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A Case Report of Rare MOG Antibody-Associated Optic Neuritis Related to Hepatitis E Virus Infection.

Hepatitis E infection is a highly prevalent viral infection, with neurological manifestations being the most common extrahepatic symptoms. H … lin oligodendrocyte glycoprotein (MOG) antibody IgG, after confirm no other related factors causing optic neuritis present, so it is considered as MOG antibody-associated optic neuritis, and this was confirmed through effective treatment. After five days of immunoglobulin therapy, along with corticosteroids and neurotrophic drugs, the bilateral optic nerve swell …

Myelin oligodendrocyte glycoprotein antibody-associated disease presenting as isolated simultaneous bilateral optic neuritis in a child.

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is the most recently defined distinct demyelinating disorder of the central nervous system which has heterogeneous clinical manifestations. Here, we present the case of isolated bilateral optic neuritis (ON) in an 11-year-old female who presented with bilateral acute and progressive loss of vision with pain on ocular movement over the past 2 days following mild fever. Neuroimaging revealed the features suggestive of isolated ON more in favor of MOGAD. Spine imaging was within the normal limits. She was seronegative for aqu…

Clinical Characteristics and Visual Outcomes of Optic Neuritis in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a neuro-immunological disorder that can cause optic neuritis (ON) and significant visual impairment. Our objective was to investigate clinical characteristics and visual outcomes in children with MOGAD-ON. METHODS: Retrospective cohort study of MOG-IgG-positive children (onset age 18 years and younger) meeting 2023 international MOGAD panel criteria who presented with ON and received neuro-ophthalmic care between 2003 and 2023 at 3 academic centers in Northern California was conducted. We captured demograph…

Recurrent optic neuritis as the first presentation of monoclonal gammopathy of undetermined significance: a case report.

BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS), which can be asymptomatic, is a premalignant proliferative disorder of plasma cells. The peripheral nervous system may be involved in MGUS, causing a monoclonal gammopathy associated peripheral neuropathy. However, involvement of the central nervous system (CNS) in MGUS was rarely reported. CASE PRESENTATION: Here we report a rare case of recurrent optic neuritis, as the first clinical presentation of MGUS, in an otherwise healthy 54-year-old Iranian male patient. He was treated with intravenous high-dose methylprednisolon…

Optic Neuritis Following Nivolumab Treatment for Metastatic Melanoma: A Case Report and Review of the Literature.

Immune checkpoint inhibitors have revolutionized the treatment of melanoma and other tumors; however, these novel drugs can trigger immune-related adverse events (irAEs), involving uncontrolled autoimmune cross-reactive damage to the brain, peripheral nerves, eyes, and connective tissue. We report an unusual case of optic neuritis and anterior uveitis following treatment with nivolumab, an anti-programmed cell death protein 1 inhibitor, in a 60-year-old Mexican woman with metastatic melanoma. We ruled out infectious, autoimmune, inflammatory, and neoplastic etiologies as the cause of optic neu…

Neuroophthalmological evaluation in primary inflammatory demyelinating diseases with special reference to optic neuritis: A prospective study.

INTRODUCTION: The involvement of ocular system especially optic neuritis (ON) is an important clinical aspect of inflammatory demyelinating disease (IDD) of the central nervous system. The primary IDD spectrum includes neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein-associated diseases (MOGAD), multiple sclerosis (MS), and clinically isolated syndrome (CIS). The clinical presentation of ON varies according to disease pathophysiology. AIM: We aimed to determine the clinical characteristics of treatment-naïve ON at baseline and on the 6-month follow-up and a…

Реагирование на телетикацепт в оптическом неврайтете, связанном с синдромом Шогрена: доклад о деле и обзор литературы.

ОПТИЧЕСКИЙ Неврит (ON) часто представляет собой первоначальный симптом множественного склероза и оптики нейромиелита. Кроме того, ОН является одним из проявлений повреждения центральной нервной системы в синдроме Шёгрена (SS). Вместе с тем исследования по вопросам, связанным с СС, являются незначительными. В настоящее время отсутствуют стандартные методы лечения лиц, связанных со СС, и коэффициент рецидивов остается высоким. МЕТОДЫ: 54-летняя пациентка продемонстрировала главным образом симптомы сухого рта и сухого глаза, а также быстро ухудшающееся зрение и боль в левом глазе. Лабораторные те

Совпадение в аннотации оригинала
BACKGROUND: Optic neuritis (ON) frequently presents as the initial symptom of multiple sclerosis and neuromyelitis optica. Additionally, ON is one of the manifestations of central nervous system damage in Sjögren's syndrome (SS). However, there is little research on SS-associated ON. Currently, there are no standard treatment methods for SS-associated ON, an…

Investigating the Relationship between Telomere-Related Gene Variants and Leukocyte Telomere Length in Optic Neuritis Patients.

Optic neuritis (ON) is a condition marked by optic nerve inflammation due to various potential triggers. Research indicates a link between telomeres and inflammation, as studies demonstrate that inflammation can lead to increased telomere shortening. Aim: We aimed to determine the associations of telomere-related telomeric repeat binding factor 1 (TERF1) rs1545827, rs10107605, and telomeric repeat binding factor 2 (TERF2) rs251796 polymorphisms and relative leukocyte telomere length (LTL) with the occurrence of ON. Methods: In this research, a total of 73 individuals diagnosed with optic neuri…

A single-center retrospective series of OCT and MRI findings in pediatric MOGAD optic neuritis patients.

BACKGROUND: Whether optical computed tomography (OCT) and magnetic resonance imaging (MRI) findings are associated with final visual acuity in children with myelin oligodendrocyte glycoprotein antibody disease (MOGAD) optic neuritis is unclear. METHODS: We retrospectively reviewed the charts of pediatric patients with MOGAD optic neuritis seen at St. Louis Children's Hospital/Barnes Jewish Hospital since 2016. RESULTS: In the 12 patients in this study, presenting visual acuity was worse in the optic neuritis-affected eyes but significantly improved from presentation to follow-up, such that, …

Association between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study.

PURPOSE: Our study aimed to explore the correlation between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis. METHODS: This retrospective, nationwide, population-based, matched case-control investigation involved 33,190 individuals diagnosed with optic neuritis, identified using the International Classification of Diseases, Ninth Revision, Clinical Modification codes 377.30 for optic neuritis or 377.32 for retrobulbar neuritis. Patient data were extracted from the Taiwan National Health Insurance Research Database. Demographic characteristics, the presence o…

Cerebrospinal fluid neurofilament light chain in acute optic neuritis and its predictive ability of multiple sclerosis.

BACKGROUND: Studies on the capability of cerebrospinal fluid neurofilament light chain (cNfL) to predict multiple sclerosis (MS) conversion in clinically isolated syndromes have yielded varying results. OBJECTIVES: To expand our understanding of cNfL in optic neuritis (ON) and investigate whether incorporating cNfL into the 2017 McDonald criteria could accelerate the diagnosis of MS in patients with ON. METHODS: cNfL was measured in diagnostic samples from 74 patients with verified ON. MS was diagnosed using the 2017 McDonald criteria with a minimum observation time of two years from ON onse…

Clinical outcomes of optic neuritis: A retrospective study at a tertiary medical center in Saudi Arabia.

OBJECTIVES: To investigate the clinical results of optic neuritis (ON) patients in a tertiary medical facility in Makkah, Kingdom of Saudi Arabia. METHODS: The data of patients assessed for ON at Makkah, Saudi Arabia's King Abdullah Medical Center (KAMC), was examined retrospectively. RESULTS: We identified 15 patients with ON. The ON was caused by multiple sclerosis (MS) in 73.3% of patients and neuromyelitis optica spectrum disorder (NMOSD) in 26.7% of patients. The disease was bilateral in 60% of patients and unilateral in 40% of patients. Additionally, 60% of patients had 2 or more episo…

Evaluating patient-reported outcome measures (PROMs) for future clinical trials in adult patients with optic neuritis.

OBJECTIVE: To search for and critically appraise the psychometric quality of patient-reported outcome measures (PROMs) developed or validated in optic neuritis, in order to support high-quality research and care. METHODS: We systematically searched MEDLINE(Ovid), Embase(Ovid), PsycINFO(Ovid) and CINAHLPlus(EBSCO), and additional grey literature to November 2021, to identify PROM development or validation studies applicable to optic neuritis associated with any systemic or neurologic disease in adults. We included instruments developed using classic test theory or Rasch analysis approaches. We…

The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis.

THE AIM: To investigate the role of Sirtuin 1 (SIRT1) level and SIRT1 (rs3818292, rs3758391, rs7895833) gene polymorphisms in patients with optic neuritis (ON) and multiple sclerosis (MS). METHODS: 79 patients with ON and 225 healthy subjects were included in the study. ON patients were divided into 2 subgroups: patients with MS (n = 30) and patients without MS (n = 43). 6 ON patients did not have sufficient data for MS diagnosis and were excluded from the subgroup analysis. DNA was extracted from peripheral blood leukocytes and genotyped by real-time polymerase chain reaction. Results were a…

COVID-19 - a potential trigger for MOGAD-associated optic neuritis: a case report and literature review.

SARS-CoV-2 affects the nervous system directly by neurotoxic action, by binding to angiotensin-converting enzyme-2 (ACE2) receptors or indirectly by inducing cytokine storm leading to disruption of the blood-brain barrier, immunological mediation, increasing blood coagulation and as a trigger for autoimmune-mediated demyelinating injuries in the central nervous system. In COVID-19 neuro-ophthalmological manifestations are not so common. Optic neuritis is the result of optic nerve inflammation and has varied causes. In many patients, signs of inflammation are not visible on the fundus, and it u…