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Keratosis lichenoides chronica: the centenary of another Kaposi's disease.

In 1895, Kaposi used the term 'lichen ruber acuminatus verrucosus et reticularis' to describe the case of a 27-year-old woman with a linear, … nct from lichen planus. KLC may be associated with internal diseases such as glomerulonephritis and lymphoproliferative disorders.

Respiratory vasculitis.

Respiratory vasculitis is characterized by granulomatous changes pathologically. Both upper and lower respiratory tracts may be involved. It … vidence suggests that polymorphic reticulosis/lymphomatoid granulomatosis may be closely related to lymphoproliferative disorders.

[TAFRO syndrome and monoclonal gammapathy: Uncommon association!].

Castleman's disease is a lymphoproliferative disorder characterized by angiofollicular lymph node hyperplasia. Recently, a new variant of multicentric Castleman's disease has been identified in Japan called TAFRO syndrome. It is characterized by a constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction and organomegaly (TAFRO). It is usually associated with polyclonal hyperimmunoglobulinemia. Here, we report the first and unique case of TAFRO syndrome with monoclonal gammapathy.

Multiple orbital tumors were cavernous hemangiomas.

Two distinct masses in the left orbit were incidentally found in a 48-year-old woman during a computed tomographic scan done to evaluate neurologic complaints. Initial diagnostic considerations focused on a lymphoproliferative disorder or other systemic disease. Orbitotomy revealed two discrete tumors, both cavernous hemangiomas. Although uncommon, cavernous hemangioma should be considered in the differential diagnosis of the patient with multiple orbital lesions.

Hepatorenal syndrome complicating chronic lymphocytic leukemia.

Hepatorenal syndrome and portal hypertension developed in a 59-year-old man with chronic lymphocytic leukemia. At autopsy, he had portal hypertension from lymphocytic infiltration of the liver with compression of the portal veins, and no other pathologic process in the liver. Histologic examination of the kidney did not reveal a lesion that could account for the observed renal insufficiency. This case report documents the association of a lymphoproliferative disorder with portal hypertension and hepatorenal syndrome.

Novel oral chidamide and valganciclovir regimen for EBV-PTLD post-hematopoietic stem cell transplantation: A case report.

RATIONALE: Epstein-Barr virus-related posttransplant lymphoproliferative disorder (EBV-PTLD) is a serious and potentially fatal complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). PATIENT CONCERNS: We report a case of a 46-year-old male who developed EBV-PTLD 3 months after haploidentical HSCT for refractory acute myeloid leukemia. The patient presented with a persistent cough and a pulmonary nodule that increased in size from 8 mm × 5 mm to 27 mm × 25 mm over 4 weeks. Increased EBV loads were also detected (peripheral blood EBV sorting: EBV-T DNA 2.09E+03,

Autoimmune Haemolytic Anaemia Due to Cold Antibodies in a Renal Cancer Patient.

Autoimmune haemolytic anaemia (AIHA) is an acquired disorder in which antibodies are produced against self-erythrocyte antigens. We distingu … subsequent clinical and analytical improvement. AIHA due to cold antibodies is a well-known PNS in lymphoproliferative disorders, although association with solid tumours, such as Kaposi's sarcoma and non-small-cell lung cancer have also been described in a small percentage. However, there are few reported cases of AIHA due to cold antibodies associated with renal carcinoma. M …

Castleman disease and paraneoplastic pemphigus in a pregnant woman: A case report.

RATIONALE: Orogenital ulcers can be observed in various conditions, such as Behcet disease, infection and also paraneoplastic pemphigus (PNP). Castleman disease (CD), which is a rare cause of paraneoplastic pemphigus represents a heterogenous lymphoproliferative disorder of unknown etiology. Paraneoplastic pemphigus associated with CD in pregnancy is rare and has not been reported yet. PATIENT CONCERNS: We report a rare case of CD in a 26-year-old pregnant woman with orogenital ulcers. The patient suffered from mucosal erosions and uveitis at 23 weeks of gestation. A retroperitoneal mass (9.7

Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report.

Sweet's syndrome is a neutrophilic dermatosis characterised by sudden onset of fever, neutrophilia, erythematous skin rashes and neutrophili … with a lymphoproliferative disorder, although the association of subcutaneous Sweet's syndrome with lymphoproliferative disorders has not been well-documented thus far. Herein, we present the case of a 48-year-old man with a 2-year history of chronic lymphocytic leukemia who developed fever and skin rashes, without any evidence of a relapse. The clinical and pathological inves …

Human herpesvirus 7 detection by quantitative real time polymerase chain reaction in primary cutaneous T-cell lymphomas and healthy subjects: lack of a pathogenic role.

BACKGROUND: Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of lymphomas where the tumour population emerges within a m … y to induce cytokine production in infected cells could make it an important pathogenic cofactor in lymphoproliferative disorders. OBJECTIVES: To investigate the presence of HHV7 DNA on CTCL and healthy skin donors (HD). METHODS: We used quantitative real time polymerase chain reaction to evaluate the potential pathogenic role of HHV7. RESULTS: Twenty-seven of 84 (32.1%) HD …

Relationship between hairy cell leukemia variant and splenic lymphoma with villous lymphocytes: presentation of a new concept.

An unusual case of low-grade B-cell lymphoproliferative disorder with peripheral lymphocytosis and splenomegaly followed for 4 1/2 years is … or as SLVL. As SLVL assumes various cytologic and histologic patterns, which overlap with different lymphoproliferative disorders, especially HCL variants, this entity appears to represent a heterogeneous group of lymphomas/leukemias that may evolve into each other. The absence of activation of c-myc and bc1-2 oncogenes as well as mutation of p53 tumor suppressor gene, togethe …

Castleman disease mimicking prostate cancer metastasis: diagnostic implications of [68Ga]Ga-PSMA-11 PET/CT.

Castleman's disease is a rare lymphoproliferative disorder that can mimic malignancy in cancer patients. This study presents a rare case of Castleman disease coexisting with prostate cancer, highlighting the potential value of gallium 68-labelled prostate-specific membrane antigen-11 ([⁶⁸Ga]Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) in distinguishing Castleman disease from prostate cancer metastasis.

Cloudy fluid, cloudy diagnosis.

Here, we report a case of a patient with cloudy effluent that was initially diagnosed as bacterial peritonitis. The persistence of a cloudy effluent despite antibiotic therapy led to an extensive peritoneal dialysis (PD) effluent analysis, with the final diagnosis being high-grade B-cell lymphoma. This case will increase the awareness of this rare presentation of a lymphoproliferative disorder reminding clinicians to consider this diagnosis as a part of the differential diagnosis PD effluent.

Case Report Unicentric Castleman disease located in the anterior mediastinum misdiagnosed as invasive thymoma: a case report.

Castleman disease is a rare lymphoproliferative disorder of unknown etiology. The localized form, which usually presents as a slow-growing mass, is most commonly located in the mediastinum. Invasion of the vena anonyma by a mass has rarely been reported. We herein describe a case of initially misdiagnosed invasive thymoma in a 72-year-old woman, but postoperatively proven to have anterior mediastinal Castleman disease with invasion of the vena anonyma.

Cervical unicentric Castleman disease presenting as a neck mass: case report and review of the literature.

Castleman disease is an uncommon lymphoproliferative disorder that usually presents asymptomatically at a single site, most commonly the mediastinum; it is rare in the head and neck. Although Castleman disease may be mistaken for a malignant process such as lymphoma, it is a benign condition that is curable with complete surgical resection. We report the case of a 43-year-old man with the hyaline vascular type of unicentric Castleman disease who presented with an isolated neck mass.

[Fever of unknown origin as initial manifestation of Castleman's disease: apropos of 2 cases].

Castleman's disease is a rare lymphoproliferative disorder with a great range of clinical presentation and localization. It usually appears in young people and its etiology is unknown. Clinical features are not specific: fever, asthenia, hypochromic anemia and hypergammaglobulinemia. We report here two cases of Castleman's disease whose peculiarity lies in the fact that the first sign was fever of unknown origin. In both cases the use of a CT scan was very important for the diagnosis.

Immunosuppressants/Immunomodulators and Malignancy.

Individuals with immunosuppressive conditions are at a higher risk of developing malignancies than those in the general population. Immunosuppression weakens tumor immunity, hinders the detection of pro-oncogenic cells, and activates oncogenic viruses. Malignancies arising in immunosuppressed patients tend to be aggressive, have a high incidence of virus-associated cancers, and are reversible in some cases. Notably, immunosuppressive agents influence the frequency and type of malignancies, as well as their clinicopathological features. Organ transplant recipients receive long-term immunosuppre

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… Post-Transplantation Lymphoproliferative Disorders (PT-LPD) and Immunosuppressive Agents ( Figure 1 ) Post-transplantation lymphoproliferative disorders (PT-LPDs) are the second most common malignant neoplasms that arise following organ or bone marrow transplantation, comprising clinically and morphologically … Figure 2 Changing patterns of rheumatoid arthritis-associated lymphoproliferative disorders according to anti-rheumatic agent [ 34 , 191 ] The clinicopathological features of rheumatoid arthritis-associated lymphoproliferative disorder (RA-LPD) also differ based on the anti-RA agent used, including methotrexate …

Clinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas.

Although the vast majority of CTCL subtypes are of the CD4+ T-helper cell differentiation phenotype, there is a spectrum of CD8+ variants that manifest wide-ranging clinical, histologic, and phenotypic features that inform the classification of the disease. CD8, like CD4, and cytotoxic molecules (including TIA and granzyme) are readily detectable via IHC staining of tissue and, when expressed on the phenotypically abnormal T-cell population, can help distinguish specific CTCL subtypes. Nonetheless, given that the histopathologic differential for CD8+ lymphoproliferative disorders and lymphomas…

H syndrome treated with Tocilizumab: two case reports and literature review.

H syndrome is a rare autosomal recessive genetic disorder characterized by the following clinical features: cutaneous hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, short stature, hallux valgus, hyperglycemia, fixed flexion contractures of the toe joints, and the proximal interphalangeal joints. In rare cases, autoinflammatory and lymphoproliferative manifestations have also been reported. This disorder is due to loss-of-function mutations in SLC29A3 gene, which encode the equilibrative nucleoside transporter ENT3. This deficiency leads to a

Rituximab as induction therapy in pediatric kidney transplantation: A single-center experience in four patients.

BACKGROUND: The anti-CD20 rituximab is often used in the treatment of children with steroid-resistant nephrotic syndrome or EBV-induced post-transplant lymphoproliferative disorder. This single-center series reports the use of rituximab as induction therapy in pediatric kidney transplantation. METHODS: Four children who received rituximab as induction therapy for kidney transplantation since 2016 were retrospectively analyzed. Clinical and laboratory data were extracted from medical records. RESULTS: The patients (2 boys and 2 girls) were aged from 6.1 to 11.9 years and were treated with rit