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Clinical Relevance of Preoperative Upper Gastrointestinal Endoscopy before Sleeve Gastrectomy: A Retrospective Cohort Study of 30-Day Outcomes.

BACKGROUND: Routine preoperative upper gastrointestinal endoscopy before sleeve gastrectomy remains debated. This study evaluated whether selected endoscopic and histopathologic findings were associated with 30-day outcomes after sleeve gastrectomy, with specific attention to reflux-related events and severity-stratified staple-line leak. METHODS: We retrospectively analyzed 315 adults who underwent laparoscopic sleeve gastrectomy at a tertiary referral center between June 2016 and December 2019. All patients underwent preoperative esophagogastroduodenoscopy with Sydney-protocol biopsies. Pos

The clinical relevance of sleep disturbance ("insomnia") in patients with advanced cancer receiving palliative care: a scoping review.

PURPOSE: Sleep disturbance ("insomnia") is common in patients with advanced cancer receiving specialist palliative care. The aim of this scoping review was to determine the clinical relevance of sleep disturbance in this cohort of patients. METHODS: Standard methodology was employed, and four databases were searched from inception (Medline, CINAHL, Embase, and APA PsycInfo). Hand searching of relevant sources was also undertaken. Included studies needed to have a sleep focus, and to utilise a validated sleep assessment tool (and/or objective measure of sleep quality). RESULTS: Sixteen studie…

Long-Term Outcomes of Patients With Adductor-Related Groin Pain: Assessing the Clinical Relevance of Imaging-Only Hernias.

BACKGROUND: Groin pain is a common and diagnostically challenging presentation. Imaging often detects hernias that are not clinically evident ('imaging-only hernias') which can lead to unnecessary surgical intervention and under-diagnosis of musculoskeletal conditions like adductor-related groin pain (ARGP). This study evaluates long-term outcomes of patients diagnosed with ARGP in a variety of settings. METHODS: This was a retrospective study of patients diagnosed with ARGP (between January 2021 and June 2024) using the Groin-MAP. Patients were categorised into groups: (1) ARGP with imaging-

Limitations of procedural learning curves: reassessment of the clinical relevance of learning curve analysis in robotic right hemicolectomy.

Learning curves in robotic right hemicolectomy (RRH) are assessed using cumulative sum (CUSUM) analysis. CUSUM was originally designed for industrial processes using external benchmarks. Medical applications rely on internal benchmarks, typically the cohort-specific median. This introduces circularity, obscures early deviations and distorts inflection points. In addition, phase definitions are based on procedural metrics with limited linkage to clinical outcomes. Current models may not reflect surgical proficiency. Data were drawn from a prospectively maintained institutional database covering

Defining and interpreting the clinical relevance of intervention effects for patient-reported outcomes: the smallest worthwhile effect construct.

In clinical research, statistically significant effects do not necessarily indicate that an intervention provides benefits that are meaningful to patients. This is particularly important for patient-reported outcomes, where thresholds used to interpret clinical relevance are often derived from within-person changes, such as the minimal clinically important difference, and then inappropriately applied to between-group effects in randomised trials and meta-analyses. This article clarifies the conceptual distinction between within-group change and between-group effects, and argues that the latter…

Effectiveness and clinical relevance of kinesio taping in musculoskeletal disorders: an overview of systematic reviews and evidence mapping.

OBJECTIVES: To investigate the effectiveness and clinical relevance of kinesio taping (KT) in musculoskeletal disorders (MSDs) at different follow-ups. DESIGN: Overview of systematic reviews (SRs) and evidence mapping. INFORMATION SOURCES: Ten electronic databases were searched for SRs published from inception to 31 December 2024, and updated on 15 October 2025. ELIGIBILITY CRITERIA: SRs with and without meta-analysis of randomised controlled trials (RCTs) were eligible for inclusion if they compared KT with interventions other than KT (eg, active interventions, no tape, placebo/sham KT) in…

Immune dysfunction in nucleotide excision repair disorders: an underrecognized clinical phenotype with relevance for inborn errors of immunity.

Nucleotide excision repair (NER) is a conserved genome maintenance pathway that removes bulky, helix-distorting DNA lesions, including ultraviolet-induced photoproducts and chemically induced adducts. By restoring DNA integrity, NER preserves transcriptional continuity and replicative fitness, thereby limiting mutagenesis, replication stress, and cell death. Inherited defects in NER genes cause rare disorders such as xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD), classically associated with photosensitivity, neurodevelopmental impairment, growth failure, and

Extravascular distribution of factor IX-review of experimental and clinical evidence, and relevance for hemophilia B replacement therapy.

Factor IX (FIX) is a relatively small molecule (55 kDa) that distributes physiologically beyond the plasma pool into the extravascular space. This contrasts with factor VIII, which is confined to the bloodstream as a consequence of its larger size (∼300 kDa) and binding to von Willebrand factor. The extravascular distribution of FIX may be significant in relation to factor replacement therapy in patients with hemophilia B. Given the increasing number of relevant publications over recent years, we critically reviewed and evaluated the experimental and clinical data relating to the extravascular

From PCOS to PMOS: An EMAS clinical guide to the proposed terminology and its relevance to menopause care.

INTRODUCTION: Polycystic ovary syndrome (PCOS) has recently been renamed polyendocrine metabolic ovarian syndrome (PMOS). This change is particularly relevant after menopause, when menstrual dysfunction and ovarian morphology are no longer useful for assessment, while cardiometabolic and other long-term health risks remain clinically significant. AIM: To review the implications of the shift in terminology from PCOS to PMOS for women in the menopausal transition and after menopause and to provide guidance for assessment and management. MATERIALS AND METHODS: This EMAS Clinical Guide is based

Clinical vs. molecular diagnosis of Gorlin syndrome: relevance of diagnostic criteria depends on the age of the patients.

BACKGROUND: Gorlin syndrome (GS) is an autosomal dominant disorder characterized by a predisposition to basal cell carcinoma and developmental defects. It is caused by pathogenic variants in the PTCH1 or SUFU genes. OBJECTIVES: To ascertain the effectiveness of molecular screening in a cohort of patients with a suspicion of GS and to describe the patients' clinical and genetic characteristics. METHODS: In total, 110 patients with a suspicion of GS were studied. The patients were seen at the genetic department of Bichat University Hospital for molecular screening. The patients' clinical and p

Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance.

Factor H (FH) is a crucial complement regulator that prevents complement-mediated injury to healthy cells and tissues. This regulatory function can be disrupted by Factor H autoantibodies (FHAA), which then leads to diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 Glomerulopathy (C3G). In pediatric aHUS, the FHAA incidence is ~10-15%, although in the Indian population, it rises to ~50%. The specific regions of FH targeted by FHAAs correlate with the pathogenic mechanism of the associated disease. In aHUS, FHAAs target the C-terminus, thereby impacting FH ability to recognize c

Detecting Noncoding RNA Associated with Dust Mite-Sensitized Allergic Rhinitis through High-Throughput Sequencing and Its Clinical Relevance.

INTRODUCTION: Allergic rhinitis (AR) is a chronic inflammatory and reactive disease of the nasal mucosa mediated by immunoglobulin E following exposure to allergens in atopic patients. The primary mediator involved is histamine release, and various immune-active cells and cytokines contribute to the inflammatory response. The condition is characterized by nasal itching, sneezing, hypersensitivity, and swelling of the nasal mucosa. Dust mites are prevalent allergens in China, and both genetic and environmental factors contribute to the development of AR. Discovering sensitizing allergens is cru

Cutting through the p-value: evaluating clinical relevance in surgical literature analyzing the approaches for inguinal hernia repair.

BACKGROUND: The introduction of evidence-based medicine has challenged many concepts. In analyzing comparative study results, it is common to find narratives highlighting favorable outcomes based on a p-value of < 0.05, without understanding the clinical impact of the observed difference. Given the prevalence of this issue in hernia surgery research, we aimed to evaluate the prevalence of studies reporting a cutoff for clinical relevance in published comparisons of open, laparoscopic, and robotic inguinal hernia repair (IHR). METHODS: We searched Hernia, Surgical Endoscopy, Annals of Surgery,…

Assessing the clinical relevance of finite element models in MARPE-induced behaviour of craniofacial structures: a biomechanical review.

Miniscrew-Assisted Rapid Palatal Expansion (MARPE) has become a widely adopted non-surgical approach for correcting maxillary transverse deficiency (MTD) in adolescents and adults. Despite its clinical success, outcomes remain highly variable, with complications such as asymmetric expansion, miniscrew loosening, and midfacial fractures influenced by patient-specific anatomical and mechanical factors. Finite Element Method (FEM) models have been increasingly used to simulate MARPE-induced craniofacial responses, offering insight into stress distribution, displacement patterns, and mechanical th

Morphogenesis of Human Scalene Muscles Between Weeks 6 and 13 of Development: Anatomical Aspects and Clinical-Functional Relevance.

The scalene muscles represent a crucial muscle group in cervical anatomy, with significant clinical and functional implications. Despite their importance, studies on their embryonic and fetal development remain scarce. This study examined the morphogenesis of the scalene muscles bilaterally in 33 developing human specimens [66 sides from 12 embryos (Weeks 6-8) and 21 fetuses (Weeks 9-13)] using serial histological sections and conventional light microscopy. The scalene blastema appeared during Week 6 of development, comprising myoblasts, mesenchymal cells, and collagen fibers, and was surround

Объемный объем мозга в реальном мире при множественном склерозе: важность методологической последовательности и клинической значимости атрофии серых веществ.

Утрата мозга (BVL) — показатель нейродегенерации, связанный с клинической инвалидностью при множественном склерозе (MS). Однако его применение в обычной клинической практике ограничено в связи с ошибками в измерениях, возникающими в результате использования различных магнитно-резонансных сканеров в различных центрах и внутри них. ЦЕЛЬ: Подтвердить существование и клиническую актуальность продольного BVL в реальной когорте MS с изменчивостью сканирования с использованием специального трубопровода количественной оценки в сочетании с согласованием после приобретения. Мы проанализировали данные МР

Совпадение в аннотации оригинала
BACKGROUND: Brain volume loss (BVL) is a marker of neurodegeneration associated with clinical disability in multiple sclerosis (MS). However … esonance imaging (MRI) scanners across and within centers. OBJECTIVE: To confirm the existence and clinical relevance of longitudinal BVL in a real-world MS cohort with scanner variability, employing a dedicated quantification pipeline combined with post-acquisition harmonization. METHODS: We analyzed MRI data from 72 MS patients scanned across multiple Belgian ce …

Cluster of Differentiation Markers and Human Leukocyte Antigen Expression in Chronic Lymphocytic Leukemia Patients: Correlations and Clinical Relevance.

Chronic lymphocytic leukemia (CLL) is a distinct category of lymphoproliferative disorder characterized by the clonal expansion of mature B cells, followed by their accumulation in primary and secondary lymphoid organs. Cluster of differentiation (CD) markers such as CD79b, CD45, CD23, CD22 and CD81 serve as reliable prognostic indicators in CLL as well as the human leukocyte antigen (HLA) with its well-documented associations with various cancers. This study aims to investigate, for the first time, potential connections between HLA typing and CD marker expression in CLL. Although it is one of

CLINICAL RELEVANCE OF ESOPHAGEAL MOTILITY DISORDERS AFTER BARIATRIC SURGERY: A PROSPECTIVE STUDY BASED ON HIGH-RESOLUTION IMPEDANCE MANOMETRY.

BACKGROUND: There is recent evidence showing that obesity is associated with gastroesophageal reflux disease and esophageal dysmotility, although symptoms are not always present. AIMS: This is a prospective study based on high-resolution manometry findings in bariatric surgery candidates and their correlation with postoperative dysphagia. METHODS: Manometric evaluation was performed on candidates for bariatric surgery from 2022 to 2024. The examination was conducted according to the protocol of the fourth version of the Chicago Classification, including different positions and provocative ma

Profile and clinical relevance of non-criteria antiphospholipid antibodies in patients diagnosed with or highly suspected of APS.

OBJECTIVE: This study investigates the positivity and relevance of non-criteria aPLs with clinical phenotypes in patients highly suspected of or diagnosed with APS. METHODS: Outpatient cases were included from a prospectively maintained database, and patients were grouped into APS (n = 168), seronegative APS (SNAPS, n = 9), those meeting the diagnostic criteria for clinical events without laboratory results (only-event, n = 15), those that had aPL positivity without clinical manifestations (asymptomatic APA, n = 39), and healthy controls (n = 88). Criteria aPL results and APS-related clinical