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Роль фитохимикатов в борьбе с нейропотической болью: сколько успехов мы добились?

Нетрофическая боль — это сложное и изнурительное состояние, вызванное повреждением нерва, которое характеризуется такими ощущениями, как горение, покалывание и стрельба. Она часто связана с такими условиями, как множественный склероз (MS), синдром Гильен-Барре (GBS) и диабетическая полиномропата. Лечение обычной боли часто обеспечивает ограниченное облегчение и сопровождается существенными побочными эффектами, подчеркивая необходимость изучения альтернативных вариантов лечения. Фитохимические вещества, являющиеся биоактивными соединениями, полученными от растений, привлекли внимание к их потен

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… Neuropathic Pain Management Neuropathic pain is often treated with antiepileptic drugs (AEDs) such as gabapentin and pregabalin, which reduce nerve excitability via calcium channel binding. … Combination therapies, such as pregabalin with TNF-α blockers, enhance anti-nociceptive effects and treatment tolerability [ 72 ]. …

Cancer Pain Is Not One-Size-Fits-All: Evolving from Tradition to Precision.

Cancer pain remains a significant challenge in oncology, profoundly affecting patients' quality of life, function, and prognosis. Historically under-recognized and managed with a uniform, opioid-centric approach, cancer pain was often inadequately treated. Advances in pain assessment, multimodal analgesia, and supportive care have improved outcomes, yet traditional algorithms frequently fail to address the complex, heterogeneous nature of cancer pain. Contemporary management is shifting toward precision and personalized medicine, integrating genetic, molecular, and biomarker data with individu

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… Adjuvant drugs for neuropathic pain encompass steroids, anxiolytics, antidepressants, hypnotics, anticonvulsants, gabapentinoids (gabapentin and pregabalin), membrane stabilizers, sodium channel blockers, and N-methyl-d-aspartate (NMDA) receptor antagonists. … Pregabalin is another anticonvulsant modulating calcium channels with adverse effects including dizziness, somnolence, edema, blurred vision, weight gain and euphoria. …

An update on malignant tumor-related stiff person syndrome spectrum disorders: clinical mechanism, treatment, and outcomes.

Stiff person syndrome (SPS) is a rare central nervous system disorder associated with malignancies. In this review, we retrieved information from PubMed, up until August 2023, using various search terms and their combinations, including SPS, stiff person syndrome spectrum disorders (SPSSDs), paraneoplastic, cancer, and malignant tumor. Data from peer-reviewed journals printed in English were organized to explain the possible relationships between different carcinomas and SPSSD subtypes, as well as related autoantigens. From literature searching, it was revealed that breast cancer was the most

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… Pregabalin Structurally, pregabalin is classified as a GABA analog or gabapentinoid ( 180 ). In a previous study, a female patient with SMS who did not respond to diazepam treatment, owing to excessive sedation, was successfully treated with a 3-month pregabalin regimen ( 181 ). … Gabapentin and pregabalin for the treatment of anxiety disorders. Clin Pharmacol Drug Develop. (2018) 7:228–32. 10.1002/cpdd.446 181. Squintani G, Bovi T, Ferigo L, Musso AM, Ottaviani S, Moretto G, et al. …

A comprehensive review on pain: Model, target, therapy, and prospect (Review).

Pain serves as both a protective physiological response essential for species survival and a global health issue affecting human well‑being and societal development. The present review systematically summarized and analyzed the research progresses on pain through a multidimensional analytical framework encompassing animal models, molecular targets, therapeutic approaches and future prospects. In animal modeling, neuropathic pain paradigms have evolved from traditional mechanical compression to composite models that combine dynamic displacement and chemical stimulation. Cancer‑induced pain mode

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… The model has validated analgesics (morphine, bosentan and pregabalin) and revealed peripheral endothelin receptor-trigeminal sensitization linkages ( 61 ). …

Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain?

Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.5% of patients experience cancer pain, significantly impacting their quality of life and causing physical and psychological burdens. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, shows potential in managing cancer pain. This review summarizes current research on rTMS for cancer pain, focusing on pain directly caused by tumors, pain from cancer treatments, postoperative pain, and cancer-related sy

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… All patients used the same and unchangeable treatment regimen: tramadol hydrochloride 100 mg twice daily, pregabalin 75 mg twice daily, gabapentin 400 mg twice daily, and amitriptyline 25 mg twice daily. … These patients primarily exhibited somatosensory-related symptoms and were also receiving vitamin B12, vitamin B1, gabapentin, amitriptyline, pregabalin, and opioid interventions. …

Neuropathic Pain Related with Spinal Disorders: A Systematic Review.

Systematic literature review. To review the evidence from high-quality studies regarding the treatment of neuropathic pain originating specifically from spinal disorders. In general, treatment guidelines for neuropathic pain cover all its various causes, including medical disease, peripheral neuropathy, and cancer. However, the natural history of neuropathic pain originating from spinal disorders may differ from that of the pain originating from other causes or lesions. An expert research librarian used terms related to neuropathic pain and spinal disorders, disc herniation, stenosis, and spin

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… Two SRs showed that gabapentin at doses of 1,200 mg or more was effective for some people with some painful neuropathies OR painful conditions, even potentially important residual biases [ 37 ], and that gabapentin (at doses up to 3,600 mg/day) and pregabalin (up to 300 mg/day) appeared to be useful … Two SRs [ 37 , 38 ] with high-quality evidence demonstrated the effectiveness of gabapentin and pregabalin and showed that these were well-tolerated with fewer adverse effects compared with those of traditional anticonvulsants and could be used as first-line medication. …

State-of-the-Art Management of Complications of Myeloma and Its Treatment.

Multiple myeloma is an incurable disease, although patient survival has increased with the availability of novel agents. Both multiple myeloma and its therapies often affect the renal, immune, skeletal, hematologic, and nervous systems. The resulting organ dysfunctions often impair the quality of life of affected patients, complicate and limit subsequent therapies, and may result in significant mortality. Research on the treatment of complications of multiple myeloma has been limited; hence, preventative and management strategies for patients with these complications are heterogeneous and ofte

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… The mainstay of symptomatic treatment has been extrapolated from the treatment used in diabetic patients, which includes antidepressants (amitriptyline, duloxetine), antiepileptics (carbamazepine, gabapentin, pregabalin), and opiates for pain control [ 71 , 72 ]. … Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain. 2004;110(3):628–638. doi: 10.1016/j.pain.2004.05.001. 72. Ziegler D, Hanefeld M, Ruhnau KJ, et al. …

Long-Term Outcomes of Pituitary Gland Preservation in Pituitary Macroadenoma Apoplexy: Case Series and Review of the Literature.

Introduction  For patients presenting with neurological changes from pituitary tumor apoplexy, urgent surgical intervention is commonly performed for diagnosis, tumor resection, and optic apparatus decompression. Although identification and preservation of the pituitary gland during the time of surgery can be challenging, it may lead to improve endocrine outcomes. Methods  A retrospective case series of all patients with macroadenomas presenting with apoplexy at Loyola University Medical Center from 2016 to 2018 was studied. Demographic, radiographic, and intraoperative characteristics were co

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… number Duration (months) Type Comparator NRS/VAS decrease Responders (%) DN 4 /NPSI/PDQ decrease Responders (%) Musculoskeletal pain conditions Billeci 88 CNP 44 3 PO 204.5±102.8 5.1 68 B DN 4 , 2.2 B 47 dB Baron 85 LBP 130 3 RCT Oxycodone 378.8±129.6 3.7 PDQ, 10.8 Baron 83 LBP 59 154 159 3 PO DB DB Pregabalin … The effect of pregabalin or duloxetine on arthritis pain: a clinical and mechanistic study in people with hand osteoarthritis . J Pain Res J Pain Res . 2017 ; 10 : 2437 – 2449 . doi: 10.2147/JPR.S147640 29066930 PMC5644551 32. Wang ZY , Shi SY , Li SJ , et al. …

Scrambler therapy for chemotherapy-induced peripheral neuropathy: A case report.

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cancer treatment, significantly affecting patients' quality of life. Current pharmacological treatments are often ineffective or poorly tolerated, necessitating alternative therapeutic approaches. Scrambler Therapy (ST), a non-invasive neuromodulation technique, has shown potential for reducing neuropathic pain, but optimal dosing regimens remain undefined.ObjectiveThis case study aims to evaluate the effectiveness of Scrambler Therapy in reducing pain levels and improving functional status

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… She previously tried multiple therapies for her neuropathic symptoms, including gabapentin, pregabalin, nortriptyline, topical menthol, and alpha-lipoic acid – all with minimal benefit. Moderate improvement was noted with venlafaxine. …

Pruritus: an overview. What drives people to scratch an itch?

Pruritus is a common complaint associated with many conditions. It negatively impacts sleep, quality of life, and mortality. Itch is transmitted along both histaminergic and non-histaminergic pathways with a complex interplay between keratinocytes, immune cells and cutaneous neurons. Individuals who present with pruritus should undergo a thorough assessment, especially those over 65 years old, to exclude underlying malignancy. Treatment no longer consists of antihistamines alone. Physicians now have an array of therapies in their armamentarium, to help alleviate this distressing symptom.

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… Oral medications, such as low dose mirtazapine and gabaergic agents (gabapentin, pregabalin) have been shown to be beneficial. Therapies to treat the underlying condition are also important. … Gabaergics, such as gabapentin and pregabalin, which are structural analogs of gamma-aminobutyric acid, have shown efficacy in treating pruritus in CKD patients 43 as well as in patients with neuropathic itch. 3 They may also be effective in other causes of chronic pruritus. …

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

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… Clinical decision‐making regarding the choice of pain medication should take into consideration the weight‐promoting, detrimental effect of the neuropathic agents such as gabapentin and pregabalin, further leading to worsening OA and exacerbating the vicious cycle. … These conditions are often treated by primary care physicians and specialists via an array of medications, including insulin, sulfonylureas, pain medications (gabapentin and pregabalin), antidepressants, antipsychotics, β‐blockers, sleep medications, and chemotherapeutic agents. …

Голова болит в радиационно изолированном синдроме: намек на неизбежное преобразование: отчет о деле.

Головные боли чаще встречаются у пациентов с множественным склерозом по сравнению с населением в целом. Однако головные боли все еще считаются редким симптомом множественного склероза, особенно когда они появляются в качестве первоначального симптома. Происхождение головной боли как симптома радиологически изолированного синдрома (РИС) является редким явлением, и это может значительно повысить вероятность развития множественного склероза. ПРЕДСТАВЛЕНИЕ СЛУЧАИ: Мы сообщаем о случае 36-year-old Иранская женщина испытывает сильную одностороннюю головную боль без других множественных симптомов скл

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… Despite the use of amitriptyline, topiramate, pregabalin, and gabapentin, patient did not experience improvements. MRI findings showed new T2 white matter lesions enhanced by gadolinium, suggesting the diagnosis of MS. …

Assessing the Therapeutic Role of Rehabilitation Programs in Chemotherapy-Induced Peripheral Neuropathy (CIPN)-A Scoping Review.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect of cancer treatment. Characterized by symptoms like pain, numbness, and muscle weakness, CIPN significantly impacts patients' quality of life. Current management strategies vary, with limited consensus on effective treatments. This scoping review aims to explore comprehensive rehabilitation interventions for CIPN, focusing on enhancing patient well-being and functional abilities. Methods: A scoping review, guided by Arksey and O'Malley's framework and Levac et al.'s refinements, was conducted to

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… 1 (5.3%) | Pregabaline 2 (10.0%) | The diagnosis of CIPN was determined by a physician based on symptom history, the presence of symmetrical stocking-glove numbness, the decline in vibration sense, or paresthesia beginning after neurotoxic chemotherapy. | In the ITT analysis, the decline in activities … Participants also took duloxetine or pregabalin. | Placebo device (SES) for the same duration with the same appearance and labeling. …

Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies.

Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa

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… Pain Gabapentin, pregabalin, duloxetine, carbamazepine Anticonvulsants or antidepressants for neuropathic pain. Bladder dysfunction Oxybutynin, tolterodine, mirabegron Anticholinergics or beta-3 agonists for overactive bladder. … Pain Gabapentin, pregabalin, duloxetine, carbamazepine Anticonvulsants or antidepressants for neuropathic pain. Bladder dysfunction Oxybutynin, tolterodine, mirabegron Anticholinergics or beta-3 agonists for overactive bladder. …

Bortezomib-induced peripheral neuropathy: from molecular mechanisms to clinical management.

Bortezomib (BTZ) is a first-generation proteasome inhibitor that has shown significant efficacy in the treatment of multiple myeloma (MM), providing significant therapeutic benefits without severely compromising overall patient health. However, one of the most common and debilitating side effects associated with BTZ therapy is bortezomib-induced peripheral neuropathy (BIPN). This condition is the leading complication observed in patients undergoing BTZ treatment and has a profound impact on treatment regimens, often necessitating dose reductions or alterations in the dosing schedule. Despite t

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… The mechanical hypersensitivity caused by BTZ can be substantially reduced through the use of Ca 2+ channel blockers, such as tramadol, pregabalin, and ethosuximide ( Duggett and Flatters, 2017 ; Yamamoto et al., 2015 ). … Pregabalin attenuates mechanical pain abnormalities in rats with BIPN and is frequently utilized in clinical settings ( Yamamoto et al., 2015 ; Maschio et al., 2019a ). …

Evidence-based supportive care in multiple myeloma.

Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clone of plasma cells in the bone marrow. MM and its therapy increase the risk of complications like anemia, osteolytic lesions, pain, infections, and renal abnormalities in MM patients. Supportive care for MM patients improves the quality of life. Treatment with bisphosphonates decreases skeletal-related events. Vertebroplasty and kyphoplasty are done in cases of vertebral compression fractures. Prophylactic antibiotics and antivirals can decrease infections related to morbidity. Plasmapheresis in patients with r

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… line First line Selective serotenin reuptake inhibitors Duloxetine 20–30 mg 60–120 mg First line First line Second line First line Venlafaxine 37.5 mg 75–225 mg First line First line Second line First line Anticonvulsants Gabapentin 100–300 mg 900–3600 mg First line First line First line First line Pregabalin … reuptake inhibitors Duloxetine | 20–30 mg | 60–120 mg | First line | First line | Second line | First line Venlafaxine | 37.5 mg | 75–225 mg | First line | First line | Second line | First line Anticonvulsants Gabapentin | 100–300 mg | 900–3600 mg | First line | First line | First line | First line Pregabalin …

Pharmacological interventions for pruritus in adult palliative care patients.

BACKGROUND: This is the second update of the original Cochrane review published in 2013 (issue 6), which was updated in 2016 (issue 11). Pru … ds, topical capsaicin, ondansetron and zinc sulphate compared to placebo and gabapentin compared to pregabalin, and very low for cromolyn sodium, paroxetine, montelukast, flumecinol, and rifampicin compared to placebo. We downgraded the certainty of the evidence mainly due to serious study limitations regarding risk of bias, imprecision, and inconsistency. F …

Management of Itch in the Elderly: A Review.

Chronic itch is common in the elderly patient and may be caused by a variety of known dermatologic and non-dermatologic conditions and can have a significant effect on quality of life. Age-related changes in barrier function, immunosenescence, and neuronal changes and neuropathies are common predisposing factors to chronic itch in this age group. Certain primary dermatologic conditions are more common in the elderly and can cause chronic itch. Also, co-morbid diseases particularly of the renal, hepatobiliary, or hematologic systems, psychologic conditions, or medications may contribute to chro

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… To moderate these unwanted effects, it is recommended that dosage of gabapentin in the elderly be initiated at 100–300 mg (pregabalin 25–75 mg) at night and slowly titrated up [ 88 ]. … Matsuda KM Sharma D Schonfeld AR Kwatra SG Gabapentin and pregabalin for the treatment of chronic pruritus J Am Acad Dermatol 2016 75 3 619 10.1016/j.jaad.2016.02.1237 27206757 102. …

Efficacy and tolerability of controlled-release oxycodone for oxaliplatin-induced peripheral neuropathy and the extension of FOLFOX therapy in advanced colorectal cancer patients.

BackgroundThe oxaliplatin-based regimen FOLFOX is widely used to treat patients with advanced colorectal cancer (CRC). However, dose-limiting toxicity after continuous oxaliplatin administration can lead to peripheral neuropathy. Several agents, including opioids, that have been employed to treat oxaliplatin-induced peripheral neuropathy (OIPN) have been examined in clinical settings regarding their protective and therapeutic effects. However, the pharmacotherapy of these agents has not yet been established. Therefore, we investigated the efficacy and tolerability of oxycodone for OIPN and sub

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… A randomized phase II trial showed that the combination of oxycodone and pregabalin was effective and safe for the treatment of neuropathic pain in cancer patients [ 18 ]. … Garassino MC Piva S La Verde N Spagnoletti I Iorno V Carbone C Febbraro A Bianchi A Bramati A Moretti A Ganzinelli M Marabese M Gentili M Torri V Farina G Randomised phase II trial ( NCT00637975 ) evaluating activity and toxicity of two different escalating strategies for pregabalin and oxycodone combination …

Atypical Calcitriol-Mediated Hypercalcemia in Late Life: A Hypothesis-Generating Case.

Calcitriol-mediated hypercalcemia is most commonly associated with granulomatous disease or lymphoma and rarely occurs without an identifiable cause. We present the case of a 96-year-old woman who developed severe symptomatic hypercalcemia with elevated 1,25-dihydroxyvitamin D (calcitriol), low 25-hydroxyvitamin D (calcidiol), suppressed parathyroid hormone, and no evidence of malignancy, granulomatous disease, endocrine dysfunction, or vitamin D intoxication. She improved with intravenous fluids, calcitonin, and corticosteroids. We hypothesize that age-related impairment of the fibroblast gro

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… Home medications included celecoxib, topical diclofenac, escitalopram, famotidine, furosemide, metoprolol, pregabalin, rosuvastatin, and pancrelipase. On arrival, she was difficult to arouse and disoriented. …