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Обоснование 4-month, параллельные, выборочно контролируемые испытания для оценки осуществимости и эффективности дистанционного обучения испаноязычных/латиноязычных лиц с множественным склерозом (FERLA MS).

ИСТОРИЯ ВОПРОСА: Испаноязычные/латиноязычные лица с множественным склерозом (МС) сталкиваются с бóльшим бременем болезней и коморбидностью из-за ограниченного доступа к медицинскому обслуживанию, недостаточной представленности в научных исследованиях и социальных факторов, определяющих состояние здоровья (SDOH). Профессиональная подготовка могла бы способствовать достижению результатов в области здравоохранения, однако в существующих исследованиях, посвященных мерам вмешательства, не представлены испаноязычные/латиноязычные страны. МЕТОДЫ: Мы предлагаем провести технико-экономическое обоснован

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… The study will be undertaken by the Exercise Neuroscience Research Laboratory (ENRL) at the University of Illinois at Chicago (UIC) and conducted using a parallel group RCT design. … The RCT examines the feasibility and efficacy of a remotely delivered exercise training program [ 26 ] compared with an attention/social contact, active control condition (stretching and flexibility) among Hispanics/Latinos with MS residing in the Chicagoland region and nearby communities of Illinois …

Feasibility of a yoga, aerobic and stretching-toning exercise program for adult cancer survivors: the STAYFit trial.

BackgroundThe use of yoga as a mind-body practice has become increasingly popular among clinical populations and older adults who use this practice to manage age and chronic disease-related symptoms. Although yoga continues to gain popularity among practitioners and researchers, pilot studies that examine its feasibility and acceptability, especially among cancer survivors, are limited. Feasibility studies play a critical role in determining whether the target population is likely to engage with larger scale efficacy and effectiveness trials. In this paper we present feasibility and acceptabil

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… The study was approved by the University of Illinois at Urbana Champaign’s Institutional Review Board (IRB# 18,922). All participants signed a written informed consent before completing any study assessments. … Funding This study was funded by the Office of the Vice Chancellor for Research, Campus Research Board Award RB#18107, University of Illinois at Urbana Champaign. …

Military Service Members with Major Lower Extremity Fractures Return to Running with a Passive-dynamic Ankle-foot Orthosis: Comparison with a Normative Population.

BACKGROUND: Lower extremity fractures represent a high percentage of reported injuries in the United States military and can devastate a ser … of 15 seconds (13 to 20) versus 13 seconds (10 to 14) (median difference 2 seconds; p < 0.001), and Illinois Agility Test result of 22 seconds (20 to 25) versus 18 seconds (16 to 20) (median difference 4; p < 0.001). Edgren side step test result of 20 meters (16 to 26) versus 24 meters (16 to 29) (median difference 4 meters; p = 0.11) and the Four Square S …

The Persistence of Stigma and Other Challenges Experienced by Medical Cannabis Users: A Thematic Synthesis of Qualitative Studies.

BackgroundThe legislation, practices, and guidance shaping patient and professional access to medical cannabis (MC) for managing chronic pain and other conditions vary widely across jurisdictions. Despite promising evidence of effectiveness, challenges persist for those trying to access or prescribe MC. Little is known about how patients navigate these complex environments. We aimed to understand the evidence related to personal lived experiences associated with using MC for chronic pain and other conditions in negotiating these challenges.SummaryWe used a framework by Thomas and Harden for co

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… ) – max of 5/state 75% college educated Bruce et al. [ 35 ] | To study the experiences of using MC as a substitution for prescription medication for chronic conditions | N = 30 dispensary members | Data collection: not stated | Dispensary members with diagnosed medical conditions eligible for MC in Illinois … | https://doi.org/10.1089/acm.2017.0184 | Stigma only mentioned in Methods “participants were not assessed for use of other MC ingestion methods at screening (other than smoked)” Illinois, USA | >18 years old | Semi-structured telephone interviews | Rheumatoid arthritis ( n = 7), spinal cord disease …

Symptomatic spinal epidural lipomatosis after combined hormonal and steroidal palliative therapy of prostate cancer.

To meet the demand for kidney transplants (KTx), organs are frequently retrieved not only from standard criteria donors (SCD; a donor who is aged <50 years and suffered brain death from any number of causes, such as traumatic injuries or a stroke) but also from expanded criteria donors (any donor aged >60 years or donors aged >50 years with two of the following: A history of high blood pressure, a creatinine serum level ≥1.5 mg/dl or death resulting from a stroke). This comes at the cost of a higher risk of primary non‑function (the permanent hyperkalemia, hyperuremia and fluid overload that r

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… UG | – Rutgers University | Program | Patient-centric immersion | – | 4th-yr UG | – The Ohio State University | Course | Immersion in clinical setting | – | 4th-yr UG | – Tulane University BME Department | Program | Team design enhancement through clinical immersion | – | 4th-yr UG | – University of Illinois … A report on a clinical immersion program at the University of Illinois Chicago showed that alumni of that program do not enter industry or find jobs more quickly than their non-immersed peers. 13 Reports on the downstream impact of clinical immersion for engineering students are rare. …

Use of therapeutic plasma exchange to treat nonsteroidal anti-inflammatory drug overdose in dogs.

BACKGROUND: Therapeutic plasma exchange (TPE) may be an effective technique for treatment of accidental nonsteroidal anti-inflammatory drug (NSAID) overdose, but information regarding the use of this technique in veterinary medicine is currently limited. OBJECTIVES: To evaluate the overall outcome for dogs with NSAID overdose treated with TPE and to determine if any presenting factors can predict or influence overall outcome. Secondary objectives included investigating TPE complications as well as the utility of other adjunctive treatments. ANIMALS: Eleven client-owned dogs presented for NSA

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… Records were reviewed for which adjunctive and supportive treatments the patients received during hospitalization, including the use of activated charcoal (ToxiBan; Lloyd, Inc, Shenandoah, Iowa), induction of emesis, IV lipid infusion (Intralipid; Baxter Healthcare Corp, Deerfield, Illinois), IV fluids … from the TPE records including time elapsed between toxin ingestion and start of the session, duration of the session, total volume of plasma replaced, number of patient plasma volumes exchanged, ACT results during the treatment, amount of heparin (Heparin Sodium; Sagent Pharmaceuticals, Schaumburg, Illinois …

Environmental and behavioural interventions for reducing physical activity limitation and preventing falls in older people with visual impairment.

BACKGROUND: Impairment of vision is associated with a decrease in activities of daily living. Avoidance of physical activity in older adults … e). Three trials assessed the fear of falling using Short Falls Efficacy Scale-International or the Illinois Fear of Falling Measure from two to 12 months, and found no evidence of a difference in mean estimates between groups (the estimates ranged from -0.88 score (95% CI -2.72 to 0.96, 114 participants) to 1.00 score (95% CI -0.13 to 2.13; 59 participant …

Cost-Effectiveness of a National Sugar-Sweetened Beverage Tax to Reduce Cancer Burdens and Disparities in the United States.

BackgroundSugar-sweetened beverage (SSB) consumption contributes to obesity, a risk factor for 13 cancers. Although SSB taxes can reduce intake, the health and economic impact on reducing cancer burdens in the United States are unknown, especially among low-income Americans with higher SSB intake and obesity-related cancer burdens.MethodsWe used the Diet and Cancer Outcome Model, a probabilistic cohort state-transition model, to project health gains and economic benefits of a penny-per-ounce national SSB tax on reducing obesity-associated cancers among US adults aged 20 years and older by inco

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… We used empirical estimates synthesized from reported changes in SSB volume sold after SSB tax implemented in Philadelphia, Pennsylvania; Cook County, Illinois; and Seattle, Washington, as the policy effect (-11.4%) ( Supplementary Methods , available online). … The most recent publications on SSB taxes reported a 21% reduction in SSB sales after implementing a penny-per-ounce tax in Cook County, Illinois, and a 22% reduction in SSB sales after implementing a 1.75 cents-per-ounce tax in Seattle, Washington ( 53 ). …

Упорное использование опиоидов связано с более коротким выживанием миэломы.

Цель &quot; Превышение &quot; содержания опиоидов связана со значительным кризисом в области общественного здравоохранения, однако по-прежнему имеет решающее значение в качестве адъюнкт-процесса лечения во многих миеломах (ММ). Остаются вопросы о балансе между выгодами от продолжающегося использования опиоидов, особенно когда миэлома пациента находится в ремиссии. Этот ретроспективный обзор посвящен ассоциации хронического опиоида (COU) среди пациентов, преимущественно цветных. 174 В одном из городских медицинских центров были изучены пациенты, получившие аутологическую трансплантацию стволовы

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… The electronic medical record was queried to obtain active opioid prescription fill data; however, the Illinois Prescription Drug Monitoring Program (PDMP) could also have been used to capture other data including the number of prescribers and pharmacies associated with opioid prescribing. … We consulted with the IRB of University of Illinois who determined that our study did not need ethical approval. An IRB official waiver of ethical approval was granted from the IRB of University of Illinois. Competing interests The authors declare no competing interests. …

Case report: CD8 positive T-cell Prolymphocytic Leukemia presenting complex karyotype with a rare chromosomal abnormality der(2)t(1;2)(q21;q37) and additional signals of the genes MYC, IGH, and TP53.

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… The panel utilized was the Vysis CLL FISH probe (Vysis: REF: 04N02-022; Abbott Molecular: Illinois, USA), with four probes: LSI ATM (11q22.3) spectrum green, LSI TP53 (17p13.1), spectrum red, CEP12 (12p11.1-q11) spectrum green, LSI D13S319 (13q14.3) spectrum red and LSI 13q34, spectrum aqua. … Besides this panel, the LSI IGH Dual Color, Break Apart Rearrangement Probe (Vysis: REF: 08L63-020 Abbott Molecular: Illinois, EUA), LSI MYC Break Apart Probe (Cytocell: REF:LPH010), AML1::ETO (RUNX1::RUNX1T1) Translocation, Dual Fusion (Cytocell:REF: CE-LPH 026, and the PML::RARA, Translocation, Dual …

Переоценка желудочно-кишечного метаногенного археома в множестве склероза и его связь с лечением.

Роль кишечного археиального микробиома (архема) в здравоохранении и болезнях по-прежнему недостаточно понятна. Метаногенные археи были связаны с множественным склерозом (МС), однако предыдущие исследования ограничивались небольшими группами и непоследовательными методологиями. Для решения этой проблемы мы провели переоценку связи между метаногенными археями и MS с использованием метагеномических данных Международного исследования множественного склероза микробиома. Мы проанализировали микробиомные профили по 115 пациентам с НР и 115 здоровым домашним хозяйствам в Буэнос-Айресе (27,8 процента),

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… Jennings, University of Illinois Urbana-Champaign, Urbana, Illinois, USA DATA AVAILABILITY Data and scripts that support our findings are available in our GitHub Repository https://github.com/YipHoChan/MS . …

From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.

Cancer drug discovery is an inefficient process, with more than 90% of newly-discovered therapies failing to gain regulatory approval. Patient-derived models of cancer offer a promising new approach to identify new treatments; however, for rare cancers, such as sarcomas, access to patient samples is limited, which precludes development of patient-derived models. To address the limited access to patient samples, we have turned to pet dogs with naturally-occurring sarcomas. Although sarcomas make up <1% of all human cancers, sarcomas represent 15% of cancers in dogs. Because dogs have similar im

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… Teddy was then referred to the Small Animal Oncology team at the University of Illinois at Urbana-Champaign for evaluation of his known leiomyosarcoma and treatment of an additional mass near the stifle. This tumor was excised and scars of the resected tumors were excised. … We would like to thank Teddy and his family for their participation in this study and the veterinary team at the University of Illinois at Urbana–Champaign for contributing to Teddy's clinical care. …

Assisted Reproductive Technology Surveillance - United States, 2018.

PROBLEM/CONDITION: Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, both the use of ART a … 135 per 1 million women. ART use exceeded 1.5 times the national rate in seven states (Connecticut, Illinois, Maryland, Massachusetts, New Jersey, New York, and Rhode Island) and the District of Columbia. ART use rates exceeded the national rate in an additional seven states (California, Delaware, Hawaii, New Hampshire, Utah, Vermont, and Virginia). Nation …

Снижение уровня эстрогена лимфатического узла вызывает неиспускающее заболевание аутоиммунной энцефаломиелита.

Эстроген, стероидный гормон, синтезированный как гонадальными, так и негональными тканями, играет ключевую роль в модуляции иммунной реакции, включая снижение частоты рецидивов при повторном излучающем многократном склерозе (МС). В этом исследовании изучалось выражение ароматазы, фермента, ответственного за синтез эстрогенов, в лимфатических узлах (ЛН) и его потенциальная роль в патогенезе MS с использованием модели мыши. Мы использовали мыши Cyp19-RFP, где клетки, которые выражают или ранее выражали ген Cyp19 (кодирование ароматазы), обозначаются красным флуоресцентным белком (RFP). RPF был о

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… All the mice were group-housed (3–5 mice per cage) in a specific pathogen-free facility with a 12-h light–dark cycle in the Veterinary Medicine Basic Sciences Building at the University of Illinois at Urbana-Champaign, Urbana, IL, USA. Diet and water were provided ad libitum. … All mouse experiments were approved by the University of Illinois Animal Care and Usage Committee (IACUC) under protocol number 22140. Reagents Recombinant IFN-β used in EAE treatment is human recombinant IFN-β-1b (Betaseron, Bayer HealthCare Pharmaceuticals), as previously reported ( 39 , 40 ). …

ICIMH 2022 Abstracts

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… Rai 1 , Abigail Herbst 1 , Reagan Mozer 3 , Rodger Kingston 4 , and Barbara Bokhour 1 1 Center for Healthcare Organization & Implementation Research, VA Bedford Healthcare System, Bedford, Massachusetts, United States 2 Center of Innovation for Complex Chronic Healthcare, Hines VA Hospital, Hines, Illinois …

Surveillance for Violent Deaths - National Violent Death Reporting System, 32 States, 2016.

PROBLEM/CONDITION: In 2016, approximately 65,000 persons died in the United States as a result of violence-related injuries. This report sum … es data collected from 32 states for 2016 (Alaska, Arizona, Colorado, Connecticut, Georgia, Hawaii, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Utah, Vermont, Virginia, Wash …

The Impact of an Embedded Oncology Pharmacist in an Outpatient Oncology Center in the Treatment of Hematologic Malignancies.

BackgroundThe growing demand for clinicians in the ambulatory oncology setting to reduce fragmentation of care and improve patient outcomes represents a need for oncology pharmacists as advanced practitioners in the provision of direct patient-centered care. These provisions can include supportive care management, drug-drug interaction evaluation, and selection of appropriate chemotherapy regimens to reduce physician workload in a cost-effective manner, while increasing physician and patient satisfaction. However, robust data are currently lacking to support the impact of pharmacists in the am

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… METHODS Northwestern Medicine Delnor Cancer Center is an outpatient cancer center located on the campus of Northwestern Medicine Delnor Hospital in Geneva, Illinois. … Based on the results of this pilot, NMDCC is progressing toward an expansion of ambulatory oncology pharmacy services, including the development of a formal collaborative practice agreement given that pharmacists in Illinois do not have prescriber status and pharmacists at NMDCC did not use any institutional …

Real-World Evaluation of Talquetamab for the Treatment of Relapsed/Refractory Multiple Myeloma (RRMM): An International Myeloma Working Group Immunotherapy Registry Real-World Analysis.

Talquetamab is a GPRC5D × CD3 bispecific antibody approved for relapsed/refractory multiple myeloma (RRMM). This is the first real-world study to comprehensively report muco-cutaneous toxicities, infections, and efficacy of talquetamab in 151 patients across five countries with the longest follow-up reported enabling better efficacy and toxicity estimates. The median age was 64 years; high-risk cytogenetics were present in 42%; ECOG ≥ 2 in 22%; 12% had creatinine clearance < 30; and 55% would not have met MonumenTAL-1 eligibility. Patients received a median of 6 prior lines of therapy, 53% wer

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… UNITED KINGDOM Luciano Costa, University of Alabama at Birmingham, Birmingham, Alabama, USA Andrew Cowan, Fred Hutchinson Cancer Center, Seattle, Washington, USA Carlos Fernández de Larrea, Hospital Clínic de Barcelona, Barcelona, SPAIN Benjamin Derman, The University of Chicago Medicine, Chicago, Illinois … Jakubowiak, University of Chicago, Chicago, Illinois, USA Murali Janakiram, City of Hope Medical Center, Newport Beach, California, USA Prashant Kapoor, Mayo Clinic, Rochester, Minnesota, USA Efstathios Kastritis, National and Kapodistrian University of Athens School of Medicine, Athens, GREECE Jonathan …

Position paper by the UKCCCR elderly cancer patients in clinical trials working group.

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… B. 3rd Treatment tolerance of elderly cancer patients entered onto phase II clinical trials: an Illinois Cancer Center study. 12 11 11 1994 2447 2452 J Clin Oncol 7964962 10.1200/JCO.1994.12.11.2447 Goodwin J. S. Samet J. M. Hunt W. C. …