такие, как микроскопия, используются для диагностики паразитических заболеваний и медицинских заболеваний, связанных с артроподами, на протяжении многих лет. Некоторые методы считаются золотыми. Однако их ограниченная чувствительность, специфичность и точность, а также потребность в дорогостоящих реагентах и высококвалифицированных технических специалистах являются критическими проблемами. В этой связи постоянно разрабатываются новые инструменты для уменьшения числа проблем. Недавно three Возникли самые современные методы: штрих-кодирование ДНК, геометрические морфометры и иску

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… They were used to identify Aedes species, such as A. aegypti and A. albopictus ; Culex species (Linnaeus) (Diptera: Culicidae), like C. gelidus , C. quinquefasciatus, and C. vishnui ; and Mansonia species (Blanchard) (Diptera: Culicidae), for example, M. annulifera , M. indiana , and M. uniformis . …

Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

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… He received his doctoral degree with honor from Health Science Center of Beijing University in 1998, then he moved to USA to continue his ophthalmic training as a postdoctoral fellow in Indiana University. … Sun received his MD from Health Science Center of Beijing University and his MBA from Kelley School of Business of Indiana University. Dr. Len Pinchuck became a member of US National Academy of Engineering (NAE) in 2012, and was elected as a member of the Selection Committee of NAE in 2015. Dr. …

Расовые различия в выживании нескольких миелом: ассоциации с трансплантацией стволовых клеток, страхованием и расширением сети медицинских учреждений.

На уровне населения чернокожие пациенты с множественной миеломой (ММ) могут выжить хуже, чем белые. Авторы изучили вопрос о том, как автологическая трансплантация стволовых клеток (ASCT), страхование и расширение сети " Медикэйд " связаны с расовыми различиями в общем уровне выживания (rwOS) в реальном мире. МЕТОДЫ: Данные, полученные 4932 больные MM (MM)24% Блэк) в Флатиронской базе данных исследований в области здравоохранения анализировался с использованием моделей " Кокс регрессиал " (rwOS), " Файн энд срей " (ASCT) и " политомная регрессия " (страхо

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… Abbreviations: aOR, adjusted odds ratio; NA, not applicable. a States (including the District of Columbia) in the study that expanded Medicaid in the 2011–2021 study period: Arkansas, Arizona, California, Colorado, Connecticut, Delaware, Hawaii, Iowa, Idaho, Illinois, Indiana, Kentucky, Louisiana, Massachusetts …

Клиническое и экономическое воздействие работников, обеспечивающих уход за пациентами, страдающими множественным склерозом, в зависимости от состояния болезни.

Справочная информация: Исследования по вопросу о партнерах по уходу за пациентами с множественным склерозом (МС) являются ограниченными. Цели: Клиническое и экономическое воздействие на партнеров по уходу за работниками оценивалось с точки зрения степени заболеваемости MS. Методы: работники с супругами/домашними партнерами с НР из базы данных о партнерах по работе (Jan. 1, 2010- Декабрь. 31, 2019) имеют право на получение пособия, если: супруг/партнер имел по крайней мере 3 Связанная с НРICD-9-CM/ICD-10-CM::340xx/G35) заявления пациентов/акушеров/болезней в рамках 1 год (последняя претензия =

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… Massachusetts, Maine, New Hampshire, New Jersey, Puerto Rico, Rhode Island, Vermont, and Virgin Islands; 1 =Delaware, New York, and Pennsylvania; 2 = District of Columbia, Maryland, North Carolina, South Carolina, Virginia, and West Virginia; 3 = Alabama, Florida, Georgia, Mississippi, and Tennessee; 4 = Indiana …

Role of bone-anabolic agents in the treatment of breast cancer bone metastases.

Skeletal metastases are an incurable complication afflicting the majority of patients who die from advanced breast cancer. They are most often osteolytic, characterized by net bone destruction and suppressed new bone formation. Life expectancy from first diagnosis of breast cancer bone metastases is several years, during which time skeletal-related events - including pain, fracture, hypercalcemia, and spinal cord compression - significantly degrade quality of life. The bone marrow niche can also confer hormonal and chemo-resistance. Most treatments for skeletal metastases target bone-destroyin

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… Acknowledgements The authors’ work was supported by funds from the Veterans Administration and the Indiana University Simon Cancer Center and Department of Medicine. …

Oral Communication abstracts

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Рекомендации Международной группы по работе с миеломой по диагностике и лечению изолированных плазмоклеточных опухолей.

Одиночные плазмоклеточные опухоли (СП) — редкие локализованные опухоли клоновых плазмоклеток, либо в костной ткани (одиночная костная плазмоклеточная опухоль), либо в мягких тканях/экстраоссозных (экстромедуллярные) с отсутствием или минимальным проникновением в костный мозг (КМ) (<10% клоновых плазмоклеток по иммуногистохимии) и отсутствием признаков системного вовлечения или событий, определяющих миелому. Приблизительно 50% СП прогрессируют в симптоматическую миелому в течение 5 лет после начальной определенной локальной радиотерапии. Увеличение доступности улучшенных диагностических и монит

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… Yogesh Jethava, Indiana Blood and Marrow Transplant Institute, Indianapolis, IN 149. Dragan Jevremovic, Mayo Clinic, Rochester, MN 150. Cristina João, Fundação Champalimaud and Champalimaud Center For The Unknown, Lisboa, Portugal 151. … David Roodman, Indiana University, Indianapolis, IN 296. Sæmundur Rögnvaldsson, University of Iceland, Reykjavík, Iceland 297. Catherine Rosales, St. Luke's Medical Center, Metro Manila, Philippines 298. Laura Rosiñol, Hospital Clínic Barcelona, Barcelona, Spain 299. …

XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression.

Multiple myeloma bone disease (MMBD) is characterized by non-healing lytic bone lesions that persist even after a patient has achieved a hematologic remission. We previously reported that p62 (sequestosome-1) in bone marrow stromal cells (BMSC) is critical for the formation of MM-induced signaling complexes that mediate OB suppression. Importantly, XRK3F2, an inhibitor of the p62-ZZ domain, blunted MM-induced Runx2 suppression in vitro, and induced new bone formation and remodeling in the presence of tumor in vivo. Additionally, we reported that MM cells induce the formation of repressive chro

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… This study was carried out in accordance with the recommendations and protocol approvals by the University of Pittsburgh and Indiana University Institutional Review Boards (IRBs). All subjects gave written informed consent in accordance with the Declaration of Helsinki. …

Autophagy in tumor immune escape and immunotherapy.

The immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment; however, the challenge of immune resistance remains significant. Autophagy, a cellular response to various stressors, involves the degradation of damaged proteins and organelles via lysosomal pathways, maintaining cellular homeostasis. This process not only supports tumor cell survival but also profoundly impacts the efficacy of cancer immunotherapies. The modulation of autophagy in tumor cells or immune cells exerts dual effects on tumor immune escape and immunotherapy. However,

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… Imiquimod/GM-CSF UbiVac II 12 NCT03057340 NSCLC Dribble vaccine Second Affiliated Hospital, School of Medicine, Zhejiang University I 30 NCT02234921 Adenocarcinoma of the Prostate Cyclophosphamide + DRibble Vaccine + HPV Vaccine + Imiquimod UbiVac I 3 NCT00798135 Breast Neoplasms (Metastasis) Itraconazole Indiana … NCT03057340 | NSCLC | Dribble vaccine | Second Affiliated Hospital, School of Medicine, Zhejiang University | I | 30 NCT02234921 | Adenocarcinoma of the Prostate | Cyclophosphamide + DRibble Vaccine + HPV Vaccine + Imiquimod | UbiVac | I | 3 NCT00798135 | Breast Neoplasms (Metastasis) | Itraconazole | Indiana …

Ситуационное нарушение эритрополиса приводит к анемии у недавно диагностированных пациентов с несколькими миэлома.

Множественная миелома (ММ), связанная с анемией 60% Пациенты и коррелируют с плохими прогнозами. В то время как в большинстве исследований основное внимание уделяется воздействию микроокружающей среды на эритропоизис в ММ, дефекты эритроидных клеток и лежащие в их основе молекулярные механизмы по-прежнему характеризуются слабой спецификой. МЕТОД: Клинические данные были собраны 300 больные с недавно диагностированным множественным миелом (НДММ) и 300 здоровый контроль. Фенотипический и транскриптомный профили костного мозга на ранней и поздней стадии эритрополии были сопоставлены между здоровы

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… Edited by: Yann Gibert , Indiana University, Purdue University Indianapolis, United States Reviewed by: Michele Cea , University of Genoa, Italy Shalini Sharma , University of Arizona, United States Tao Guan , Shanxi Provincial Cancer Hospital, China Abbreviations: MM, multiple myeloma; NDMM, newly …

Тенденции в области смертности, связанной с множественной миеломой в Соединенных Штатах, 1999-2023.

Несмотря на значительные терапевтические достижения, большое число миелом (ММ) по-прежнему является важным фактором смертности от рака в Соединенных Штатах. Понимание долгосрочных моделей смертности имеет важное значение для разработки справедливых стратегий в области клинического и общественного здравоохранения. 1999-2023 для оценки связанных с MM смертей среди взрослых ≥25 Годы. Коэффициенты смертности, скорректированные с учетом возраста, рассчитывались на основе прямой стандартизации 2000 Население США. Временные тенденции были изучены с использованием регрессии &quot; Compoint &quot; для

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… 38 | 45 | 1002 | 18.42 | 4.73 (3.35 to 6.49) | 3.17 (2.30 to 4.27) | -0.86 (-1.67 to -0.04)* Idaho | 48 | 73 | 1407 | 52.08 | 6.45 (4.76 to 8.56) | 4.66 (3.64 to 5.88) | -0.84 (-1.68 to 0.01) Illinois | 487 | 407 | 11712 | -16.43 | 6.36 (5.79 to 6.92) | 3.96 (3.57 to 4.35) | -1.60 (-1.81 to -1.39)* Indiana …

The indignities of shielding during the COVID-19 pandemic for people with sickle cell disorders: an interpretative phenomenological analysis.

This article seeks to understand the first-hand experiences of people with sickle cell, a recessively inherited blood disorder, who were identified as clinically extremely vulnerable during the COVID-19 pandemic. Part of a larger sequential mixed-methods study, this article uses a selective sample of eight qualitative semi-structured interviews, which were analysed using interpretative phenomenological analysis (IPA). The first stage of IPA focused on practical concerns participants had correlated to understanding shielding and their feelings about being identified as clinically extremely vuln

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… Bloomington, IN: Indiana University Press. Kafer A. (2021). After crip, crip afters. South Atl. Q. 120, 415–434. doi: 10.1215/00382876-8916158 Kavanagh P. L., Fasipe T. A., Wun T. (2022). Sickle cell disease: a review. JAMA 328, 57–68. doi: 10.1001/jama.2022.10233, PMID: Kemp O., Horne G. …

Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration.

Low-magnitude (≤1 g) high-frequency (≥30 Hz) (LMHF) vibration has been shown to enhance bone mineral density. However, its regulation in breast cancer bone metastasis remains controversial for breast cancer patients and elder populations. Yoda1, an activator of the mechanosensitive Piezo1 channel, could potentially intensify the effect of LMHF vibration by enhancing the mechanoresponse of osteocytes, the major mechanosensory bone cells with high expression of Piezo1. In this study, we treated osteocytes with mono- (Yoda1 only or vibration only) or combined treatment (Yoda1 and LMHF vibration)

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… Bonewald, Indiana University) is a murine osteocyte-like cell line. …

Circulating biomarkers in diagnosis and management of cardiac amyloidosis: a review for internist.

Cardiac amyloidosis (CA) is due to extracellular myocardial deposition of misfolded proteins resulting in severe cardiac dysfunction and death. The precursors of amyloid fibrils, able of determining a relevant cardiac infiltration, are immunoglobulin-free light chains (AL amyloidosis) and transthyretin (TTR) (both wild and mutated types). The diagnosis of amyloidosis represents a challenge for the clinician given its rarity and its protean clinical presentation, thus an early diagnosis remains a cornerstone for the prognosis of these patients, also in light of the growing available treatments.

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… prognostic systems for ATTR cardiac amyloidosis ATTRwt transthyretin wild-type-related amyloidosis, ATTRv heredo-familial transthyretin-related amyloidosis, NT-proBNP N-Terminal pro-brain natriuretic peptide, cTnT cardiac troponin T (sensitive second-generation assay, Roche Diagnostics, Indianapolis, Indiana …

Treatment effects of human amnion-derived mesenchymal stem cells for skin lesions and metastatic pulmonary calcification in calciphylaxis patients - case series and literature review.

BACKGROUND: Calciphylaxis, also termed calcific uremic arteriolopathy (CUA) in patients with end-stage kidney disease (ESKD), is a rare and fatal condition characterized by cutaneous ischemic necrosis. METHODS: Three patients with calciphylaxis and metastatic pulmonary calcification (MPC) were treated with human amnion-derived mesenchymal stem cells (hAMSCs). Effects were evaluated using the Visual Analogue Scale (VAS), modified Bates-Jensen Wound Assessment Tool for CUA (BWAT-CUA), wound quality of life questionnaire (Wound-QoL), and histological analysis. MPC was assessed by high-resolution

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… A 0.014’ wire (Boston Scientific, Marlborough, MA) was used to cross the lesions with the assistance of a 3-Fr multipurpose support-catheter (Cook Medical, Bloomington, Indiana). …