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Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species.

A collection of clinical (n = 47) and environmental (n = 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 μg/ml, respectively, compared with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B, and 4.08 μg/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of ski…

Echinocandins in antifungal pharmacotherapy.

OBJECTIVES: Echinocandins are the newest addition of the last decade to the antifungal armamentarium, which, owing to their unique mechanism … Y FINDINGS: Clinical studies have demonstrated that the echinocandins - caspofungin, micafungin and anidulafungin - are equivalent, if not superior, to the mainstay antifungal therapies involving amphotericin B and fluconazole. Moreover, echinocandin regimen has been shown to be more cost-effective and economical. Hence, the echinocandins have found favour in t …

Evaluation of direct antifungal susceptibility testing using E-test for four antifungal agents in candidemia patients.

Candidemia is associated with high morbidity and mortality. Delayed initiation of effective and appropriate antifungal therapy correlates wi … ans. The minimum inhibitory concentrations (MICs) of fluconazole, voriconazole, amphotericin B, and anidulafungin were determined using ET-dir and compared to ET method (ET-sd). Essential agreement, categorical agreement, error rates, and bias were analyzed for all species and specifically for C. albicans. The essential agreement between ET-dir and ET-sd exceed …

Outbreak of Candida auris in Spain: A comparison of antifungal activity by three methods with published data.

Candida auris is an emerging pathogen causing candidaemia outbreaks in several countries for which azole, amphotericin B (AmB) and echinocandin resistance has been reported. In this study, the antifungal susceptibilities of 73 Spanish C. auris isolates (56 bloodstream and 17 urine) to eight antifungal agents were determined using three methods. Isolates were identified by internal transcribed spacer (ITS) sequencing, and minimum inhibitory concentrations (MICs) of fluconazole, isavuconazole, itraconazole, posaconazole, voriconazole, anidulafungin, micafungin and AmB were determined by EUCAST m…

In vitro activity of rezafungin against common and rare Candida species and Saccharomyces cerevisiae.

BACKGROUND: Rezafungin is a novel echinocandin with excellent activity against common Candida species; however, limited data are available regarding rare Candida species. METHODS: We determined the in vitro susceptibility of 689 clinical isolates of 5 common and 19 rare Candida species, as well as Saccharomyces cerevisiae. The activity of rezafungin was compared with that of anidulafungin, caspofungin, micafungin, amphotericin B and fluconazole, using CLSI broth microdilution methodology (Fourth Edition: M27). RESULTS: Rezafungin MIC90 values were 0.06 mg/L for Candida albicans (n=125), Cand…

Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance.

OBJECTIVES: To define the antifungal susceptibility patterns of the most common non-albicans Candida spp. in China. METHODS: We evaluated t … e and itraconazole. Overall, 97.7%-100% of isolates were susceptible to caspofungin, micafungin and anidulafungin, but 2.3% of C. glabrata were non-susceptible to anidulafungin. There was no azole/echinocandin co-resistance. Disc diffusion and Sensititre YeastOne(TM) methods showed >95% categorical agreement for fluconazole and voriconazole. CONCLUSIONS: In su …

[Antifungal susceptibility of clinical isolates of Scopulariopsis species].

INTRODUCTION: Scopulariopsis is a common soil saprophyte. In the last years the infections caused by Scopulariopsis species have increased, … ole, posaconazole, voriconazole and 5-fluorocytosine, and minimun effective concentration (MECs) to anidulafungin, caspofungin and micafungin. RESULTS: Our data confirm the high in vitro resistance of Scopulariopsis to antifungal agents. Anidulafungin, caspofungin, micafungin (MICs ≥ 8 mg/L), 5-fluorocytosine (MICs ≥ 64 mg/L), and fluconazole (MICs ≥ 128 mg/L) …

Podospora bulbillosa keratitis: A case series with molecular confirmation from North-east India.

This case series reports three patients aged 56-62 years, with rare fungal keratitis caused by Podospora bulbillosa presenting as unilateral severe non-pigmented keratitis. All cases were culture positive. The fungal species identification was confirmed by ITS rDNA region sequencing. Antifungal susceptibility testing showed lower MICs for voriconazole, amphotericin B, and anidulafungin than for natamycin. Treatment with topical and systemic antifungal and surgical interventions resulted in healing with improved vision in one patient only. A review of the available literature indicates that the…

Three cases of vulvovaginal candidiasis due to Candida nivariensis.

Candida nivariensis is emerging as a highly resistant species of the Candida glabrata complex causing invasive and mucocutaneous infections. In this study, three cases of vulvovaginal candidiasis caused by C. nivariensis are described and identified by Internal Transcribed Spacer 1-2 sequencing. All isolates were susceptible in vitro to anidulafungin, micafungin, caspofungin, 5-flucytosine, posaconazole, voriconazole, itraconazole, amphotericin B, and showed dose-dependent susceptibility to fluconazole. In two patients, three doses of oral fluconazole were effective, while one patient develope…

Methicillin-Resistant Staphylococcus aureus and Candida albicans Secondary Bloodstream Co-Infection in a Patient with Tubular Oesophageal Duplication.

UNLABELLED: Gastrointestinal duplications are rare congenital anomalies usually found incidentally in asymptomatic adult patients. We report a case of methicillin-resistant Staphylococcus aureus and Candida albicans secondary bloodstream co-infection in a 57-year-old male patient with a communicating tubular oesophageal duplication. The patient completed 21 days of medical treatment with vancomycin and anidulafungin and remained well without any complications, over 2 years of follow-up. LEARNING POINTS: Tubular oesophageal duplications are rare and often asymptomatic.Candida spp. seem to faci…

Evaluation of Sensititre YeastOne for antifungal susceptibility testing of Candida (Candidozyma) auris: misclassification of FKS1 mutants and overestimation of caspofungin resistance in a global collection of isolates.

UNLABELLED: Sensititre YeastOne (SYO) is a widely used commercial colorimetric assay, yet its performance for C. auris remains uncertain. We … esistance-like colorimetric phenotype. Applying an adjusted interpretive threshold of 0.25 mg/L for anidulafungin and micafungin, and reading growth inhibition endpoints for caspofungin, eliminated the corresponding errors. SYO reliably detects fluconazole and amphotericin B resistance (using the SYO-specific WT-ULV) but frequently misclassifies echinocandin re …

Effectiveness and Safety of Empirical Antifungal Strategies in Critically Ill, Non-Neutropenic Patients: A Multi-Center Observational Study.

INTRODUCTION: Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in critically ill patients. While early empiric … zole (63.16%) compared to those receiving caspofungin (76.80%), liposomal amphotericin B (75%), and anidulafungin (84.83%) (p = 0.028). Regarding safety, fluconazole demonstrated the lowest incidence of hepatotoxicity (13.16%) and nephrotoxicity (7.89%). In contrast, anidulafungin was associated with the highest rate of hepatotoxicity (33.79%, p=0.035), and cas …

Central line-associated Cyberlindnera fabianii fungemia: A case report and review of diagnostic and therapeutic challenges.

INTRODUCTION: Cyberlindnera fabianii is an uncommon opportunistic yeast increasingly recognized as a cause of invasive fungal infections, pa … cterial therapy was initiated, and the hemodialysis catheter was removed. Antifungal treatment with anidulafungin was started, leading to clinical improvement. Species identification was achieved using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), which revealed C. fabianii. Antifungal susceptibility testing demons …

Is the superbug fungus really so scary? A systematic review and meta-analysis of global epidemiology and mortality of Candida auris.

BACKGROUND: Candida auris is a new pathogen called "superbug fungus" which caused panic worldwide. There are no large-scale epidemiology stu … ied depending on the clades. Resistance to fluconazole, amphotericin B, caspofungin, micafungin and anidulafungin in C. auris were 91, 12, 12.1, 0.8 and 1.1%. The overall mortality of C. auris infection was 39%. Furthermore, subgroup analyses showed that mortality was higher in bloodstream infections (45%), and lower in Europe (20%). CONCLUSIONS: Over 4000 cas …

Antifungal susceptibility profiles of candidemia isolates on the east coast of Peninsular Malaysia and reliability of Etest compared to Sensititre YeastOne.

UNLABELLED: Candidemia is a major cause of morbidity and mortality worldwide. The rising prevalence of non-albicans Candida species (NACs), … . glabrata. Etest demonstrated an inconsistent agreement with SYO, particularly for fluconazole and anidulafungin, with high major and very major error rates. NACs dominate candidemia in Malaysia's east coast, with significant azole resistance, while echinocandins and amphotericin B remain effective. Comparative analysis demonstrated poor agreement and elevated …

Investigation of clonal relationship in hospital-associated Candida parapsilosis isolates.

PURPOSE: We aimed to investigate the clonal relationship and antifungal susceptibility of C. parapsilosis isolated from hospitalized patient … ic DNA (RAPD) PCR method was used for molecular genotyping of isolates. MIC values for fluconazole, anidulafungin and amphotericin B were determined according to the M27-A3 CLSI broth microdilution reference method guideline. RESULTS: Seven different band patterns (A-G) were detected in 277 isolates by RAPD PCR method. According to the rank order of the isolat …

Identification and susceptibility testing of oral candidiasis in advanced cancer patients.

BACKGROUND: Patients with advanced cancer are prone to develop different opportunistic oral infection due to anti-cancer treatment or the ma … gene sequencing. Etest was performed on RPMI agar, and the antifungals fluconazole, amphotericin B, anidulafungin and nystatin were applied. RESULTS: Fifty-six isolates from 45 patients were identified. Seven different Candida species and one Saccharomyces species were detected. The results of biochemical identification were confirmed with sequencing analysis. …

Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates.

Among 119 echinocandin non-wild-type (non-WT) Candida glabrata strains from two global surveys, mutations in fks hot spots (HSs) were detected in 28 (from 7 countries and 8 U.S. states): 24 strains (85.7%) had non-WT MICs for micafungin, 22 (78.6%) for anidulafungin, and 25 (89.3%) for caspofungin. The most common FKS substitutions among non-WT strains were at positions F659 (n = 7) and S663 (n = 7). Three isolates displaying WT MIC results had F625Y, L630I, and D632Y substitutions or non-HS mutations. Mutations that have been reported to decrease the echinocandin binding to the 1,3-β-d-glucan…

Больше, чем кажется на первый взгляд: Nocardia farcinica, Candida dubliniensis и Aspergillus spp. совместное инфекция у пациента с множественным миэломой, лечащегося различными режимами лечения.

КОЛИЧЕСТВО: Инвазивные инфекционные инфекции Нокардийской фарциники, видов Аспергиллуса (Spp.) и Candida dubliniensis представляют собой редкие инфекционные осложнения у пациентов, у которых диагностировали множественные миеломы. В данном случае мы описываем пациента, получившего three с протеиновыми ингибиторами, кортикостероидами, циклофосфамидом и линалидомидом, которые были одновременно инфицированы этими веществами. three Оппортунистические патогены. Инфекция кровеносного потока C. dubliniensis 4 Недели анидулуфунгина. Аспергиллус был очищен. 12 недель с вориконазолом. Н. фарсиническое ле

Совпадение в аннотации оригинала
BACKGROUND: Invasive infections by Nocardia farcinica, Aspergillus species (spp.) and Candida dubliniensis are rare infectious complications … opportunistic pathogens. A blood stream infection with C. dubliniensis was treated with 4 weeks of anidulafungin. Aspergillus spp. was treated for 12 weeks with voriconazole. N. farcinica treatment was continued indefinitely with co-trimoxazole and moxifloxacin after regression at discharge of brain abscesses and the pulmonary aspergilloma. CONCLUSION: The di …

Meningitis caused by Candida dubliniensis in a patient with liver cirrhosis: A case report and review of the literature.

UNLABELLED: Candida meningitis is almost always caused by Candia albicans, but other species, such as Candida dubliniensis, can cause it on … mb swelling for two weeks. C. dubliniensis was isolated and treated with liposomal amphotericin and anidulafungin. The scarcity of such infections makes the best treatment regimen undetermined. 2012 ELSEVIER LTD: All rights reserved.