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First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis.

Predicting long-term prognosis and choosing the appropriate therapeutic approach in patients with Multiple Sclerosis (MS) at the time of diagnosis is crucial in view of a personalized medicine. We investigated the impact of early therapeutic response on the 5-year prognosis of patients with relapsing-remitting MS (RRMS). We recruited patients from MSBase Registry covering the period between 1996 and 2022. All patients were diagnosed with RRMS and actively followed-up for at least 5 years to explore the following outcomes: clinical relapses, confirmed disability worsening (CDW) and improvement

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… 2.8) Lebanon 156 (2.0) 72 (1.9) United States 153 (1.9) 35 (0.9) Switzerland 141 (1.8) 14 (0.4) Egypt 92 (1.2) 1 (0.0) Argentina 86 (1.1) 35 (0.9) United Kingdom 73 (0.9) 18 (0.5) Tunisia 67 (0.8) 19 (0.5) Ireland 61 (0.8) 1 (0.0) Croatia 54 (0.7) 0 (0.0) Brazil 51 (0.6) 40 (1.1) UAE 47 (0.6) 0 (0.0) Oman … Hospitalar Universitario de Sao Joao, Porto, Portugal), Bruce Taylor (Royal Hobart Hospital, Hobart, Australia), Orla Gray (South Eastern HSC Trust, Belfast, United Kingdom), Pamela McCombe (Royal Brisbane and Women's Hospital, Brisbane, Australia), Abdullah Al-Asmi (Sultan Qaboos University, Al-Khodh, Oman …

Characteristics and outcomes of Bahraini pediatric patients sent abroad for bone marrow transplantation: A ten-year retrospective cohort study.

BackgroundBone marrow transplantation (BMT) is a breakthrough procedure for patients with hematological and oncological conditions, particularly when all other treatments fail. Its indications vary between patients and settings, and its outcomes depend on the donor type, transplantation facility, and center expertise. In countries where transplantation facilities are lacking, sending patients abroad for transplantation might be a safe and effective alternative to leaving the patient to face eventual disease morbidity or even mortality if the procedure is not performed locally. However, studies

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… Similarly, a study from Oman conducted by Dennison et al [ 30 ] also showed a predominance of patients undergoing primary allogeneic BMT, but with a higher percentage of 97%. … Hematopoietic stem cell transplantation in Oman. Bone Marrow Transplant. 2008;42 Suppl 1:S109–S113. doi: 10.1038/bmt.2008.131. 31. …

Evaluation of Neurosurgery Consultations in Hospitalized Geriatric Patients During and After the COVID-19 Pandemic.

Background and Objectives: This study aims to evaluate neurosurgery consultations for elderly patients during and following the COVID-19 pandemic. Materials and Methods: This study included patients aged 65 and older who were hospitalized in non-neurosurgery departments at Istinye University Gaziosmanpasa Medical Park Hospital and were referred for neurosurgery consultations between 1 April 2020 and 31 May 2024. Patients in the intensive care unit and emergency department were excluded. The period from 1 April 2020 to 30 April 2022 was defined as the pandemic period, and from 1 May 2022 to 31

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… A study in Oman reported that one-third of geriatric neurosurgery patients had trauma-related conditions [ 1 ]. … Geriatric neurosurgery in high-income developing countries: A Sultanate of Oman experience Psychiatry Int. 2022 3 264 272 10.3390/psychiatryint3040021 2. …

A year in pharmacology: new drugs approved by the US food and drug administration in 2025.

The US Food and Drug Administration approved 45 new drugs and 4 new cellular and gene therapy products in 2025, that is, a total of 49 new medical therapies. Oncology, hematology/immunotherapy, and cardiovascular/respiratory drugs remain most frequent. Among oncology drugs, there is a trend for targeting ever smaller subtypes of malignancies and/or rarer malignancies. Trends over the past 6 years include steady levels of first-in-indication (about 10%), first-in-class (about 38%), and next-in-class (about 51%) approvals. Along with a large share of approvals in orphan indications (> 50%), fast

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… Orally administered gepotidacin demonstrated efficacy comparable to or greater than nitrofurantoin, with generally mild to moderate AEs, most commonly diarrhea and nausea (Scangarella-Oman et al. 2025 ; Wagenlehner et al. 2025 ). … Br J Haematol 185:647–655. 10.1111/bjh.15831 Ross JDC, Wilson J, Workowski KA, Taylor SN, Lewis DA, Gatsi S, Flight W, Scangarella-Oman NE, Jakielaszek C, Lythgoe D, Powell M, Janmohamed S, Absalon J, Perry C (2025) Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): …

An update review on Commiphora molmol and related species.

The origins of myrrh and frankincense are traced to the Arabian Peninsula. According to Herodotus (5th century BC): "Arabia is the only coun … ys and later by camel caravans, reached Jerusalem and Egypt from the Dhofar region of what is today Oman, through Yemen, turning north to follow the Red Sea coast. It is likely that the same or similar species of the resin-bearing plants grew across the Red Sea in the area that is now Somalia and Ethiopia, while the collection of the gum resins was ini …

Decision-making by cancer patients and the role of a counselling facility for complementary and alternative medicine: a cohort study.

ObjectiveThe aim of this cohort study was to gain insight on influencing factors on the decision-making process in conventional medicine compared to complementary and alternative medicine (CAM).MethodsA standardized questionnaire was distributed among cancer patients who attended the counselling facility for CAM of a German university hospital in 2020.ResultsFifty patients (30.3%) returned the questionnaire. After counselling on CAM, most patients made a decision in CAM but also in conventional medicine. Thus, the focus on informed decision-making during counselling on CAM had a strong effect

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… Psychol Bull 112:155–159. 10.1037//0033-2909.112.1.155 19565683 10.1037//0033-2909.112.1.155 Dehkordi A Heydarnejad MS Fatehi D Quality of life in cancer patients undergoing chemotherapy Oman Med J 2009 24 204 207 10.5001/omj.2009.40 22224186 PMC3251183 Dehkordi A, Heydarnejad MS, Fatehi D (2009) Quality … Oman Med J 24:204–207. 10.5001/omj.2009.40 22224186 10.5001/omj.2009.40 PMC3251183 Efficace F Gaidano G Sprangers M Cottone F Breccia M Voso MT Caocci G Stauder R Di Tucci AA Sanpaolo G Selleslag D Angelucci E Platzbecker U Mandelli F Preference for involvement in treatment decisions and request for …

Bilateral Knee Effusions Secondary to Zoledronic Acid Infusion.

Intravenous zoledronic acid is an established and generally well tolerated form of antiresorptive therapy for osteoporosis. Although mild arthralgias are a well-documented manifestation of the acute phase response to intravenous bisphosphonates, more severe musculoskeletal reactions manifesting as debilitating pain and joint effusions have been rarely documented in the current literature. In this case report, we discuss the case of a 55-year-old woman who developed severe painful bilateral knee effusions within 1 week of her first zoledronic acid infusion for osteoporosis. Prescribing physicia…

Global, regional, and national burden of 34 cancer groups across 204 countries and territories, 1990-2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021.

IntroductionDetailed, comprehensive, and timely reporting on cancer incidence, mortality, and associated burdens is essential for understanding the evolving trends of this complex disease. This study aims to evaluate the burdens of 34 types of cancer across 204 countries and territories from 1990 to 2021, incorporating the latest epidemiological data to provide a framework for policy discussions, resource allocation, and research prioritization.MethodsUsing data from the Global Burden of Disease (GBD) 2021 study, we analyzed 34 cancer types across 204 countries from 1990 to 2021, stratifying b

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… For instance, Mongolia had the highest ASMR at 214.7, while Oman reported the lowest at 44.1. The USA, Monaco, and New Zealand recorded the highest ASIR and ASPR values, with the USA leading in both categories. … ASDRs were most severe in Mongolia (5526.0) and Zimbabwe (5381.8), while the lowest were found in Oman (1095.5) and Maldives (1146.9). …

Rare Loxoscelism-Associated IgG Coombs-Positive Hemolytic Anemia Treated Successfully With Systemic Corticosteroids.

Loxoscelism-associated hemolytic anemia is a rare but critical complication of brown recluse spider bites. It may lead to various systemic manifestations, including jaundice, dark urine, and anemia-related symptoms, in addition to general loxoscelism symptoms such as skin lesions, fever, myalgia, nausea, and vomiting. Prompt diagnosis is crucial and requires recognizing typical laboratory findings such as low hemoglobin, elevated lactate dehydrogenase, reduced haptoglobin levels, and possibly a positive direct antiglobulin test. There is no definitive guideline for the treatment of loxoscelism

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… Oman Med J. 2007;22:62–63. 14. Loxoscelism: cutaneous and hematologic manifestations. Nguyen N, Pandey M. Adv Hematol. 2019;2019:4091278. doi: 10.1155/2019/4091278. 15. Cutaneous-hemolytic loxoscelism following brown recluse spider envenomation: new understandings. …

Burden of Disease, Treatment Patterns, and Healthcare Resource Utilization in Multiple Myeloma in the Middle East and North Africa Region: A Targeted Literature Review.

Globally, the multiple myeloma (MM) landscape varies widely, with incidence, treatment patterns, outcomes, and healthcare resource utilization (HCRU) differing across countries and regions. Many factors contribute to these differences, including ethnicity, awareness, and socioeconomic influences. This is the first analysis aiming to explore factors associated with myeloma incidence and patient characteristics in the Middle East and North Africa (MENA) region. A literature search was conducted using PubMed and Embase from 1 January 2015 to 30 May 2025. Articles reporting outcomes of interest in

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… region. a Age-standardized incidence rate reported by geography and sex, where reported [ 7 , 19 – 23 ]; b age distribution of MM cases in Saudi Arabia reported in 2022 [ 24 ]. a MENA encompasses the countries of Afghanistan, Algeria, Bahrain, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman … In a study examining the financial burden of MM in the Gulf region (Saudi Arabia, Kuwait, the UAE, Qatar, and Oman), the weighted average annual direct cost per patient was US $125,000–372,000; patients with RRMM incurred greater individual costs than those with NDMM [ 85 ]. …

Дискриминативная ассимиляция магического и ретинального нерва, толщина слоя в множестве склероза и оптического нерита.

ЦЕЛЬ: Определение дискриминативных способностей макулярного и сетчатого слоя нервно-паралитического волокна (RNFL) в множестве склероза (MS) по сравнению с нормальным и выявление оптического неврита (ON) у пациентов, страдающих НР. МЕТОДЫ: Это межсекторальное исследование по вопросам контроля за конкретными случаями включало в себя 133 Возрастной состав участников 30-45 годы: 66 Определённые пациенты MS18 ) и 67 :: контроль за состоянием здоровья в зависимости от возраста и пола. Был установлен диагноз MS ≥5 За годы до поступления в школу. К числу критериев исключения относятся другие невролог

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… 90.5 | 83 | - Bock et al. , 2010 31 | Germany | 20–59 | Stratus OCT | - | 97 | 86.2 | 105.2 Talebi et al. , 2013 25 | Northern Iran | 22–54 | Stratus OCT | 88.25 | 93.01 | 83.01 | 100.7 Abalo-Lojo et al. , 2018 32 | Spain | 25–64 | Cirrus HD-OCT | - | 90 | 74.2 | 96.8 Al-Mujaini et al. , 2021 26 | Oman … tomography findings in relapsing-remitting multiple sclerosis patients of the Northwest of Iran Iran J Neurol 2013 12 81 6 24250910 PMC3829296 26 Al-Mujaini AS Al-Mujaini MS Sabt BI Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: A four-year follow-up study from Oman …

Juvenile-onset Systemic Lupus Erythematosus: Recent Advances in Pathogenesis and Treatment.

PURPOSE OF REVIEW: This review summarizes recent advances in understanding the pathogenesis and therapeutic landscape of juvenile-onset systemic lupus erythematosus (jSLE), with a focus on how emerging genetic and immunologic insights inform patient stratification, targeted treatments, and Treat-to-Target (T2T) approaches in pediatric care. RECENT FINDINGS: Studies of (ultra-)rare gene variants (e.g., affecting TLR7, UNC93B1, PLD4, PTPN2, BACH2) aided in understanding key pathogenic pathways, and allowed linking these to associated clinical phenotypes. Multi-ancestral genomic studies and cumu

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… Laboratory tests revealed hypocomplementemia, anti-C1q antibodies, and ANCA positivity. [ 24 ] DNASE1L3 c.643delT/p.Trp215GlyfsX2 (homozygous) Arabic from Oman 15 families: The monogenic lupus cohort showed a young age at onset (mostly before 5 years). … IKZF2 c.1536T >G/p.Tyr512Ter (heterozygous) Arabic from Oman 2 siblings, one had jSLE (boy), the other had primary anti-phospholipid syndrome (girl). 5 remaining siblings are carriers with no symptoms. …

Бремя множественной миеломы в азиатских странах 1990 в адрес 2021 и прогнозирование тенденций 2050:: анализ, основанный на Глобальном исследовании бремени болезней 2021.

Множественная миелома (ММ) создает растущую угрозу для здоровья населения во всем мире, причем региональные различия в бремени болезней становятся все более заметными. Являясь самым густонаселенным континентом, Азия переживает быстрые демографические и социально-экономические изменения и играет решающую роль в формировании эволюционной траектории глобального бремени ММ. Цель этого исследования заключается в оценке бремени болезней, связанных с множественной миеломой в азиатских странах. 1990 в адрес 2021Данные этого исследования были получены на основе исследования глобального бремени болезней

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… West Asia comprises Türkiye, the Islamic Republic of Iran, Iraq, Saudi Arabia, Yemen, Oman, the United Arab Emirates, Qatar, Kuwait, Bahrain, Lebanon, Jordan, the Syrian Arab Republic, Palestine, Israel, Cyprus, Armenia, Azerbaijan, and Georgia. … 26.09–55.09] | 444.86 [324.18–602.48] | 45.96 [33.7–62.25] | 0.3 [0.11– 0.49] Palestine | 2.84 [1.68–4.14] | 31.24 [18.68–44.99] | 10.35 [6.02–13.67] | 37.18 [21.86–49.08] | 0.59 [0.53– 0.64] Bahrain | 0.75 [0.55–1.07] | 38.74 [28.86–55.51] | 4.23 [2.4–6.28] | 41.25 [24.46–57.9] | –0.02 [–0.18 to 0.14] Oman …

Case Report: Management of Primary Tracheobronchial Light Chain Amyloidosis in a Patient With Biclonal Gammopathy Using a Systemic Bortezomib-Based Regimen.

Primary tracheobronchial light chain (AL) amyloidosis is a rare and heterogeneous disease characterized by the buildup of amyloid deposits in the airway mucosa. Although its treatment remains challenging, the current view is that the localized form can be treated conservatively due to its slow progression. While radiotherapy has proven effective in treating localized form of the disease, some patients do not respond to local treatment and continue to experience poor quality of life, highlighting the need to explore additional treatment strategies. In this report, we discuss a case of primary t

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… Oman Med J. (2015) 30:216–8. 10.5001/omj.2015.45 7. Thomas VE, Smith J, Benson MD, Dasgupta NR. Amyloidosis: diagnosis and new therapies for a misunderstood and misdiagnosed disease. Neurodegener Dis Manag. (2019) 9:289–99. 10.2217/nmt-2019-0020 8. …

A comprehensive economic assessment of the burden of obesity in Kuwait.

BackgroundObesity is a complex public health issue that has risen to epidemic proportions globally. The aim of this study was to estimate the economic costs associated with obesity from governmental and societal perspectives in the State of Kuwait in 2024.MethodsA disease-specific prevalence-based cost-of-illness framework was applied. Key parameters include prevalence of obesity and its related comorbidities, relative risks, healthcare resources, income rate and growth, and lost workdays for patients and relatives, all were derived from literature. The outcomes measured were total healthcare

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… The hierarchy for cost data collection prioritized Kuwaiti data, then expanded to other GCC countries—Bahrain, Oman, Qatar, Saudi Arabia, and the United Arab Emirates—due to their socioeconomic and cultural similarities, comparable disease profiles (especially for obesity-related conditions), and similar … The prevalence of online food delivery service usage and its association with anthropometric measurements in Muscat, Oman; a cross-sectional study . Prev Med Rep . 2025 ; 50 : 102966 . doi: 10.1016/j.pmedr.2025.102966 40007952 PMC11852691 9 Shaban L , Alkazemi D . …

Use of Herbal Medicine Is Associated With Late-Stage Presentation in Tanzanian Patients With Cancer: A Survey to Assess the Utilization of and Reasons for the Use of Herbal Medicine.

PurposeIn Tanzania, patients with cancer present late with advanced stages. Among other reasons, the use of herbal medicine (HM) might contribute to delay in diagnosis and treatment. This study aims to understand the utilization of HM and the reasons for its' use.MethodsA semistructured 30-item questionnaire with closed- and open-ended questions was applied to a cohort of patients with cancer at Kilimanjaro Christian Medical Centre. Content analysis was performed for answers to open-ended questions.ResultsThree hundred two patients were interviewed, 50.9% males and 49.1% females. The mean age

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… Broom A Nayar K Tovey P et al Indian cancer patients' use of traditional, complementary and alternative medicine (TCAM) and delays in presentation to hospital Oman Med J 24 99 – 102 2009 10.5001/omj.2009.24 PMC3273946 22334854 21. …

Ультрафиолетовое излучение и нейродегенерация: молекулярные механизмы, лежащие в основе двойного нейрозащитного и нейротоксичного воздействия.

Ультрафиолетовое излучение имеет сложную, зачастую противоречивую связь с риском/прогрессом нейродегенерации, охватывающую клинически диагностированные заболевания [Заболевания Паркинсона (PD), болезни Альцгеймера (AD), множественный склероз (MS) и амиотропический боковой склероз (ALS)] или промежуточные фенотипы (уменьшенный нейрогенесис, потеря гиппокампального объема). Цель этого обзора заключается в выявлении двойного воздействия УФ-излучения путем сбора и обобщения экспериментальных (доклинических и переводческих) данных, а также эпидемиологических данных. Нынешняя литература демонстрируе

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… However, since it is entirely absorbed within the ozone layer, it is not an important area for research for this particular study ( Oman, 2022 ). … Brain Res. 37 201–208. 10.1016/0169-328x(95)00315-j Oman L. (2022). Why do We Care About Atmospheric Ozone?. Geneva: World Meteorological Organization Orii K., Lee Y., Kondo N., McKinnon P. (2006). …

Navigating the Diagnostic and Management Challenges of Suspected Cardiac Amyloidosis in Resource-Limited Settings: Ethiopia Experience.

This report discusses the diagnostic and therapeutic complexities encountered in resource-limited environments when assessing patients suspected of cardiac amyloidosis (CA). The study describes a case involving a patient who initially presented with heart failure symptoms and eventually received a CA diagnosis after 13 months and four primary physician visits, primarily based on discrepancies observed between electrocardiographic and echocardiographic findings, alongside elevated cardiac troponin levels. The case underscores the limited awareness of CA among primary healthcare providers in Eth

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… Major knowledge gaps were identified in different surveys among primary care providers in the United States and practicing cardiologists in the United Arab Emirates, Kuwait, Bahrain, Qatar, Oman, and Romania and health care providers in Egypt that range from lack of awareness among health care providers …

Autologous hematopoietic stem cell transplant at a tertiary care centre in India: achieving comparable outcomes with adaptations.

Autologous stem cell transplantation (ASCT) is the standard treatment for many high-risk solid tumors. Patients undergoing ASCT should be managed in a dedicated hematopoietic stem cell transplantation (HSCT) unit with isolation rooms, high-efficiency particulate air (HEPA) filters, and positive pressure. We report the outcomes of the first 20 pediatric patients who underwent ASCT in isolation rooms with no HEPA filters or positive pressure. Moreover, the isolation rooms were not part of a dedicated HSCT unit. Data from 20 patients were analyzed. All patients included in the study underwent ASC

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… Oman Med J. 2019; 34: 34-43. 25. Jain R, Hans R, Totadri S, Trehan A, Sharma RR, Menon P, et al. Autologous stem cell transplant for high-risk neuroblastoma: Achieving cure with low-cost adaptations. Pediatr Blood Cancer. 2020; 67: e28273. …

Abstracts from the 13th International Conference for Healthcare and Medical Students (ICHAMS).

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