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Clinical and laboratory features of adult biphenotypic acute leukemia.

AIM: To analyze the clinical and biological characteristics of adult BAL. METHODS: We identified 22 cases (4.4%) of BAL from 496 newly diag … ION: BAL patients showed a much higher incidence of older age, CD34 antigen expression, presence of Philadelphia chromosome, liver, spleen and lymphonodes infiltration and resistance to therapy.

Epidemiology of chronic myeloid leukaemia (CML).

Reliable epidemiological information on chronic myeloproliferative disorders (CMPDs), notably Philadelphia (Ph)/BCR-ABL-positive chronic myeloid leukaemia (CML), is rare. Incidence rates vary from 0.6 to 2.0 cases per 100 000 inhabitants, increase with age and are higher in men than in women. Geographic and/or ethnic variations might contribute to the variability of incidences among registries. Prevalence rate has increased by use of tyrosine kinase inhibitors. In daily clinical practice, some CML management areas are not in line with the current recommendations. Problematic areas are sub-opti…

Anterior leaflet on the leash: unusual cause of congenital severe mitral regurgitation.

Isolated-congenital mitral regurgitation is infrequently seen in adults. In its mechanism, the entire mitral apparatus or different components separately can play a role [Gallet B. Use of echocardiography in mitral regurgitation for the assessment of its mechanism and aetiology for the morphological analysis of the mitral valve. Ann Cardiol Angeiol 2003;52(2):70-7; Valdes-Cruz LM, O'Cayre R. Echocardiographic Diagnosis of Congenital Heart Disease. Philadelphia, NY: Lippincott-Raven; 1998; Carpentier A, Branchini B, Cour JC, Asfaou E, Villani M, Deloche A et al. Congenital malformations of the …

Association of antibiotics in infancy with early childhood obesity.

IMPORTANCE: Obesity in children and adults is associated with significant health burdens, making prevention a public health imperative. Infa … s. The study spanned a network of primary care practices affiliated with the Children's Hospital of Philadelphia including both teaching clinics and private practices in urban Philadelphia, Pennsylvania, and the surrounding region. All children with annual visits at ages 0 to 23 months, as well 1 or more visits at ages 24 to 59 months, were enrolled. The cohor …

CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials.

BACKGROUND: CNS relapse of acute lymphocytic leukaemia is difficult to treat. Durable remissions of relapsed or refractory B-cell acute lymp … nical trials (Pedi CART19, 13BT022, ENSIGN, ELIANA, and 16CT022) done at the Children's Hospital of Philadelphia (Philadelphia, PA, USA), in which participants received CD19-directed CAR T-cell therapy between April 17, 2012, and April 16, 2019. The trials required control of CNS disease at enrolment and infusion and excluded treatment in the setting of acute …

The impact of additional cytogenetic abnormalities at diagnosis and during therapy with tyrosine kinase inhibitors in Chronic Myeloid Leukaemia.

BACKGROUND: Chronic Myeloid Leukemia's (CML) treatment was optimized since the development of tyrosine kinase inhibitors (TKI) and an increa … m ACAs at diagnosis group, the most frequent major route ACAs were trisomy 8, trisomy 19 and second Philadelphia (Ph) chromosome and the most frequent minor route ACAs were monosomies and structural abnormalities (inversions and translocations). From the ACAs during the TKI group, the most frequent major route cytogenetic abnormalities in Ph positive and negat …

Cytogenetic pattern of childhood leukemia in Taiwan.

BACKGROUND: Cytogenetic analyses of leukemic cells can be used to define specific subgroups of leukemia with different prognoses and, thereb … had a normal karyotype. Three of the five adult-type chronic myeloid leukemia patients had standard Philadelphia chromosome, and the other two had a variant-form of Philadelphia chromosome. Both of the patients with juvenile myelomonocytic leukemia and one patient with myelodysplastic syndrome had a normal karyotype. CONCLUSIONS: Most findings were similar to …

Clinical Characteristics and Diagnosis of Ph-Positive Mixed Phenotype Acute Leukemia.

BACKGROUND: The goal was to improve the clinical cognition of Ph-positive mixed phenotype acute leukemia and avoid misdiagnosis or delayed diagnosis. METHODS: The clinical manifestations and laboratory results (bone marrow cell morphology, multiparameter flow cytometry, and cytogenetics) of a case of Ph-positive mixed phenotype acute leukemia were analyzed, and related literature was reviewed. RESULTS: Blood routine: WBC 386.35 x 109/L, HGB 117.00 g/L, PLT 31 x 109/L; 80% of the original cells can be seen by artificial classification. Morphological examination of bone marrow cells showed tha

"Instead of just taking my baby, they could've actually given me a chance": Experiences with plans of safe care among birth parents impacted by perinatal substance use.

BACKGROUND: Federal legislation mandates healthcare providers to notify child protective service (CPS) agencies and offer a voluntary care plan called a "plan of safe care" (POSC) for all infants born affected by prenatal substance use. While POSCs aim to provide supportive services for families impacted by substance use, little is known about birth parents' perceptions and experiences. OBJECTIVE: To examine birth parents' perceptions and experiences regarding POSC. PARTICIPANTS AND SETTING: Parents offered a POSC in Philadelphia in the prior year were included. METHODS: This is a qualitati…

Проверка на готовность: острая церебральная малярия, представленная в качестве лица с высоким риском заболевания вирусом Эболы в одной из больниц США.

В 2019 году 42-летний африканский мужчина, работавший в качестве исследователя болезни вируса Эбола (ЭВД), приехал из Демократической Республики Конго (ДРК), недалеко от продолжающейся эпидемии ЭВД, в Филадельфию и был доставлен в больницу отделения неотложной помощи Пенсильванского университета с изменившимся психическим состоянием, рвотой, диареей и лихорадкой. Он был классифицирован как "мокрый" человек под следствием по ЭВД, и его прибытие активировало наш командный центр по чрезвычайным ситуациям в больнице и группы биореакции. Его обнаружили в септическом шоке с многосистемной дисфункцие

Совпадение в аннотации оригинала
In 2019, a 42-year-old African man who works as an Ebola virus disease (EVD) researcher traveled from the Democratic Republic of Congo (DRC), near an ongoing EVD epidemic, to Philadelphia and presented to the Hospital of the University of Pennsylvania Emergency Department with altered mental status, vomiting, diarrhea, and fever. He was classified as a "wet"…

Expedited Scheduling of Interval Tubal Ligation: A Randomized Controlled Trial.

OBJECTIVE: To assess whether expedited scheduling for permanent contraception increases the proportion of patients completing interval tubal ligation within 6 months of delivery. METHODS: We randomly assigned patients with unfulfilled immediate postpartum tubal ligation requests to standard scheduling after a postpartum office visit or an expedited process in which we scheduled the interval tubal ligation surgery before discharge from the hospital. The primary outcome was proportion of participants undergoing tubal contraceptive procedures within 6 months of delivery. Secondary outcomes inclu

Reducing Ischemic Injury From Indwelling Peripheral Arterial Catheters in a Pediatric Cardiac ICU: A Quality Improvement Initiative.

OBJECTIVES: To reduce the number of ischemic arterial catheter injuries in children with congenital or acquired heart disease. DESIGN: This is a quality improvement study with pre- and postintervention groups. SETTING: University-affiliated pediatric cardiac center in a quaternary care freestanding children's hospital. PATIENTS: All patients with an indwelling peripheral arterial catheter placed in the Children's Hospital of Philadelphia Cardiac Center associated with an admission to the Cardiac Intensive Cardiac Unit from January 2015 to July 2017 are included. Patients with umbilical arte…

Decrease in the incidence of threatened preterm labor after implementation of transvaginal ultrasound cervical length universal screening.

BACKGROUND: It is unknown if universal second-trimester transvaginal ultrasound (TVU) cervical length (CL) screening in asymptomatic women w … ry-31 December), and in 2014 (1 January-31 December) at Thomas Jefferson University Hospital (TJU) (Philadelphia, PA). These 2 years were chosen as a new protocol for universal TVU CL screening was started on 1 January 2012. This protocol involved one measurement of TVU CL in all singleton gestations without a prior SPTB at 18 0/7 - 23 6/7 week, the time of th …

Rituximab-Treated Pemphigus Foliaceus in a Schizophrenic Patient: A Challenging Exercise in Diagnosis, Management, and Follow-Up.

Dermatology was consulted in the care of a 58-year-old man with a history of paranoid schizophrenia, neuroleptic malignant syndrome, a positive purified protein derivative test, and a lack of bathing for approximately 4 years who had been admitted to the hospital because of thick, crusted lesions over an increasing portion of his body. Admitted involuntarily, he was disinterested in the history, physical examination, and diagnostic testing. Comorbid schizophrenia presented a unique challenge because he was unable to participate in his care effectively. His story was told through caregivers. Al

Reducing Underserved Children's Exposure to Tobacco Smoke: A Randomized Counseling Trial With Maternal Smokers.

INTRODUCTION: Addressing maternal smoking and child tobacco smoke exposure is a public health priority. Standard care advice and self-help m … ad a child aged <4 years exposed to two or more maternal cigarettes/day at baseline. INTERVENTION: Philadelphia Family Rules for Establishing Smoke-free Homes (FRESH) included 16 weeks of counseling. Using a behavioral shaping approach within an individualized cognitive-behavioral therapy framework, counseling reinforced efforts to adopt increasingly challeng …

All physical activity may not be associated with a lower likelihood of adolescent smoking uptake.

OBJECTIVE: Research has documented that physical activity is associated with a lower risk of adolescent smoking uptake, yet it is unclear whether this relationship exists for all types of physical activity. We sought to determine whether certain types of physical activity are associated with a decreased or an increased risk of adolescent smoking uptake. METHODS: In this longitudinal cohort study, adolescents (n=1356) were surveyed every six months for four years (age 14-18years old). Smoking and physical activity were measured at each of the eight time-points. Physical activity that was negat

Young Adults' Provision of Support to Middle-Aged Parents.

OBJECTIVES: Middle-aged adults often provide support to aging parents, but researchers know little about support that young adults provide middle-aged parents. This study examined support that young adults provide parents and explanations for that support from both offspring's and parents' perspectives. METHOD: Young adults (n = 515, mean age = 22.34) and their parents (n = 364, mean age = 50.09) from the Family Exchanges Study reported support that offspring provide parents. Participants also reported parental personal problems, parental disability status, relationship quality, and support t

Impact of cannabis use during stabilization on methadone maintenance treatment.

BACKGROUND AND OBJECTIVES: Illicit drug use, particularly of cannabis, is common among opiate-dependent individuals and has the potential to impact treatment in a negative manner. METHODS: To examine this, patterns of cannabis use prior to and during methadone maintenance treatment (MMT) were examined to assess possible cannabis-related effects on MMT, particularly during methadone stabilization. Retrospective chart analysis was used to examine outpatient records of patients undergoing MMT (n = 91), focusing specifically on past and present cannabis use and its association with opiate abstine

Hypertrophic cardiomyopathy in neonates with congenital hyperinsulinism.

INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is a well-recognised complication in infants of diabetic mothers and is attributed to a comp … review of infants, age <3 months, with congenital hyperinsulinism managed by Children's Hospital of Philadelphia over a 3.5-year period. DATA: Gestational age, birth weight, hyperinsulinism form and treatments, echocardiogram results, cardiac/respiratory complications. RESULTS: 68 infants were included, 58 requiring pancreatectomy for diffuse (n=28) or focal …

Congenital brain anomalies associated with the hypoplastic left heart syndrome.

This study details the type, frequency, and clinical presentation of developmental brain anomalies in 41 infants with the hypoplastic left heart syndrome encountered during a 52-month interval. Overall, 29% of the infants had either a major or minor central nervous system abnormality. Overt central nervous system malformations, including 3 cases of agenesis of the corpus callosum and 1 case of holoprosencephaly, were seen in 4 infants (10%). Micrencephaly (brain weight at autopsy more than 2 SDs below the mean for age) was found in 27% of the infants. An immature cortical mantle was seen in 21