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Green synthesis of Al2O3 nanoparticles and their bactericidal potential against clinical isolates of multi-drug resistant Pseudomonas aeruginosa.

The high prevalence of extended-spectrum β-lactamases (76.3 %) and metallo-β-lactamases (7.3 %) amongst the bacteria Pseudomonas aeruginosa is a critical problem that has set forth an enormous therapeutic challenge. The suggested role of nanoparticles as next generation antibiotics, and inadequate information on antibacterial activity of aluminium oxide nanoparticles has led us to investigate the green synthesis of aluminium oxide nanoparticles (Al2O3 NPs) using leaf extracts of lemongrass and its antibacterial activity against extended-spectrum β-lactamases and metallo-β-lactamases clinical i

Antibacterial Activity of Traditional Medicinal Plants: Combating Antibiotics Resistance in Animal Wound Infections.

The rise of antibiotic resistance poses a significant challenge to veterinary medicine, particularly in the treatment of wound infections in … epared using various solvents, were utilized for testing. Ethanol extracts of Loranthus acaciae and Cymbopogon proximus at concentrations of 60-90 µL demonstrated the largest inhibition zones, ranging from 55.5 ± 3.85 to 57.5 ± 2.5 mm against E. coli and S. aureus. Inhibition zones for Streptococcus spp. and Pseudomonas spp. ranged from 50 ± 2 to 48.3 ± 1.7 …

(-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models.

Background: (-)-Carveol (p-Mentha-6,8-dien-2-ol) is a monocyclic monoterpenic alcohol, present in essential oils of plant species such as Cymbopogon giganteus, Illicium pachyphyllum and in spices such as Carum carvi (cumin). Pharmacological studies report its antitumor, antimicrobial, neuroprotective, vasorelaxant, antioxidant and anti-inflammatory activity. Hypothesis/Purpose: The objective of this study was to evaluate the acute non-clinical oral toxicity, gastroprotective activity of monoterpene (-)-Carveol in animal models and the related mechanisms of action. Methods: Acute toxicity was a…

Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models.

BACKGROUND: The emerging resistance of Plasmodium species to currently available anti-malarials remains a public health concern, hence the need for new effective, safe and affordable drugs. Natural products remain a reliable source of drugs. Nefang is a polyherbal anti-malarial of the Cameroonian folklore medicine with demonstrated in vitro antiplasmodial and antioxidant activities. It is composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, Ocimum gratissimum (leaves). This study aimed at investigating the suppressive, prophylactic…

Antifungal activity of different essential oils against Malassezia pathogenic species.

ETHNOPHARMACOLOGICAL RELEVANCE: Plants produce essential oils in response to physiological stresses, pathogen attacks and ecological factors … ls were active at the tested conditions. In addition, two clinical studies used essential oils from Cymbopogon citratus and C. flexuosus formulated in shampoo, cream or lotion for the successful treatment of dandruff and P. versicolor. CONCLUSIONS: Results of these studies indicate worthy prospects for clinical application of essential oils and there is an …

Medicinal plants used to treat TB in Ghana.

AIMS: The current study was designed to document medicinal plant species that are traditionally used to treat tuberculosis (TB) by Ghanaian … G.L. Webster leaves (Phyllanthaceae), Dissotis rotundifolia (Sm.) Triana, leaves (Melastomataceae), Cymbopogon giganteus Chiov. Leaves (Poaceae), Cyperus articulatus L. roots (Cyperaceae), Allium sativum L. bulb (Amaryllidaceae), Zingiber officinale Roscoe, rhizomes (Zingiberaceae), Allium cepa L. bulbs (Amaryllidaceae), Allium cepa L. leaves (Amaryllidaceae …

Repellency of citronella for head lice: double-blind randomized trial of efficacy and safety.

BACKGROUND: Head lice move easily from head to head. The lack of safe, effective repellents leads to reinfestation. OBJECTIVES: To test the efficacy of a slow-release citronella formulation as a repellent against the head louse. METHODS: During 4 months in 2003 a randomized, placebo-controlled double-blind clinical study was conducted in four elementary schools; 103 children were treated with the test formulation and 95 with a placebo. RESULTS: A significant difference was observed during the second examination 2 months later, when 12.0% of the children treated with the test repellent and 5

Could essential oils enhance biopolymers performance for wound healing? A systematic review.

BACKGROUND: Millions of people in the world suffer from chronic wounds of different etiologies such as diabetic foot and leg ulcers, without … RESULTS: Treatments with EO from species of genders Lavandula, Croton, Blumea, Eucalyptus, Pinus, Cymbopogon, Eucalyptus, Cedrus, Abies, Rosmarinus, Origanum, Salvia and Plectranthus, have shown positive results in rodent wounds. All of these EO were mainly composed by monoterpenoids-thymol, 1,8-cineole, linalool-or monoterpenes, as limonene or pinenes. Ex …

Medicinal and aromatic plants assisted bioremediation of ammonical and bacterial contaminants in aquaponics water.

An experiment was conducted under laboratory conditions to examine the effect of sixteen medicinal and aromatic plants (MAPs), namely Aloe barbadensis, Cymbopogen citratus, Bacopa monnieri, Senna sigueana, Plantado ovata, Asparagus racemosses, Phylanthus emblica, Vitex negundo, Cammiphora wightii, Cymbopogon martini, Andrographis paniculate, Ocimum tenuiflorum, Gymnema sylvestre, Centella asiatica, Adhatoda vasica, and Cyamopsis tetragonoloba in the removal of total ammonia-N (TAN) from aquaponics water. The different dried and grounded MAPs were added @ 100 mgl-1 into individual conical flask…

Antimicrobial activity of commercially available essential oils against Streptococcus mutans.

INTRODUCTION: Many essential oils have been advocated for use in complementary medicine for bacterial and fungal infections. However, few of the many claims of therapeutic efficacy have been validated adequately by either in vitro testing or in vivo clinical trials. OBJECTIVE: To study the antibacterial activity of nine commercially available essential oils against Streptococcus mutans in vitro and to compare the antibacterial activity between each material. METHODOLOGY: Nine pure essential oils; wintergreen oil, lime oil, cinnamon oil, spearmint oil, peppermint oil, lemongrass oil, cedarwoo

Multitarget inhibitory effects of lemongrass essential oil on Porphyromonas gingivalis: synergistic regulation of heme utilization, biofilm formation, and the metabolic pathway of ferroptosis.

BACKGROUND: Severe periodontitis has impacted upwards of 1 billion people worldwide, posing a public health challenge. Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen implicated in periodontal dysbiosis and disease progression. Lemongrass essential oil (LEO), extracted from Cymbopogon citratus (DC.) Stapf, has shown clinical benefits in periodontitis management, yet its mechanisms remain poorly understood. METHODS: Antibacterial and bactericidal activities of LEO against P. gingivalis were evaluated, along with its effects on heme uptake and storage, early biofilm-related phen…

An updated and comprehensive review of the antiviral potential of essential oils and their chemical constituents with special focus on their mechanism of action against various influenza and coronaviruses.

Essential oils and their chemical constituents have been reported with well documented antimicrobial effects against a range of bacterial, f … s of viral life cycle by targeting the redox signalling pathway. Essential oils of Thymus vulgaris, cymbopogon citratus and Rosmarinus officinalis have been found to destabilize the Tat/TAR-RNA complex of HIV-1 virus, this complex being essential for HIV-1 replication. Being lipophilic in nature, essential oils can penetrate viral membranes easily leading to …

The ethnopharmacological study of plant drugs used traditionally in Djibouti for malaria treatment.

ETHNOPHARMACOLOGICAL RELEVANCE: Djibouti was a country where malaria has been endemic for centuries. The local population use the plants as … bathing (1 %). The best antiplasmodial activities were observed in the dichloromethane extracts of Cymbopogon commutatus and the ethyl acetate extracts of Aloe rigens and Terminalia brownii, with IC50 values of 9.8, 5, and 7.5 μg/mL, respectively. Their toxicity/activity levels were very favorable with selectivity indices of 5.6, 8.1, and 11.8 for C. commut …

Antimicrobial Potential of Commercially Produced Citronella Oil: An In Vitro and In Silico Investigation.

INTRODUCTION: Antimicrobial resistance poses a significant global health threat in the 21st century. The COVID-19 pandemic, caused by SARS-CoV-2, has further emphasized the need for novel and effective alternative therapeutics, especially from natural sources. Despite the known bioactivity of citronella oil, its potential as a broad-spectrum antimicrobial and antiviral agent remains underexplored. This study aimed to evaluate the antibacterial, antifungal, and antiviral potential of commercially produced citronella oil using in vitro and in silico approaches. METHODS: The chemical constituent

In vitro acaricidal activity of essential oils and their binary mixtures against ixodes scapularis (Acari: Ixodidae).

Ixodes scapularis ticks are vectors of infectious agents that cause illness in humans, including Lyme disease. Recent years have seen a surg … by lowering the risk of tick bites. We investigated the acaricidal activity of EOs from lemongrass (Cymbopogon citratus), geranium (Pelargonium x asperum), savory thyme (Thymus saturejoides), and white thyme (Thymus zygis) on I. scapularis. The interactions (i.e., synergistic, antagonistic, or additive) of their binary mixtures were also evaluated. EO sample …

Use of Household Cluster Investigations to Identify Factors Associated with Chikungunya Virus Infection and Frequency of Case Reporting in Puerto Rico.

BACKGROUND: Chikungunya virus (CHIKV) is transmitted by Aedes species mosquitoes and is the cause of an acute febrile illness characterized by potentially debilitating arthralgia. After emerging in the Caribbean in late 2013, the first locally-acquired case reported to public health authorities in Puerto Rico occurred in May 2014. During June-August 2014, household-based cluster investigations were conducted to identify factors associated with infection, development of disease, and case reporting. METHODOLOGY/PRINCIPAL FINDINGS: Residents of households within a 50-meter radius of the residenc

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… Human leukaemia cell line (HL-60) treated with EO of Cymbopogon flexuosus and its major constituent isointermedeol has been reported to lower NF- κ B which is one of the contributing multiple pathways resulting in apoptosis [ 58 ]. … Z Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense Oncology Letters 2013 6 4 1140 1146 2-s2.0-84881584693 24137478 10.3892/ol.2013.1520 PMC3796379 114 Stone S Vasconcellos F Lenardão E do Amaral R Jacob R Leite FL Evaluation of potential use of Cymbopogon …

Adjuvant Properties of Caffeic Acid in Cancer Treatment.

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK

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… Ipomoea aquatica (Water spinach) | 1130 | [ 35 ] | Clerodendrum thomsoniae | 770 | [ 35 ] Ipomoea batatas (Sweet Potato) | 125 | [ 38 ] | Coffea canephora (Coffea) | 12,330 | [ 35 ] Lactuca sativa (Lettuce) | 2580 | [ 35 ] | Ginkgo biloba (Ginkgo) | 398 | [ 39 ] Morus alba (Mulberry) | 250 | [ 35 ] | Cymbopogon …

Оценка стабильности жажды в пальчиках (Eleusine coracana L.) с использованием многовариантных подходов.

Пальцы, как правило, выращиваются в полузасушливых тропиках, где они выращиваются главным образом фермерами-добытчиками. Однако урожайность зерна остается низкой из-за сложного количественного характера этой особенности и ее низкой наследственности. Таким образом, взаимодействие генотипа х с окружающей средой (ГЭИ) оказывает значительное влияние на производство. В этом исследовании изучается воздействие ГЭИ на качество генотипов пальца в различных средах, при этом особое внимание уделяется чувствительности урожая к изменчивости климата. Цель этого исследования заключалась в оценке воздействия

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… Insights Into Genotype × Environment Interactions Affecting Essential Oil Yield and Quality Stability in Cymbopogon Species and Genotypes Biochemical Systematics and Ecology 2025 123 p. 105068 10.1016/j.bse.2025.105068 29 Kroonenberg P. M. …