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Association of postpartum oxytocin dose and postpartum bleeding outcomes in nulliparous patients at term.

BACKGROUND: Postpartum hemorrhage is a leading cause of morbidity and mortality. The use of prophylactic oxytocin in the third stage of labor is globally accepted as standard of care for the prevention of postpartum hemorrhage; however, the most effective dose of oxytocin is unknown. While studies suggest a possible benefit of higher doses of postpartum prophylactic oxytocin, results are inconclusive, and data are limited. OBJECTIVE: Our objective was to compare rates of postpartum hemorrhage and the need for additional postpartum hemorrhage interventions between high-dose (80 international u

Implementing a bundle for evidence-based cesarean delivery may not be as beneficial as expected: a multicenter, pre- and post-study.

BACKGROUND: Standardization of procedures improves outcomes. Though systematic reviews have summarized the evidence-based steps of cesarean delivery, their bundled implementation has not been investigated. OBJECTIVE: In this preimplementation and postimplementation trial, we sought to ascertain if bundled evidence-based steps of cesarean delivery, compared with the surgeon's preference, improve outcomes. STUDY DESIGN: A Standards for Reporting Implementation Studies compliant, multicenter preimplementation and postimplementation trial at 4 teaching hospitals was conducted. The preimplementat

Comparison of the safety and 24-36-month efficacy of medial unicompartmental knee arthroplasty versus total knee arthroplasty in elderly patients (≥ 75 years) with isolated medial-compartment knee osteoarthritis.

The number of very elderly patients presenting with end-stage knee osteoarthritis (OA) is rising rapidly, yet the comparative merits of medial unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in this group remain insufficiently characterised. We compared the perioperative safety and short-term clinical and patient-reported efficacy of the two procedures in patients aged 75 years and older with isolated medial-compartment OA. This single-centre retrospective cohort study compared patients aged ≥ 75 years undergoing primary medial UKA or TKA for isolated medial-compartm

Outcomes of Total Hip Arthroplasty for Traumatic versus Non-Traumatic Hip Pathology: A Prospective Cohort Study.

INTRODUCTION: Total hip arthroplasty (THA) is an established procedure for pain relief and functional restoration in both traumatic and non-traumatic hip pathologies, yet comparative data from the Indian population remain limited. This prospective study aimed to compare intraoperative parameters, early post-operative course, and 3-month functional outcomes of THA performed for traumatic femoral neck fractures versus heterogeneous non-traumatic etiologies in an Eastern Indian tertiary care center. MATERIAL AND METHODS: This single-center, prospective comparative study was conducted at All Indi

A prevention protocol reduces spinal cord ischemia in patients undergoing branched/fenestrated endovascular aortic repair.

OBJECTIVE: Spinal cord ischemia (SCI) is a devastating complication that is associated with thoracoabdominal aortic repair, with higher risk associated with increased aortic coverage length, making patients undergoing branched/fenestrated endovascular repair (B/FEVAR) particularly vulnerable. A bundled SCI prevention protocol was previously reported to reduce SCI rates when compared to a historic cohort in a single-center study. Therefore, this analysis aims to further validate and update outcomes associated with the protocol given the routine implementation of this strategy at two institution

Racial/ethnic disparity in severe maternal morbidity among women who conceived by in vitro fertilization.

BACKGROUND: In vitro fertilization (IVF) as a fertility treatment is associated with adverse perinatal outcomes. Racial/ethnic disparity in severe maternal morbidity (SMM) in women who conceived by IVF is understudied. OBJECTIVE: To examine differences in the association between race/ethnicity and SMM between women who conceived spontaneously and those who conceived using IVF. METHODS: We included all singleton live births and stillbirths in the United States, 2016-2021; data were obtained from the National Center for Health Statistics. Maternal race/ethnicity included non-Hispanic White (NH

Coagulopathy of hospitalised COVID-19: A Pragmatic Randomised Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG - RAPID Trial): A structured summary of a study protocol for a randomised controlled trial.

OBJECTIVES: To determine the effect of therapeutic anticoagulation, with low molecular weight heparin (LMWH) or unfractionated heparin (UFH, high dose nomogram), compared to standard care in hospitalized patients admitted for COVID-19 with an elevated D-dimer on the composite outcome of intensive care unit (ICU) admission, non-invasive positive pressure ventilation, invasive mechanical ventilation or death up to 28 days. TRIAL DESIGN: Open-label, parallel, 1:1, phase 3, 2-arm randomized controlled trial PARTICIPANTS: The study population includes hospitalized adults admitted for COVID-19 prio

Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.

IMPORTANCE: Major warfarin-related bleeding occurs more frequently in African Americans than in other populations. Identification of potential genetic factors related to this adverse event may help identify at-risk patients. OBJECTIVE: To identify genetic factors associated with warfarin-related bleeding in patients of African descent at an international normalized ratio (INR) of less than 4. DESIGN, SETTING, AND PARTICIPANTS: A case-control genome-wide association study involving patients of African descent taking warfarin was conducted in a discovery cohort (University of Chicago [2009-201

Allogeneic hematopoietic cell transplantation without myeloablative conditioning for patients with advanced hematologic malignancies.

BACKGROUND: The effect of allogeneic hematopoietic cell transplantation (alloHCT) on hematologic malignancies is based on the graft-versus-malignancy effect. Obtaining this effect with reduced toxicity has been possible by non-myeloablative (NMA) alloHCT. Once mixed chimeric status, and host versus graft with graft versus host tolerance are achieved, further strengthening of chimerism and graft-versus-malignancy effect can be obtained by donor lymphocyte infusions (DLIs) when needed. METHODS: The patient group consisted of 13 patients with advanced hematological malignancies: seven had CML, f

[Determination of Candida colonization and Candida score in patients in anesthesia intensive care unit].

The colonization rate of Candida spp. reaches up to 80% in patients who reside in intensive care units (ICUs) more than a week, and the mean rate of development of invasive disease is 10% in colonized patients. Since invasive candidiasis (IC) in ICU patients presents with septic shock and high mortality rate, rapid diagnosis and treatment are crucial. The aim of this study was to assess the relationship between invasive infection and the determination of Candida colonization index (CI) and Candida score (CS) in patients admitted to ICU who are at high risk for IC and likely to benefit from ear

Pegcetacoplan Delivers Real-World Therapeutic Benefits and Reduces Disease Burden for Patients With Paroxysmal Nocturnal Haemoglobinuria: A Systematic Literature Review of Pegcetacoplan Real-World Clinical and Patient-Reported Outcomes.

AIMS: Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra-rare, acquired, non-malignant haematological disorder that, if left untreated, can lead to significant morbidity. This systematic literature review (SLR) summarized real-world evidence (RWE) for pegcetacoplan, a complement 3/3b inhibitor (C3i) available since 2021. METHODS: The SLR (PROSPERO-CRD420251043506) followed 2020 PRISMA guidelines and included RW studies of pegcetacoplan (n > 1 pts.; English; to April 2025) in adults (age ≥ 18 years) with PNH. RESULTS: Of 409 identified records, 39 qualified, representing 12 distinct studi

Do patients with a single abnormal OGTT value need a globally admitted definition such as "borderline GDM"? Pregnancy outcomes of these women and the evaluation of new inflammatory markers.

INTRODUCTION: One of the approaches to diagnose Gestational Diabetes Mellitus (GDM) is to detect two or more elevated values in 3-h Glucose … ute fetal distress (AFD), IUGR, preterm delivery, cesarean delivery rate, macrosomia, labor arrest, blood component transfusion, post-partum complication and stillbirth than healthy controls. Statistical analysis of comparison between group 2 and 3 has revealed that; patients with single elevated OGTT had more peripartum complication (p = .032; odds ratio [OR] = 1.2, 95% CI: …

Cultural and religious barriers in the Middle East leading to delayed management of acute HIV case resulting in irreversible blindness: a case report.

UNLABELLED: According to the latest report from the WHO, the HIV attacks the body's immune system, mainly the CD4 helper T cells component of the white blood cells. HIV kills CD4 cells, infirm the immunity against opportunistic infections, bacterial infections such as tuberculosis and fungal infections, severe other viral infections such as Cytomegalovirus (CMV), and some malignancies, if not diagnosed early and managed properly, it can lead to a life-threatening debilitating condition of AIDS. It is important to follow-up cases of HIV regularly, as currently there is no radical cure for this

Robotic-assisted minimally invasive surgery for gynecologic and urologic oncology: an evidence-based analysis.

OBJECTIVE: An application was received to review the evidence on the 'The Da Vinci Surgical System' for the treatment of gynecologic malignancies (e.g. endometrial and cervical cancers). Limitations to the current standard of care include the lack of trained physicians on minimally invasive surgery and limited access to minimally invasive surgery for patients. The potential benefits of 'The Da Vinci Surgical System' include improved technical manipulation and physician uptake leading to increased surgeries, and treatment and management of these cancers. The demand for robotic surgery for the t

Remote patient monitoring for management of diabetes mellitus in pregnancy is associated with improved maternal and neonatal outcomes.

BACKGROUND: Diabetes mellitus is a common medical complication of pregnancy, and its treatment is complex. Recent years have seen an increase in the application of mobile health tools and advanced technologies, such as remote patient monitoring, with the aim of improving care for diabetes mellitus in pregnancy. Previous studies of these technologies for the treatment of diabetes in pregnancy have been small and have not clearly shown clinical benefit with implementation. OBJECTIVE: Remote patient monitoring allows clinicians to monitor patients' health data (such as glucose values) in near re

Maternal marijuana use, adverse pregnancy outcomes, and neonatal morbidity.

BACKGROUND: The Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network previously demonstrated an association between stillbirth and maternal marijuana use as defined by the presence of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid in the umbilical cord homogenate. However, the relationship between marijuana use and perinatal complications in live births is uncertain. OBJECTIVE: Our aim was to examine if maternal marijuana use is associated with increased odds of adverse pregnancy outcomes and neonatal morbidity among

Management of urinary stones by experts in stone disease (ESD 2025).

The formation of kidney stones is a complex biologic process involving interactions among genetic, anatomic, dietary, and environmental factors. Traditional lithogenic models were based on urine supersaturation in relation to the activity of crystallization promoters and inhibitors. However, modern research has added new principles such as the "renal epithelial cell response" and the role of inflammation and oxidative stress leading to the development of a "multi-hit hypothesis". A strong correlation between urinary stones and kidney damage has been well demonstrated by both cohort and case-co

Delayed gastric emptying in critical illness: is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?

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Evaluation of transfusion pyrexia: a review of differential diagnosis and management.

Background/purpose. Transfusion pyrexia (fever) is an important clinical sign/symptom occurring either as an isolated event or as part of a constellation of signs and symptoms in relation to blood transfusion. It is an important cause of morbidity and may be an important sign of life-threatening complications of blood transfusion. Pyrexia is often a reason for the discontinuation of a blood transfusion episode, and adequate evaluation remains a challenge for clinicians. The decision to stop a blood transfusion episode on account of fever is often a difficult one. This paper reviews the differe

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… Febrile Nonhaemolytic Transfusion Reaction (FNHTR) The occurrence of a febrile nonhaemolytic reaction is an important complication of a blood component transfusion because of its possible confusion with other more dangerous transfusion reactions, such as acute haemolysis, sepsis, and transfusion-related …

Poster Abstracts

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