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Burkholderia pseudomallei: the unbeatable foe?

Although melioidosis has been recognized in Thailand for many years and considerable progress in term of diagnosis and treatment was achieved, B. pseudomallei is still "the unbeatable foe", for several reasons as outlined here: under-recognition, high case-fatality rate, unacceptable relapse rate and a "time-bomb" for sero-positive patients. Melioidosis is largely restricted to certain geographical areas. In Thailand, it had long been considered a rare disease in Thailand until ten cases with culture-proven melioidosis were reported by Sompone Punyagupta and his associates at a meeting of the

Hemophagocytic Lymphohistiocytosis (HLH) in Patients with Tick-Borne Illness: A Scoping Review of 98 Cases.

Hemophagocytic lymphohistiocytosis (HLH) secondary to tick-borne infections is a rare but potentially life-threatening syndrome. We performed a scoping review according to PRISMA guidelines to systematically analyze the existing literature on the topic. A total of 98 patients were included, with a mean age of 43.7 years, of which 64% were men. Most cases, 31%, were reported from the USA. Immunosuppression was present in 21.4%, with the most common cause being previous solid organ transplantation. Constitutional symptoms were the most common, observed in 83.7% of the patients, while fever was r

Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis.

The central nervous system (CNS) is a highly complex network comprising long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain. Under neuroinflammatory conditions, as in the case of viral encephalitides, the infiltration of leukocytes is often required for efficient viral clearance and recovery. The orchestration of leukocyte migration into the inflamed CNS is largely coordinated by a large family of chemotactic cytokines and their receptors. In this review, we will summarize our current un

Low-Bacterial Diet in Cancer Patients: A Systematic Review.

The low-bacterial diet (LBD) is a widely used dietary regimen to reduce the risk of food-borne infections in patients with neutropenic cancer, but its role is controversial due to its unclear benefits. The purpose of this study was to provide an updated analysis of the available evidence on the efficacy of the LBD to reduce the risk of infections, mortality rates, and quality of life (QoL) in neutropenic patients with cancer. A systematic literature search was conducted in the biomedical databases Cochrane Library, PubMed, CINHAL, and EMBASE. The process of the screening, selection, inclusion

Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.

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Primary causes of hospital admission in HTLV-1 infected patients: infectious complications, predictors of mortality and long-term survival outcomes.

BACKGROUND: Human T-cell lymphotropic virus type 1 (HTLV-1) is a globally prevalent retrovirus associated with adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite substantial research, the high mortality risk among HTLV-1 carriers remains poorly understood. OBJECTIVE: This study aimed to identify primary causes of hospital admission, predictors of mortality, and long-term survival outcomes in HTLV-1-infected patients. METHODS: A retrospective cohort study was conducted in two referral hospitals in Mashhad, Iran, from 2011 to 2

Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection

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Роль Гут Микробиота в неврологических, психиатрических и неевроразвитых расстройствах.

АИМ: Эта статья направлена на изучение роли человеческого кишечного микробиота (ГМ) в патогенезе неврологических, психиатрических и нейроразвитых расстройств, с уделением особого внимания его влиянию на здоровье и болезни и изучением потенциальных терапевтических стратегий, ориентированных на модификацию ГМ. МАТЕРИАЛЫ И МЕТОДЫ: Предусмотрен всеобъемлющий анализ состава кишечного микробиота и его взаимодействия с человеческим телом, в частности его роли в неврологических и психиатрических условиях. В обзоре обсуждаются факторы, влияющие на состав ГМ, включая родовой режим, грудное вскармливание

Stem Cell Transplantation

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Свободные цепочки света, как новые биомаркеры отдельных заболеваний.

Для оказания помощи в диагностике и прогнозировании будущих клинических событий или прогрессирующих заболеваний необходимы диагностические и перспективные маркеры. В качестве перспективных биомаркеров отдельных заболеваний рассматривались бесплатные световые цепи (ФЛК) Δ и Δ. В настоящее время измерения FLC используются в повседневной диагностике, например, множественной миэломы, и хорошо понятна полезность FLC в качестве биомаркеров моноколональных гаммопатий. В связи с этим в настоящем обзоре основное внимание уделяется исследованиям, касающимся КЛС как новых потенциальных биомаркеров других

Purpura fulminans secondary to Capnocytophaga canimorsus bacteraemia following a dog bite: A case report and review of literature.

IntroductionInfection due to Capnocytophaga canimorsus may result in a wide variety of clinical presentations. We present a case of life-threatening Capnocytophaga canimorsus infection with evolution of ecchymosis to purpura fulminans.Case descriptionWe present a case of a 43-year-old male with a history of excessive alcohol consumption who presented with features of sepsis following a dog bite. This was associated with a striking, widespread purpuric rash. A causative pathogen, C. canimorsus was identified through blood culture and 16S RNA sequencing. His initially purpuric rash underwent bul

Diseases of the Nervous System

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Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders.

This study aimed to assess the feasibility of diagnosing secondary pulmonary fungal infections (PFIs) in patients with hematological malignancies (HM) using computerized tomography (CT) imaging and a support vector machine (SVM) algorithm. A total of 100 patients with HM complicated by secondary PFI underwent CT scans, and they were included in the training group. Concurrently, 80 patients with the same underlying disease who were treated at our institution were included in the test group. The types of pathogens among different PFI patients and the CT imaging features were compared. Radiomic f

Совпадение в полном тексте источника
… Existing and emerging blood-borne pathogens: Impact on the safety of blood transfusion for the hematology/oncology patient. … Hematol Oncol Clin North Am. 2019;33(5):739–48. 10.1016/j.hoc.2019.05.002 31466601 Wagner SJ Leiby DA Roback JD Existing and emerging blood-borne pathogens: Impact on the safety of blood transfusion for the hematology/oncology patient Hematol Oncol Clin North Am 2019 33 5 739 48 31466601 10.1016/j.hoc …

Cancer health disparities in racial/ethnic minorities in the United States.

There are well-established disparities in cancer incidence and outcomes by race/ethnicity that result from the interplay between structural, socioeconomic, socio-environmental, behavioural and biological factors. However, large research studies designed to investigate factors contributing to cancer aetiology and progression have mainly focused on populations of European origin. The limitations in clinicopathological and genetic data, as well as the reduced availability of biospecimens from diverse populations, contribute to the knowledge gap and have the potential to widen cancer health dispar

The Role of Gamma Delta T Lymphocytes in Physiological and Pathological Condition-Focus on Psoriasis, Atopic Dermatitis, Autoimmune Disorders, Cancer and Lymphomas.

Gamma delta (γδ) T cells are a heterogeneous population of cells that play roles in inflammation, host tissue repair, clearance of viral and bacterial pathogens, regulation of immune processes, and tumor surveillance. Recent research suggests that these are the main skin cells that produce interleukin-17 (I-17). Furthermore, γδ T cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation. γδ T cells are found in epithelial tissues, where many cancers develop. There, they participate in antitumor immunity as cytotoxic cells or as immune coordinators.

Abstracts from the ISSAID 2021 Periodic Congress : Virtual. May - Dec 2021

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2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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Mortality and morbidity in populations in the vicinity of coal mining: a systematic review.

BACKGROUND: Evidence of the association of coal mining with health outcomes such as increased mortality and morbidity in the general population has been provided by epidemiological studies in the last 25 years. Given the diverse sources of data included to investigate different health outcomes in the exposed populations, the International Classification of Diseases (ICD) can be used as a single classification standard to compare the findings of studies conducted in different socioeconomic and geographic contexts. The ICD classifies diagnoses of diseases and other disorders as codes organized b

Комплексное исследование двустороннего взаимодействия между микробиомами человека и злокачественными заболеваниями крови и гематологическими условиями: акцент на новых терапевтических стратегиях.

Микробиота человека играет ключевую роль в поддержании хомостаза, регулируя иммунную реакцию, метаболизм и гематопоисис. Микробиальный дисбиоз все чаще ассоциируется с иммунной дисфункцией, воспалением и аномалиями костного мозга, которые могут привести к гематологическим заболеваниям. В настоящем обзоре резюмируются текущие данные о роли микробиота в нормальном гематопоисе и ее потенциальной причастности к доброкачественным и злокачественным гематологическим расстройствам.МЕТОДЫ: Обзор описательной литературы был проведен на основе всестороннего поиска основных научных баз данных без временны

Community-acquired pneumonia

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