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[The clinic of apathy in schizophrenia: a critical review of the issue].

INTRODUCTION: Today the concept of apathy is subject to many questions. This psychological state is present and predominant in different dis … actors of negative symptoms. In this case, apathy is going to be assessed by the factor "motivation/pleasure" including anhedonia, asociality and avolition. This factor will provide the possibility of a better assessment of apathy. Concerning specific scales (like AES), there are gaps such as a lack of standardization in the execution and the quotation. Fu …

[Efficacy of atypical antipsychotics in depressive syndromes].

Depression is a frequent symptom in psychiatry, either isolated (major depression) or entangled with other psychiatric symptoms (psychotic d … ough the release of dopamine in prefrontal cortex, thus improving psychomotor activity, motivation, pleasure, appetite, etc. The dopamine deficit in cortical prefrontal areas was thus an unifying hypothesis to explain both some symptoms of depression and negative symptoms of schizophrenia. Studies in animal confirm this view and show that the association o …

Evaluation of ventricular septal defects in horses using two-dimensional and Doppler echocardiography.

Ventricular septal defects (VSDs) were diagnosed in 27 horses; in 26 affected horses systolic murmurs were detected over both sides of the c … g or competing successfully either before or after the diagnosis of the VSD. Two horses were useful pleasure horses, 3 horses presented in congestive heart failure, 1 horse developed signs of congestive heart failure, 2 horses were lost to follow-up and 2 are still alive but are small and stunted. The successful racehorses usually had a membranous VSD that …

Dalpiciclib combined with pyrotinib and endocrine therapy in women with ER-positive, HER2-positive advanced breast cancer: A prospective, multicenter, single-arm, phase 2 trial.

BACKGROUND: Combination of HER2-targeted therapy and endocrine therapy offers a more tolerable alternative to HER2-targeted chemotherapy regimens for estrogen receptor (ER)-positive, HER2-positive advanced breast cancer (ABC), but with compromised efficacy. The addition of cyclin-dependent kinase 4/6 (CDK4/6) inhibition may enhance the durability of anti-tumor responses, offering a potential chemotherapy-sparing alternative, although its role in the frontline setting remains uncertain. We performed a multicenter, single-arm, phase 2 clinical trial (PLEASURABLE) to assess the activity and safet

Personality Traits Affect the Cost-Effectiveness of Total Knee Arthroplasty.

OBJECTIVE: To assess the clinical benefit and compare the cost-effectiveness of total knee arthroplasty (TKA) in patients with different personality traits. METHODS: The present study was retrospectively conducted from January 2017 to May 2018. A total of 232 patients between 46 and 71 years old who underwent unilateral, primary TKA with the diagnosis of knee osteoarthritis were interviewed. Three types of data were required to compare the cost-effectiveness differences among groups: personality traits, postoperative clinical outcomes about health-related quality of life, and costs associated

Biology of Vibrio cholera. Editorial overview.

In this monographic issue, we have the pleasure to present contributions from six of the leading laboratories at the forefront of Vibrio cholerae genetics, ecology and evolution, together with a brief tribute by Diego Romero to Doctor Jaime Ferrán y Clua, a pioneering Spanish bacteriologist who developed the first vaccine against this pathogen. V. cholerae is a free-living aquatic bacterium that interacts with and infects a variety of organisms. In humans it causes cholera, the deadly diarrhoea that was responsible for millions of deaths during seven pandemics since 1817, and still thousands e…

Geriatric Cardiology: Coming of Age.

BACKGROUND: Women with polycystic ovary syndrome experience increased health complications during and after pregnancy, including a higher pr … hopeless?" and (2) "Since your new baby was born, how often have you had little interest or little pleasure in doing things you usually enjoyed?" In addition, postpartum depressed mood and anhedonia were assessed separately and as a combined variable. Here, weighted adjusted prevalence ratios and 95% confidence intervals were used to assess the associatio …

Formerly Smoking and Currently Smoking Cancer Survivors' View on Smoking Cessation - A Qualitative Study.

BACKGROUND: Drastic life events, such as a cancer diagnosis, do not necessarily lead to a reduction in unhealthy and dysfunctional behaviors … inued smoking after a cancer diagnosis included managing nicotine cravings and stress, experiencing pleasure and boredom relief, and a perceived lack of negative health consequences. Some participants reported smoking to cope with treatment-related discomfort. A general lack of knowledge regarding the link between smoking and cancer contributed to low moti …

Home-based intervention strategy to reduce new chlamydia infection among young men: the HIS-UK RCT.

BACKGROUND: Sexually transmitted infections pose a significant public health challenge in the United Kingdom, prompting the Department of Health and Social Care to prioritise sexually transmitted infection rate reduction as a means of addressing sexual health inequalities. Correct and consistent condom use is the most effective method of reducing sexually transmitted infection transmission. METHODS: A randomised controlled trial with three arms (two intervention arms and one control arm) was conducted to evaluate the effectiveness and cost-effectiveness of the home-based intervention strategy

[Current status of the female condom in Africa].

The female condom was developed in the 1980s. It is a contraceptive device used by women that protects against both pregnancy and sexually-t … ever, some women liked it because it provided dual protection against pregnancy and STDs and sexual pleasure. The moderate level of acceptability to male partners may be overestimated because women whose partners disliked the device would be more likely to discontinue its use. The studies of acceptability reviewed here show that use of the female condom in …

Walking to health.

Walking is a rhythmic, dynamic, aerobic activity of large skeletal muscles that confers the multifarious benefits of this with minimal adverse effects. Walking, faster than customary, and regularly in sufficient quantity into the 'training zone' of over 70% of maximal heart rate, develops and sustains physical fitness: the cardiovascular capacity and endurance (stamina) for bodily work and movement in everyday life that also provides reserves for meeting exceptional demands. Muscles of the legs, limb girdle and lower trunk are strengthened and the flexibility of their cardinal joints preserved

Insomnia disorder subtypes derived from life history and traits of affect and personality.

BACKGROUND: Insomnia disorder is the second most prevalent mental disorder, and it is a primary risk factor for depression. Inconsistent clinical and biomarker findings in patients with insomnia disorder suggest that heterogeneity exists and that subtypes of this disease remain unrecognised. Previous top-down proposed subtypes in nosologies have had insufficient validity. In this large-scale study, we aimed to reveal robust subtypes of insomnia disorder by use of data-driven analyses on a multidimensional set of biologically based traits. METHODS: In this series of studies, we recruited parti

[Depressive symptomatology and sleep apnea syndrome].

The sleep apnea syndrome (SAS), which is defined by more than 5 apneas or hypopneas per hour of sleep (9), is quite a frequent affection whi … o, work), loss of initiative, difficulties to organise tasks, fall of performances and reduction of pleasure usually felt in pleasant events (15). The physic symptomatology dominated the psychic one. The sleep disorganization, more than metabolic consequences of apneas, could be involved in this associated depressive state. Other neuropsychiatric troubles …

Полуструктурированный клинический интервью для оценки компульсивного сексуального поведения (SSCI-CSB): Развитие, надежность и валидность.

Цели Оценка компульсивного сексуального поведения (КСП) требует тонких подходов к оценке, идеально через клинические интервью. Однако ни одно из нескольких доступных клинических интервью для КСП не продемонстрировало сильные психометрические свойства. Чтобы решить эту проблему, мы разработали Semi-Structured Clinical Interview for the assessment of CSB (SSCI-CSB), интервью, которое собирает информацию о проявлениях, симптомах и клиническом течении КСП. Цель этого исследования состояла в том, чтобы проанализировать его надежность и обоснованность в выборке пациентов, нуждающихся в лечении некон

Совпадение в полном тексте источника
… Increasing sense of tension and arousal immediately prior to initiating the problematic sexual behavior (anticipation of pleasure). □ □ □ √ Criterion 15. … The last criterion with a low percentage of endorsement was “lack of pleasure/need of relief.” …

Характеристики самоидентифицированных сексуальных азартных игроков в клинике азартных заболеваний.

Фон и цели Исследования сексуального зависимости процветали в последний десятилетний период, стимулированные развитием большого количества онлайн-сексуальных активностей. Несмотря на накопление исследований, однако, доказательства, собранные в клинических образцах людей, ищущих лечение, остаются редкими. Целью этого исследования было описать характеристики (социodemографические, сексуальные привычки и сопутствующие заболевания) самоназначенных «сексуальных зависимых». Методы Образец составлял 72 пациента, обратившихся в поликлинический центр лечения по поводу своих сексуальных поведений. Данны

Совпадение в полном тексте источника
… The main reasons considered by the patients to promote addictive sexual disorders are reported in Table  3 , the most prevalent being searching for pleasure or arousal. A comprehensive list of the negative outcomes resulting from sexual addiction is provided in Table  4 . … In other words, both addictive-like sexual behaviors and paraphilia could have a similar function related to the conversion of an aversive or intolerable emotional state into a more tolerable and pleasurable one ( Kahr, 2007 ; Krueger & Kaplan, 2001 ). …

Comparative Effectiveness of Psychotherapy vs Antidepressants for Depression in Heart Failure: A Randomized Clinical Trial.

IMPORTANCE: Heart failure (HF) affects more than 6 million adults in the US and more than 64 million adults worldwide, with 50% prevalence of depression. Patients and clinicians lack information on which interventions are more effective for depression in HF. OBJECTIVE: To compare the effectiveness of behavioral activation psychotherapy (BA) vs antidepressant medication management (MEDS) on patient-centered outcomes inpatients with HF and depression. DESIGN, SETTING, AND PARTICIPANTS: This pragmatic randomized comparative effectiveness trial was conducted from 2018 to 2022, including 1-year f

[Can one talk of benzodiazepine "drunkenness"? About acute benzodiazepine intoxication, without suicidal or mortiferous tendencies].

BACKGROUNDS: When we refer to "drunkenness", more often than not, we think of alcohol or cannabis being the instigator rather than pharmacol … europhysiological models of reward systems of the brain, and can tend to be limited to a search for pleasure. Moreover, "drunkenness" may be considered as a leak, a regression or a kind of renouncement. It may sometimes be a search for sedation, for conscious sleep, or to avoid reality. And, finally, "drunkenness" may be suicidal. Since the launch of benzo …

Human morality and temperament.

This chapter has tried to make two points. First, the concept of morality refers to a developmental cascade of phenomena whose essential fea … ed societies where the balance between the feeling of virtue that follows enhancing another and the pleasure that follows the enhancing of self has shifted toward favoring the latter state. Increasing numbers of Americans do not regard their gender, ethnicity, vocation, place of residence, or friendships or the religion of their parents as distinctive sour …

[Was Snow White a transsexual?].

The Rorschach Ink Blot test is considered to be an essential analytical instrument when studying the personalities of individuals presenting … nent danger in a passive manner. This in itself creates a great feeling of relief, if not of actual pleasure in the subject (28). In this article, we postulated in a purely speculative manner, the existence of one or several modalities in the transsexual dynamics. Nevertheless, one can ask oneself about the possibility of a request based on a desire rather …

Повторение повторяющихся поведенческих паттернов: серия случаев с компульсивным поведением, трicho-тillomania, ненужной саморазрушительной поведенческой активностью и синдромом жаждущего еды.

Заболевание вынужденного сексуального поведения (CSBD), трichoэпилепсия (TTM), расстройство жор (BED) и ненужное самоповреждение (NSSI) классифицируются в отдельных категориях в Межправительственной классификации болезней, 11-е издание (ICD-11). В этом серийном случае旨在 explore общие импульсивные и вынужденные черты этих расстройств, несмотря на их общую феноменологию и сопутствующие расстройства. Также обсуждается инсайт, механизмы вознаграждения и связанные нейробиологические понимания повторяющихся действий. В конце также подчеркивается потенциальная роль глиаминергических препаратов в их л

Совпадение в полном тексте источника
… CASE SERIES Case-1 A 20-year-old male presenting with a three-year history of obsessive-compulsive symptoms, predominantly fear of hand-contamination, followed by washing compulsions, later accompanied by pleasurable sexual urges toward same-sex. … All the disorders exhibit repetitive behaviors maintained through positive or negative reinforcement, where actions are repeated to experience pleasure or escape negative emotions despite adverse outcomes, depending on the insight into behavior. …