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[Wood chip alveolitis].

A 52 year old farmer was referred to us for investigation of suspected farmer's lung. For many years the farmer had been exposed to hay, straw, pigeons, and fuel chip dust. Under exertion he suffered from shortness of breath. In the farmer's own fuel chips we could identify Aspergillus fumigatus, Paecilomyces species and Mucor species. In the farmer's blood we found IgG-antibodies against his own fuel chips, thermophilic actinomycetes, Penicillium species, Mucor species and Aspergillus fumigatus. We did not detect any IgG-antibodies against pigeon serum or pigeon faeces. In order to determine …

A synergistic alliance between nematophagous fungi and organic matter against plant-parasitic nematodes: a systematic review.

Nematophagous fungi (NF) are essential biological control agents for managing plant-parasitic nematode (PPN) populations, which cause signif … ording to our analysis, Trichoderma species dominate in commercial biocontrol applications, whereas Paecilomyces species are the most reported NF in OM-enhanced nematode management. Even though they are recently identified, other genera, including Talaromyces, Pochonia, and Arthrobotrys, are seldom used under field conditions. Both NF and OM have been shown to …

In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin.

In the course of our screening for antitrypanosomal compounds from soil microorganisms, as well as from the antibiotics library of the Kitasato Institute for Life Sciences, we found three peptide antibiotics, leucinostatin (A and B), alamethicin I and tsushimycin, which exhibited potent or moderate antitrypanosomal activity. We report here the in vitro and in vivo antitrypanosomal properties and cytotoxicities of leucinostatin A and B, alamethicin I and tsushimycin compared with suramin. We also discuss their possible mode of action. This is the first report of in vitro and in vivo trypanocida

Cordyceps cicadae polysaccharides ameliorate ulcerative colitis by modulating the gut microbiota and regulating the bile acid/FXR/NF-κB signaling pathway.

BACKGROUND: Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease, closely linked to dysbiosis of the intestinal microbiota and abnormal bile acid homeostasis. Polysaccharides derived from Paecilomyces cicadae (CCP) exhibit immunomodulatory and anti-inflammatory effects. However, their therapeutic potential and underlying mechanisms in UC remain poorly elucidated. PURPOSE: This research seeks to evaluate the therapeutic efficacy of CCP in the treatment of UC and utilizing the "microbiota-bile acid metabolism-immunity" axis, elucidates the mechanisms by which CCP enhances …

Prevalence and risk factors for superficial fungal infections among Italian Navy Cadets.

BACKGROUND: Limited studies on the prevalence and risk factors for superficial mycoses are available. OBJECTIVE: The aim of this paper was … cruris. Non-dermatophytic filamentous fungi (Penicillium spp., Fusarium spp., Aspergillus spp. and Paecilomyces spp.), not considered pathogenic, were isolated in 48 samples. None of the risk factors analysed were significantly associated with fungal infection. Only 2 subjects out of the 33 people affected were aware of their condition. They both had tinea pe …

Purpureocillium lilacinum tattoo-related skin infection in a kidney transplant recipient.

Purpureocillium lilacinum is an emerging pathogenic mold among immunocompromised hosts that causes cutaneous infections related to skin breakdown. We present the first reported case of P. lilacinum tattoo-related skin infection, to our knowledge. A kidney transplant recipient recently treated for acute cellular rejection presented with skin papules overlying a tattoo. Diagnosis was confirmed on culture, histology, and 18S ribosomal RNA polymerase chain reaction. The morphological features on culture characteristic of P. lilacinum included violet colonies on malt extract agar, long tapering bru

From chaos to tranquillity: a modern approach to the identification, nomenclature and phylogeny of Aspergillus, Penicillium and other Eurotiales, including an updated accepted species list.

Eurotiales is a diverse and speciose order and includes economically important genera like Aspergillus, Penicillium, Paecilomyces and Talaromyces. Historically, species identifications based on morphology are challenging. The publication of accepted species lists and the availability of representative DNA sequences for type strains have contributed greatly towards accurate species identification and facilitated the description of many new species. However, despite current advancements, a proportion of newly described species within these taxonomically challenging genera represent, in fact, exi…

[Rasamsonia argillacea in Patient with Immunodeficiency: First Suspected Case in Türkiye].

Rasamsonia species are thermophilic fungi that primarily cause infection in immunocompromised patients. R.argillacea species complex is frequently misidentified as a pathogen due to its morphological similarity to the genera Penicillium and Paecilomyces and its incidence remains undetermined. This situation further complicates the process of timely diagnosis and treatment. Rasamsonia species can be identified using internal transcribed spacer (ITS) sequence analysis, which is considered the primary fungal barcode. Accurate species identification is imperative for the administration of appropri…

A review on clinical cases of rare mold infections and their antifungal treatment strategies.

In recent years, with the growing population of immunocompromised individuals, infections caused by rare environmental molds have become increasingly prevalent and clinically significant. Due to frequent misdiagnosis and difficult clinical management, the overall disease burden of such infections poses a major challenge in clinical practice. This article aims to fill the knowledge gap by reviewing cases of rare mold infections from January 2020 to February 2026, analyzing the susceptible populations, identification techniques, antifungal susceptibility testing, and antifungal treatment strateg

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… Paecilomyces spp . Paecilomyces spp . exist worldwide as saprophytic fungi in soil, where they decompose organic matter, and occasionally serve as insect parasites ( Schinabeck and Ghannoum, 2003 ). … People with normal immune function rarely contract Paecilomyces spp ., but such infections can still occur. In recent years, with the advances in mass spectrometry and molecular diagnostic technologies, rare isolates such as Paecilomyces variotii have been increasingly reported. …

[Research on the surgery treatment and etiology of fungal endophthalmitis].

Objective: To evaluate the efficacy of vitrectomy and etiological diagnosis in the treatment of fungal endophthalmitis. Methods: A retrospec … positive results in 12 eyes, including candida albicans in 6 eyes, fusarium, candida parapsilosis, paecilomyces lilacinus, asoergullus terreus, mulan candida and aspergillus in 1 eye respectively. Based on etiological diagnosis, 14 eyes received amphotericin B intraocular injection during operation, and 9 patients received fluconazole (venous transfusion or o …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… In such cases, instruments are contaminated with Ulocladium botrytis , Phoma spp., Fusarium spp., Penicillium spp., Cladosporium spp., Cryptococcus spp., Paecilomyces variotti , Rhodotorula mucilaginosa , and Trichosporon mucoides [ 121 , 122 , 123 , 124 ]. 3. … Hyalohyphomycosis Hyalohyphomycosis includes several diseases caused by opportunistic hyaline non-dematiaceous molds or yeasts, such as Aspergillus spp., Acremonium spp., Basidiomycota, Beauvaria spp., Chaetoconidium spp., Chrysosporium spp., Fusarium spp., Microascus spp., Paecilomyces spp., Penicillium …

TB AND OTHER CHEST INFECTIONS

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Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells.

Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell cytotoxicity that can be used in combination with immunotherapy to achieve therapeutic efficiency. Cordycepin, a bioactive compound that can be extracted from some Cordyceps spp. has been reported to effectively inhibit tumor growth, however, the mechanism of its tumor sensitization activity that enhances immune cell cytotoxicity is unknown. In the present study, we investigated the potency of cordycepin to sensitize a l

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… Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): A randomized and double-blind clinical trial. BMC Complement. Altern. Med. 2019;19:77. doi: 10.1186/s12906-019-2483-y. 19. Jin Y., Meng X., Qiu Z., Su Y., Yu P., Qu P. …

30 years in service, 1996-2026: Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).

The Infectious Diseases Working Party (AGIHO) was established in 1996 as one of the subgroups of the German Society of Hematology and Medical Oncology (DGHO). Marking its 30th anniversary this year, the AGIHO reflects on a period of significant achievement and growth. Beyond its core mission of developing evidence-based clinical practice guidelines for the prevention, diagnosis, and management of infections in patients with cancer, the AGIHO has evolved into a vital platform for clinical trials, collaborative research, and postgraduate medical education. To ensure long-term sustainability and

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… Sprute R Salmanton-García J Sal E Malaj X Falces-Romero I Hatvani L Characterization and outcome of invasive infections due to Paecilomyces variotii : analysis of patients from the FungiScope® registry and literature reports J Antimicrob Chemother 2021 76 3 765 74 10.1093/jac/dkaa481 33254240 PMC7879145 … Sprute R, Salmanton-García J, Sal E, Malaj X, Falces-Romero I, Hatvani L et al (2021) Characterization and outcome of invasive infections due to Paecilomyces variotii : analysis of patients from the FungiScope® registry and literature reports. …

Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas.

Immunology and microbiology research has witnessed remarkable growth and innovation globally, playing a pivotal role in advancing our understanding of immune mechanisms, disease pathogenesis, and therapeutic interventions. This manuscript presents a comprehensive exploration of the key areas in immunology research, spanning from the utilisation of bacterial proteins as antibody reagents to the intricate realms of clinical immunology and disease management. The utilisation of bacterial immunoglobulin-binding proteins (IBPs), including protein A (SpA), protein G (SpG), and protein L (SpL), has r

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… .; Fusarium dimerum ; Penicillium ; Paecilomyces variotii ; Scedosporium. | Candida spp. Parasites | Giardia duodenalis ; Giardia intestinalis ; Cryptosporidium spp.; Schistosoma species; Blastocystis hominis ; Fasciola spp.; Trichostrongylus spp. …

10th Trends in Medical Mycology Held on 8 to 11 October 2021, Aberdeen, Scotland, Organized by the European Confederation of Medical Mycology (ECMM).

Plenary Sessions: [...].

Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment.

Chemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors' resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals

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… The potential antioxidant properties of Mate tea can be further enhanced by enzymatic biotransformation catalyzed by Paecilomyces variotii tannase , leading to a 43% increase [ 45 ]. …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… .; Fresh bulbs | ( 36 ) Paecilomyces sp. | | J : 22.7 mm dd : 10 mm | | J (1%) | Ilam, Iran | Shallot; A. ascalonicum Linn.; Fresh bulbs | ( 36 ) Aspergillus niger | | J: 22 mm dd : 10 mm | | J (1%) | Ilam, Iran | Shallot; A. ascalonicum Linn.; Fresh bulbs | ( 36 ) | | E : MIC = 62.5 μg/ml | pH …

Infections in Recipients of Hematopoietic Stem Cell Transplants

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… Other Molds Non- Aspergillus molds such as Alternaria, Pseudallescheria/Scedosporium, Paecilomyces, Fusarium, and Phialophora spp. are infrequent causes of invasive tissue infections whose clinical appearance is similar to that of Aspergillus infection. …

The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session.

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