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Constipation in children: fibre and probiotics.

INTRODUCTION: Prevalence of childhood constipation has been estimated at 0.7% to 29.6% in the general population worldwide; most children ha … bulk-forming laxatives, enemas, faecal softeners, fibre, macrogols, oral fluids, osmotic laxatives, prebiotics, probiotics, stimulant laxatives, and surgical disimpaction.

Arabinoxylans and arabinogalactans: a comprehensive treatise.

The functional and nutraceutical importance of various foods is often attributed to the bioactive molecules present in them. A number of com … reby protect the body from cardiovascular disorders like atherosclerosis. Additionally, they act as prebiotics for microorganisms residing in the gastrointestinal tract.

Predominance of caecal injury in a new dextran sulphate sodium treatment in rats: histopathological and fermentative characteristics.

OBJECTIVES: Cyclic administrations of dextran sulphate sodium (DSS) alternating with distilled water usually induce chronic colitis after a … nic alterations. This model could contribute to the study of potential anti-inflammatory effects of prebiotics.

The Role and Mechanisms of Gut Microbiota in the Progression of Hepatic Encephalopathy.

Hepatic encephalopathy (HE) is a severe complication of end-stage liver disease that is associated with high mortality; however, its therape … logical treatments, drug therapies (lactulose and rifaximin), live microbial therapies (probiotics, prebiotics, synbiotics, faecal microbiota transplantation, etc.), and dietary adjustments. Emerging approaches, such as engineered bacteria and phage therapy, are also discussed, along with the barriers to their clinical translation and safety considerations. …

Probiotics as antioxidant, antistress, and growth-enhancing agents in monogastric animals: a narrative review.

Probiotics, defined as living microorganisms that confer health benefits when administered in adequate amounts, have demonstrated significan … nd gut barrier regulation, optimizing dosing strategies and exploring synergistic combinations with prebiotics and phytogenic additives. Such targeted approaches can maximize the benefits of probiotics and support sustainable, precision-driven monogastric production systems.

Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's disease - Mechanisms and therapeutic frontiers.

Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by cognitive impairment and neuronal degeneration, is increas … f microglia with senolytics and stimulation of TREM2; regulation of gut microbiota with probiotics, prebiotics, lifestyle modification, dietary intervention; and fecal microbiota transplantation. Precision medicine approaches incorporating microbiome profiling and immunogenetic analysis will enhance these treatments. This review combines mechanistic insight …

Biotics: The Food Ingredients Supporting the Intestinal Microbiota and Immune System in Psoriasis.

Psoriasis is a chronic immune-mediated inflammatory skin disease affecting 4 million new individuals worldwide each year. Although the etiol … st studies matching our screening criteria used lactic acid bacteria along with oligosaccharides as prebiotics. Probiotics have shown promising results in suppressing inflammatory pathways and alleviating the symptoms of psoriasis by modulating the gut microbiota. After several weeks of intervention, patients showed microbiome changes along with reduced leve …

Understanding gut microbiota dysbiosis as a plausible link between obstructive sleep apnea (OSA), viral infections, and lifestyle diseases.

Obstructive sleep apnea (OSA) is a multifactorial disorder which is influenced by intermittent hypoxia, sleep fragmentation, and systemic in … to host immunity and respiratory outcomes. The review highlights upon the therapeutic potentials of prebiotics and probiotics supplementation for modulating gut dysbiosis. It discusses the role of these therapeutic interventions in improving metabolic homeostasis, reducing inflammation, and potentially mitigating OSA-related complications. Collectively, this …

Microbiome Therapies in Inflammatory Bowel Disease, Diabetes and Obesity: From Mechanistic Insights to Clinical Translation.

INTRODUCTION: This study aims to explore novel clinical microbiome therapeutics for Inflammatory Bowel Disease (IBD), diabetes, and obesity. … : Gut microbiome therapies with promising effects in IBD, diabetes, and obesity include probiotics, prebiotics, Fecal Microbiota Transplantation (FMT), engineered bacterial therapies, and dietary interventions. These interventions have been shown to reduce inflammation, enhance insulin sensitivity, promote weight loss, and promote metabolic health. These eff …

American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma clinical protocol for nutrition support in adult trauma.

ABSTRACT: The provision of nutrition in adult trauma patients requires a detailed and personalized approach to achieve optimal patient outco … otic trauma patients warrant specialized nutrition care. Immunonutrition, glutamine, and probiotics/prebiotics are not currently recommended for trauma or burn patients. (J Trauma Acute Care Surg. 2026; 00:000-000 Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.). LEVEL OF EVIDENCE: Therapeutic/care management; Level V.

The role of gut microbiome disruption in the development of metabolic dysfunction-associated kidney disease.

Metabolic dysfunction-associated kidney disease (MDAKD) is increasingly recognised as a major clinical consequence of the global rise in obe … ans. Emerging therapeutic strategies targeting the gut microbiota, including dietary interventions, prebiotics, probiotics, sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor agonists, and faecal microbiota transplantation, may offer novel approaches to slowing CKD progression and improving metabolic health. However, further mechanis …

Translating gut microbiome research into therapies for type 1 diabetes.

Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β-cells, for which lifelong insulin therapy remains the standard … ed in T1D. Subsequently, we address recent advances in gut microbiome-based therapies, ranging from prebiotics to faecal microbiota transplantation (FMT) in both preclinical and clinical studies. Observational studies in T1D have demonstrated alterations in short-chain fatty acid, secondary bile acid and tryptophan metabolism, as well as changes in the abund …

Oral Microbiota, the Oral-Brain Axis, and Neurodegeneration: Mechanisms and Dietary Modulation.

The oral microbiota represents a complex and dynamic microbial ecosystem that plays a critical role in preserving both oral and systemic hom … ned sugars may promote dysbiosis and inflammatory signaling, whereas (poly)phenols, probiotics, and prebiotics may support microbial eubiosis and exert neuroprotective effects through modulation of host-microbe interactions. Although current evidence remains largely observational and mechanistic, the diet-oral microbiota-brain axis represents a promising tar …

Gut-Brain Signaling in Parkinson's Disease: A Narrative Review.

The formulation of the gut-brain-microbiota axis (GBA) theory has led to new research directions that have expanded our understanding of the … n GBA has paved the way for the identification of novel treatment strategies, including probiotics, prebiotics, synbiotics, postbiotics, antibiotics, and fecal microbiota transplantation (FMT), aimed at not only symptomatic but also disease-modifying treatment of PD. In this article, we propose a novel approach to GBA as a link between gut microbiota and gut …

Gut microbiota and the kidney-gut-skin axis in chronic kidney disease-associated pruritus: mechanisms and therapeutic implications.

Chronic kidney disease-associated pruritus (CKD-aP) is a highly prevalent and debilitating symptom in patients with chronic kidney disease ( … systematically evaluates gut-targeted and metabolism-targeted interventions, including probiotics, prebiotics, synbiotics, AST-120, fecal microbiota transplantation, phytochemicals, Uremia Clearance Granules, and vitamin D-related strategies. Current evidence is mostly associative and is mainly derived from general CKD/ESKD populations, animal models, and i …

Microbiota-driven mechanisms in multisystem diseases: integrative evidence across cardiovascular, metabolic, neurological and autoimmune disorders.

The human microbiota represents one of the body's most influential biological systems, engaging in constant metabolic, immunological, and ne … ntions aimed at restoring microbial homeostasis, including targeted dietary strategies, probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and microbiome-directed pharmacological approaches. Collectively, the evidence positions the microbiota as a central regulator of human health and disease, offering a compelling platform for next-genera …

The gut microbiota-short-chain fatty acid-inflammation axis in Parkinson's disease motor dysfunction: mechanisms and future of dietary interventions.

Parkinson's disease (PD) is a neurodegenerative disorder characterized mainly by motor dysfunction that severely affects quality of life. In … in PD motor dysfunction, focusing on the potential mechanisms by which specific dietary strategies-prebiotics, probiotics, and the Mediterranean diet, and emerging patterns such as ketogenic diets (KD) and intermittent fasting (IF)-may ameliorate motor symptoms through modulation of this axis, while critically appraising the limitations and inconsistencies …

The role of intestinal microbial metabolites in polycystic ovary syndrome: mechanistic insights and intervention prospects.

BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder among women of reproductive age, defined by the cor … lipopolysaccharide, branched-chain amino acids, tryptophan metabolism, gut-ovary axis, probiotics, prebiotics, postbiotics, and fecal microbiota transplantation. Original basic research, clinical observational studies, randomized controlled trials, systematic reviews, meta-analyses, and clinical guidelines related to PCOS and gut microbiota were prioritized …

Комплексное исследование двустороннего взаимодействия между микробиомами человека и злокачественными заболеваниями крови и гематологическими условиями: акцент на новых терапевтических стратегиях.

Микробиота человека играет ключевую роль в поддержании хомостаза, регулируя иммунную реакцию, метаболизм и гематопоисис. Микробиальный дисбиоз все чаще ассоциируется с иммунной дисфункцией, воспалением и аномалиями костного мозга, которые могут привести к гематологическим заболеваниям. В настоящем обзоре резюмируются текущие данные о роли микробиота в нормальном гематопоисе и ее потенциальной причастности к доброкачественным и злокачественным гематологическим расстройствам.МЕТОДЫ: Обзор описательной литературы был проведен на основе всестороннего поиска основных научных баз данных без временны

Совпадение в аннотации оригинала
BACKGROUND: The human microbiota plays a key role in maintaining host homeostasis by regulating immune responses, metabolism, and hematopoie … ase progression and therapeutic responses. Microbiota-targeted interventions, including probiotics, prebiotics, dietary interventions, fecal microbiota transplantation, and other microbiome-based therapies, have shown potential as adjunctive therapeutic strategies. CONCLUSIONS: Current evidence suggests that microbiota dysbiosis may contribute to the pathog …

2'-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation.

2'-Fucosyllactose (2'-FL), a predominant human milk oligosaccharide, plays a crucial role in the development of the infant gut microbiota an … ereby prevented AD. Our findings provide novel insights into the therapeutic potential of combining prebiotics and probiotics to modulate the gut - skin axis and support immune tolerance in early life, offering a promising strategy for infantile AD management and prevention.