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Temperature-Dependent Dynamics of Superoxide and Peroxide Anions in Hydrocarbon Catalytic Oxidation Over Single-Atom Pt Catalysts.

Understanding the properties of reactive oxygen species (ROS) is crucial for efficient oxidation catalyst design, yet their dynamics during oxidative reactions are still unclear. Herein, using a CeZrO2-supported single-atom Pt catalyst (PtSA/CeZrO2), we studied temperature-dependent behaviors of superoxide (O2 •-) and peroxide (O2 2-) anions and how multiple ROS are involved in the catalytic oxidation of mixed hydrocarbons. We show that O2 •- species, having an unpaired electron and a Pt-O-O structure, accounts for surface reactivity at lower temperatures, which is critical to toluene ring-ope

Glycemic status, antioxidant enzyme and lipid peroxidation among patients with diabetes mellitus in Buea Regional Hospital in Cameroon.

BACKGROUND: Oxidative stress has been suggested to play a role in the pathogenesis of type 2 diabetes mellitus (T2DM) and development of complications by altering antioxidant levels and inducing lipid peroxidation. Although patients with T2DM are reported to be under oxidative stress because of prolonged exposure to hyperglycemia, the influence of glycemic control in diabetes on enhanced free-radical activity is poorly understood. AIM: To evaluate the levels of malondialdehyde (MDA) - a marker of lipid peroxidation and catalase (CAT) - an antioxidant enzyme in patients with T2DM categorized b

TFPT Abundance Is Associated with Growth-Related Phenotypes and Cellular Features Linked to Lipid Peroxidation Defense in Hepatocellular Carcinoma.

TCF3 fusion partner (TFPT) remains insufficiently characterized in hepatocellular carcinoma (HCC), particularly in relation to tumor growth and cellular features linked to lipid peroxidation defense. We integrated public transcriptomic and clinical datasets and established stable TFPT-knockdown and TFPT-overexpression models in MHCC97-H and Huh-7 cells. TFPT expression was higher in HCC tissues and selected HCC cell lines. In TCGA-LIHC, higher TFPT expression was associated with shorter overall survival after multivariable adjustment (HR, 1.37; 95% CI, 1.06-1.77), although this association was

Hydrogen peroxide contributes to SYP-14288-induced multidrug resistance in Rhizoctonia solani by modulating detoxification and efflux pathways.

SYP-14288 is an effective antifungal compound against Rhizoctonia solani, the causal agent of rice sheath blight. The chemical acts through its unique uncoupling mechanism. Previous studies have demonstrated that SYP-14288-resistant mutants of R. solani develop multidrug resistance (MDR), but the underlying mechanisms remain unclear. In this study, in SYP-14288-resistant mutants, hydrogen peroxide (H₂O₂) accumulated at higher levels, which may activated oxidative stress signaling and upregulated detoxification pathways. Compared with the parental strain, these mutants also showed significantly

3-n-Butylphthalide Protects SH-SY5Y Cells from Ferroptosis by Inhibiting ACSL4-Mediated Lipid Peroxidation.

Parkinson's disease (PD) is the second most common neurodegenerative disorder, and its pathogenesis is closely associated with oxidative stress, mitochondrial dysfunction, and iron-dependent cell death. In our previous study, we showed that 3-n-butylphthalide (NBP) alleviates behavioral deficits in a PD mouse model. However, the underlying mechanisms remain unclear. Here, we found that NBP treatment significantly attenuated ferroptosis induced by Erastin or RSL3 in SH-SY5Y cells, as evidenced by improved cell viability, reduced reactive oxygen species (ROS) production, decreased mitochondrial

Ferryl species-independent PMSO2 formation: Multiple oxygen atom transfer pathways in Fe2+-based peroxide activation.

Methyl phenyl sulfoxide (PMSO) is widely used to identify ferryl-oxo species ([FeIV=O]2+) in Fenton and Fenton-like advanced oxidation proce … formation. Instead, all the transferred oxygen atoms were shown to originate from the corresponding peroxides, particularly from the distal oxygen atoms with unsaturated electronic structures. Notably, PMSO2 was readily generated in various iron-free peroxide activation systems, and molecular orbital of high-valent iron complexes combined with thermodynamic …

IFN𝛾 and IFN𝛾 mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation.

Type I interferons (IFN-I) and IFNγ exert divergent effects during tuberculosis, but the mechanisms that determine whether macrophage activation promotes host defense or inflammatory pathology remain incompletely understood. Here, we dissect the interplay between IFN-I and IFNγ in macrophage activation using genetically susceptible B6.Sst1S macrophages. We show that, during tumor necrosis factor (TNF) stimulation, susceptible macrophages enter a persistent pathological activation state (pPAS) characterized by sustained lipid peroxidation and super-induction of IFN-I responses. This pathologica

Comparison of neutralization and disinfection kinetics in povidone iodine- and hydrogen peroxide-based soft contact lens care solutions.

PURPOSE: To assess and compare the time-dependent disinfection efficacy against standard microbial strains and the neutralization kinetics of two commercially available soft contact lens care systems, one based on 0.05% povidone iodine and one based on 3.42% hydrogen peroxide. METHODS: To assess neutralization kinetics of each system, the concentration of the active disinfectants was quantified via iodometric titration (hydrogen peroxide) and high-performance liquid chromatography (povidone iodine) at intervals from 0.5 min to the minimum recommended disinfection time (MRDT). Disinfecting eff

Benzoyl Peroxide Wash Is Efficacious in Reducing Cutibacterium acnes Surgical Site Infections After Posterior Spine Surgeries.

BACKGROUND AND OBJECTIVES: Cutibacterium acnes has been identified as a causative agent of spine surgical site infections (SSIs). Benzoyl peroxide (BPO) has long been used to treat acne vulgaris caused by C. acnes. In this study, we examined the efficacy of applying BPO to reduce SSIs after posterior spine surgeries. METHODS: Our institution implemented a new protocol in February 2024 to apply 5% BPO preoperatively to the surgical site for all patients undergoing posterior spine operations. These patients were compared with historical controls who underwent preoperative skin preparation with

Lipid droplets as redox-active organelles after spinal cord injury: lipid peroxidation, mitochondrial dysfunction, and neuroinflammation.

OBJECTIVES: Spinal cord injury (SCI) causes myelin breakdown and membrane disruption, leading to the release and redistribution of cholesterol, fatty acids, and other lipids within the lesion. The resulting disruption of lipid homeostasis can promote sustained lipid peroxidation, neuroinflammation, and repair failure. In recent years, lipid droplets (LDs) have been recognized as highly dynamic organelles that coordinate lipid storage, mobilization, energy metabolism, and stress responses. However, the stage- and cell-specific roles of LDs in lipid-redox dysregulation after SCI remain poorly un

An on-tissue parallel d0/d20-meladrazine derivatization approach for fatty acid peroxidation products imaging in adult zebrafish.

BACKGROUND: Mass spectrometry imaging (MSI) enables the simultaneous acquisition of spatial distribution, abundance, and structural information of multiple molecules in biological tissues, yet it faces inherent challenges in detecting poorly ionizable or low-abundance analytes. Fatty aldehydes (FALs) and oxygenated fatty acids (oxo-FAs), key subclasses of fatty acid peroxidation products (FAPPs), are of profound physiological and pathological significance. However, their mass spectrometric detection remains a formidable challenge, particularly for in situ desorption and analysis in biological

Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne: Pooled Analysis by Age and Sex.

BACKGROUND: Acne pathophysiology and presentation may differ by patient age or sex. In clinical trials, clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel demonstrated efficacy and a positive safety profile in participants with moderate-to-severe acne. This post hoc analysis evaluated CAB efficacy/safety by age and sex. METHODS: In one phase 2 and two phase 3 double-blind, randomized, 12-week trials, participants aged ≥9 years with moderate to severe acne applied once-daily CAB or vehicle. Efficacy endpoints included Evaluator's Global Severity Score ≥2-grade red

Anthocyanin-Incorporated Chromogenic Agar for Rapid, Selective Detection of Streptococcus pneumoniae via Hydrogen Peroxide-Mediated Oxidation.

The rapid and cost-effective identification of Streptococcus pneumoniae (S. pneumoniae) is crucial for the prompt treatment of pneumonia and meningitis. However, conventional culture methods are time-consuming and molecular techniques are prohibitively expensive in resource-limited settings. To address this challenge, we developed a novel anthocyanin chromogenic agar as a diagnostic tool for the selective and rapid detection of S. pneumoniae. Unlike traditional pH-based indicators, this method exploits the unique oxidative capability of S. pneumoniae, which releases excessive amounts of hydrog

LOX-1 mediated lipid peroxidation leads to dysfunction of tumor infiltrating CD8+ T cells in ovarian cancer.

Abnormal lipid accumulation in the tumor microenvironment (TME) promotes lipid peroxidation in tumor-infiltrating CD8+T cells (CD8+TILs), driving their dysfunction and impairing antitumor immunity in ovarian cancer (OC). To elucidate the underlying immunosuppressive mechanisms, we integrated clinical specimens, mouse models, and in-vitro validation. Notably, CD8+TILs from OC patients exhibited pronounced lipid peroxidation signatures. Elevated oxidized low-density lipoprotein (oxLDL) levels were detected in ovarian tumor interstitial fluid (TIF), tumor mass-derived supernatants, and tissue sec

Длиннокаменистые толстые кислоты как движущие факторы нейроинфламмации в нейродегенерации: механистические связи с липидом пероксидацией, Ферроптозом и митохондриальной дисфункцией.

Фон: Нейродегенеративные заболевания (НИ) рассматриваются главным образом как расстройства, характеризующиеся серьезным иммунометаболическим дисбалансом, характеризующимся текущей нейроинфламмацией и глиальной активацией. Хотя митохондриальная дисфункция и окислительный стресс являются хорошо известными особенностями, метаболические факторы в верхнем течении, связывающие эти патологические процессы, по-прежнему плохо понимаются. Методы: В ходе этого обзора мы изучили недавние доклинические и клинические исследования, в ходе которых были изучены связи между липидным метаболизмом, иммунометаболи

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… During these initial phases, lipid peroxidation is initiated under heightened oxidative stress, largely driven by an LCFA imbalance. Cells rely on specific localized defenses against lipid peroxidation. … The massive efflux of superoxide radicals drives lipid peroxidation of neuronal polyunsaturated fatty acids (LC-PUFAs). The existing iron imbalance and the unchecked accumulation of lipid peroxides act as the primary initiation signals for ferroptosis. 3.3. …

Photodynamic inactivation of bacterial biofilms on absorbable collagen membranes using indocyanine green in aqueous and hydrogen peroxide solutions.

Microbial contamination of absorbable collagen membranes used in guided bone regeneration (GBR) may compromise healing outcomes. This study aimed to investigate whether the minimum inhibitory concentration (MIC) of hydrogen peroxide (H2O2) can improve the antibacterial effect of indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (PDT) on absorbable collagen membranes while reducing the need for high H2O2 concentrations. A laboratory-based model was developed using Streptococcus sanguinis and Staphylococcus aureus. The biofilms were treated with ICG (1.29 mM), H2O2 (at MIC), or

Comparison of the effectiveness of automatic and manual plasma-treated hydrogen peroxide mist disinfection in various teaching hospital environments.

BACKGROUND: Automatic disinfection technologies have been developed to improve the reliability and thoroughness of hospital disinfection. However, it is not clear whether automated systems can achieve similar disinfection results to those obtained by well-trained professionals using manual methods. We evaluated the disinfection efficacies of automatic and manual plasma-treated hydrogen peroxide mist (PTHPM) systems in various hospital environments. METHODS: Disinfection was performed in 23 rooms in a teaching hospital, covering various hospital wards, outpatient departments, and emergency roo

Mitochondrial targeting ratiometric theranostic probe activated by hydrogen peroxide toward tracking pH variations in therapeutic processes.

BACKGROUND: At present, cancer remains one of the most devastating health challenges worldwide. Its high mortality rate, metastatic potential, and resistance to conventional treatments make it particularly lethal. Under these circumstances, developing comprehensive theranostic probe that can combine precise tumor detection with efficient treatment has become an urgent priority. Particularly, activatable theranostic probe that can dynamically monitor the changes of cells during the treatment intervention process has become a new research hotspot, bringing hope for more accurate diagnosis and ef

Impact of hydrogen peroxide photolysis on viable bacterial count and composition of in vivo dental biofilm-an ex vivo study.

BACKGROUND: A bactericidal technique utilizing hydrogen peroxide (H₂O₂) photolysis, which generates hydroxyl radicals, was developed. Since it has demonstrated the potential to kill in vitro Streptococcus mutans biofilms, this technique has the possibility to be applied to dental caries. However, its efficacy on in vivo cariogenic dental biofilms remains unclear. This study aimed to evaluate the bactericidal effect of H₂O₂ photolysis on in vivo biofilms obtained from volunteers, focusing on its potential application in dental caries treatment. METHODS: Sixteen participants, prescreened for the

Dysregulation of mitochondrial α-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked Parkinson's disease models.

Dysregulation of mitochondrial function has been implicated in Parkinson's disease (PD), but the role of mitochondrial metabolism in disease pathogenesis remains to be elucidated. Using an unbiased metabolomic analysis of purified mitochondria, we identified alterations in α-ketoglutarate dehydrogenase (KGDH) pathway upon loss of PD-linked CHCHD2 protein. KGDH, a rate-limiting enzyme complex in the tricarboxylic acid cycle, was decreased in CHCHD2-deficient male mouse brains and human dopaminergic neurons. This deficiency of KGDH led to elevated α-ketoglutarate and increased lipid peroxidation