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The efficacy and safety of ketorolac for postoperative pain management in lumbar spine surgery: a meta-analysis of randomized controlled trials.

BACKGROUND: Ketorolac is widely utilized for postoperative pain management, including back pain after lumbar spinal surgery. Several trials have assessed the efficacy of Ketorolac alone and in combination with other analgesics such as bupivacaine, morphine, epinephrine, paracetamol, and pregabalin. However, the effects and safety profile of ketorolac in these contexts remain controversial. OBJECTIVE: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of Ketorolac administration, both as a monotherapy and in combination…

Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study.

BACKGROUND: Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying w … d dose accordingly. Future research should investigate whether a similar interaction exists between pregabalin and opioids.

Elucidation of pathophysiology and treatment of neuropathic pain.

Neuropathic pain, pain arising as a direct consequence of a lesion or disease affecting the somatosensory system, is relatively common, occu … ide effects. In patients with a history of cardiovascular disorders, glaucoma, and urine retention, pregabalin and gabapentine are emerging as first-line treatment for neuropathic pain. In addition these anti-epileptic drugs have a favourable safety profile with minimal concerns regarding drug interactions and showing no interference with hepatic enzymes. Al …

[Mechanism of Spatholobi Caulis in inhibiting microglial activation to intervene neuropathic pain through TLR4/MyD88/NF-κB signaling].

Based on network pharmacology and molecular docking combined with animal experimental validation, this study aims to explore the mechanism o … , high-dose, medium-dose, and low-dose groups of Spatholobi Caulis, and a positive control group of Pregabalin, with eight rats in each group. The NP model was established by chronic constriction injury(CCI) to the sciatic nerve of rats in all groups except the sham group in which only the sciatic nerve was exposed without ligation. Dosing was initiated afte …

Is mannitol the treatment of choice for patients with ciguatera fish poisoning?

CONTEXT: Ciguatera fish poisoning arises primarily from consumption of carnivorous reef fish caught in tropical and sub-tropical waters. Cig … hree overlapping case series that describe using amitriptyline, fluoxetine, duloxetine, gabapentin, pregabalin, or tocainide. For each of these, a long duration of treatment appears to be necessary to maintain symptomatic improvement. None of these treatments has been shown to be superior to mannitol. CONCLUSIONS: It is reasonable to consider using intraven …

A look back at the most influential drug approvals of 2005.

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Лекарства для борьбы с центральной нервной болью в результате лежащих в ее основе условий - систематический обзор.

В ходе этого систематического обзора была проведена оценка нынешней литературы, касающейся анальгетического лечения центральной нейропотической боли (КНБ) в условиях центральной нервной системы (КНС), таких, как повреждения спинного мозга, множественный склероз, посттравматические расстройства и болезнь Паркинсона. Цель этого систематического обзора заключалась в сопоставлении нынешнего алгоритмического подхода к УНП, который, как правило, не носит дискриминационного характера между основополагающими условиями, с тем, чтобы РСТ изучали рекомендованные алгоритмом и нерекомендуемые лекарственные

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… 28 VAS, 0–10 NPS, 0–10 VAS, both drugs compared from baseline to 8 weeks, p < 0.001 * Pregabalin, pain reduction compared to gabapentin at 4 weeks, p = 0.045 * Pregabalin, pain reduction compared to gabapentin at 8 weeks, p > 0.05 NPS pregabalin compared to gabapentin, p > 0.05 VAS, 0–4–8 week: … Gabapentin: 7.78 ± 1.27, 4.36 ± 1.30 (−43.96%), 3.57 ± 1.21 (−54.11%) Pregabalin: 8.05 ± 1.26, 3.68 ± 1.15 (−54.29%), 3.36 ± 1.11 (−58.26%) NPS “Pain intensity” 0–8 week: Gabapentin: 52.1% ± 18.1 Pregabalin: 54.5% ± 17.8 Poor Kumru et al., 2018 [ 39 ] SCI Baclofen 13 NRS, 0–10 NPSI, 0–10 BPI, …

Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China: A Retrospective, Database, Multicenter Study (ReTARdant) Protocol.

IntroductionNeuropathic pain (NP), including diabetic peripheral neuropathic pain (DPNP) and chemotherapy-induced peripheral neuropathy (CIPN) as common subtypes, imposes a significant clinical burden on patients, severely affecting their quality of life. The real-world evidence on demographic characteristics, treatment patterns, and adherence data of DPNP and CIPN is still limited.MethodsA multicenter, retrospective, observational study using electronic medical record (EMR) systems involving approximately 600 patients with DPNP and 400 with CIPN from nine hospitals was planned. The study peri

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… Pregabalin was found to be the most preferred, and opioids were the least used analgesic in China. … In a head-to-head comparison of dosing patterns of duloxetine and pregabalin, the mean initial daily dose was 54.3 mg for duloxetine and 171.8 mg for pregabalin. …

Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia.

BACKGROUND: Duloxetine is a balanced serotonin and noradrenaline reuptake inhibitor licensed for the treatment of major depressive disorders … .Improved direct comparisons of duloxetine with other antidepressants and with other drugs, such as pregabalin, that have already been shown to be efficacious in neuropathic pain would be appropriate. Unbiased economic comparisons would further help decision making, but no high quality study includes economic data.

Neuromodulators for pain management in rheumatoid arthritis.

BACKGROUND: Pain management is a high priority for patients with rheumatoid arthritis (RA). Despite deficiencies in research data, neuromodulators have gained widespread clinical acceptance as adjuvants in the management of patients with chronic musculoskeletal pain. OBJECTIVES: The aim of this review was to determine the efficacy and safety of neuromodulators in pain management in patients with RA. Neuromodulators included in this review were anticonvulsants (gabapentin, pregabalin, phenytoin, sodium valproate, lamotrigine, carbamazepine, levetiracetam, oxcarbazepine, tiagabine and topiramat…

Treatment of neuropathic pain in cancer survivors: a scoping review of pharmacological, exercise, and psychosocial interventions.

Background and purposeNeuropathic pain is a debilitating late effect among cancer survivors. This scoping review aims to provide an overview of pharmacological, psychological, and exercise interventions for neuropathic pain among cancer survivors and to identify further relevant research areas. Patient/material and methods: PubMed, PsychInfo, and EMBASE were systematically searched for studies published from January 2004 to January 2026 and abstract and full text screening was carried out. The target population was cancer survivors who had completed primary treatment and have no active disease

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… Pregabalin had more adverse effects than duloxetine [ 28 ]. … In the double-blind crossover study by Hincker et al., ( n = 26) they found no significant difference between pregabalin and placebo after 28 days in reduction of average daily pain intensity (22.5% [pregabalin] vs. 10.7% [placebo], p = 0.23) or worst pain (29.2% [pregabalin] vs. 16.0% [placebo], p = …

Опиоидная токсичность связана с Тирзепатидом у пациента с хроническим оральным морфином.

Тирзепатид, двойной глюкозно-зависимый несулинотропический полипептид/глукагон-подобный peptide-1 (В тыс.GLP-1) рецептор агонист, задерживает опорожнение желудка и может изменить фармакокинетические препараты, используемые совместно для лечения пероральных заболеваний, в частности те, которые имеют узкие терапевтические показатели. Мы сообщаем о первом случае опасной для жизни опиоидной токсичности, вызванной началом тирцепатида у пациента при хронической пероральной устойчивой терапии. A 53-year-old человек с первичным прогрессивным множественным склерозом, осложненным квадриплегией, поддержи

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… Pregabalin is of particular pharmacokinetic concern because it is predominantly renally excreted unchanged; therefore, the same AKI that impaired M6G clearance would also reduce pregabalin clearance and increase its plasma concentrations [ 12 ]. … This was clinically recognized by the admitting team, who reduced pregabalin from 100 mg to 50 mg four times daily at admission alongside morphine reduction. …

Антиконвульсантная терапия в тригеминальной невралгии: системный обзор класса.

Фон/цели Trigemenal Neuralgia (TN) — хроническое нервное заболевание, характеризующееся внезапной, сильной болью в лице. Антиконвульсанты являются краеугольным камнем фармакологического управления, однако сравнительных данных, основанных на фармакологическом классе, по-прежнему недостаточно. Этот систематический обзор был направлен на оценку эффективности и безопасности антиконвульсантов в TN, стратифицированных их механизмом действий. 2020 Руководящие принципы. Исследования с использованием фармакологического подхода, включая пациентов с ТН, опубликованные на английском языке с тех пор 2000,

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… Gabapentin (GBP) and pregabalin are being used more frequently, especially for patients with coexisting neuropathic pain conditions. … Moreover, both GBP and pregabalin are especially useful in patients with prominent continuous pain or in those unable to tolerate first-line agents [ 40 , 41 , 42 ]. …

Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.

INTRODUCTION: This guideline establishes clinical practice recommendations for treatment of restless legs syndrome (RLS) and periodic limb m … moderate certainty of evidence). UNLABELLED: 3. In adults with RLS, the AASM recommends the use of pregabalin over no pregabalin (strong recommendation, moderate certainty of evidence). UNLABELLED: 4. In adults with RLS, the AASM recommends the use of IV ferric carboxymaltose over no IV ferric carboxymaltose in patients with appropriate iron status (see go …

Последние достижения в лечении и профилактике периферической нейропатии после многократного лечения миеломы.

Заболеваемость множественной миеломой (ММ) из года в год увеличивается, и для контроля за состоянием требуется химиотерапия. С появлением новых протеиновых ингибиторов, иммуномодуляторов и моноклональных антител, прогнозы пациентов значительно улучшились. Однако периферическая нейропатия, вызванная лекарственными препаратами, ограничивает дозу и продолжительность лечения, что серьезно сказывается на качестве жизни пациентов и результатах лечения. Несмотря на то, что нейропатии, вызванные химиотерапией, привлекли к себе большое внимание, их механизм и эффективные профилактические и лечебные мер

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… Gabapentin and pregabalin In clinical practice, gabapentin and pregabalin are the most commonly used drugs for the management of PN symptoms in patients with MM. MM patients with symptoms of sensory allergy, tingling, or even mild pain benefited from the gabapentin trial. … and neurological impairment. 36 Patients who do not respond well to gabapentin may be significantly improved clinically by switching to pregabalin. …

Indian Society for Study of Pain, Cancer Pain Special Interest Group Guidelines on Pharmacological Management of Cancer Pain (Part III).

The Indian Society for Study of Pain (ISSP), Cancer Pain Special Interest Group, guidelines on pharmacological management of cancer pain in adults provide a structured, step-wise approach which will help to improve the management of cancer pain and to provide patients with a minimally acceptable quality of life. The guidelines have been developed based on the available literature and evidence, to suit the needs, patient population, and situations in India. A questionnaire based on the key elements of each sub draft addressing certain inconclusive areas where evidence was lacking, was made avai

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… Pregabalin exhibits an additional anxiolytic activity. … The percentages of patients requiring morphine at the last visit were 56.7% (amitriptyline), 33.3% (gabapentin), 16.7% (pregabalin), and 100% (placebo).[ 14 ] Number needed to treat (NNT) for pregabalin[ 13 ] is 7.7, while number needed to treat to harm (NNH) is 13.9. …

Clinical Characteristics of Neuropathic Pain and Its Relationship with Cancer in Different Corporal Areas-A Systematic Review.

Background: Neuropathic pain (NP) and cancer are caused by nerve damage due to cancer or treatments such as chemotherapy, radiotherapy, and surgery, with a prevalence that can reach up to 40%. Causes of neuropathic cancer pain (NCP) include direct nerve invasion or compression by the tumor, as well as neural toxicity associated with treatments. This type of pain is classified into several categories, such as plexopathy, radiculopathy, and peripheral neuropathies. Methods: Medline, Web of Science, Google Scholar, CINAHL, and LILACS databases were searched until October 2024. Two authors indepen

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… In the study by Jiang [ 27 ], pregabalin exhibited a significant reduction in pain scores on the Numeric Rating Scale (NRS) compared to the placebo group. … TENOR collaborative study group Post hoc analysis of pregabalin vs. non-pregabalin treatment in patients with cancer-related neuropathic pain: Better pain relief, sleep and physical health Clin. Transl. Oncol. 2011 13 656 663 10.1007/s12094-011-0711-0 21865137 49. Coffeen U. Sotomayor-Sobrino M.A. …

Gabapentinoids and unexplained death in general practice: Case series and feasibility study arising from a critical incident.

BACKGROUND: Prescribing epidemiology in general practice shows gabapentinoid drugs to be independently associated with unexpected, drug-related death. There is an increasing trend of gabapentinoid deaths throughout Europe and North America. OBJECTIVES: The overall aim of this study was to assess how patient, practice and health system factors might be associated with gabapentinoid prescribing in primary care. METHODS: Case series following a critical incident of an unexpected death in a patient prescribed a gabapentinoid drug in a single general practice. Unexpected and expected deaths in pa

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… | 11 | Pregabalin 100 mg | Osteoporosis pain | Rheumatology Yes | Yes | No | No | No | Pancreatic Cancer 22 | 80–89 | F | 7 | 12 | Pregabalin 225 mg | Sciatica | Endocrinology Yes | No | Buprenorphine | No | No | Old age 23 | 30–39 | M | 2 | 14 | Pregabalin 150 mg BD | Unclear | Unclear | Unclear | … All present in urine with pregabalin identified additionally. …

Melatonin for preoperative and postoperative anxiety in adults.

BACKGROUND: Anxiety in relation to surgery is a well-known problem. Melatonin offers an alternative treatment to benzodiazepines for amelior … tudy with oxazepam). Other comparators in a small number of studies were gabapentin, clonidine, and pregabalin. No studies were judged to be at low risk of bias for all domains. Most studies were judged to be at unclear risk of bias overall. Eight studies were judged to be at high risk of bias in one or more domain, and thus, to be at high risk of bias overa …

Drug-induced herpes zoster: a pharmacovigilance analysis of FDA adverse event reports from 2004 to 2024.

BACKGROUND: Herpes zoster severely impacts patients' quality of life and therapeutic results. This research utilized data from the FDA Adverse Event Reporting System (FAERS) to examine the prevalence and attributes of drug-induced herpes zoster. METHODS: We analyzed FAERS reports about zoster from Q1 2004 to Q3 2024 and developed a list of possible pathogenic agents. Ranked the 30 medicines with the greatest incidence of reported herpes zoster cases. Statistical disproportionality analysis was employed to identify an elevated reporting frequency of herpes zoster linked to a particular medicat

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… Pregabalin, a γ-aminobutyric acid analog, is commonly used to treat neuropathic pain, epilepsy, and generalized anxiety disorder. … However, pregabalin’s analgesic effect may mask the early symptoms of herpes zoster, delaying diagnosis and treatment ( Yamamoto et al., 2018 ). …