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Adera2.0: A Drug Repurposing Workflow for Neuroimmunological Investigations Using Neural Networks.

Drug repurposing in the context of neuroimmunological (NI) investigations is still in its primary stages. Drug repurposing is an important method that bypasses lengthy drug discovery procedures and focuses on discovering new usages for known medications. Neuroimmunological diseases, such as Alzheimer's, Parkinson's, multiple sclerosis, and depression, include various pathologies that result from the interaction between the central nervous system and the immune system. However, the repurposing of NI medications is hindered by the vast amount of information that needs mining. We previously prese

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… Amygdalin | C1=CC=C(C=C1)C(C#N)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)O)O | Amygdalin was reported to suppress oxidative damage. Porphyrin | C1=CC2=CC3=CC=C(N3)C=C4C=CC(=N4)C=C5C=CC(=N5)C=C1N2 | Porphyrin constitutes a part of the heme in the hemoglobin and myoglobin. … Conversely, amygdalin, on the other hand, is predicted to be of high risk in three of the four categories, highlighting the limitations of our workflow in terms of being inherently unaware of toxicity. …

Effect of Houpo-Mahuang Decoction on aggravated asthma induced by cigarette smoke and the expression of TRPA1 and tight junctions in mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Cigarette smoke (CS) is a common environmental irritant and a risk factor for asthma, as it induces as well … UPLC-QTOF-MS, the chemical components of HPMHD, including ephedrine, pseudoephedrine, laetrile, and amygdalin amide, were identified by 51 signal peaks. Compared with those in the NS group, the eosinophil number in the peripheral blood and the eosinophils and neutrophils percentages in BALF of the OVA + CS group were remarkably increased. Following the inha …

First Report of Bacterial Leaf Spot of Basil Caused by Pseudomonas viridiflava in Argentina.

In June 1998, during a cool, humid period, typical bacterial spot symptoms were observed on basil plantlets (Ocimun basilicum L. 'Royal Loui … om D-glucose, mannitol, mesoinositol and sorbitol, but not from D-arabinose, L-rhamnose, melibiose, amygdalin, or sucrose. Bacteria used D-tartrate, pyruvate, and citrate, but not benzoate. The strains did not hydrolyze starch, exhibited an oxidative metabolism of glucose, and did not reduce nitrates to nitrites or accumulate poly-β-hydroxybutyrate inclusio …

Regulation on mitophagy in adenomyosis by Guizhi Fuling Wan.

ETHNOPHARMACOLOGICAL RELEVANCE: Guizhi Fuling Wan (GZFLW), a canonical herbal formulation originating from Synopsis of the Golden Chamber, has been widely utilized in managing pain-associated disorders. While its therapeutic efficacy in adenomyosis (AM) characterized by severe dysmenorrhea is well-documented, the underlying pharmacological mechanisms remain elusive. Emerging evidence suggests that hypoxic mitochondrial damage in endometrial tissue constitutes a pathological hallmark of AM, wherein mitophagy regulation through the PINK1/Parkin signaling pathway plays a pivotal role in mitochond

Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles.

Cancer is the leading cause of death globally, and conventional treatments have limited efficacy with severe side effects. The use of nanotechnology has the potential to reduce the side effects of drugs by creating efficient and controlled anticancer drug delivery systems. Nanoparticles (NPs) used as drug carriers offer several advantages, including enhanced drug protection, biodistribution, selectivity and, pharmacokinetics. Therefore, this review is devoted to various organic (lipid, polymeric) as well as inorganic nanoparticles based on different building units and providing a wide range of

Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill.

Cancer still has elevated morbidity and mortality, which undoubtedly impacts the life quality of affected individuals. Remarkable advances have been made in cancer therapy, although the toxicities of traditional therapies remain an obvious challenge. Dahuang Zhechong Pill (DHZCP), developed by Zhongjing Zhang in the Synopsis of the Golden Chamber, represents an effective anticancer traditional Chinese medicine (TCM). In this review, it was found that DHZCP is therapeutically utilized in liver, lung, gastric, pancreatic and other cancers in clinic. Pharmacological evidence showed that its anti-

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… Gallic acid C 7 H 6 O 5 N 80 Myristic acid C 14 H 28 O 2 Y 11 Rhapontin C 21 H 24 O 9 Y 81 Vitamin A C 20 H 30 O Y 12 Physion 8- O - β - D -glucoside C 22 H 22 O 10 N 82 Vitamin E C 29 H 50 O 2 Y 13 Sennoside A C 42 H 38 O 20 N 83 Vitamin K C 31 H 46 O 2 Y 14 Persicae Semen & Armeniacae Semen Amarum Amygdalin … Y 11 | Rhapontin | C 21 H 24 O 9 | Y | 81 | | Vitamin A | C 20 H 30 O | Y 12 | Physion 8- O - β - D -glucoside | C 22 H 22 O 10 | N | 82 | | Vitamin E | C 29 H 50 O 2 | Y 13 | Sennoside A | C 42 H 38 O 20 | N | 83 | | Vitamin K | C 31 H 46 O 2 | Y 14 | Persicae Semen & Armeniacae Semen Amarum | Amygdalin …

Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition.

The properties and meridian affinities of Chinese herbal medicine are closely associated with their therapeutic efficacy. This review focuses on approved antitumour Chinese medicines listed in the Pharmacopoeia of the People's Republic of China (2020 Edition, Volume I), highlighting their key components. Statistical methods were used to analyse the properties, flavours and channel tropisms of antitumour traditional Chinese medicine (TCM), including both proprietary formulations and commercially available individual herbs. Distinctive patterns were identified by comparing herb profiles with con

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… Mechanistically, amygdalin induces apoptosis by downregulating the mRNA expression of antiapoptotic genes, including Survivin and X-linked inhibitor of apoptosis protein ( XIAP ), and modulating the expression of the lncRNAs GAS5 and MALAT1. 13 Bitter-Hot Medicinals Bitter-hot medicinals form a distinct … The anti-cancer effect of amygdalin on human cancer cell lines. Mol Biol Rep . 2019;46(2):2059–2066. doi: 10.1007/s11033-019-04656-3 14. Chen T, Li B, Qiu Y, Qiu Z, Qu P. Functional mechanism of Ginsenosides on tumor growth and metastasis. …

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.

The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms

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… hepatotoxicity | case report | [ 117 ] Renshen (ginseng)+selenium | gefitinib | lung adenocarcinoma | disease progression speeding | case report | [ 118 ] Injections of Nerium oleander | ifosfamide+etoposide | knee synovial carcinoma | hepatotoxicity, cardiopulmonary arrest | case report | [ 119 ] Amygdalin … Life threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C. Ann. Pharmacother. 2005;39(9):1566–1569. doi: 10.1345/aph.1E634. 121. Noomhorm N., Chang C.J., Wen C.S., Wang J.Y., Chen J.L., Tseng L.M., Chen W.S., Chiu J.H., Shyr Y.M. …

The therapeutic potential of colchicine in oncology studies: from structural modification and targeted delivery to clinical management.

Colchicine, a classical microtubule-targeting agent (MTA), exhibits remarkable anti-tumor potential, but its clinical translation is severely restricted by a narrow therapeutic window, systemic off-target toxicity, and complex pharmacokinetic vulnerabilities. Driven by the objective of "toxicity reduction and efficacy enhancement," this review comprehensively summarizes colchicine's multidimensional translational research. First, precise chemical modifications of its tricyclic scaffold and multi-site synergistic strategies are analyzed, exploring structure-activity relationship (SAR) mechanism

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… Notably, these PD interactions are context-dependent: colchicine synergizes with amygdalin in osteosarcoma but exhibits antagonism in chondrosarcoma ( Aydin et al., 2021 ). Thus, colchicine’s PD synergy relies heavily on the tumor’s specific molecular phenotype and microenvironment. … The combination of amygdalin with some anticancer, antiparasitic, and antigout drugs against MG63, Saos2, SW1353, and FL cells in vitro . J. Med. Food 24, 1230–1234. 10.1089/jmf.2020.0143 Bagnato J. D., Eilers A. L., Horton R. A., Grissom C. B. (2004). …

Cancer Metabolism as a Therapeutic Target and Review of Interventions.

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and

ATF3/SLC31A1-Mediated Cuproptosis Contributes to Bortezomib-Induced Peripheral Neurotoxicity and Intervention by (-)-Epigallocatechin Gallate.

Bortezomib (BTZ), the first-generation proteasome inhibitor, has been approved for the treatment of relapsed, refractory, and newly diagnosed multiple myeloma. Despite its remarkable antitumor efficacy, BTZ treatment is severely limited by a high incidence of systemic adverse reactions, primarily due to its non-selective cytotoxicity toward rapidly dividing normal cells and its potent neurotoxic effects on peripheral neurons. Bortezomib-induced peripheral neurotoxicity (BIPN) manifests as neuropathic pain and sensory abnormalities, affecting up to 31% to 64% of patients and limiting BTZ's clin

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… Amygdalin, 81. D-(−)-Mandelic acid, 82. Ganoderic acid H, 83. Isorhapontigenin, 84. Crustecdysone, 85. Panaxadiol, 86. Ginsenoside Rk3, 87. Ginsenoside Re, 88. Ginsenoside Rb2, 89. Cinnamyl alcohol. 4.4. Proteomics RSC96 cells ( n = 3) were collected for proteomic analysis. …

Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer.

Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different

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… She started with alternative therapy CBD oil (1 drop sublingually/day) and Laetrile tablets, which contain purified amygdalin (500 mg 4 times/day). After two months, CT imaging showed a dramatic decrease in the size of the tumor [ 150 ]. …

Nanomaterials in gene therapy and genome editing: challenges and emerging directions.

Nanomaterials are redefining the landscape of gene and genome editing, yet their translation to clinical reality remains constrained by multiple unresolved challenges. While they provide structural and functional advantages for delivering nucleic acids and CRISPR/Cas systems across biological barriers, their behavior within living systems is often unpredictable, leading to issues such as off-target editing, immune activation, and inconsistent biodistribution. The design of nanocarriers, whether lipid-based, polymeric, inorganic, must therefore balance efficiency with safety, integrating physic

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… Amygdalin: a review on its characteristics, antioxidant potential, gastrointestinal microbiota intervention, anticancer therapeutic and mechanisms, toxicity, and encapsulation. Biomolecules. 2022;12:1514. 16. Aljabali AAA, El-Tanani M, Tambuwala MM. …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

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… Reduced wound closure to 8.6% (vs. 65.7% control) | ( 120 ) Bitter almond | Water/oil/water (W/O/W) dual nanoemulsion | Bitter almond oil as hydrophobic phase in dual emulsion | Graphene oxide (GO) nanocarrier coated with gelatin-polyvinylpyrrolidone (PVP-G-GO) | Quercetin (QC), bitter almond oil (amygdalin …

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