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Rapid COVID-19 Antigen Testing in Croatia: Risk Perception Plays an Important Role in the Epidemic Control.

Aim: To explore the clinical presentation and epidemiological history of the subjects who underwent SARS-CoV-2 antigen testing. Methods: We included 1,000 consecutive subjects who presented themselves at the diagnostic clinic in Croatia and analyzed their symptoms and epidemiological history. All subjects were classified into three groups, according to their reason of arrival; symptomatic, contacts of confirmed patients, and those who were tested due to administrative reasons. Results: On average, there were 24% of positive antigen results; the positivity rate was 51% among symptomatic, 16% in

The New Gravity: How Generative AI Remapped Innovation and What Academia Must Do Next.

Artificial intelligence is rapidly reshaping clinical research, diagnostics, health system operations, and medical education. Frontier gener … cation habits and governance into training and practice can help ensure that generative AI supports clinical reasoning while preserving trust, equity, and scientific rigor. This viewpoint addresses academic leaders, curriculum committees, residency directors, faculty developers, and accreditors. Safe clinical AI requires sustained academic leadership.

Defining Relapse and Disease Activity in Neurosarcoidosis: A Systematic Review and Proposed Framework.

PURPOSE OF REVIEW: There is no consensus or standardized framework to characterize disease activity in CNS neurosarcoidosis, and the existin … h further validation, this approach has the potential to standardize research practices and improve clinical reasoning and communication.

[Factors impeding obstructed teeth in their eruption. Case report].

With preparation of six study cases the objective of the authors was to abrow colleagues' attention to the fact that teeth remained in impactio and retention might cause complaints not only due to normal anatomical reasons but some complications might occur resulting from anomaly of development. The authors consider the topic extremely important by reason of the case's varieties and the clinical observations made recently and frequently. An increased attention to this case is reasonable since eruption of teeth might happen in case of removal of obstructic fact in time, permanent row of teeth r

Why Do Patients With Gout Not Take Allopurinol?

OBJECTIVE: The objectives of this study were to examine the reasons patients give for nonadherence to allopurinol and to examine differences in intentional nonadherence for patients who did and did not achieve serum urate (SU) levels at treatment target. METHODS: Sixty-nine men with gout attending rheumatology clinics, all prescribed allopurinol for ≥ 6 months, completed the Intentional Non-Adherence Scale (INAS). Differences in the types of intentional nonadherence were analyzed between those who did and did not achieve SU at treatment target (< 0.36 mmol/L, 6 mg/dL). RESULTS: The most freq

Labiaplasty of the labia minora: patients' indications for pursuing surgery.

INTRODUCTION: Limited information is available regarding patients' indication for seeking labiaplasty of the labia minora. AIM: The aim of this article is to investigate a patient's indications for seeking labiaplasty of the labia minora. METHODS: This is a retrospective review of the medical records of all patients undergoing labiaplasty at our clinic over a 27-month period. MAIN OUTCOME MEASURES: Indications for surgery were assessed using standardized questionnaires during the patients' initial history and physical. Patients were divided into three groups as based on the questionnaire, i

Exploring primary care providers' perspectives on clinical decision support for venous thromboembolism diagnosis: a qualitative study.

OBJECTIVES: Diagnosing venous thromboembolism (VTE) in primary care is challenging due to non-specific symptoms and competing clinical deman … hould be actionable, context-aware, minimally disruptive and supportive of rather than directive to clinical reasoning. CONCLUSIONS: PCPs viewed diagnostic CDS for VTE as potentially beneficial but also potentially burdensome depending on how it is implemented within clinical workflows. Acceptance of CDS appears to depend not only on technical performance but also …

Simulation-Based Education to Support Nurses' Critical Thinking in Delirium Recognition: A Scoping Review.

AIM: To map how simulation-based education supports the development of critical thinking skills required for nurses to recognize delirium in … ith critical thinking, including observational accuracy, recognition of fluctuating cognitive cues, clinical reasoning, reflective awareness, empathy and communication within interprofessional teams. Structured debriefing played a central role in helping nurses analyse decision-making processes and integrate experiential learning into clinical judgement. Several stu …

АИ для научно обоснованной рекомендации в отношении лечения онкологии: ослепленная оценка крупных языковых моделей и агентских рабочих процессов.

Медицина, основанная на доказательствах, имеет решающее значение для принятия клинических решений, однако исследования свидетельствуют о том, что значительная часть решений о лечении не в полной мере учитывает последние данные. Большие языковые модели (ММЛ) говорят о том, что они способны устранить этот пробел, однако их надежность для медицинских рекомендаций остается неопределенной. five Рекомендации МЛМ в различных областях 50 клинические сценарии, связанные с множественным диагностированием миэломы, постановкой, лечением и управлением, с использованием унифицированного лимита улик по состо

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… Our qualitative analysis highlights a crucial challenge in medical AI models: the gap between information processing and clinical reasoning. …

[Imaging of acute abdomen in childhood and adolescence].

Acute abdominal pain in childhood is a frequent reason for a medical consultation. The main diseases that lead to the clinical situation of acute abdomen show a significant age dependency. It is reasonable to group such ailments into three age categories: (1) the neonatal and infant period, (2) toddlerhood to kindergarten and (3) school age children. The task of the pediatric radiological examination is the differential diagnostic correlation of symptoms to the respective diseases. In children ultrasound is the appropriate method of choice.

[Neurophysiological and clinical aspect of patients with carpal tunnel syndrome].

In the group of patients with carpal tunnel syndrome (CTS), besides paresthesias in their fingers, we can see paresthesias in forearm; pain in elbow, sholder and neck, which is a reason for complicated diagnosis of it. This kind of complexnost of differential diagnosis pain in hand, is a reason for complet and strict diagnostic procedure. There are 30 patients with clinical and neurophysological findings for CTS in this paper who made provocative tests. Analising their results we made diagnosis of KTS.

Delineating the Cognitive Profile of ODLURO Syndrome: Emergent Clues on the Endophenotype Across KMT2 Disorders.

O'Donnell-Luria-Rodan syndrome (ODLURO) is a very rare disorder caused by heterozygous pathogenic variants in KMT2E. While intellectual disability is associated with this syndrome based on retrospective chart review, the neurocognitive phenotype remains unexplored. This case series provides insight into the cognitive profile of ODLURO and discusses these trends in the context of other better-characterized disorders in the KMT2 families. This study involved a retrospective chart review of psychological or neuropsychological assessment reports from 10 patients with a likely pathogenic or pathoge

Reasons for Hospitalization and In-Hospital Mortality in Adults With Dermatomyositis and Polymyositis.

OBJECTIVE: Dermatomyositis (DM) and polymyositis (PM) are systemic autoimmune diseases that have been associated with high in-hospital mortality (IHM). The aim of this study was to use the National Inpatient Sample (NIS), a large US population database, to determine the reasons for hospitalization and IHM in patients with DM and PM. METHODS: We conducted a medical records review of adult DM/PM hospitalizations in 2016 and 2017 in acute care hospitals across the United States using the NIS. The reasons for IHM and reasons for hospitalization were divided into 19 broad categories based on their

General practice encounters for young patients with autism spectrum disorder in Australia.

This study compared the patient demographics and reasons for encounter in general practice for patients <25 years with and without an autism spectrum disorder identified as a reason for encounter and/or problem managed. The Bettering the Evaluation and Care of Health programme collected information about clinical activities in Australian general practice. Each year, the programme recruited a random sample of 1000 general practitioners, each of whom collected data for 100 consecutive consultations (encounters). Encounters with patients <25 years, where at least one autism spectrum disorder was

Women's reasons for choosing abortion method: A systematic literature review.

AIMS: We aim to describe and classify reasons behind women's choice between medical and surgical abortion. METHODS: A systematic literature review was conducted in PubMed and PsycINFO in October 2015. The subjects were women in early pregnancy opting for abortion at clinics or hospitals in high-income countries. We extracted women's reasons for choice of abortion method and analysed these qualitatively, looking at main reasons for choosing either medical or surgical abortion. RESULTS: Reasons for choice of method were classified to five main groups: technical nature of the intervention, fear

Experience of Thai women in Bangkok with Norplant-2 implants.

A prospective study of the Norplant-2 contraceptive subdermal implant system was conducted in Bangkok, Thailand. The objective of the study was to evaluate the efficacy, adverse effects, and overall acceptability of Norplant-2 implants. A total of 140 women were enrolled in a 3-year clinical trial. The mean age was 29 years. Of all the acceptors, 70% had completed primary school. The continuation rates at years 1, 2, and 3 were, respectively, 94%, 89%, and 83%. No accidental pregnancies occurred throughout the 3 years of use in this study. Personal reasons were the leading cause for terminatio

Comparison of drug retention rates between TNF inhibitors and tocilizumab for Takayasu arteritis: a multicenter retrospective study.

OBJECTIVE: We compared the drug retention rate of tumor necrosis factor (TNF) inhibitors (TNFi) and tocilizumab in Takayasu arteritis (TAK) as an index of balance between effectiveness and safety in a real-world setting. METHOD: We included 50 TAK patients who received biologics in nine hospitals. All patients fulfilled the 1990 American College of Rheumatology classification criteria for TAK. We retrospectively collected clinical information. We analyzed the drug retention rates and the reasons for discontinuation regarding TNFi and tocilizumab. RESULTS: The prednisolone dose at the start o

Bundling HIV and TB Care at a District-Level Center in Sierra Leone: A high-yield method for diagnosing co-infection with TB and antiretroviral treatment failure among people living with HIV.

BACKGROUND: Protocols for HIV care are widely accepted by all international organizations and are proven to reduce mortality and complications from living with HIV. Unfortunately, executing best practice recommendations in Sierra Leone is difficult due to shortages in staff, training, and medications. METHODS: From June 2016 to August 2016, we implemented both an HIV guideline-based clinical evaluation protocol and a patient-centered workflow for TB screening and CD4 testing in the HIV clinic at Koidu Government Hospital (KGH) in rural Sierra Leone. The primary outcome of interest was how oft

The Buffalo Concussion Treadmill and Bike Tests in People With Mild-to-Moderate Traumatic Brain Injury: An Exploratory Clinical Audit.

OBJECTIVE: To assess the performance on the Buffalo Concussion Treadmill and Bike Tests in nonathletic people following a mild-to-moderate traumatic brain injury. SETTING: An outpatient rehabilitation clinic. PARTICIPANTS: Forty-nine patients with mild-to-moderate traumatic brain injury who underwent the Buffalo Concussion Treadmill or Bike Test as usual clinical care. DESIGN: A retrospective clinical audit. MAIN MEASURES: Demographics and brain injury-specific clinical data, Depression Anxiety Stress Scale; Rivermead Post-Concussion Symptom Questionnaire, and performance outcomes on the B

Short to midterm outcomes of one hundred and seventy one MoPyC radial head prostheses: meta-analysis.

BACKGROUND: The MoPyC implant is an uncemented long-stemmed radial head prosthesis that obtains primary press-fit fixation via controlled expansion of the stem. Current literature regarding MoPyC implants appears promising; however, sample sizes in these studies are small. Our primary objective was to evaluate the short- to midterm clinical outcomes of a large sample of the MoPyC prostheses. The secondary objective was to determine the reasons for failure of the MoPyC devices. METHODS: Four electronic databases were queried for literature published between January 2000 and March 2017. Article